3kxu - Revision history

OCA at 16:18, 1 November 2023

OCA — Wed, 01 Nov 2023 16:18:20 GMT

←Older revision		Revision as of 16:18, 1 November 2023
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	==Crystal structure of human ferritin FTL498InsTC pathogenic mutant==		==Crystal structure of human ferritin FTL498InsTC pathogenic mutant==
-	<StructureSection load='3kxu' size='340' side='right' caption='[[3kxu]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='3kxu' size='340' side='right'caption='[[3kxu]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kxu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KXU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CD:CADMIUM+ION'>CD</scene~~>, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~FTL ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kxu OCA], [~~http~~://pdbe.org/3kxu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kxu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kxu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kxu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kxu OCA], [https://pdbe.org/3kxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kxu RCSB], [https://www.ebi.ac.uk/pdbsum/3kxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kxu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN] Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:[https://omim.org/entry/600886 600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.<ref>PMID:20159981</ref> Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:[https://omim.org/entry/606159 606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.<ref>PMID:20159981</ref> <ref>PMID:16116125</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~Q6S4P3_HUMAN Q6S4P3_HUMAN]~~] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis (By similarity).~~[RuleBase~~:~~RU000622]~~	+	[https://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).<ref>PMID:19923220</ref> <ref>PMID:20159981</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Ferritin\|Ferritin]]	+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Arosio, P~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Estaintot, B Langlois d~~]]	+	[[Category: Arosio P]]
-	[[Category: Gallois, B]]	+	[[Category: Gallois B]]
-	[[Category: Granier, T]]	+	[[Category: Granier T]]
-	[[Category: ~~Disorder]]~~	+	[[Category: Langlois d'Estaintot B]]
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Iron storage protein]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 07:12, 2 January 2019

OCA — Wed, 02 Jan 2019 07:12:47 GMT

←Older revision		Revision as of 07:12, 2 January 2019
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		+
	==Crystal structure of human ferritin FTL498InsTC pathogenic mutant==		==Crystal structure of human ferritin FTL498InsTC pathogenic mutant==
	<StructureSection load='3kxu' size='340' side='right' caption='[[3kxu]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='3kxu' size='340' side='right' caption='[[3kxu]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kxu OCA], [http://pdbe.org/3kxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kxu RCSB], [http://www.ebi.ac.uk/pdbsum/3kxu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kxu OCA], [http://pdbe.org/3kxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kxu RCSB], [http://www.ebi.ac.uk/pdbsum/3kxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kxu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/3kxu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/3kxu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:48, 9 February 2016

OCA — Tue, 09 Feb 2016 22:48:27 GMT

←Older revision		Revision as of 22:48, 9 February 2016
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	<StructureSection load='3kxu' size='340' side='right' caption='[[3kxu]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='3kxu' size='340' side='right' caption='[[3kxu]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kxu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kxu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KXU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kxu RCSB], [http://www.ebi.ac.uk/pdbsum/3kxu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kxu OCA], [http://pdbe.org/3kxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kxu RCSB], [http://www.ebi.ac.uk/pdbsum/3kxu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kxu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kxu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arosio, P]]		[[Category: Arosio, P]]
	[[Category: Estaintot, B Langlois d]]		[[Category: Estaintot, B Langlois d]]

OCA at 10:04, 25 December 2014

OCA — Thu, 25 Dec 2014 10:04:28 GMT

←Older revision		Revision as of 10:04, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kxu RCSB], [http://www.ebi.ac.uk/pdbsum/3kxu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kxu RCSB], [http://www.ebi.ac.uk/pdbsum/3kxu PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q6S4P3_HUMAN Q6S4P3_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis (By similarity).[RuleBase:RU000622]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:24, 18 December 2014

OCA — Thu, 18 Dec 2014 16:24:50 GMT

←Older revision		Revision as of 16:24, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3kxu~~\| ~~PDB~~=3kxu \| ~~SCENE~~= }}	+	==Crystal structure of human ferritin FTL498InsTC pathogenic mutant==
-	===~~Crystal~~ structure of ~~human ferritin FTL498InsTC pathogenic mutant~~===	+	<StructureSection load='3kxu' size='340' side='right' caption='[[3kxu]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20159981}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kxu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KXU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kxu RCSB], [http://www.ebi.ac.uk/pdbsum/3kxu PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/3kxu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nucleotide insertions that modify the C terminus of ferritin light chain (FTL) cause neurodegenerative movement disorders named neuroferritinopathies, which are inherited with dominant transmission. The disorders are characterized by abnormal brain iron accumulation. Here we describe the biochemical and crystallographic characterization of pathogenic FTL mutant p.Phe167SerfsX26 showing that it is a functional ferritin with an altered conformation of the C terminus. Moreover we analyze functional and stability properties of ferritin heteropolymers made of 20-23 H-chains and 1-4 L-chains with representative pathogenic mutations or the last 10-28 residues truncated. All the heteropolymers containing the pathogenic or truncated mutants had a strongly reduced capacity to incorporate iron, both when expressed in Escherichia coli, and in vitro when iron was supplied as Fe(III) in the presence of ascorbate. The mutations also reduced the physical stability of the heteropolymers. The data indicate that even a few mutated L-chains are sufficient to alter the permeability of 1-2 of the 6 hydrophobic channels and modify ferritin capacity to incorporate iron. The dominant-negative action of the mutations explains the dominant transmission of the disorder. The data support the hypothesis that hereditary ferritinopathies are due to alterations of ferritin functionality and provide new input on the mechanism of the function of isoferritins.

-	~~==Function==~~	+	Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation.,Luscieti S, Santambrogio P, Langlois d'Estaintot B, Granier T, Cozzi A, Poli M, Gallois B, Finazzi D, Cattaneo A, Levi S, Arosio P J Biol Chem. 2010 Apr 16;285(16):11948-57. Epub 2010 Feb 16. PMID:20159981<ref>PMID:20159981</ref>
-	~~[[http://www.uniprot.org/uniprot/Q6S4P3_HUMAN Q6S4P3_HUMAN]] Stores iron~~ in a ~~soluble, non~~-~~toxic~~, ~~readily available form~~. ~~Important for iron homeostasis~~ (~~By similarity~~).~~[RuleBase~~:~~RU000622]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3kxu]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3KXU OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Ferritin\|Ferritin]]		*[[Ferritin\|Ferritin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020159981</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arosio, P.]]	+	[[Category: Arosio, P]]
-	[[Category: Estaintot, B Langlois d.]]	+	[[Category: Estaintot, B Langlois d]]
-	[[Category: Gallois, B.]]	+	[[Category: Gallois, B]]
-	[[Category: Granier, T.]]	+	[[Category: Granier, T]]
	[[Category: Disorder]]		[[Category: Disorder]]
	[[Category: Iron]]		[[Category: Iron]]
	[[Category: Iron storage protein]]		[[Category: Iron storage protein]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 20:11, 24 March 2013

OCA — Sun, 24 Mar 2013 20:11:35 GMT

←Older revision		Revision as of 20:11, 24 March 2013
Line 1:		Line 1:
-	[[Image:3kxu.png\|left\|200px]]
-
	{{STRUCTURE_3kxu\| PDB=3kxu \| SCENE= }}		{{STRUCTURE_3kxu\| PDB=3kxu \| SCENE= }}
-
	===Crystal structure of human ferritin FTL498InsTC pathogenic mutant===		===Crystal structure of human ferritin FTL498InsTC pathogenic mutant===
		+	{{ABSTRACT_PUBMED_20159981}}

-	~~{{ABSTRACT_PUBMED_20159981}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q6S4P3_HUMAN Q6S4P3_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis (By similarity).[RuleBase:RU000622]

	==About this Structure==		==About this Structure==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020159981</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020159981</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arosio, P.]]		[[Category: Arosio, P.]]

OCA at 15:25, 20 October 2012

OCA — Sat, 20 Oct 2012 15:25:09 GMT

←Older revision		Revision as of 15:25, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3kxu]] is a 1 chain structure ~~of [[Ferritin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXU OCA].	+	[[3kxu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXU OCA].

	==See Also==		==See Also==

OCA at 18:19, 26 July 2012

OCA — Thu, 26 Jul 2012 18:19:16 GMT

←Older revision		Revision as of 18:19, 26 July 2012
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	[[Image:3kxu.png\|left\|200px]]		[[Image:3kxu.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3kxu\| PDB=3kxu \| SCENE= }}		{{STRUCTURE_3kxu\| PDB=3kxu \| SCENE= }}

	===Crystal structure of human ferritin FTL498InsTC pathogenic mutant===		===Crystal structure of human ferritin FTL498InsTC pathogenic mutant===

-
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	{{ABSTRACT_PUBMED_20159981}}		{{ABSTRACT_PUBMED_20159981}}

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	==See Also==		==See Also==
-	*[[Ferritin]]	+	*[[Ferritin\|Ferritin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20159981~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020159981</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arosio, P.]]		[[Category: Arosio, P.]]

OCA: Protected "3kxu" [edit=sysop:move=sysop]

OCA — Mon, 27 Dec 2010 01:53:57 GMT

Protected "3kxu" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:53, 27 December 2010

OCA at 01:53, 27 December 2010

OCA — Mon, 27 Dec 2010 01:53:56 GMT

←Older revision		Revision as of 01:53, 27 December 2010
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-	{{Seed}}
	[[Image:3kxu.png\|left\|200px]]		[[Image:3kxu.png\|left\|200px]]

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	-->		-->
	{{ABSTRACT_PUBMED_20159981}}		{{ABSTRACT_PUBMED_20159981}}
-
-	==Disease==
-	Known disease associated with this structure: Basal ganglia disease, adult-onset OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=134790 134790]], Hyperferritinemia-cataract syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=134790 134790]]

	==About this Structure==		==About this Structure==
-	~~3KXU~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXU OCA].	+	[[3kxu]] is a 1 chain structure of [[Ferritin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KXU OCA].
		+
		+	==See Also==
		+	*[[Ferritin]]

	==Reference==		==Reference==
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	[[Category: Iron storage protein]]		[[Category: Iron storage protein]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 08:59:59 2010''