3kz0 - Revision history

OCA at 08:27, 6 September 2023

OCA — Wed, 06 Sep 2023 08:27:25 GMT

←Older revision		Revision as of 08:27, 6 September 2023
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	==MCL-1 complex with MCL-1-specific selected peptide==		==MCL-1 complex with MCL-1-specific selected peptide==
-	<StructureSection load='3kz0' size='340' side='right' caption='[[3kz0]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='3kz0' size='340' side='right'caption='[[3kz0]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kz0]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kz0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KZ0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SO4:SULFATE+ION'>SO4</scene~~>, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.349Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~BCL2L3, MCL1 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz0 OCA], [~~http~~://pdbe.org/3kz0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kz0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kz0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kz0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz0 OCA], [https://pdbe.org/3kz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kz0 RCSB], [https://www.ebi.ac.uk/pdbsum/3kz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kz0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>	+	[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/3kz0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/3kz0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3kz0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kz0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Dutta, S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Fire, E~~]]	+	[[Category: Dutta S]]
-	[[Category: ~~Grant, R A]]~~	+	[[Category: Fire E]]
-	~~[[Category: Keating, A~~ E]]	+	[[Category: Grant RA]]
-	[[Category: ~~Sauer, R T~~]]	+	[[Category: Keating AE]]
-	[[Category: ~~Anti-apoptotic~~]]	+	[[Category: Sauer RT]]
-	[[Category: ~~Apoptosis]]~~	+
-	~~[[Category: Bcl-2]]~~	+
-	~~[[Category: Bh3]]~~	+
-	~~[[Category: Mitochondrion~~]]	+

OCA at 08:45, 1 November 2017

OCA — Wed, 01 Nov 2017 08:45:01 GMT

←Older revision		Revision as of 08:45, 1 November 2017
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3kz0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kz0" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Bcl-2\|Bcl-2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:44, 5 August 2016

OCA — Fri, 05 Aug 2016 04:44:53 GMT

←Older revision		Revision as of 04:44, 5 August 2016
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		+
	==MCL-1 complex with MCL-1-specific selected peptide==		==MCL-1 complex with MCL-1-specific selected peptide==
	<StructureSection load='3kz0' size='340' side='right' caption='[[3kz0]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3kz0' size='340' side='right' caption='[[3kz0]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KZ0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL2L3, MCL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL2L3, MCL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kz0 RCSB], [http://www.ebi.ac.uk/pdbsum/3kz0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz0 OCA], [http://pdbe.org/3kz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kz0 RCSB], [http://www.ebi.ac.uk/pdbsum/3kz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kz0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kz0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kz0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dutta, S]]		[[Category: Dutta, S]]
	[[Category: Fire, E]]		[[Category: Fire, E]]

OCA at 23:04, 24 December 2014

OCA — Wed, 24 Dec 2014 23:04:51 GMT

←Older revision		Revision as of 23:04, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kz0 RCSB], [http://www.ebi.ac.uk/pdbsum/3kz0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kz0 RCSB], [http://www.ebi.ac.uk/pdbsum/3kz0 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:35, 9 December 2014

OCA — Tue, 09 Dec 2014 09:35:19 GMT

←Older revision		Revision as of 09:35, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3kz0.~~png~~\|~~left~~\|200px]]	+	==MCL-1 complex with MCL-1-specific selected peptide==
		+	<StructureSection load='3kz0' size='340' side='right' caption='[[3kz0]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KZ0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL2L3, MCL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kz0 RCSB], [http://www.ebi.ac.uk/pdbsum/3kz0 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/3kz0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interactions among Bcl-2 family proteins are important for regulating apoptosis. Prosurvival members of the family interact with proapoptotic BH3 (Bcl-2-homology-3)-only members, inhibiting execution of cell death through the mitochondrial pathway. Structurally, this interaction is mediated by binding of the alpha-helical BH3 region of the proapoptotic proteins to a conserved hydrophobic groove on the prosurvival proteins. Native BH3-only proteins exhibit selectivity in binding prosurvival members, as do small molecules that block these interactions. Understanding the sequence and structural basis of interaction specificity in this family is important, as it may allow the prediction of new Bcl-2 family associations and/or the design of new classes of selective inhibitors to serve as reagents or therapeutics. In this work, we used two complementary techniques--yeast surface display screening from combinatorial peptide libraries and SPOT peptide array analysis--to elucidate specificity determinants for binding to Bcl-x(L)versus Mcl-1, two prominent prosurvival proteins. We screened a randomized library and identified BH3 peptides that bound to either Mcl-1 or Bcl-x(L) selectively or to both with high affinity. The peptides competed with native ligands for binding into the conserved hydrophobic groove, as illustrated in detail by a crystal structure of a specific peptide bound to Mcl-1. Mcl-1-selective peptides from the screen were highly specific for binding Mcl-1 in preference to Bcl-x(L), Bcl-2, Bcl-w, and Bfl-1, whereas Bcl-x(L)-selective peptides showed some cross-interaction with related proteins Bcl-2 and Bcl-w. Mutational analyses using SPOT arrays revealed the effects of 170 point mutations made in the background of a peptide derived from the BH3 region of Bim, and a simple predictive model constructed using these data explained much of the specificity observed in our Mcl-1 versus Bcl-x(L) binders.

-	~~{{STRUCTURE_3kz0\| PDB=3kz0 \| SCENE= }}~~	+	Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL.,Dutta S, Gulla S, Chen TS, Fire E, Grant RA, Keating AE J Mol Biol. 2010 May 21;398(5):747-62. Epub 2010 Apr 2. PMID:20363230<ref>PMID:20363230</ref>

-	~~===MCL-1 complex with MCL-1-specific selected peptide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20363230}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3kz0]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA].~~	+

	==See Also==		==See Also==
	*[[Bcl-2\|Bcl-2]]		*[[Bcl-2\|Bcl-2]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020363230<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dutta, S.]]	+	[[Category: Dutta, S]]
-	[[Category: Fire, E.]]	+	[[Category: Fire, E]]
-	[[Category: Grant, R A.]]	+	[[Category: Grant, R A]]
-	[[Category: Keating, A E.]]	+	[[Category: Keating, A E]]
-	[[Category: Sauer, R T.]]	+	[[Category: Sauer, R T]]
	[[Category: Anti-apoptotic]]		[[Category: Anti-apoptotic]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA at 10:01, 20 October 2012

OCA — Sat, 20 Oct 2012 10:01:46 GMT

←Older revision		Revision as of 10:01, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3kz0]] is a 4 chain structure ~~of [[Bcl-2]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA].	+	[[3kz0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA].

	==See Also==		==See Also==

OCA: Protected "3kz0" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 00:45:08 GMT

Protected "3kz0" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:45, 26 July 2012

OCA at 00:45, 26 July 2012

OCA — Thu, 26 Jul 2012 00:45:06 GMT

←Older revision		Revision as of 00:45, 26 July 2012
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-	{{Seed}}
	[[Image:3kz0.png\|left\|200px]]		[[Image:3kz0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kz0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kz0\| PDB=3kz0 \| SCENE= }}		{{STRUCTURE_3kz0\| PDB=3kz0 \| SCENE= }}

	===MCL-1 complex with MCL-1-specific selected peptide===		===MCL-1 complex with MCL-1-specific selected peptide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20363230}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20363230 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20363230}}		{{ABSTRACT_PUBMED_20363230}}

	==About this Structure==		==About this Structure==
-	~~3KZ0~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA].	+	[[3kz0]] is a 4 chain structure of [[Bcl-2]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA].
		+
		+	==See Also==
		+	*[[Bcl-2\|Bcl-2]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20363230~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020363230</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dutta, S.]]		[[Category: Dutta, S.]]
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	[[Category: Bh3]]		[[Category: Bh3]]
	[[Category: Mitochondrion]]		[[Category: Mitochondrion]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:05:14 2010''

OCA at 06:05, 20 May 2010

OCA — Thu, 20 May 2010 06:05:15 GMT

←Older revision		Revision as of 06:05, 20 May 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3kz0.~~jpg~~\|left\|200px]]	+	[[Image:3kz0.png\|left\|200px]]

	<!--		<!--
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	[[Category: Mitochondrion]]		[[Category: Mitochondrion]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ May ~~5 11~~:57:27 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:05:14 2010''

OCA at 08:57, 5 May 2010

OCA — Wed, 05 May 2010 08:57:29 GMT

←Older revision		Revision as of 08:57, 5 May 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kz0.jpg\|left\|200px]]

-	The ~~entry 3kz0~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kz0", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kz0\| PDB=3kz0 \| SCENE= }}

-	~~Authors: Dutta, S., Fire, E., Grant, R.A., Sauer, R.T., Keating, A.E.~~	+	===MCL-1 complex with MCL-1-specific selected peptide===

-	Description: MCL-1 complex with MCL-1-specific selected peptide

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 31 13~~:20:25 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20363230}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20363230 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20363230}}
		+
		+	==About this Structure==
		+	3KZ0 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ0 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20363230</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Dutta, S.]]
		+	[[Category: Fire, E.]]
		+	[[Category: Grant, R A.]]
		+	[[Category: Keating, A E.]]
		+	[[Category: Sauer, R T.]]
		+	[[Category: Anti-apoptotic]]
		+	[[Category: Apoptosis]]
		+	[[Category: Bcl-2]]
		+	[[Category: Bh3]]
		+	[[Category: Mitochondrion]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:57:27 2010''