3kuq - Revision history

OCA at 08:24, 6 September 2023

OCA — Wed, 06 Sep 2023 08:24:08 GMT

←Older revision		Revision as of 08:24, 6 September 2023
Line 1:		Line 1:

	==Crystal structure of the DLC1 RhoGAP domain==		==Crystal structure of the DLC1 RhoGAP domain==
-	<StructureSection load='3kuq' size='340' side='right' caption='[[3kuq]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3kuq' size='340' side='right'caption='[[3kuq]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kuq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KUQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kuq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KUQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~DLC1, ARHGAP7, KIAA1723, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuq OCA], [~~http~~://pdbe.org/3kuq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kuq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kuq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kuq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuq OCA], [https://pdbe.org/3kuq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kuq RCSB], [https://www.ebi.ac.uk/pdbsum/3kuq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kuq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN]] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>	+	[https://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/3kuq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/3kuq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kuq ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kuq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Rho GTPase activating protein 3D structures\|Rho GTPase activating protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Large Structures]]
-	[[Category: Bochkarev, A]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bochkarev A]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Bountra C]]
-	[[Category: MacKenzie, F]]	+	[[Category: Edwards AM]]
-	[[Category: Nedyalkova, L]]	+	[[Category: MacKenzie F]]
-	[[Category: Park, H]]	+	[[Category: Nedyalkova L]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Park H]]
-	[[Category: Shen, L]]	+	[[Category: Shen L]]
-	[[Category: Tempel, W]]	+	[[Category: Tempel W]]
-	[[Category: Tong, Y]]	+	[[Category: Tong Y]]
-	[[Category: Weigelt, J]]	+	[[Category: Weigelt J]]
-	[[Category: Zhong, N]]	+	[[Category: Zhong N]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Gtpase activation]]~~	+
-	~~[[Category: Hydrolase activator]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 08:42, 1 November 2017

OCA — Wed, 01 Nov 2017 08:42:13 GMT

←Older revision		Revision as of 08:42, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of the DLC1 RhoGAP domain==		==Crystal structure of the DLC1 RhoGAP domain==
	<StructureSection load='3kuq' size='340' side='right' caption='[[3kuq]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3kuq' size='340' side='right' caption='[[3kuq]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DLC1, ARHGAP7, KIAA1723, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DLC1, ARHGAP7, KIAA1723, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuq OCA], [http://pdbe.org/3kuq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kuq RCSB], [http://www.ebi.ac.uk/pdbsum/3kuq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuq OCA], [http://pdbe.org/3kuq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kuq RCSB], [http://www.ebi.ac.uk/pdbsum/3kuq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kuq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 37:		Line 38:
	[[Category: Weigelt, J]]		[[Category: Weigelt, J]]
	[[Category: Zhong, N]]		[[Category: Zhong, N]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cytoplasm]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]
	[[Category: Hydrolase activator]]		[[Category: Hydrolase activator]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Sgc]]		[[Category: Sgc]]

OCA at 12:03, 7 February 2016

OCA — Sun, 07 Feb 2016 12:03:00 GMT

←Older revision		Revision as of 12:03, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3kuq' size='340' side='right' caption='[[3kuq]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3kuq' size='340' side='right' caption='[[3kuq]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kuq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KUQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kuq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KUQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DLC1, ARHGAP7, KIAA1723, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DLC1, ARHGAP7, KIAA1723, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kuq RCSB], [http://www.ebi.ac.uk/pdbsum/3kuq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuq OCA], [http://pdbe.org/3kuq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kuq RCSB], [http://www.ebi.ac.uk/pdbsum/3kuq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kuq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bochkarev, A]]		[[Category: Bochkarev, A]]

OCA at 14:56, 24 December 2014

OCA — Wed, 24 Dec 2014 14:56:05 GMT

←Older revision		Revision as of 14:56, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kuq RCSB], [http://www.ebi.ac.uk/pdbsum/3kuq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kuq RCSB], [http://www.ebi.ac.uk/pdbsum/3kuq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN]] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:43, 18 December 2014

OCA — Thu, 18 Dec 2014 15:43:33 GMT

←Older revision		Revision as of 15:43, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3kuq\| PDB=3kuq \| SCENE= }}~~	+	==Crystal structure of the DLC1 RhoGAP domain==
-	===Crystal structure of the DLC1 RhoGAP domain===	+	<StructureSection load='3kuq' size='340' side='right' caption='[[3kuq]], [[Resolution\|resolution]] 2.30Å' scene=''>
-		+	== Structural highlights ==
-	==~~Function~~==	+	<table><tr><td colspan='2'>[[3kuq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KUQ FirstGlance]. <br>
-	[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~RHG07_HUMAN RHG07_HUMAN~~]] ~~Functions as~~ a ~~GTPase-activating protein for~~ the ~~small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling~~. ~~This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation~~. ~~Also functions in vivo as an activator of the phospholipase PLCD1~~. ~~Active DLC1 increases cell migration velocity but reduces directionality~~.<~~ref~~>~~PMID:18786931~~</~~ref~~> <~~ref~~>~~PMID~~:~~19170769~~</~~ref~~> <~~ref~~>~~PMID~~:~~19710422~~</~~ref~~>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DLC1, ARHGAP7, KIAA1723, STARD12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==~~About this Structure==~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kuq RCSB], [http://www.ebi.ac.uk/pdbsum/3kuq PDBsum]</span></td></tr>
-	[[~~3kuq~~]] ~~is a 1 chain structure with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki~~/~~Homo_sapiens~~ Homo sapiens]. ~~Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~3KUQ~~ OCA].	+	</table>
-		+	== Evolutionary Conservation ==
-	==~~Reference~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	<~~references group~~="~~xtra~~"/><~~references~~/>	+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/3kuq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: MacKenzie, F.]]	+	[[Category: MacKenzie, F]]
-	[[Category: Nedyalkova, L.]]	+	[[Category: Nedyalkova, L]]
-	[[Category: Park, H.]]	+	[[Category: Park, H]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Shen, L.]]	+	[[Category: Shen, L]]
-	[[Category: Tempel, W.]]	+	[[Category: Tempel, W]]
-	[[Category: Tong, Y.]]	+	[[Category: Tong, Y]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Zhong, N.]]	+	[[Category: Zhong, N]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]
	[[Category: Hydrolase activator]]		[[Category: Hydrolase activator]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomics consortium]]

OCA: Protected "3kuq" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 20:47:27 GMT

Protected "3kuq" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:47, 4 April 2013

OCA at 20:47, 4 April 2013

OCA — Thu, 04 Apr 2013 20:47:13 GMT

←Older revision		Revision as of 20:47, 4 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3kuq.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kuq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kuq\| PDB=3kuq \| SCENE= }}		{{STRUCTURE_3kuq\| PDB=3kuq \| SCENE= }}
-
	===Crystal structure of the DLC1 RhoGAP domain===		===Crystal structure of the DLC1 RhoGAP domain===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN]] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>

	==About this Structure==		==About this Structure==
-	~~3KUQ~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUQ OCA].	+	[[3kuq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUQ OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 29:		Line 24:
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
	[[Category: Zhong, N.]]		[[Category: Zhong, N.]]
-	[[Category: Alternative splicing]]
-	[[Category: Cytoplasm]]
	[[Category: Gtpase activation]]		[[Category: Gtpase activation]]
		+	[[Category: Hydrolase activator]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 20:05:26 2010''

OCA at 18:05, 27 January 2010

OCA — Wed, 27 Jan 2010 18:05:26 GMT

←Older revision		Revision as of 18:05, 27 January 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kuq.jpg\|left\|200px]]

-	The ~~entry 3kuq~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kuq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kuq\| PDB=3kuq \| SCENE= }}

-	Authors: Nedyalkova, L., Tempel, W., Tong, Y., MacKenzie, F., Shen, L., Zhong, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)	+	===Crystal structure of the DLC1 RhoGAP domain===

-	Description: Crystal structure of the DLC1 RhoGAP domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 9 14~~:44:~~50 2009~~''	+	==About this Structure==
		+	3KUQ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUQ OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bochkarev, A.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: MacKenzie, F.]]
		+	[[Category: Nedyalkova, L.]]
		+	[[Category: Park, H.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Shen, L.]]
		+	[[Category: Tempel, W.]]
		+	[[Category: Tong, Y.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Zhong, N.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Gtpase activation]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomics consortium]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 20:05:26 2010''

OCA: New page: '''Unreleased structure''' The entry 3kuq is ON HOLD Authors: Nedyalkova, L., Tempel, W., Tong, Y., MacKenzie, F., Shen, L., Zhong, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Wei...

OCA — Wed, 09 Dec 2009 12:44:50 GMT

New page: '''Unreleased structure''' The entry 3kuq is ON HOLD Authors: Nedyalkova, L., Tempel, W., Tong, Y., MacKenzie, F., Shen, L., Zhong, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Wei...

New page

'''Unreleased structure'''

The entry 3kuq is ON HOLD

Authors: Nedyalkova, L., Tempel, W., Tong, Y., MacKenzie, F., Shen, L., Zhong, N., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)

Description: Crystal structure of the DLC1 RhoGAP domain

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 9 14:44:50 2009''