3kvj - Revision history

OCA at 08:24, 6 September 2023

OCA — Wed, 06 Sep 2023 08:24:58 GMT

←Older revision		Revision as of 08:24, 6 September 2023
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	==Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution==		==Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution==
-	<StructureSection load='3kvj' size='340' side='right' caption='[[3kvj]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='3kvj' size='340' side='right'caption='[[3kvj]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kvj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KVJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kvj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KVJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1X5:2-[(CYCLOPROPYLCARBONYL)AMINO]-5-[METHYL(PYRIDIN-3-YLMETHYL)AMINO]BENZOIC+ACID'>1X5</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DET:UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DET</scene>, <scene name='pdbligand=DOR:(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>DOR</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.94Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kvk\|3kvk]], [[3kvl\|3kvl]], [[3kvm\|3kvm]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1X5:2-[(CYCLOPROPYLCARBONYL)AMINO]-5-[METHYL(PYRIDIN-3-YLMETHYL)AMINO]BENZOIC+ACID'>1X5</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DET:UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DET</scene>, <scene name='pdbligand=DOR:(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>DOR</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kvj OCA], [https://pdbe.org/3kvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kvj RCSB], [https://www.ebi.ac.uk/pdbsum/3kvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kvj ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kvj OCA], [~~http~~://pdbe.org/3kvj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kvj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kvj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kvj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[~~http~~://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>	+	[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.	+	[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/3kvj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/3kvj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3kvj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kvj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydroorotate dehydrogenase 3D structures\|Dihydroorotate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~McLean, L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Zhang, Y~~]]	+	[[Category: McLean L]]
-	[[Category: ~~Flavoprotein]]~~	+	[[Category: Zhang Y]]
-	~~[[Category: Fmn]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Mitochondrion]]~~	+
-	~~[[Category: Mitochondrion inner membrane]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Protein-antiproliferative agent complex]]~~	+
-	~~[[Category: Pyrimidine biosynthesis]]~~	+
-	~~[[Category: Transit peptide]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 08:42, 1 November 2017

OCA — Wed, 01 Nov 2017 08:42:35 GMT

←Older revision		Revision as of 08:42, 1 November 2017
Line 33:		Line 33:
	</div>		</div>
	<div class="pdbe-citations 3kvj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kvj" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
Line 49:		Line 46:
	[[Category: Mitochondrion inner membrane]]		[[Category: Mitochondrion inner membrane]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
		+	[[Category: Polymorphism]]
	[[Category: Protein-antiproliferative agent complex]]		[[Category: Protein-antiproliferative agent complex]]
	[[Category: Pyrimidine biosynthesis]]		[[Category: Pyrimidine biosynthesis]]
	[[Category: Transit peptide]]		[[Category: Transit peptide]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

OCA at 14:13, 5 August 2016

OCA — Fri, 05 Aug 2016 14:13:26 GMT

←Older revision		Revision as of 14:13, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution==		==Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution==
	<StructureSection load='3kvj' size='340' side='right' caption='[[3kvj]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='3kvj' size='340' side='right' caption='[[3kvj]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kvj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KVJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kvj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KVJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1X5:2-[(CYCLOPROPYLCARBONYL)AMINO]-5-[METHYL(PYRIDIN-3-YLMETHYL)AMINO]BENZOIC+ACID'>1X5</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DET:UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DET</scene>, <scene name='pdbligand=DOR:(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>DOR</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1X5:2-[(CYCLOPROPYLCARBONYL)AMINO]-5-[METHYL(PYRIDIN-3-YLMETHYL)AMINO]BENZOIC+ACID'>1X5</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DET:UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DET</scene>, <scene name='pdbligand=DOR:(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>DOR</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kvk\|3kvk]], [[3kvl\|3kvl]], [[3kvm\|3kvm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kvk\|3kvk]], [[3kvl\|3kvl]], [[3kvm\|3kvm]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Dihydroorotate_dehydrogenase~~ Dihydroorotate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kvj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kvj RCSB], [http://www.ebi.ac.uk/pdbsum/3kvj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kvj OCA], [http://pdbe.org/3kvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kvj RCSB], [http://www.ebi.ac.uk/pdbsum/3kvj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kvj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kvj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kvj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 40:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydroorotate dehydrogenase]]~~	+	[[Category: Human]]
-	~~[[Category: Homo sapiens~~]]	+
	[[Category: McLean, L]]		[[Category: McLean, L]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]

OCA at 15:44, 18 December 2014

OCA — Thu, 18 Dec 2014 15:44:16 GMT

←Older revision		Revision as of 15:44, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3kvj\| PDB=3kvj \| SCENE= }}~~	+	==Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution==
-	===Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution===	+	<StructureSection load='3kvj' size='340' side='right' caption='[[3kvj]], [[Resolution\|resolution]] 1.94Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20153645}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kvj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KVJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1X5:2-[(CYCLOPROPYLCARBONYL)AMINO]-5-[METHYL(PYRIDIN-3-YLMETHYL)AMINO]BENZOIC+ACID'>1X5</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DET:UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DET</scene>, <scene name='pdbligand=DOR:(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>DOR</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kvk\|3kvk]], [[3kvl\|3kvl]], [[3kvm\|3kvm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHODH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase Dihydroorotate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kvj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kvj RCSB], [http://www.ebi.ac.uk/pdbsum/3kvj PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/3kvj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Amino-benzoic acid derivatives 1-4 were found to be inhibitors for DHODH by virtual screening, biochemical, and X-ray crystallographic studies. X-ray structures showed that 1 and 2 bind to DHODH as predicted by virtual screening, but 3 and 4 were found to be structurally different from the corresponding compounds initially identified by virtual screening.

-	~~==Disease==~~	+	Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures.,McLean LR, Zhang Y, Degnen W, Peppard J, Cabel D, Zou C, Tsay JT, Subramaniam A, Vaz RJ, Li Y Bioorg Med Chem Lett. 2010 Mar 15;20(6):1981-4. Epub 2010 Jan 25. PMID:20153645<ref>PMID:20153645</ref>
-	~~[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in~~ DHODH ~~are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim~~.~~org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia~~, ~~cleft lip and/or palate~~, ~~hypoplasia or aplasia of the posterior elements of the limbs~~, ~~coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families~~, ~~each consisting of 2 affected siblings born to unaffected~~, ~~nonconsanguineous parents~~, ~~have been described among a total of around 30 reported cases~~.<ref>PMID:~~19915526~~</ref>	+
-		+
-	~~==Function==~~	+
-	~~[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3kvj]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3KVJ OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:020153645</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Dihydroorotate dehydrogenase]]		[[Category: Dihydroorotate dehydrogenase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: McLean, L.]]	+	[[Category: McLean, L]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Flavoprotein]]		[[Category: Flavoprotein]]
	[[Category: Fmn]]		[[Category: Fmn]]

OCA: Protected "3kvj" [edit=sysop:move=sysop]

OCA — Sun, 24 Mar 2013 23:42:21 GMT

Protected "3kvj" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:42, 24 March 2013

OCA at 23:42, 24 March 2013

OCA — Sun, 24 Mar 2013 23:42:19 GMT

←Older revision		Revision as of 23:42, 24 March 2013
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-	{{Seed}}
-	[[Image:3kvj.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kvj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kvj\| PDB=3kvj \| SCENE= }}		{{STRUCTURE_3kvj\| PDB=3kvj \| SCENE= }}
-
	===Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution===		===Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution===
		+	{{ABSTRACT_PUBMED_20153645}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20153645}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20153645 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_20153645}}~~	+

	==About this Structure==		==About this Structure==
-	~~3KVJ~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVJ OCA].	+	[[3kvj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVJ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20153645~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020153645</ref><references group="xtra"/><references/>
	[[Category: Dihydroorotate dehydrogenase]]		[[Category: Dihydroorotate dehydrogenase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
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	[[Category: Mitochondrion inner membrane]]		[[Category: Mitochondrion inner membrane]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Polymorphism]]
	[[Category: Protein-antiproliferative agent complex]]		[[Category: Protein-antiproliferative agent complex]]
	[[Category: Pyrimidine biosynthesis]]		[[Category: Pyrimidine biosynthesis]]
	[[Category: Transit peptide]]		[[Category: Transit peptide]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 15:21:56 2010''

OCA at 13:21, 10 March 2010

OCA — Wed, 10 Mar 2010 13:21:57 GMT

←Older revision		Revision as of 13:21, 10 March 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3kvj.~~jpg~~\|left\|200px]]	+	[[Image:3kvj.png\|left\|200px]]

	<!--		<!--
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	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar ~~3 16~~:44:45 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 15:21:56 2010''

OCA at 14:44, 3 March 2010

OCA — Wed, 03 Mar 2010 14:44:47 GMT

←Older revision		Revision as of 14:44, 3 March 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kvj.jpg\|left\|200px]]

-	The ~~entry 3kvj~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kvj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kvj\| PDB=3kvj \| SCENE= }}

-	~~Authors: McLean, L., Zhang, Y~~.	+	===Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution===

-	Description: Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec~~ 16 12:37:~~26 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20153645}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20153645 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20153645}}
		+
		+	==About this Structure==
		+	3KVJ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20153645</ref><references group="xtra"/>
		+	[[Category: Dihydroorotate dehydrogenase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: McLean, L.]]
		+	[[Category: Zhang, Y.]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Fmn]]
		+	[[Category: Membrane]]
		+	[[Category: Mitochondrion]]
		+	[[Category: Mitochondrion inner membrane]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Polymorphism]]
		+	[[Category: Protein-antiproliferative agent complex]]
		+	[[Category: Pyrimidine biosynthesis]]
		+	[[Category: Transit peptide]]
		+	[[Category: Transmembrane]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 16:44:45 2010''

OCA at 10:37, 16 December 2009

OCA — Wed, 16 Dec 2009 10:37:27 GMT

←Older revision		Revision as of 10:37, 16 December 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3kvj is ON HOLD	+	The entry 3kvj is ON HOLD until Paper Publication

-	Authors: L.~~MCLEAN~~, Y.~~ZHANG~~	+	Authors: McLean, L., Zhang, Y.

	Description: Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution		Description: Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec ~~9 14~~:45:08 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 12:37:26 2009''

OCA: New page: '''Unreleased structure''' The entry 3kvj is ON HOLD Authors: L.MCLEAN, Y.ZHANG Description: Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inh...

OCA — Wed, 09 Dec 2009 12:45:08 GMT

New page: '''Unreleased structure''' The entry 3kvj is ON HOLD Authors: L.MCLEAN, Y.ZHANG Description: Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inh...

New page

'''Unreleased structure'''

The entry 3kvj is ON HOLD

Authors: L.MCLEAN, Y.ZHANG

Description: Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 9 14:45:08 2009''