3l8j - Revision history

OCA at 08:32, 6 September 2023

OCA — Wed, 06 Sep 2023 08:32:49 GMT

←Older revision		Revision as of 08:32, 6 September 2023
Line 1:		Line 1:

	==Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity==		==Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity==
-	<StructureSection load='3l8j' size='340' side='right' caption='[[3l8j]], [[Resolution\|resolution]] 3.05Å' scene=''>	+	<StructureSection load='3l8j' size='340' side='right'caption='[[3l8j]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l8j]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3L8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L8J FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.05Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">PDCD10, CCM3, TFAR15 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8j OCA], [https://pdbe.org/3l8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l8j RCSB], [https://www.ebi.ac.uk/pdbsum/3l8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l8j ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8j OCA], [~~http~~://pdbe.org/3l8j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3l8j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3l8j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3l8j ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Hereditary cerebral cavernous malformation. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:[~~http~~://omim.org/entry/603285 603285]]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.<ref>PMID:15543491</ref>	+	[https://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN] Hereditary cerebral cavernous malformation. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:[https://omim.org/entry/603285 603285]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.<ref>PMID:15543491</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).<ref>PMID:15543491</ref> <ref>PMID:17360971</ref> <ref>PMID:20332113</ref>	+	[https://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN] Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).<ref>PMID:15543491</ref> <ref>PMID:17360971</ref> <ref>PMID:20332113</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Cell death protein\|Cell death protein]]	+	*[[Cell death protein 3D structures\|Cell death protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Boggon~~, T J~~]]	+	[[Category: Large Structures]]
-	[[Category: He, Y]]	+	[[Category: Boggon TJ]]
-	[[Category: Ji, W]]	+	[[Category: He Y]]
-	[[Category: Li, X]]	+	[[Category: Ji W]]
-	[[Category: Min, W]]	+	[[Category: Li X]]
-	[[Category: Zhang, H]]	+	[[Category: Min W]]
-	[[Category: Zhang, R]]	+	[[Category: Zhang H]]
-	~~[[Category: Cerebral cavernous malformation]]~~	+	[[Category: Zhang R]]
-	~~[[Category: Dimerization]]~~	+
-	~~[[Category: Fat domain]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 06:51, 2 January 2019

OCA — Wed, 02 Jan 2019 06:51:20 GMT

←Older revision		Revision as of 06:51, 2 January 2019
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l8j_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l8j_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:44, 5 August 2016

OCA — Fri, 05 Aug 2016 05:44:09 GMT

←Older revision		Revision as of 05:44, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity==		==Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity==
	<StructureSection load='3l8j' size='340' side='right' caption='[[3l8j]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='3l8j' size='340' side='right' caption='[[3l8j]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l8j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l8j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L8J FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD10, CCM3, TFAR15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD10, CCM3, TFAR15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l8j RCSB], [http://www.ebi.ac.uk/pdbsum/3l8j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8j OCA], [http://pdbe.org/3l8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l8j RCSB], [http://www.ebi.ac.uk/pdbsum/3l8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l8j ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l8j ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3l8j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Boggon, T J]]		[[Category: Boggon, T J]]
	[[Category: He, Y]]		[[Category: He, Y]]

OCA at 16:53, 18 December 2014

OCA — Thu, 18 Dec 2014 16:53:04 GMT

←Older revision		Revision as of 16:53, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3l8j\| PDB=3l8j \| SCENE= }}~~	+	==Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity==
-	===Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity===	+	<StructureSection load='3l8j' size='340' side='right' caption='[[3l8j]], [[Resolution\|resolution]] 3.05Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20489202}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3l8j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L8J FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDCD10, CCM3, TFAR15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l8j RCSB], [http://www.ebi.ac.uk/pdbsum/3l8j PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Hereditary cerebral cavernous malformation. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:[http://omim.org/entry/603285 603285]]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.<ref>PMID:15543491</ref>		[[http://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Hereditary cerebral cavernous malformation. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:[http://omim.org/entry/603285 603285]]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.<ref>PMID:15543491</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).<ref>PMID:15543491</ref> <ref>PMID:17360971</ref> <ref>PMID:20332113</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l8j_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CCM3 mutations are associated with cerebral cavernous malformation (CCM), a disease affecting 0.1-0.5% of the human population. CCM3 (PDCD10, TFAR15) is thought to form a CCM complex with CCM1 and CCM2; however, the molecular basis for these interactions is not known. We have determined the 2.5 A crystal structure of CCM3. This structure shows an all alpha-helical protein containing two domains, an N-terminal dimerization domain with a fold not previously observed, and a C-terminal focal adhesion targeting (FAT)-homology domain. We show that CCM3 binds CCM2 via this FAT-homology domain and that mutation of a highly conserved FAK-like hydrophobic pocket (HP1) abrogates CCM3-CCM2 interaction. This CCM3 FAT-homology domain also interacts with paxillin LD motifs using the same surface, and partial CCM3 co-localization with paxillin in cells is lost on HP1 mutation. Disease-related CCM3 truncations affect the FAT-homology domain suggesting a role for the FAT-homology domain in the etiology of CCM.

-	~~==Function==~~	+	Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.,Li X, Zhang R, Zhang H, He Y, Ji W, Min W, Boggon TJ J Biol Chem. 2010 Jul 30;285(31):24099-107. Epub 2010 May 19. PMID:20489202<ref>PMID:20489202</ref>
-	[[http://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure ~~and assembly~~ of ~~the Golgi complex. Important~~ for ~~KDR/VEGFR2 signaling~~. ~~Increases the stability of KDR/VEGFR2 and prevents its breakdown~~. ~~Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development~~ (~~By similarity~~).~~<ref>~~PMID:~~15543491</ref> <ref>PMID:17360971</ref>~~ <ref>PMID:~~20332113~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3l8j]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:020489202</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Cell death protein\|Cell death protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Boggon, T J.]]	+	[[Category: Boggon, T J]]
-	[[Category: He, Y.]]	+	[[Category: He, Y]]
-	[[Category: Ji, W.]]	+	[[Category: Ji, W]]
-	[[Category: Li, X.]]	+	[[Category: Li, X]]
-	[[Category: Min, W.]]	+	[[Category: Min, W]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
-	[[Category: Zhang, R.]]	+	[[Category: Zhang, R]]
	[[Category: Cerebral cavernous malformation]]		[[Category: Cerebral cavernous malformation]]
	[[Category: Dimerization]]		[[Category: Dimerization]]
	[[Category: Fat domain]]		[[Category: Fat domain]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA: Protected "3l8j" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 20:39:09 GMT

Protected "3l8j" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:39, 4 April 2013

OCA at 20:39, 4 April 2013

OCA — Thu, 04 Apr 2013 20:39:07 GMT

←Older revision		Revision as of 20:39, 4 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3l8j.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3l8j", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3l8j\| PDB=3l8j \| SCENE= }}		{{STRUCTURE_3l8j\| PDB=3l8j \| SCENE= }}
-
	===Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity===		===Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity===
		+	{{ABSTRACT_PUBMED_20489202}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Hereditary cerebral cavernous malformation. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:[http://omim.org/entry/603285 603285]]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.<ref>PMID:15543491</ref>

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20489202}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).<ref>PMID:15543491</ref> <ref>PMID:17360971</ref> <ref>PMID:20332113</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 20489202 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20489202}}~~	+

	==About this Structure==		==About this Structure==
-	~~3L8J~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA].	+	[[3l8j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20489202~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020489202</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Boggon, T J.]]		[[Category: Boggon, T J.]]
Line 36:		Line 26:
	[[Category: Fat domain]]		[[Category: Fat domain]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:06:44 2010''

OCA at 04:02, 2 June 2010

OCA — Wed, 02 Jun 2010 04:02:38 GMT

←Older revision		Revision as of 04:02, 2 June 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3l8j.~~jpg~~\|left\|200px]]	+	[[Image:3l8j.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity===		===Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20489202}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20489202 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20489202}}

	==About this Structure==		==About this Structure==
	3L8J is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA].		3L8J is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20489202</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Boggon, T J.]]		[[Category: Boggon, T J.]]
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	[[Category: Protein binding]]		[[Category: Protein binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu May 20 09~~:49:02 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:06:44 2010''

OCA at 06:49, 20 May 2010

OCA — Thu, 20 May 2010 06:49:04 GMT

←Older revision		Revision as of 06:49, 20 May 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3l8j.jpg\|left\|200px]]

-	The ~~entry 3l8j~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3l8j", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3l8j\| PDB=3l8j \| SCENE= }}

-	~~Authors: Li~~, ~~X., Zhang, R., Zhang, H., He, Y., Min, W., Boggon, T.J.~~	+	===Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity===

-	Description: Protein X

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Feb 3~~ 09:18:19 2010''	+	==About this Structure==
		+	3L8J is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8J OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Boggon, T J.]]
		+	[[Category: He, Y.]]
		+	[[Category: Ji, W.]]
		+	[[Category: Li, X.]]
		+	[[Category: Min, W.]]
		+	[[Category: Zhang, H.]]
		+	[[Category: Zhang, R.]]
		+	[[Category: Cerebral cavernous malformation]]
		+	[[Category: Dimerization]]
		+	[[Category: Fat domain]]
		+	[[Category: Protein binding]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:49:02 2010''

OCA at 07:18, 3 February 2010

OCA — Wed, 03 Feb 2010 07:18:20 GMT

←Older revision		Revision as of 07:18, 3 February 2010
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3l8j is ON HOLD	+	The entry 3l8j is ON HOLD until Paper Publication

	Authors: Li, X., Zhang, R., Zhang, H., He, Y., Min, W., Boggon, T.J.		Authors: Li, X., Zhang, R., Zhang, H., He, Y., Min, W., Boggon, T.J.
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	Description: Protein X		Description: Protein X

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 13 13~~:34:16 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:18:19 2010''

OCA: New page: '''Unreleased structure''' The entry 3l8j is ON HOLD Authors: Li, X., Zhang, R., Zhang, H., He, Y., Min, W., Boggon, T.J. Description: Protein X ''Page seeded by [http://oca.weizmann....

OCA — Wed, 13 Jan 2010 11:34:16 GMT

New page: '''Unreleased structure''' The entry 3l8j is ON HOLD Authors: Li, X., Zhang, R., Zhang, H., He, Y., Min, W., Boggon, T.J. Description: Protein X ''Page seeded by [http://oca.weizmann....

New page

'''Unreleased structure'''

The entry 3l8j is ON HOLD

Authors: Li, X., Zhang, R., Zhang, H., He, Y., Min, W., Boggon, T.J.

Description: Protein X

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 13:34:16 2010''