3l7g - Revision history

OCA at 08:32, 6 September 2023

OCA — Wed, 06 Sep 2023 08:32:34 GMT

←Older revision		Revision as of 08:32, 6 September 2023
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	==Crystal structure of organophosphate anhydrolase/prolidase==		==Crystal structure of organophosphate anhydrolase/prolidase==
-	<StructureSection load='3l7g' size='340' side='right' caption='[[3l7g]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3l7g' size='340' side='right'caption='[[3l7g]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l7g]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Altsx Altsx~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3L7G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l7g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Alteromonas_sp. Alteromonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L7G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=M44:N,N~~-~~BIS(1-METHYLETHYL)PHOSPHORODIAMIDIC+ACID'>M44</scene>~~, ~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3l24\|3l24]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M44:N,N-BIS(1-METHYLETHYL)PHOSPHORODIAMIDIC+ACID'>M44</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">opaA, pepQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=232 ALTSX])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7g OCA], [https://pdbe.org/3l7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l7g RCSB], [https://www.ebi.ac.uk/pdbsum/3l7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l7g ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7g OCA], [~~http~~://pdbe.org/3l7g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3l7g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3l7g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3l7g ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PEPQ_ALTSX PEPQ_ALTSX]] Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position and a nonpolar amino acid at the N-terminal position. Also catalyzes the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds including insecticide paraoxon and nerve gases such as diisopropylfluorophosphate (DFP), O-isopropyl methylphosphonofluoridate (sarin), O-pinacolyl methylphosphonofluoridate (soman), and O-cyclohexyl methylphosphonofluoridate.<ref>PMID:8633861</ref> <ref>PMID:2001997</ref> <ref>PMID:9079288</ref> <ref>PMID:10866401</ref>	+	[https://www.uniprot.org/uniprot/PEPQ_ALTSX PEPQ_ALTSX] Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position and a nonpolar amino acid at the N-terminal position. Also catalyzes the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds including insecticide paraoxon and nerve gases such as diisopropylfluorophosphate (DFP), O-isopropyl methylphosphonofluoridate (sarin), O-pinacolyl methylphosphonofluoridate (soman), and O-cyclohexyl methylphosphonofluoridate.<ref>PMID:8633861</ref> <ref>PMID:2001997</ref> <ref>PMID:9079288</ref> <ref>PMID:10866401</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Altsx~~]]	+	[[Category: Alteromonas sp]]
-	[[Category: ~~Nickitenko, A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Quiocho, F~~ A]]	+	[[Category: Nickitenko A]]
-	[[Category: ~~Vyas, N K~~]]	+	[[Category: Quiocho FA]]
-	[[Category: ~~Detoxification]]~~	+	[[Category: Vyas NK]]
-	~~[[Category: Dipeptidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Manganese]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Metalloprotease]]~~	+
-	~~[[Category: Pita-bread]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 06:32, 2 January 2019

OCA — Wed, 02 Jan 2019 06:32:23 GMT

←Older revision		Revision as of 06:32, 2 January 2019
Line 1:		Line 1:
		+
	==Crystal structure of organophosphate anhydrolase/prolidase==		==Crystal structure of organophosphate anhydrolase/prolidase==
	<StructureSection load='3l7g' size='340' side='right' caption='[[3l7g]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3l7g' size='340' side='right' caption='[[3l7g]], [[Resolution\|resolution]] 2.70Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l24\|3l24]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l24\|3l24]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">opaA, pepQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=232 ALTSX])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">opaA, pepQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=232 ALTSX])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7g OCA], [http://pdbe.org/3l7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l7g RCSB], [http://www.ebi.ac.uk/pdbsum/3l7g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7g OCA], [http://pdbe.org/3l7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l7g RCSB], [http://www.ebi.ac.uk/pdbsum/3l7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l7g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l7/3l7g_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l7/3l7g_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:00, 8 February 2016

OCA — Mon, 08 Feb 2016 00:00:01 GMT

←Older revision		Revision as of 00:00, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3l7g' size='340' side='right' caption='[[3l7g]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3l7g' size='340' side='right' caption='[[3l7g]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l7g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Alteromonas_sp. Alteromonas sp.~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L7G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l7g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Altsx Altsx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L7G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M44:N,N-BIS(1-METHYLETHYL)PHOSPHORODIAMIDIC+ACID'>M44</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M44:N,N-BIS(1-METHYLETHYL)PHOSPHORODIAMIDIC+ACID'>M44</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l24\|3l24]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l24\|3l24]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">opaA, pepQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=232 ~~Alteromonas sp.~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">opaA, pepQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=232 ALTSX])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l7g RCSB], [http://www.ebi.ac.uk/pdbsum/3l7g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7g OCA], [http://pdbe.org/3l7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l7g RCSB], [http://www.ebi.ac.uk/pdbsum/3l7g PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l7g ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3l7g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alteromonas sp~~]]	+	[[Category: Altsx]]
	[[Category: Nickitenko, A]]		[[Category: Nickitenko, A]]
	[[Category: Quiocho, F A]]		[[Category: Quiocho, F A]]

OCA at 19:07, 24 December 2014

OCA — Wed, 24 Dec 2014 19:07:17 GMT

←Older revision		Revision as of 19:07, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l7g RCSB], [http://www.ebi.ac.uk/pdbsum/3l7g PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l7g RCSB], [http://www.ebi.ac.uk/pdbsum/3l7g PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PEPQ_ALTSX PEPQ_ALTSX]] Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position and a nonpolar amino acid at the N-terminal position. Also catalyzes the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds including insecticide paraoxon and nerve gases such as diisopropylfluorophosphate (DFP), O-isopropyl methylphosphonofluoridate (sarin), O-pinacolyl methylphosphonofluoridate (soman), and O-cyclohexyl methylphosphonofluoridate.<ref>PMID:8633861</ref> <ref>PMID:2001997</ref> <ref>PMID:9079288</ref> <ref>PMID:10866401</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:22, 18 December 2014

OCA — Thu, 18 Dec 2014 17:22:31 GMT

←Older revision		Revision as of 17:22, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3l7g~~\| ~~PDB~~=3l7g \| ~~SCENE~~= }}	+	==Crystal structure of organophosphate anhydrolase/prolidase==
-	===~~Crystal~~ structure of ~~organophosphate anhydrolase~~/~~prolidase~~===	+	<StructureSection load='3l7g' size='340' side='right' caption='[[3l7g]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20000741}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3l7g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Alteromonas_sp. Alteromonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L7G FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M44:N,N-BIS(1-METHYLETHYL)PHOSPHORODIAMIDIC+ACID'>M44</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3l24\|3l24]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">opaA, pepQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=232 Alteromonas sp.])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l7g RCSB], [http://www.ebi.ac.uk/pdbsum/3l7g PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l7/3l7g_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The organophosphate acid anhydrolase (OPAA) is a member of a class of bimetalloenzymes that hydrolyze a variety of toxic acetylcholinesterase-inhibiting organophosphorus compounds, including fluorine-containing chemical nerve agents. It also belongs to a family of prolidases, with significant activity against various Xaa-Pro dipeptides. Here we report the X-ray structure determination of the native OPAA (58 kDa mass) from Alteromonas sp. strain JD6.5 and its cocrystal with the inhibitor mipafox [N,N'-diisopropyldiamidofluorophosphate (DDFP)], a close analogue of the nerve agent organophosphate substrate diisopropyl fluorophosphate (DFP). The OPAA structure is composed of two domains, amino and carboxy domains, with the latter exhibiting a "pita bread" architecture and harboring the active site with the binuclear Mn(2+) ions. The native OPAA structure revealed unexpectedly the presence of a well-defined nonproteinaceous density in the active site whose identity could not be definitively established but is suggestive of a bound glycolate, which is isosteric with a glycine (Xaa) product. All three glycolate oxygens coordinate the two Mn(2+) atoms. DDFP or more likely its hydrolysis product, N,N'-diisopropyldiamidophosphate (DDP), is present in the cocrystal structure and bound by coordinating the binuclear metals and forming hydrogen bonds and nonpolar interactions with active site residues. An unusual common feature of the binding of the two ligands is the involvement of only one oxygen atom of the glycolate carboxylate and the product DDP tetrahedral phosphate in bridging the two Mn(2+) ions. Both structures provide new understanding of ligand recognition and the prolidase and organophosphorus hydrolase catalytic activities of OPAA.

-	~~==Function==~~	+	Structural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase.,Vyas NK, Nickitenko A, Rastogi VK, Shah SS, Quiocho FA Biochemistry. 2010 Jan 26;49(3):547-59. PMID:20000741<ref>PMID:20000741</ref>
-	~~[[http://www.uniprot.org/uniprot/PEPQ_ALTSX PEPQ_ALTSX]] Splits dipeptides with a prolyl or hydroxyprolyl residue in~~ the ~~C-terminal position and a nonpolar amino acid at~~ the ~~N-terminal position~~. ~~Also catalyzes the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds including insecticide paraoxon and nerve gases such as diisopropylfluorophosphate (DFP)~~, ~~O-isopropyl methylphosphonofluoridate (sarin)~~, ~~O-pinacolyl methylphosphonofluoridate~~ (~~soman~~)~~, and O~~-~~cyclohexyl methylphosphonofluoridate~~.~~<ref>~~PMID:~~8633861</ref> <ref>PMID:2001997</ref> <ref>PMID:9079288</ref>~~ <ref>PMID:~~10866401~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3l7g]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Alteromonas_sp~~. ~~Alteromonas sp.]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3L7G OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020000741</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
-	[[Category: Alteromonas sp.]]	+	</StructureSection>
-	[[Category: Nickitenko, A.]]	+	[[Category: Alteromonas sp]]
-	[[Category: Quiocho, F A.]]	+	[[Category: Nickitenko, A]]
-	[[Category: Vyas, N K.]]	+	[[Category: Quiocho, F A]]
		+	[[Category: Vyas, N K]]
	[[Category: Detoxification]]		[[Category: Detoxification]]
	[[Category: Dipeptidase]]		[[Category: Dipeptidase]]

OCA: Protected "3l7g" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 20:00:08 GMT

Protected "3l7g" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:00, 4 April 2013

OCA at 19:59, 4 April 2013

OCA — Thu, 04 Apr 2013 19:59:59 GMT

←Older revision		Revision as of 19:59, 4 April 2013
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-	{{Seed}}
-	[[Image:3l7g.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3l7g", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3l7g\| PDB=3l7g \| SCENE= }}		{{STRUCTURE_3l7g\| PDB=3l7g \| SCENE= }}
-
	===Crystal structure of organophosphate anhydrolase/prolidase===		===Crystal structure of organophosphate anhydrolase/prolidase===
		+	{{ABSTRACT_PUBMED_20000741}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/PEPQ_ALTSX PEPQ_ALTSX]] Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position and a nonpolar amino acid at the N-terminal position. Also catalyzes the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds including insecticide paraoxon and nerve gases such as diisopropylfluorophosphate (DFP), O-isopropyl methylphosphonofluoridate (sarin), O-pinacolyl methylphosphonofluoridate (soman), and O-cyclohexyl methylphosphonofluoridate.<ref>PMID:8633861</ref> <ref>PMID:2001997</ref> <ref>PMID:9079288</ref> <ref>PMID:10866401</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20000741}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20000741 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20000741}}~~	+

	==About this Structure==		==About this Structure==
-	~~3L7G~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Alteromonas_sp. Alteromonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7G OCA].	+	[[3l7g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Alteromonas_sp. Alteromonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7G OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20000741~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020000741</ref><references group="xtra"/><references/>
	[[Category: Alteromonas sp.]]		[[Category: Alteromonas sp.]]
	[[Category: Nickitenko, A.]]		[[Category: Nickitenko, A.]]
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	[[Category: Pita-bread]]		[[Category: Pita-bread]]
	[[Category: Protease]]		[[Category: Protease]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 17:11:47 2010''

OCA at 15:11, 10 February 2010

OCA — Wed, 10 Feb 2010 15:11:48 GMT

←Older revision		Revision as of 15:11, 10 February 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3l7g.jpg\|left\|200px]]

-	The ~~entry 3l7g~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3l7g", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3l7g\| PDB=3l7g \| SCENE= }}

-	~~Authors: Vyas, N.K., Nickitenko, A., Quiocho, F.A.~~	+	===Crystal structure of organophosphate anhydrolase/prolidase===

-	Description: Crystal structure of organophosphate anhydrolase/prolidase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 27 19~~:16:16 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20000741}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20000741 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20000741}}
		+
		+	==About this Structure==
		+	3L7G is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Alteromonas_sp. Alteromonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7G OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20000741</ref><references group="xtra"/>
		+	[[Category: Alteromonas sp.]]
		+	[[Category: Nickitenko, A.]]
		+	[[Category: Quiocho, F A.]]
		+	[[Category: Vyas, N K.]]
		+	[[Category: Detoxification]]
		+	[[Category: Dipeptidase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Manganese]]
		+	[[Category: Metal-binding]]
		+	[[Category: Metalloprotease]]
		+	[[Category: Pita-bread]]
		+	[[Category: Protease]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 17:11:47 2010''

OCA at 17:16, 27 January 2010

OCA — Wed, 27 Jan 2010 17:16:17 GMT

←Older revision		Revision as of 17:16, 27 January 2010
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3l7g is ON HOLD ~~until sometime in the future~~	+	The entry 3l7g is ON HOLD

-	Authors: Vyas, ~~Nand~~ K., Nickitenko, ~~Alexei~~, Quiocho, ~~Florante~~ A.	+	Authors: Vyas, N.K., Nickitenko, A., Quiocho, F.A.

	Description: Crystal structure of organophosphate anhydrolase/prolidase		Description: Crystal structure of organophosphate anhydrolase/prolidase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan ~~13 13~~:34:04 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:16:16 2010''

OCA at 11:34, 13 January 2010

OCA — Wed, 13 Jan 2010 11:34:05 GMT

←Older revision		Revision as of 11:34, 13 January 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3l7g is ON HOLD	+	The entry 3l7g is ON HOLD until sometime in the future

	Authors: Vyas, Nand K., Nickitenko, Alexei, Quiocho, Florante A.		Authors: Vyas, Nand K., Nickitenko, Alexei, Quiocho, Florante A.
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	Description: Crystal structure of organophosphate anhydrolase/prolidase		Description: Crystal structure of organophosphate anhydrolase/prolidase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan ~~6 09~~:14:29 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 13:34:04 2010''