3l8w - Revision history

OCA at 16:21, 1 November 2023

OCA — Wed, 01 Nov 2023 16:21:51 GMT

←Older revision		Revision as of 16:21, 1 November 2023
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	<StructureSection load='3l8w' size='340' side='right'caption='[[3l8w]], [[Resolution\|resolution]] 1.00Å' scene=''>		<StructureSection load='3l8w' size='340' side='right'caption='[[3l8w]], [[Resolution\|resolution]] 1.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l8w]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aspfl Aspfl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3L8W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L8W FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=4PO:ALPHA-(4-PYRIDYL~~-1~~-OXIDE)-N-TERT-BUTYLNITRONE'>4PO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~ACE~~:~~ACETYL+GROUP~~'>~~ACE~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4PO:ALPHA-(4-PYRIDYL-1-OXIDE)-N-TERT-BUTYLNITRONE'>4PO</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[1r51\|1r51]]~~, ~~[[1r4s\|1r4s]], [[1r4u\|1r4u]], [[1r56\|1r56]], [[1wrr\|1wrr]], [[1xt4\|1xt4]], [[3l9g\|3l9g]], [[3lbg\|3lbg]]~~<~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8w OCA], [https://pdbe.org/3l8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l8w RCSB], [https://www.ebi.ac.uk/pdbsum/3l8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l8w ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8w OCA], [~~http~~://pdbe.org/3l8w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3l8w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3l8w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3l8w ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.	+	[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Urate ~~Oxidase~~\|Urate ~~Oxidase~~]]	+	*[[Urate oxidase 3D structures\|Urate oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aspfl]]~~	+	[[Category: Aspergillus flavus]]
-	~~[[Category: Factor independent urate hydroxylase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chiadmi, M]]	+	[[Category: Chiadmi M]]
-	[[Category: ~~Gabison, L]]~~	+	[[Category: Colloc'h N]]
-	~~[[Category: Prange, T]]~~	+	[[Category: Gabison L]]
-	~~[[Category: H,~~ N ~~Colloc~~]]	+	[[Category: Prange T]]
-	[[Category: ~~Inhibition aspergillus flavus~~]]	+
-	[[Category: ~~Oxidoreductase]]~~	+
-	~~[[Category: Peroxisome]]~~	+
-	~~[[Category: Purine metabolism]]~~	+
-	~~[[Category: Uric acid degradation]]~~	+
-	~~[[Category: Xanthine~~]]	+

OCA at 13:32, 25 December 2019

OCA — Wed, 25 Dec 2019 13:32:21 GMT

←Older revision		Revision as of 13:32, 25 December 2019
Line 1:		Line 1:

	==Urate oxidase from aspergillus flavus complexed with xanthin==		==Urate oxidase from aspergillus flavus complexed with xanthin==
-	<StructureSection load='3l8w' size='340' side='right' caption='[[3l8w]], [[Resolution\|resolution]] 1.00Å' scene=''>	+	<StructureSection load='3l8w' size='340' side='right'caption='[[3l8w]], [[Resolution\|resolution]] 1.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3l8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L8W FirstGlance]. <br>		<table><tr><td colspan='2'>[[3l8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L8W FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 3l8w" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3l8w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Urate Oxidase\|Urate Oxidase]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 40:
	[[Category: Aspfl]]		[[Category: Aspfl]]
	[[Category: Factor independent urate hydroxylase]]		[[Category: Factor independent urate hydroxylase]]
		+	[[Category: Large Structures]]
	[[Category: Chiadmi, M]]		[[Category: Chiadmi, M]]
	[[Category: Gabison, L]]		[[Category: Gabison, L]]

OCA at 07:01, 28 February 2018

OCA — Wed, 28 Feb 2018 07:01:25 GMT

←Older revision		Revision as of 07:01, 28 February 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l8w_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l8w_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 39:		Line 39:
	[[Category: Chiadmi, M]]		[[Category: Chiadmi, M]]
	[[Category: Gabison, L]]		[[Category: Gabison, L]]
-	[[Category: H, N Colloc]]
	[[Category: Prange, T]]		[[Category: Prange, T]]
		+	[[Category: H, N Colloc]]
	[[Category: Inhibition aspergillus flavus]]		[[Category: Inhibition aspergillus flavus]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:51, 1 November 2017

OCA — Wed, 01 Nov 2017 08:51:08 GMT

←Older revision		Revision as of 08:51, 1 November 2017
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3l8w" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3l8w" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Urate Oxidase\|Urate Oxidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:08, 4 August 2016

OCA — Thu, 04 Aug 2016 12:08:41 GMT

←Older revision		Revision as of 12:08, 4 August 2016
Line 1:		Line 1:
		+
	==Urate oxidase from aspergillus flavus complexed with xanthin==		==Urate oxidase from aspergillus flavus complexed with xanthin==
	<StructureSection load='3l8w' size='340' side='right' caption='[[3l8w]], [[Resolution\|resolution]] 1.00Å' scene=''>		<StructureSection load='3l8w' size='340' side='right' caption='[[3l8w]], [[Resolution\|resolution]] 1.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3l8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aspergillus_flavus Aspergillus flavus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L8W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3l8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L8W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4PO:ALPHA-(4-PYRIDYL-1-OXIDE)-N-TERT-BUTYLNITRONE'>4PO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4PO:ALPHA-(4-PYRIDYL-1-OXIDE)-N-TERT-BUTYLNITRONE'>4PO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r51\|1r51]], [[1r4s\|1r4s]], [[1r4u\|1r4u]], [[1r56\|1r56]], [[1wrr\|1wrr]], [[1xt4\|1xt4]], [[3l9g\|3l9g]], [[3lbg\|3lbg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r51\|1r51]], [[1r4s\|1r4s]], [[1r4u\|1r4u]], [[1r56\|1r56]], [[1wrr\|1wrr]], [[1xt4\|1xt4]], [[3l9g\|3l9g]], [[3lbg\|3lbg]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Urate_oxidase Urate oxidase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l8w RCSB], [http://www.ebi.ac.uk/pdbsum/3l8w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8w OCA], [http://pdbe.org/3l8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l8w RCSB], [http://www.ebi.ac.uk/pdbsum/3l8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l8w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l8w ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3l8w" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aspergillus flavus~~]]	+	[[Category: Aspfl]]
-	[[Category: ~~Urate oxidase~~]]	+	[[Category: Factor independent urate hydroxylase]]
	[[Category: Chiadmi, M]]		[[Category: Chiadmi, M]]
	[[Category: Gabison, L]]		[[Category: Gabison, L]]

OCA at 09:10, 25 December 2014

OCA — Thu, 25 Dec 2014 09:10:39 GMT

←Older revision		Revision as of 09:10, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l8w RCSB], [http://www.ebi.ac.uk/pdbsum/3l8w PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l8w RCSB], [http://www.ebi.ac.uk/pdbsum/3l8w PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:32, 9 December 2014

OCA — Tue, 09 Dec 2014 08:32:46 GMT

←Older revision		Revision as of 08:32, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3l8w.~~png~~\|~~left~~\|200px]]	+	==Urate oxidase from aspergillus flavus complexed with xanthin==
		+	<StructureSection load='3l8w' size='340' side='right' caption='[[3l8w]], [[Resolution\|resolution]] 1.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3l8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L8W FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4PO:ALPHA-(4-PYRIDYL-1-OXIDE)-N-TERT-BUTYLNITRONE'>4PO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1r51\|1r51]], [[1r4s\|1r4s]], [[1r4u\|1r4u]], [[1r56\|1r56]], [[1wrr\|1wrr]], [[1xt4\|1xt4]], [[3l9g\|3l9g]], [[3lbg\|3lbg]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Urate_oxidase Urate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l8w RCSB], [http://www.ebi.ac.uk/pdbsum/3l8w PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l8w_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Urate oxidase (uricase; EC 1.7.3.3; UOX) from Aspergillus flavus catalyzes the oxidation of uric acid in the presence of molecular oxygen to 5-hydroxyisourate in the degradation cascade of purines; intriguingly, catalysis proceeds using neither a metal ion (Fe, Cu etc.) nor a redox cofactor. UOX is a tetrameric enzyme with four active sites located at the interface of two subunits; its structure was refined at atomic resolution (1 A) using new crystal data in the presence of xanthine and at near-atomic resolution (1.3-1.7 A) in complexes with the natural substrate (urate) and two inhibitors: 8-nitroxanthine and 8-thiouric acid. Three new features of the structural and mechanistic behaviour of the enzyme were addressed. Firstly, the high resolution of the UOX-xanthine structure allowed the solution of an old structural problem at a contact zone within the tetramer; secondly, the protonation state of the substrate was determined from both a halochromic inhibitor complex (UOX-8-nitroxanthine) and from the H-atom distribution in the active site, using the structures of the UOX-xanthine and the UOX-uric acid complexes; and thirdly, it was possible to extend the general base system, characterized by the conserved catalytic triad Thr-Lys-His, to a large water network that is able to buffer and shuttle protons back and forth between the substrate and the peroxo hole along the reaction pathway.

-	~~{{STRUCTURE_3l8w\| PDB=3l8w \| SCENE= }}~~	+	Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand.,Gabison L, Chiadmi M, El Hajji M, Castro B, Colloc'h N, Prange T Acta Crystallogr D Biol Crystallogr. 2010 Jun;66(Pt 6):714-24. Epub 2010 May 15. PMID:20516624<ref>PMID:20516624</ref>

-	~~===Urate oxidase from aspergillus flavus complexed with xanthin===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20516624}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3l8w]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aspergillus_flavus Aspergillus flavus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA].~~	+

	==See Also==		==See Also==
	*[[Urate Oxidase\|Urate Oxidase]]		*[[Urate Oxidase\|Urate Oxidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020516624<~~/~~ref~~><~~ref group="xtra">PMID:009360612</ref><ref group="xtra">PMID:016545381</ref><ref group="xtra">PMID:018638417</ref><ref group="xtra">PMID:018375516</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aspergillus flavus]]		[[Category: Aspergillus flavus]]
	[[Category: Urate oxidase]]		[[Category: Urate oxidase]]
-	[[Category: Chiadmi, M.]]	+	[[Category: Chiadmi, M]]
-	[[Category: Gabison, L.]]	+	[[Category: Gabison, L]]
-	[[Category: H, N Colloc.]]	+	[[Category: H, N Colloc]]
-	[[Category: Prange, T.]]	+	[[Category: Prange, T]]
	[[Category: Inhibition aspergillus flavus]]		[[Category: Inhibition aspergillus flavus]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 14:57, 20 October 2012

OCA — Sat, 20 Oct 2012 14:57:30 GMT

←Older revision		Revision as of 14:57, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3l8w]] is a 1 chain structure ~~of [[Urate Oxidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA].	+	[[3l8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA].

	==See Also==		==See Also==

OCA at 16:49, 26 July 2012

OCA — Thu, 26 Jul 2012 16:49:04 GMT

←Older revision		Revision as of 16:49, 26 July 2012
Line 1:		Line 1:
	[[Image:3l8w.png\|left\|200px]]		[[Image:3l8w.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3l8w", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3l8w\| PDB=3l8w \| SCENE= }}		{{STRUCTURE_3l8w\| PDB=3l8w \| SCENE= }}

	===Urate oxidase from aspergillus flavus complexed with xanthin===		===Urate oxidase from aspergillus flavus complexed with xanthin===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20516624}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20516624 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20516624}}		{{ABSTRACT_PUBMED_20516624}}

OCA at 05:10, 4 April 2012

OCA — Wed, 04 Apr 2012 05:10:02 GMT

←Older revision		Revision as of 05:10, 4 April 2012
Line 13:		Line 13:

	<!--		<!--
-	The line below this paragraph, {{~~ABSTRACT_PUBMED_9360612~~}}, adds the Publication Abstract to the page	+	The line below this paragraph, {{ABSTRACT_PUBMED_20516624}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where ~~9360612~~ is the PubMed ID number.	+	(as it appears on PubMed at http://www.pubmed.gov), where 20516624 is the PubMed ID number.
	-->		-->
-	{{~~ABSTRACT_PUBMED_9360612~~}}	+	{{ABSTRACT_PUBMED_20516624}}

	==About this Structure==		==About this Structure==
-	[[3l8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA].	+	[[3l8w]] is a 1 chain structure of [[Urate Oxidase]] with sequence from [http://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA].
		+
		+	==See Also==
		+	*[[Urate Oxidase\|Urate Oxidase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~9360612~~</ref><ref group="xtra">PMID:~~16545381~~</ref><ref group="xtra">PMID:~~18638417~~</ref><ref group="xtra">PMID:~~18375516~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020516624</ref><ref group="xtra">PMID:009360612</ref><ref group="xtra">PMID:016545381</ref><ref group="xtra">PMID:018638417</ref><ref group="xtra">PMID:018375516</ref><references group="xtra"/>
	[[Category: Aspergillus flavus]]		[[Category: Aspergillus flavus]]
	[[Category: Urate oxidase]]		[[Category: Urate oxidase]]
Line 29:		Line 32:
	[[Category: H, N Colloc.]]		[[Category: H, N Colloc.]]
	[[Category: Prange, T.]]		[[Category: Prange, T.]]
-	[[Category: Acetylation]]
	[[Category: Inhibition aspergillus flavus]]		[[Category: Inhibition aspergillus flavus]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]