3l31 - Revision history

OCA at 08:30, 20 March 2024

OCA — Wed, 20 Mar 2024 08:30:27 GMT

←Older revision		Revision as of 08:30, 20 March 2024
Line 1:		Line 1:

	==Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP==		==Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP==
-	<StructureSection load='3l31' size='340' side='right' caption='[[3l31]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3l31' size='340' side='right'caption='[[3l31]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l31]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Clope Clope~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L31 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3L31 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l31]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens_str._13 Clostridium perfringens str. 13]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L31 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Related_structure~~\|~~Related:]]</b></td><td class="sblockDat">[[3l2b\|3l2b~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CPE2055 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~195102 CLOPE])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l31 OCA], [https://pdbe.org/3l31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l31 RCSB], [https://www.ebi.ac.uk/pdbsum/3l31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l31 ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3l31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l31 OCA], [~~http~~://pdbe.org/3l31 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3l31 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3l31 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3l31 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IPYR_CLOPE IPYR_CLOPE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l31 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l31 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Nucleotide-binding cystathionine beta-synthase (CBS) domains serve as regulatory units in numerous proteins distributed in all kingdoms of life. However, the underlying regulatory mechanisms remain to be established. Recently, we described a subfamily of CBS domain-containing pyrophosphatases (PPases) within family II PPases. Here, we express a novel CBS-PPase from Clostridium perfringens (CPE2055) and show that the enzyme is inhibited by AMP and activated by a novel effector, diadenosine 5',5-P1,P4-tetraphosphate (AP(4)A). The structures of the AMP and AP(4)A complexes of the regulatory region of C. perfringens PPase (cpCBS), comprising a pair of CBS domains interlinked by a DRTGG domain, were determined at 2.3 A resolution using X-ray crystallography. The structures obtained are the first structures of a DRTGG domain as part of a larger protein structure. The AMP complex contains two AMP molecules per cpCBS dimer, each bound to a single monomer, whereas in the activator-bound complex, one AP(4)A molecule bridges two monomers. In the nucleotide-bound structures, activator binding induces significant opening of the CBS domain interface, compared with the inhibitor complex. These results provide structural insight into the mechanism of CBS-PPase regulation by nucleotides.
-
-	Crystal structures of the CBS and DRTGG domains of the regulatory region of Clostridiumperfringens pyrophosphatase complexed with the inhibitor, AMP, and activator, diadenosine tetraphosphate.,Tuominen H, Salminen A, Oksanen E, Jamsen J, Heikkila O, Lehtio L, Magretova NN, Goldman A, Baykov AA, Lahti R J Mol Biol. 2010 May 7;398(3):400-13. Epub 2010 Mar 19. PMID:20303981<ref>PMID:20303981</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3l31" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clope~~]]	+	[[Category: Clostridium perfringens str. 13]]
-	[[Category: ~~Inorganic diphosphatase~~]]	+	[[Category: Large Structures]]
-	[[Category: Baykov~~, A A~~]]	+	[[Category: Baykov AA]]
-	[[Category: Goldman, A]]	+	[[Category: Goldman A]]
-	[[Category: Heikkila, O]]	+	[[Category: Heikkila O]]
-	[[Category: Jamsen, J]]	+	[[Category: Jamsen J]]
-	[[Category: Lahti, R]]	+	[[Category: Lahti R]]
-	[[Category: Lehtio, L]]	+	[[Category: Lehtio L]]
-	[[Category: Magretova~~, N N~~]]	+	[[Category: Magretova NN]]
-	[[Category: Oksanen, E]]	+	[[Category: Oksanen E]]
-	[[Category: Salminen, A]]	+	[[Category: Salminen A]]
-	[[Category: Tuominen, H]]	+	[[Category: Tuominen H]]
-	~~[[Category: Amp]]~~	+
-	~~[[Category: Bateman domain]]~~	+
-	~~[[Category: Cbs domain]]~~	+
-	~~[[Category: Clostridium perfringen]]~~	+
-	~~[[Category: Drtgg]]~~	+
-	~~[[Category: Family ii]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inorganic]]~~	+
-	~~[[Category: Pyrophosphatase~~]]	+

OCA at 06:56, 2 January 2019

OCA — Wed, 02 Jan 2019 06:56:51 GMT

←Older revision		Revision as of 06:56, 2 January 2019
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/3l31_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/3l31_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:09, 5 August 2016

OCA — Fri, 05 Aug 2016 03:09:11 GMT

←Older revision		Revision as of 03:09, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP==		==Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP==
	<StructureSection load='3l31' size='340' side='right' caption='[[3l31]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3l31' size='340' side='right' caption='[[3l31]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l31]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Clostridium_perfringens Clostridium perfringens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L31 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l31]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clope Clope]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L31 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l2b\|3l2b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l2b\|3l2b]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPE2055 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1502 Clostridium perfringens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPE2055 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=195102 CLOPE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l31 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l31 RCSB], [http://www.ebi.ac.uk/pdbsum/3l31 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l31 OCA], [http://pdbe.org/3l31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l31 RCSB], [http://www.ebi.ac.uk/pdbsum/3l31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l31 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l31 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3l31" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clostridium perfringens~~]]	+	[[Category: Clope]]
	[[Category: Inorganic diphosphatase]]		[[Category: Inorganic diphosphatase]]
	[[Category: Baykov, A A]]		[[Category: Baykov, A A]]

OCA at 15:11, 18 December 2014

OCA — Thu, 18 Dec 2014 15:11:37 GMT

←Older revision		Revision as of 15:11, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3l31\| PDB=3l31 \| SCENE= }}~~	+	==Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP==
-	===Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP===	+	<StructureSection load='3l31' size='340' side='right' caption='[[3l31]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20303981}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3l31]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L31 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l2b\|3l2b]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPE2055 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1502 Clostridium perfringens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l31 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l31 RCSB], [http://www.ebi.ac.uk/pdbsum/3l31 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/3l31_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nucleotide-binding cystathionine beta-synthase (CBS) domains serve as regulatory units in numerous proteins distributed in all kingdoms of life. However, the underlying regulatory mechanisms remain to be established. Recently, we described a subfamily of CBS domain-containing pyrophosphatases (PPases) within family II PPases. Here, we express a novel CBS-PPase from Clostridium perfringens (CPE2055) and show that the enzyme is inhibited by AMP and activated by a novel effector, diadenosine 5',5-P1,P4-tetraphosphate (AP(4)A). The structures of the AMP and AP(4)A complexes of the regulatory region of C. perfringens PPase (cpCBS), comprising a pair of CBS domains interlinked by a DRTGG domain, were determined at 2.3 A resolution using X-ray crystallography. The structures obtained are the first structures of a DRTGG domain as part of a larger protein structure. The AMP complex contains two AMP molecules per cpCBS dimer, each bound to a single monomer, whereas in the activator-bound complex, one AP(4)A molecule bridges two monomers. In the nucleotide-bound structures, activator binding induces significant opening of the CBS domain interface, compared with the inhibitor complex. These results provide structural insight into the mechanism of CBS-PPase regulation by nucleotides.

-	~~==About this Structure==~~	+	Crystal structures of the CBS and DRTGG domains of the regulatory region of Clostridiumperfringens pyrophosphatase complexed with the inhibitor, AMP, and activator, diadenosine tetraphosphate.,Tuominen H, Salminen A, Oksanen E, Jamsen J, Heikkila O, Lehtio L, Magretova NN, Goldman A, Baykov AA, Lahti R J Mol Biol. 2010 May 7;398(3):400-13. Epub 2010 Mar 19. PMID:20303981<ref>PMID:20303981</ref>
-	~~[[3l31]] is a 2 chain structure~~ with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3L31 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020303981</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Clostridium perfringens]]		[[Category: Clostridium perfringens]]
	[[Category: Inorganic diphosphatase]]		[[Category: Inorganic diphosphatase]]
-	[[Category: Baykov, A A.]]	+	[[Category: Baykov, A A]]
-	[[Category: Goldman, A.]]	+	[[Category: Goldman, A]]
-	[[Category: Heikkila, O.]]	+	[[Category: Heikkila, O]]
-	[[Category: Jamsen, J.]]	+	[[Category: Jamsen, J]]
-	[[Category: Lahti, R.]]	+	[[Category: Lahti, R]]
-	[[Category: Lehtio, L.]]	+	[[Category: Lehtio, L]]
-	[[Category: Magretova, N N.]]	+	[[Category: Magretova, N N]]
-	[[Category: Oksanen, E.]]	+	[[Category: Oksanen, E]]
-	[[Category: Salminen, A.]]	+	[[Category: Salminen, A]]
-	[[Category: Tuominen, H.]]	+	[[Category: Tuominen, H]]
	[[Category: Amp]]		[[Category: Amp]]
	[[Category: Bateman domain]]		[[Category: Bateman domain]]

OCA: Protected "3l31" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 20:50:01 GMT

Protected "3l31" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:50, 4 April 2013

OCA at 20:49, 4 April 2013

OCA — Thu, 04 Apr 2013 20:49:59 GMT

←Older revision		Revision as of 20:49, 4 April 2013
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-	{{Seed}}
-	[[Image:3l31.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3l31", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3l31\| PDB=3l31 \| SCENE= }}		{{STRUCTURE_3l31\| PDB=3l31 \| SCENE= }}
-
	===Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP===		===Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20303981}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20303981 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20303981}}		{{ABSTRACT_PUBMED_20303981}}

	==About this Structure==		==About this Structure==
-	~~3L31~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L31 OCA].	+	[[3l31]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L31 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20303981~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020303981</ref><references group="xtra"/><references/>
	[[Category: Clostridium perfringens]]		[[Category: Clostridium perfringens]]
	[[Category: Inorganic diphosphatase]]		[[Category: Inorganic diphosphatase]]
Line 45:		Line 29:
	[[Category: Inorganic]]		[[Category: Inorganic]]
	[[Category: Pyrophosphatase]]		[[Category: Pyrophosphatase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 10:22:27 2010''

OCA at 07:22, 21 April 2010

OCA — Wed, 21 Apr 2010 07:22:29 GMT

←Older revision		Revision as of 07:22, 21 April 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3l31.jpg\|left\|200px]]

-	The ~~entry 3l31~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3l31", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3l31\| PDB=3l31 \| SCENE= }}

-	~~Authors: Tuominen~~, ~~H., Salminen, A., Oksanen, E., Jamsen, J., Heikkila, O., Lehtio, L., Magretova, N.N., Goldman, A., Baykov, A.A., Lahti, R.~~	+	===Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP===

-	Description: Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 13 13~~:33:38 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20303981}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20303981 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20303981}}
		+
		+	==About this Structure==
		+	3L31 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L31 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20303981</ref><references group="xtra"/>
		+	[[Category: Clostridium perfringens]]
		+	[[Category: Inorganic diphosphatase]]
		+	[[Category: Baykov, A A.]]
		+	[[Category: Goldman, A.]]
		+	[[Category: Heikkila, O.]]
		+	[[Category: Jamsen, J.]]
		+	[[Category: Lahti, R.]]
		+	[[Category: Lehtio, L.]]
		+	[[Category: Magretova, N N.]]
		+	[[Category: Oksanen, E.]]
		+	[[Category: Salminen, A.]]
		+	[[Category: Tuominen, H.]]
		+	[[Category: Amp]]
		+	[[Category: Bateman domain]]
		+	[[Category: Cbs domain]]
		+	[[Category: Clostridium perfringen]]
		+	[[Category: Drtgg]]
		+	[[Category: Family ii]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inorganic]]
		+	[[Category: Pyrophosphatase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 10:22:27 2010''

OCA at 11:33, 13 January 2010

OCA — Wed, 13 Jan 2010 11:33:38 GMT

←Older revision		Revision as of 11:33, 13 January 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3l31 is ON HOLD	+	The entry 3l31 is ON HOLD until Paper Publication

	Authors: Tuominen, H., Salminen, A., Oksanen, E., Jamsen, J., Heikkila, O., Lehtio, L., Magretova, N.N., Goldman, A., Baykov, A.A., Lahti, R.		Authors: Tuominen, H., Salminen, A., Oksanen, E., Jamsen, J., Heikkila, O., Lehtio, L., Magretova, N.N., Goldman, A., Baykov, A.A., Lahti, R.
Line 7:		Line 7:
	Description: Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP		Description: Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 23 09~~:26:~~30 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 13:33:38 2010''

OCA: New page: '''Unreleased structure''' The entry 3l31 is ON HOLD Authors: Tuominen, H., Salminen, A., Oksanen, E., Jamsen, J., Heikkila, O., Lehtio, L., Magretova, N.N., Goldman, A., Baykov, A.A., ...

OCA — Wed, 23 Dec 2009 07:26:31 GMT

New page: '''Unreleased structure''' The entry 3l31 is ON HOLD Authors: Tuominen, H., Salminen, A., Oksanen, E., Jamsen, J., Heikkila, O., Lehtio, L., Magretova, N.N., Goldman, A., Baykov, A.A., ...

New page

'''Unreleased structure'''

The entry 3l31 is ON HOLD

Authors: Tuominen, H., Salminen, A., Oksanen, E., Jamsen, J., Heikkila, O., Lehtio, L., Magretova, N.N., Goldman, A., Baykov, A.A., Lahti, R.

Description: Crystal structure of the CBS and DRTGG domains of the regulatory region of Clostridium perfringens pyrophosphatase complexed with the inhibitor, AMP

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:26:30 2009''