3l5v - Revision history

OCA at 08:31, 6 September 2023

OCA — Wed, 06 Sep 2023 08:31:46 GMT

←Older revision		Revision as of 08:31, 6 September 2023
Line 1:		Line 1:

	==Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution==		==Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution==
-	<StructureSection load='3l5v' size='340' side='right' caption='[[3l5v]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3l5v' size='340' side='right'caption='[[3l5v]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l5v]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L5V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3L5V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l5v]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L5V FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~>, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3l5p\|3l5p]], [[3l5r\|3l5r]], [[3l5s\|3l5s]], [[3l5t\|3l5t]], [[3l5u\|3l5u]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5v OCA], [https://pdbe.org/3l5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l5v RCSB], [https://www.ebi.ac.uk/pdbsum/3l5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l5v ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3l5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5v OCA], [~~http~~://pdbe.org/3l5v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3l5v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3l5v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3l5v ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l5/3l5v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l5/3l5v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3l5v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3l5v" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~McLean, L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Zhang, Y~~]]	+	[[Category: McLean L]]
-	[[Category: ~~Acetylation]]~~	+	[[Category: Zhang Y]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Inflammatory response]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein-ligand complex]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 08:49, 1 November 2017

OCA — Wed, 01 Nov 2017 08:49:13 GMT

←Older revision		Revision as of 08:49, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution==		==Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution==
	<StructureSection load='3l5v' size='340' side='right' caption='[[3l5v]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3l5v' size='340' side='right' caption='[[3l5v]], [[Resolution\|resolution]] 1.70Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l5p\|3l5p]], [[3l5r\|3l5r]], [[3l5s\|3l5s]], [[3l5t\|3l5t]], [[3l5u\|3l5u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l5p\|3l5p]], [[3l5r\|3l5r]], [[3l5s\|3l5s]], [[3l5t\|3l5t]], [[3l5u\|3l5u]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5v OCA], [http://pdbe.org/3l5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l5v RCSB], [http://www.ebi.ac.uk/pdbsum/3l5v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5v OCA], [http://pdbe.org/3l5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l5v RCSB], [http://www.ebi.ac.uk/pdbsum/3l5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l5v ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 31:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 3l5v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3l5v" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
	== References ==		== References ==
	<references/>		<references/>
Line 41:		Line 39:
	[[Category: McLean, L]]		[[Category: McLean, L]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]
		+	[[Category: Acetylation]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
		+	[[Category: Cytoplasm]]
	[[Category: Immune response]]		[[Category: Immune response]]
	[[Category: Inflammatory response]]		[[Category: Inflammatory response]]

OCA at 20:55, 9 February 2016

OCA — Tue, 09 Feb 2016 20:55:40 GMT

←Older revision		Revision as of 20:55, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3l5v' size='340' side='right' caption='[[3l5v]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3l5v' size='340' side='right' caption='[[3l5v]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l5v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L5V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l5v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L5V FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l5p\|3l5p]], [[3l5r\|3l5r]], [[3l5s\|3l5s]], [[3l5t\|3l5t]], [[3l5u\|3l5u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l5p\|3l5p]], [[3l5r\|3l5r]], [[3l5s\|3l5s]], [[3l5t\|3l5t]], [[3l5u\|3l5u]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l5v RCSB], [http://www.ebi.ac.uk/pdbsum/3l5v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5v OCA], [http://pdbe.org/3l5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l5v RCSB], [http://www.ebi.ac.uk/pdbsum/3l5v PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l5v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3l5v" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: McLean, L]]		[[Category: McLean, L]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]

OCA at 15:25, 18 December 2014

OCA — Thu, 18 Dec 2014 15:25:58 GMT

←Older revision		Revision as of 15:25, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3l5v\| PDB=3l5v \| SCENE= }}~~	+	==Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution==
-	===Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution===	+	<StructureSection load='3l5v' size='340' side='right' caption='[[3l5v]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20185308}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3l5v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L5V FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l5p\|3l5p]], [[3l5r\|3l5r]], [[3l5s\|3l5s]], [[3l5t\|3l5t]], [[3l5u\|3l5u]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l5v RCSB], [http://www.ebi.ac.uk/pdbsum/3l5v PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l5/3l5v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the course of a fragment screening campaign by in silico docking followed by X-ray crystallography, a novel binding site for migration inhibitory factor (MIF) inhibitors was demonstrated. The site is formed by rotation of the side-chain of Tyr-36 to reveal a surface binding site in MIF that is hydrophobic and surrounded by aromatic side-chain residues. The crystal structures of two small inhibitors that bind to this site and of a quinolinone inhibitor, that spans the canonical deep pocket near Pro-1 and the new surface binding site, have been solved. These results suggest new opportunities for structure-based design of MIF inhibitors.

-	~~==Function==~~	+	Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.,McLean LR, Zhang Y, Li H, Choi YM, Han Z, Vaz RJ, Li Y Bioorg Med Chem Lett. 2010 Mar 15;20(6):1821-4. Epub 2010 Feb 6. PMID:20185308<ref>PMID:20185308</ref>
-	~~[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression~~ of MIF ~~at sites of inflammation suggests~~ a ~~role as mediator in regulating the function of macrophages in host defense~~. ~~Counteracts the anti-inflammatory activity of glucocorticoids~~. ~~Has phenylpyruvate tautomerase and dopachrome tautomerase activity~~ (~~in vitro~~)~~, but the physiological substrate is not known~~. ~~It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity~~.~~<ref>~~PMID:~~15908412</ref>~~<ref>PMID:~~17443469~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3l5v]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3L5V OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:020185308</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: McLean, L.]]	+	[[Category: McLean, L]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Immune response]]		[[Category: Immune response]]

OCA: Protected "3l5v" [edit=sysop:move=sysop]

OCA — Sun, 24 Mar 2013 18:54:16 GMT

Protected "3l5v" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:54, 24 March 2013

OCA at 18:54, 24 March 2013

OCA — Sun, 24 Mar 2013 18:54:14 GMT

←Older revision		Revision as of 18:54, 24 March 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3l5v.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3l5v", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3l5v\| PDB=3l5v \| SCENE= }}		{{STRUCTURE_3l5v\| PDB=3l5v \| SCENE= }}
-
	===Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution===		===Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution===
		+	{{ABSTRACT_PUBMED_20185308}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20185308}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref><ref>PMID:17443469</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 20185308~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20185308}}~~	+

	==About this Structure==		==About this Structure==
-	~~3L5V~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L5V OCA].	+	[[3l5v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L5V OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20185308~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020185308</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: McLean, L.]]		[[Category: McLean, L.]]
	[[Category: Zhang, Y.]]		[[Category: Zhang, Y.]]
-	[[Category: Acetylation]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
-	[[Category: Cytoplasm]]
	[[Category: Immune response]]		[[Category: Immune response]]
	[[Category: Inflammatory response]]		[[Category: Inflammatory response]]
Line 37:		Line 25:
	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 13:48:10 2010''

OCA at 11:48, 10 March 2010

OCA — Wed, 10 Mar 2010 11:48:11 GMT

←Older revision		Revision as of 11:48, 10 March 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3l5v.jpg\|left\|200px]]

-	The ~~entry 3l5v~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3l5v", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3l5v\| PDB=3l5v \| SCENE= }}

-	~~Authors: McLean, L., Zhang, Y~~.	+	===Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution===

-	Description: Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 27 19~~:15:59 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20185308}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20185308 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20185308}}
		+
		+	==About this Structure==
		+	3L5V is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L5V OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20185308</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: McLean, L.]]
		+	[[Category: Zhang, Y.]]
		+	[[Category: Acetylation]]
		+	[[Category: Cytokine]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Immune response]]
		+	[[Category: Inflammatory response]]
		+	[[Category: Innate immunity]]
		+	[[Category: Isomerase]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein-ligand complex]]
		+	[[Category: Secreted]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 13:48:10 2010''

OCA at 17:15, 27 January 2010

OCA — Wed, 27 Jan 2010 17:15:59 GMT

←Older revision		Revision as of 17:15, 27 January 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3l5v is ON HOLD	+	The entry 3l5v is ON HOLD until Paper Publication

-	Authors: L.~~MCLEAN~~, Y.~~ZHANG~~	+	Authors: McLean, L., Zhang, Y.

-	Description: ~~CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR~~ (MIF) ~~WITH GLYCEROL AT~~ 1.70A ~~RESOLUTION~~	+	Description: Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 30 13~~:49:~~07 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:15:59 2010''

OCA: New page: '''Unreleased structure''' The entry 3l5v is ON HOLD Authors: L.MCLEAN, Y.ZHANG Description: CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH GLYCEROL AT 1.70A RE...

OCA — Wed, 30 Dec 2009 11:49:08 GMT

New page: '''Unreleased structure''' The entry 3l5v is ON HOLD Authors: L.MCLEAN, Y.ZHANG Description: CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH GLYCEROL AT 1.70A RE...

New page

'''Unreleased structure'''

The entry 3l5v is ON HOLD

Authors: L.MCLEAN, Y.ZHANG

Description: CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH GLYCEROL AT 1.70A RESOLUTION

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 13:49:07 2009''