3l3x - Revision history

OCA at 08:46, 1 November 2017

OCA — Wed, 01 Nov 2017 08:46:52 GMT

←Older revision		Revision as of 08:46, 1 November 2017
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		+
	==Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3==		==Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3==
	<StructureSection load='3l3x' size='340' side='right' caption='[[3l3x]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3l3x' size='340' side='right' caption='[[3l3x]], [[Resolution\|resolution]] 1.55Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l3z\|3l3z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l3z\|3l3z]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, DHTR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, DHTR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l3x OCA], [http://pdbe.org/3l3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l3x RCSB], [http://www.ebi.ac.uk/pdbsum/3l3x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l3x OCA], [http://pdbe.org/3l3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l3x RCSB], [http://www.ebi.ac.uk/pdbsum/3l3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l3x ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 31:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 3l3x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3l3x" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Androgen receptor\|Androgen receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:31, 9 February 2016

OCA — Tue, 09 Feb 2016 00:31:38 GMT

←Older revision		Revision as of 00:31, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3l3x' size='340' side='right' caption='[[3l3x]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='3l3x' size='340' side='right' caption='[[3l3x]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L3X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L3X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l3z\|3l3z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l3z\|3l3z]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, DHTR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, DHTR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l3x RCSB], [http://www.ebi.ac.uk/pdbsum/3l3x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l3x OCA], [http://pdbe.org/3l3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l3x RCSB], [http://www.ebi.ac.uk/pdbsum/3l3x PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l3x ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3l3x" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: He, A]]		[[Category: He, A]]
	[[Category: Li, J]]		[[Category: Li, J]]

OCA at 15:49, 18 December 2014

OCA — Thu, 18 Dec 2014 15:49:57 GMT

←Older revision		Revision as of 15:49, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3l3x\| PDB=3l3x \| SCENE= }}~~	+	==Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3==
-	===Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3===	+	<StructureSection load='3l3x' size='340' side='right' caption='[[3l3x]], [[Resolution\|resolution]] 1.55Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20086010}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3l3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L3X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l3z\|3l3z]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AR, DHTR, NR3C4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l3x RCSB], [http://www.ebi.ac.uk/pdbsum/3l3x PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ANDR_HUMAN ANDR_HUMAN]] Defects in AR are the cause of androgen insensitivity syndrome (AIS) [MIM:[http://omim.org/entry/300068 300068]]; previously known as testicular feminization syndrome (TFM). AIS is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype.<ref>PMID:2594783</ref> <ref>PMID:8413310</ref> <ref>PMID:1775137</ref> <ref>PMID:16129672</ref> <ref>PMID:2082179</ref> <ref>PMID:1999491</ref> <ref>PMID:1609793</ref> <ref>PMID:1426313</ref> <ref>PMID:1487249</ref> <ref>PMID:1307250</ref> <ref>PMID:1569163</ref> <ref>PMID:1464650</ref> <ref>PMID:1430233</ref> <ref>PMID:1316540</ref> <ref>PMID:1480178</ref> <ref>PMID:8224266</ref> <ref>PMID:8103398</ref> <ref>PMID:8281140</ref> <ref>PMID:8325950</ref> <ref>PMID:8096390</ref> <ref>PMID:8446106</ref> [:]<ref>PMID:8162033</ref> <ref>PMID:7981687</ref> <ref>PMID:7981689</ref> <ref>PMID:7962294</ref> <ref>PMID:8040309</ref> <ref>PMID:7929841</ref> <ref>PMID:7993455</ref> <ref>PMID:7970939</ref> <ref>PMID:8830623</ref> <ref>PMID:7641413</ref> <ref>PMID:7671849</ref> <ref>PMID:7633398</ref> <ref>PMID:7537149</ref> <ref>PMID:7581399</ref> <ref>PMID:8723113</ref> <ref>PMID:9039340</ref> <ref>PMID:9001799</ref> <ref>PMID:8626869</ref> <ref>PMID:8768864</ref> <ref>PMID:8918984</ref> <ref>PMID:8683794</ref> <ref>PMID:8647313</ref> <ref>PMID:8809734</ref> <ref>PMID:9106550</ref> <ref>PMID:9160185</ref> <ref>PMID:9007482</ref> <ref>PMID:8990010</ref> <ref>PMID:9255042</ref> <ref>PMID:9252933</ref> <ref>PMID:9328206</ref> <ref>PMID:9302173</ref> <ref>PMID:9544375</ref> <ref>PMID:9698822</ref> <ref>PMID:9788719</ref> <ref>PMID:9610419</ref> <ref>PMID:9856504</ref> <ref>PMID:9554754</ref> [:]<ref>PMID:9851768</ref> <ref>PMID:9627582</ref> <ref>PMID:10571951</ref> <ref>PMID:10221692</ref> <ref>PMID:10404311</ref> <ref>PMID:10022458</ref> <ref>PMID:10221770</ref> <ref>PMID:10590024</ref> <ref>PMID:10458483</ref> <ref>PMID:10690872</ref> <ref>PMID:11587068</ref> <ref>PMID:11744994</ref> <ref>PMID:16595706</ref> Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (SMAX1) [MIM:[http://omim.org/entry/313200 313200]]; also known as Kennedy disease. SMAX1 is an X-linked recessive form of spinal muscular atrophy. Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX1 occurs only in men. Age at onset is usually in the third to fifth decade of life, but earlier involvement has been reported. It is characterized by slowly progressive limb and bulbar muscle weakness with fasciculations, muscle atrophy, and gynecomastia. The disorder is clinically similar to classic forms of autosomal spinal muscular atrophy. Note=Caused by trinucleotide CAG repeat expansion. In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.<ref>PMID:15851746</ref> Note=Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor. Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) [MIM:[http://omim.org/entry/312300 312300]]; also known as Reifenstein syndrome. PAIS is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ANDR_HUMAN ANDR_HUMAN]] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.<ref>PMID:14664718</ref> <ref>PMID:18084323</ref> <ref>PMID:19345326</ref> <ref>PMID:20980437</ref> <ref>PMID:15563469</ref> <ref>PMID:17591767</ref> <ref>PMID:17911242</ref> [[http://www.uniprot.org/uniprot/NCOA3_HUMAN NCOA3_HUMAN]] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/3l3x_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transcription activation by androgen receptor (AR), which depends on recruitment of coactivators, is required for the initiation and progression of prostate cancer, yet the mechanisms of how hormone-activated AR interacts with coactivators remain unclear. This is because AR, unlike any other nuclear receptor, prefers its own N-terminal FXXLF motif to the canonical LXXLL motifs of coactivators. Through biochemical and crystallographic studies, we identify that steroid receptor coactivator-3 (SRC3) (also named as amplified in breast cancer-1 or AIB1) interacts strongly with AR via synergistic binding of its first and third LXXLL motifs. Mutagenesis and functional studies confirm that SRC3 is a preferred coactivator for hormone-activated AR. Importantly, AR mutations found in prostate cancer patients correlate with their binding potency to SRC3, corroborating with the emerging role of SRC3 as a prostate cancer oncogene. These results provide a molecular mechanism for the selective utilization of SRC3 by hormone-activated AR, and they link the functional relationship between AR and SRC3 to the development and growth of prostate cancer.

-	~~==Disease==~~	+	Identification of SRC3/AIB1 as a preferred coactivator for hormone-activated androgen receptor.,Zhou XE, Suino-Powell KM, Li J, He Y, Mackeigan JP, Melcher K, Yong EL, Xu HE J Biol Chem. 2010 Mar 19;285(12):9161-71. Epub 2010 Jan 19. PMID:20086010<ref>PMID:20086010</ref>
-	~~[[http://www.uniprot.org/uniprot/ANDR_HUMAN ANDR_HUMAN]] Defects in AR are the cause~~ of ~~androgen insensitivity syndrome (AIS) [MIM:[http:~~/~~/omim.org/entry/300068 300068]]; previously known~~ as ~~testicular feminization syndrome (TFM). AIS is an X~~-~~linked recessive form of pseudohermaphroditism due end-organ resistance to~~ androgen. ~~Affected males have female external genitalia~~, ~~female breast development~~, ~~blind vagina~~, ~~absent uterus and female adnexa~~, ~~and abdominal or inguinal testes~~, ~~despite a normal 46~~,~~XY karyotype~~.<ref>PMID:2594783</ref><ref>PMID:8413310</ref><ref>PMID:1775137</ref><ref>PMID:16129672</ref><ref>PMID:2082179</ref><ref>PMID:1999491</ref><ref>PMID:1609793</ref><ref>PMID:1426313</ref><ref>PMID:1487249</ref><ref>PMID:1307250</ref><ref>PMID:1569163</ref><ref>PMID:1464650</ref><ref>PMID:1430233</ref><ref>PMID:1316540</ref><ref>PMID:1480178</ref><ref>PMID:8224266</ref><ref>PMID:8103398</ref><ref>PMID:8281140</ref><ref>PMID:8325950</ref><ref>PMID:8096390</ref><ref>PMID:8446106</ref>[:]<ref>PMID:8162033</ref><ref>PMID:7981687</ref><ref>PMID:7981689</ref><ref>PMID:7962294</ref><ref>PMID:8040309</ref><ref>PMID:7929841</ref><ref>PMID:7993455</ref><ref>PMID:7970939</ref><ref>PMID:8830623</ref><ref>PMID:7641413</ref><ref>PMID:7671849</ref><ref>PMID:7633398</ref><ref>PMID:7537149</ref><ref>PMID:7581399</ref><ref>PMID:8723113</ref><ref>PMID:9039340</ref><ref>PMID:9001799</ref><ref>PMID:8626869</ref><ref>PMID:8768864</ref><ref>PMID:8918984</ref><ref>PMID:8683794</ref><ref>PMID:8647313</ref><ref>PMID:8809734</ref><ref>PMID:9106550</ref><ref>PMID:9160185</ref><ref>PMID:9007482</ref><ref>PMID:8990010</ref><ref>PMID:9255042</ref><ref>PMID:9252933</ref><ref>PMID:9328206</ref><ref>PMID:9302173</ref><ref>PMID:9544375</ref><ref>PMID:9698822</ref><ref>PMID:9788719</ref><ref>PMID:9610419</ref><ref>PMID:9856504</ref><ref>PMID:9554754</ref>[:]<ref>PMID:9851768</ref><ref>PMID:9627582</ref><ref>PMID:10571951</ref><ref>PMID:10221692</ref><ref>PMID:10404311</ref><ref>PMID:10022458</ref><ref>PMID:10221770</ref><ref>PMID:10590024</ref><ref>PMID:10458483</ref><ref>PMID:10690872</ref><ref>PMID:11587068</ref><ref>PMID:11744994</ref><ref>PMID:16595706</ref> Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (~~SMAX1~~) ~~[MIM~~:~~[http://omim.org/entry/313200 313200]]; also known as Kennedy disease. SMAX1 is an X~~-~~linked recessive form of spinal muscular atrophy~~. Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX1 occurs only in men. Age at onset is usually in the third to fifth decade of life, but earlier involvement has been reported. It is characterized by slowly progressive limb and bulbar muscle weakness with fasciculations, muscle atrophy, and gynecomastia. The disorder is clinically similar to classic forms of autosomal spinal muscular atrophy. Note=Caused by trinucleotide CAG repeat expansion. In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.<ref>PMID:~~15851746~~</ref> Note=Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor. Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) [MIM:[http://omim.org/entry/312300 312300]]; also known as Reifenstein syndrome. PAIS is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations.	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.org/uniprot/ANDR_HUMAN ANDR_HUMAN]] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.<~~ref~~>~~PMID:14664718~~</~~ref~~><ref>PMID:18084323</ref><ref>PMID:19345326</ref><ref>PMID:20980437</ref><ref>PMID:15563469</ref><ref>PMID:17591767</ref><ref>PMID:17911242</ref> [[http://www.uniprot.org/uniprot/NCOA3_HUMAN NCOA3_HUMAN]] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9.	+	</div>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~3l3x~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3X OCA].	+	*[[Androgen receptor\|Androgen receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020086010</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: He, A.]]	+	[[Category: He, A]]
-	[[Category: Li, J.]]	+	[[Category: Li, J]]
-	[[Category: MacKeigan, J P.]]	+	[[Category: MacKeigan, J P]]
-	[[Category: Melcher, K.]]	+	[[Category: Melcher, K]]
-	[[Category: Suino-Powell, K M.]]	+	[[Category: Suino-Powell, K M]]
-	[[Category: Xu, H E.]]	+	[[Category: Xu, H E]]
-	[[Category: Yong, E L.]]	+	[[Category: Yong, E L]]
-	[[Category: Zhou, X E.]]	+	[[Category: Zhou, X E]]
	[[Category: Androgen receptor]]		[[Category: Androgen receptor]]
	[[Category: Ligand binding domain]]		[[Category: Ligand binding domain]]

OCA: Protected "3l3x" [edit=sysop:move=sysop]

OCA — Sun, 24 Mar 2013 23:50:58 GMT

Protected "3l3x" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:50, 24 March 2013

OCA at 23:50, 24 March 2013

OCA — Sun, 24 Mar 2013 23:50:56 GMT

←Older revision		Revision as of 23:50, 24 March 2013
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-	{{Seed}}
-	[[Image:3l3x.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3l3x", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3l3x\| PDB=3l3x \| SCENE= }}		{{STRUCTURE_3l3x\| PDB=3l3x \| SCENE= }}
-
	===Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3===		===Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3===
		+	{{ABSTRACT_PUBMED_20086010}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ANDR_HUMAN ANDR_HUMAN]] Defects in AR are the cause of androgen insensitivity syndrome (AIS) [MIM:[http://omim.org/entry/300068 300068]]; previously known as testicular feminization syndrome (TFM). AIS is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype.<ref>PMID:2594783</ref><ref>PMID:8413310</ref><ref>PMID:1775137</ref><ref>PMID:16129672</ref><ref>PMID:2082179</ref><ref>PMID:1999491</ref><ref>PMID:1609793</ref><ref>PMID:1426313</ref><ref>PMID:1487249</ref><ref>PMID:1307250</ref><ref>PMID:1569163</ref><ref>PMID:1464650</ref><ref>PMID:1430233</ref><ref>PMID:1316540</ref><ref>PMID:1480178</ref><ref>PMID:8224266</ref><ref>PMID:8103398</ref><ref>PMID:8281140</ref><ref>PMID:8325950</ref><ref>PMID:8096390</ref><ref>PMID:8446106</ref>[:]<ref>PMID:8162033</ref><ref>PMID:7981687</ref><ref>PMID:7981689</ref><ref>PMID:7962294</ref><ref>PMID:8040309</ref><ref>PMID:7929841</ref><ref>PMID:7993455</ref><ref>PMID:7970939</ref><ref>PMID:8830623</ref><ref>PMID:7641413</ref><ref>PMID:7671849</ref><ref>PMID:7633398</ref><ref>PMID:7537149</ref><ref>PMID:7581399</ref><ref>PMID:8723113</ref><ref>PMID:9039340</ref><ref>PMID:9001799</ref><ref>PMID:8626869</ref><ref>PMID:8768864</ref><ref>PMID:8918984</ref><ref>PMID:8683794</ref><ref>PMID:8647313</ref><ref>PMID:8809734</ref><ref>PMID:9106550</ref><ref>PMID:9160185</ref><ref>PMID:9007482</ref><ref>PMID:8990010</ref><ref>PMID:9255042</ref><ref>PMID:9252933</ref><ref>PMID:9328206</ref><ref>PMID:9302173</ref><ref>PMID:9544375</ref><ref>PMID:9698822</ref><ref>PMID:9788719</ref><ref>PMID:9610419</ref><ref>PMID:9856504</ref><ref>PMID:9554754</ref>[:]<ref>PMID:9851768</ref><ref>PMID:9627582</ref><ref>PMID:10571951</ref><ref>PMID:10221692</ref><ref>PMID:10404311</ref><ref>PMID:10022458</ref><ref>PMID:10221770</ref><ref>PMID:10590024</ref><ref>PMID:10458483</ref><ref>PMID:10690872</ref><ref>PMID:11587068</ref><ref>PMID:11744994</ref><ref>PMID:16595706</ref> Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (SMAX1) [MIM:[http://omim.org/entry/313200 313200]]; also known as Kennedy disease. SMAX1 is an X-linked recessive form of spinal muscular atrophy. Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX1 occurs only in men. Age at onset is usually in the third to fifth decade of life, but earlier involvement has been reported. It is characterized by slowly progressive limb and bulbar muscle weakness with fasciculations, muscle atrophy, and gynecomastia. The disorder is clinically similar to classic forms of autosomal spinal muscular atrophy. Note=Caused by trinucleotide CAG repeat expansion. In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.<ref>PMID:15851746</ref> Note=Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor. Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) [MIM:[http://omim.org/entry/312300 312300]]; also known as Reifenstein syndrome. PAIS is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations.

-	<!--	+	==Function==
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_20086010}}~~, ~~adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/ANDR_HUMAN ANDR_HUMAN]] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.<ref>PMID:14664718</ref><ref>PMID:18084323</ref><ref>PMID:19345326</ref><ref>PMID:20980437</ref><ref>PMID:15563469</ref><ref>PMID:17591767</ref><ref>PMID:17911242</ref> [[http://www.uniprot.org/uniprot/NCOA3_HUMAN NCOA3_HUMAN]] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9.
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 20086010 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20086010}}~~	+

	==About this Structure==		==About this Structure==
-	~~3L3X~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3X OCA].	+	[[3l3x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3X OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20086010~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020086010</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: He, A.]]		[[Category: He, A.]]
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	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Steroid receptor coactivator 3]]		[[Category: Steroid receptor coactivator 3]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 13:06:43 2010''

OCA at 10:06, 31 March 2010

OCA — Wed, 31 Mar 2010 10:06:44 GMT

←Older revision		Revision as of 10:06, 31 March 2010
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	[[Category: Ligand binding domain]]		[[Category: Ligand binding domain]]
	[[Category: Prostate cancer]]		[[Category: Prostate cancer]]
		+	[[Category: Protein binding]]
	[[Category: Steroid receptor coactivator 3]]		[[Category: Steroid receptor coactivator 3]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 3 08~~:59:27 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 13:06:43 2010''

OCA at 06:59, 3 February 2010

OCA — Wed, 03 Feb 2010 06:59:28 GMT

←Older revision		Revision as of 06:59, 3 February 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3l3x.~~jpg~~\|left\|200px]]	+	[[Image:3l3x.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3===		===Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20086010}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20086010 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20086010}}

	==About this Structure==		==About this Structure==
-	3L3X is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3X OCA].	+	3L3X is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3X OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20086010</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: He, A.]]		[[Category: He, A.]]
Line 29:		Line 38:
	[[Category: Steroid receptor coactivator 3]]		[[Category: Steroid receptor coactivator 3]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 13 14~~:44:11 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 08:59:27 2010''

OCA at 12:44, 13 January 2010

OCA — Wed, 13 Jan 2010 12:44:12 GMT

←Older revision		Revision as of 12:44, 13 January 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3l3x.jpg\|left\|200px]]

-	The ~~entry 3l3x~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3l3x", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3l3x\| PDB=3l3x \| SCENE= }}

-	~~Authors: X. Edward Zhou, Kelly M. Suino~~-~~Powell, Jun Li, Ajian He, Jeffrey P. MacKeigan, Karsten Melcher, Eu-Leong Yong, H. Eric Xu~~	+	===Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3===

-	Description: Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 30~~ 13:48:~~24 2009~~''	+	==About this Structure==
		+	3L3X is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3X OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: He, A.]]
		+	[[Category: Li, J.]]
		+	[[Category: MacKeigan, J P.]]
		+	[[Category: Melcher, K.]]
		+	[[Category: Suino-Powell, K M.]]
		+	[[Category: Xu, H E.]]
		+	[[Category: Yong, E L.]]
		+	[[Category: Zhou, X E.]]
		+	[[Category: Androgen receptor]]
		+	[[Category: Ligand binding domain]]
		+	[[Category: Prostate cancer]]
		+	[[Category: Steroid receptor coactivator 3]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:44:11 2010''

OCA: New page: '''Unreleased structure''' The entry 3l3x is ON HOLD Authors: X. Edward Zhou, Kelly M. Suino-Powell, Jun Li, Ajian He, Jeffrey P. MacKeigan, Karsten Melcher, Eu-Leong Yong, H. Eric Xu ...

OCA — Wed, 30 Dec 2009 11:48:25 GMT

New page: '''Unreleased structure''' The entry 3l3x is ON HOLD Authors: X. Edward Zhou, Kelly M. Suino-Powell, Jun Li, Ajian He, Jeffrey P. MacKeigan, Karsten Melcher, Eu-Leong Yong, H. Eric Xu ...

New page

'''Unreleased structure'''

The entry 3l3x is ON HOLD

Authors: X. Edward Zhou, Kelly M. Suino-Powell, Jun Li, Ajian He, Jeffrey P. MacKeigan, Karsten Melcher, Eu-Leong Yong, H. Eric Xu

Description: Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 13:48:24 2009''