3l1v - Revision history

OCA at 08:28, 6 September 2023

OCA — Wed, 06 Sep 2023 08:28:32 GMT

←Older revision		Revision as of 08:28, 6 September 2023
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	==Crystal structure of GmhB from E. coli in complex with calcium and phosphate.==		==Crystal structure of GmhB from E. coli in complex with calcium and phosphate.==
-	<StructureSection load='3l1v' size='340' side='right' caption='[[3l1v]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='3l1v' size='340' side='right'caption='[[3l1v]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l1v]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3L1V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l1v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L1V FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~>, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.954Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3l1u\|3l1u]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<~~tr id~~='~~gene~~'><~~td class="sblockLbl"~~><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">b0200, gmhB, JW0196, yaeD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l1v OCA], [https://pdbe.org/3l1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l1v RCSB], [https://www.ebi.ac.uk/pdbsum/3l1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l1v ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l1v OCA], [~~http~~://pdbe.org/3l1v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3l1v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3l1v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3l1v ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~GMHB_ECOLI GMHB_ECOLI]~~] Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate ~~(HBP)~~ by removing the phosphate group at the C-7 position~~. Also catalyzes the dephosphorylation of fructose-1,6-bisphosphate (Fru1,6bisP)~~.<ref>PMID:11751812</ref> <ref>PMID:16990279</ref>	+	[https://www.uniprot.org/uniprot/GMHBB_ECOLI GMHBB_ECOLI] Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position.<ref>PMID:11751812</ref> <ref>PMID:16990279</ref> <ref>PMID:20050615</ref> <ref>PMID:31449400</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/3l1v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/3l1v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli]]~~	+	[[Category: Escherichia coli K-12]]
-	~~[[Category: Junop, M S]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Sugiman~~-~~Marangos, S N~~]]	+	[[Category: Junop MS]]
-	[[Category: ~~Carbohydrate metabolism~~]]	+	[[Category: Sugiman-Marangos SN]]
-	[[Category: ~~Cytoplasm~~]]	+
-	[[Category: ~~Heptose]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lipopolysaccharide biosynthesis]]~~	+
-	~~[[Category: Lps biosynthesis]]~~	+
-	~~[[Category: Sugar phosphatase]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 09:35, 25 October 2017

OCA — Wed, 25 Oct 2017 09:35:03 GMT

←Older revision		Revision as of 09:35, 25 October 2017
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	[[Category: Sugiman-Marangos, S N]]		[[Category: Sugiman-Marangos, S N]]
	[[Category: Carbohydrate metabolism]]		[[Category: Carbohydrate metabolism]]
		+	[[Category: Cytoplasm]]
	[[Category: Heptose]]		[[Category: Heptose]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
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	[[Category: Lps biosynthesis]]		[[Category: Lps biosynthesis]]
	[[Category: Sugar phosphatase]]		[[Category: Sugar phosphatase]]
		+	[[Category: Zinc]]

OCA at 03:07, 13 July 2016

OCA — Wed, 13 Jul 2016 03:07:38 GMT

←Older revision		Revision as of 03:07, 13 July 2016
Line 1:		Line 1:
		+
	==Crystal structure of GmhB from E. coli in complex with calcium and phosphate.==		==Crystal structure of GmhB from E. coli in complex with calcium and phosphate.==
	<StructureSection load='3l1v' size='340' side='right' caption='[[3l1v]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3l1v' size='340' side='right' caption='[[3l1v]], [[Resolution\|resolution]] 1.95Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l1u\|3l1u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l1u\|3l1u]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0200, gmhB, JW0196, yaeD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0200, gmhB, JW0196, yaeD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l1v OCA], [http://pdbe.org/3l1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l1v RCSB], [http://www.ebi.ac.uk/pdbsum/3l1v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l1v OCA], [http://pdbe.org/3l1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l1v RCSB], [http://www.ebi.ac.uk/pdbsum/3l1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l1v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 19:36, 9 February 2016

OCA — Tue, 09 Feb 2016 19:36:40 GMT

←Older revision		Revision as of 19:36, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3l1v' size='340' side='right' caption='[[3l1v]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='3l1v' size='340' side='right' caption='[[3l1v]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L1V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L1V FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l1u\|3l1u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l1u\|3l1u]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0200, gmhB, JW0196, yaeD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~562 Escherichia coli~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0200, gmhB, JW0196, yaeD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l1v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l1v RCSB], [http://www.ebi.ac.uk/pdbsum/3l1v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l1v OCA], [http://pdbe.org/3l1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l1v RCSB], [http://www.ebi.ac.uk/pdbsum/3l1v PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l1v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3l1v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli~~]]	+	[[Category: Ecoli]]
	[[Category: Junop, M S]]		[[Category: Junop, M S]]
	[[Category: Sugiman-Marangos, S N]]		[[Category: Sugiman-Marangos, S N]]

OCA at 09:04, 25 December 2014

OCA — Thu, 25 Dec 2014 09:04:53 GMT

←Older revision		Revision as of 09:04, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l1v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l1v RCSB], [http://www.ebi.ac.uk/pdbsum/3l1v PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l1v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l1v RCSB], [http://www.ebi.ac.uk/pdbsum/3l1v PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GMHB_ECOLI GMHB_ECOLI]] Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate (HBP) by removing the phosphate group at the C-7 position. Also catalyzes the dephosphorylation of fructose-1,6-bisphosphate (Fru1,6bisP).<ref>PMID:11751812</ref> <ref>PMID:16990279</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:00, 18 December 2014

OCA — Thu, 18 Dec 2014 18:00:47 GMT

←Older revision		Revision as of 18:00, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3l1v\| PDB=3l1v \| SCENE= }}~~	+	==Crystal structure of GmhB from E. coli in complex with calcium and phosphate.==
-	===Crystal structure of GmhB from E. coli in complex with calcium and phosphate.===	+	<StructureSection load='3l1v' size='340' side='right' caption='[[3l1v]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20050699}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3l1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L1V FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l1u\|3l1u]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0200, gmhB, JW0196, yaeD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l1v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l1v RCSB], [http://www.ebi.ac.uk/pdbsum/3l1v PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/3l1v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lipopolysaccharide is a major component of the outer membrane of gram-negative bacteria and provides a permeability barrier to many commonly used antibiotics. ADP-heptose residues are an integral part of the LPS inner core, and mutants deficient in heptose biosynthesis demonstrate increased membrane permeability. The heptose biosynthesis pathway involves phosphorylation and dephosphorylation steps not found in other pathways for the synthesis of nucleotide sugar precursors. Consequently, the heptose biosynthetic pathway has been marked as a novel target for antibiotic adjuvants, which are compounds that facilitate and potentiate antibiotic activity. D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) catalyzes the third essential step of LPS heptose biosynthesis. This study describes the first crystal structure of GmhB and enzymatic analysis of the protein. Structure-guided mutations followed by steady state kinetic analysis, together with established precedent for HAD phosphatases, suggest that GmhB functions through a phosphoaspartate intermediate. This study provides insight into the structure-function relationship of GmhB, a new target for combatting gram-negative bacterial infection.

-	~~==Function==~~	+	Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli.,Taylor PL, Sugiman-Marangos S, Zhang K, Valvano MA, Wright GD, Junop MS Biochemistry. 2010 Feb 9;49(5):1033-41. PMID:20050699<ref>PMID:20050699</ref>
-	~~[[http://www.uniprot.org/uniprot/GMHB_ECOLI GMHB_ECOLI]] Converts~~ the D-~~glycero-~~beta-D~~-manno~~-heptose 1,7-bisphosphate ~~intermediate into D-glycero-beta-D-manno-heptose 1-phosphate~~ (~~HBP~~) ~~by removing the phosphate group at the C-7 position~~. ~~Also catalyzes the dephosphorylation of fructose~~-1,~~6-bisphosphate~~ (~~Fru1,6bisP~~).~~<ref>~~PMID:~~11751812</ref>~~ <ref>PMID:~~16990279~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3l1v]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020050699</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Junop, M S.]]	+	[[Category: Junop, M S]]
-	[[Category: Sugiman-Marangos, S N.]]	+	[[Category: Sugiman-Marangos, S N]]
	[[Category: Carbohydrate metabolism]]		[[Category: Carbohydrate metabolism]]
	[[Category: Heptose]]		[[Category: Heptose]]

OCA: Protected "3l1v" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 20:44:06 GMT

Protected "3l1v" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:44, 4 April 2013

OCA at 20:44, 4 April 2013

OCA — Thu, 04 Apr 2013 20:44:04 GMT

←Older revision		Revision as of 20:44, 4 April 2013
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-	{{Seed}}
-	[[Image:3l1v.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3l1v", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3l1v\| PDB=3l1v \| SCENE= }}		{{STRUCTURE_3l1v\| PDB=3l1v \| SCENE= }}
-
	===Crystal structure of GmhB from E. coli in complex with calcium and phosphate.===		===Crystal structure of GmhB from E. coli in complex with calcium and phosphate.===
		+	{{ABSTRACT_PUBMED_20050699}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/GMHB_ECOLI GMHB_ECOLI]] Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate (HBP) by removing the phosphate group at the C-7 position. Also catalyzes the dephosphorylation of fructose-1,6-bisphosphate (Fru1,6bisP).<ref>PMID:11751812</ref> <ref>PMID:16990279</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20050699}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 20050699 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20050699}}~~	+

	==About this Structure==		==About this Structure==
-	~~3L1V~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA].	+	[[3l1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20050699~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020050699</ref><references group="xtra"/><references/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Junop, M S.]]		[[Category: Junop, M S.]]
	[[Category: Sugiman-Marangos, S N.]]		[[Category: Sugiman-Marangos, S N.]]
	[[Category: Carbohydrate metabolism]]		[[Category: Carbohydrate metabolism]]
-	[[Category: Cytoplasm]]
	[[Category: Heptose]]		[[Category: Heptose]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 34:		Line 20:
	[[Category: Lps biosynthesis]]		[[Category: Lps biosynthesis]]
	[[Category: Sugar phosphatase]]		[[Category: Sugar phosphatase]]
-	[[Category: Zinc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 09:56:09 2010''

OCA at 07:56, 17 February 2010

OCA — Wed, 17 Feb 2010 07:56:10 GMT

←Older revision		Revision as of 07:56, 17 February 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3l1v.~~jpg~~\|left\|200px]]	+	[[Image:3l1v.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Crystal structure of GmhB from E. coli in complex with calcium and phosphate.===		===Crystal structure of GmhB from E. coli in complex with calcium and phosphate.===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20050699}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20050699 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20050699}}

	==About this Structure==		==About this Structure==
-	3L1V is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA].	+	3L1V is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20050699</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Junop, M S.]]		[[Category: Junop, M S.]]
Line 27:		Line 36:
	[[Category: Zinc]]		[[Category: Zinc]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 6~~ 09:38:33 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 09:56:09 2010''

OCA at 07:38, 6 January 2010

OCA — Wed, 06 Jan 2010 07:38:34 GMT

←Older revision		Revision as of 07:38, 6 January 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3l1v.jpg\|left\|200px]]

-	The ~~entry 3l1v~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3l1v", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3l1v\| PDB=3l1v \| SCENE= }}

-	~~Authors: Sugiman-Marangos, S~~.~~N., Junop, M.S~~.	+	===Crystal structure of GmhB from E. coli in complex with calcium and phosphate.===

-	Description: Crystal structure of GmhB from E. coli in complex with calcium and phosphate.

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 23~~ 09:25:~~49 2009~~''	+	==About this Structure==
		+	3L1V is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1V OCA].
		+	[[Category: Escherichia coli]]
		+	[[Category: Junop, M S.]]
		+	[[Category: Sugiman-Marangos, S N.]]
		+	[[Category: Carbohydrate metabolism]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Heptose]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lipopolysaccharide biosynthesis]]
		+	[[Category: Lps biosynthesis]]
		+	[[Category: Sugar phosphatase]]
		+	[[Category: Zinc]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 6 09:38:33 2010''