3laq - Revision history

OCA at 06:44, 2 January 2019

OCA — Wed, 02 Jan 2019 06:44:42 GMT

←Older revision		Revision as of 06:44, 2 January 2019
Line 1:		Line 1:
		+
	==Structure-based engineering of species selectivity in the uPA-uPAR interaction==		==Structure-based engineering of species selectivity in the uPA-uPAR interaction==
	<StructureSection load='3laq' size='340' side='right' caption='[[3laq]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3laq' size='340' side='right' caption='[[3laq]], [[Resolution\|resolution]] 3.20Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plau ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Plaur ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plau ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Plaur ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3laq OCA], [http://pdbe.org/3laq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3laq RCSB], [http://www.ebi.ac.uk/pdbsum/3laq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3laq OCA], [http://pdbe.org/3laq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3laq RCSB], [http://www.ebi.ac.uk/pdbsum/3laq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3laq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/la/3laq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/la/3laq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:22, 8 February 2016

OCA — Mon, 08 Feb 2016 02:22:17 GMT

←Older revision		Revision as of 02:22, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3laq' size='340' side='right' caption='[[3laq]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3laq' size='340' side='right' caption='[[3laq]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3laq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LAQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3laq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LAQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fd6\|2fd6]], [[3bt1\|3bt1]], [[3bt2\|3bt2]], [[2fat\|2fat]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fd6\|2fd6]], [[3bt1\|3bt1]], [[3bt2\|3bt2]], [[2fat\|2fat]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plau ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), Plaur ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plau ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Plaur ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3laq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3laq RCSB], [http://www.ebi.ac.uk/pdbsum/3laq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3laq OCA], [http://pdbe.org/3laq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3laq RCSB], [http://www.ebi.ac.uk/pdbsum/3laq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3laq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3laq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
	[[Category: Huang, M]]		[[Category: Huang, M]]

OCA at 19:52, 24 December 2014

OCA — Wed, 24 Dec 2014 19:52:06 GMT

←Older revision		Revision as of 19:52, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3laq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LAQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3laq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LAQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fd6\|2fd6]], [[3bt1\|3bt1]], [[3bt2\|3bt2]], [[2fat\|2fat]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fd6\|2fd6]], [[3bt1\|3bt1]], [[3bt2\|3bt2]], [[2fat\|2fat]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plau ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Plaur ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plau ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Plaur ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3laq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3laq RCSB], [http://www.ebi.ac.uk/pdbsum/3laq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3laq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3laq RCSB], [http://www.ebi.ac.uk/pdbsum/3laq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UROK_MOUSE UROK_MOUSE]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. [[http://www.uniprot.org/uniprot/UPAR_MOUSE UPAR_MOUSE]] Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
-	[[Category: Huang, M.]]	+	[[Category: Huang, M]]
	[[Category: Atf]]		[[Category: Atf]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]

OCA at 10:58, 29 September 2014

OCA — Mon, 29 Sep 2014 10:58:05 GMT

←Older revision		Revision as of 10:58, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3laq.~~png~~\|~~left~~\|200px]]	+	==Structure-based engineering of species selectivity in the uPA-uPAR interaction==
		+	<StructureSection load='3laq' size='340' side='right' caption='[[3laq]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3laq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LAQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fd6\|2fd6]], [[3bt1\|3bt1]], [[3bt2\|3bt2]], [[2fat\|2fat]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plau ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Plaur ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3laq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3laq RCSB], [http://www.ebi.ac.uk/pdbsum/3laq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/la/3laq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The high affinity interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) is decisive for cell surface-associated plasminogen activation. Because plasmin activity controls fibrinolysis in a variety of pathological conditions, including cancer and wound healing, several intervention studies have focused on targeting the uPA.uPAR interaction in vivo. Evaluations of such studies in xenotransplanted tumor models are, however, complicated by the pronounced species selectivity in this interaction. We now report the molecular basis underlying this difference by solving the crystal structure for the murine uPA.uPAR complex and demonstrate by extensive surface plasmon resonance studies that the kinetic rate constants for this interaction can be swapped completely between these orthologs by exchanging only two residues. This study not only discloses the structural basis required for a successful rational design of the species selectivity in the uPA.uPAR interaction, which is highly relevant for functional studies in mouse models, but it also suggests the possible development of general inhibitors that will target the uPA.uPAR interaction across species barriers.

-	~~{{STRUCTURE_3laq\| PDB=3laq \| SCENE= }}~~	+	Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy.,Lin L, Gardsvoll H, Huai Q, Huang M, Ploug M J Biol Chem. 2010 Apr 2;285(14):10982-92. Epub 2010 Feb 4. PMID:20133942<ref>PMID:20133942</ref>

-	~~===Structure-based engineering~~ of ~~species selectivity in~~ the ~~uPA-uPAR interaction===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20133942}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3laq]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA].~~	+

	==See Also==		==See Also==
	*[[Urokinase\|Urokinase]]		*[[Urokinase\|Urokinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020133942<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]

OCA at 08:34, 20 October 2012

OCA — Sat, 20 Oct 2012 08:34:51 GMT

←Older revision		Revision as of 08:34, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3laq]] is a 4 chain structure ~~of [[Urokinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA].	+	[[3laq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA].

	==See Also==		==See Also==

OCA: Protected "3laq" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 19:59:18 GMT

Protected "3laq" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:59, 25 July 2012

OCA at 19:59, 25 July 2012

OCA — Wed, 25 Jul 2012 19:59:15 GMT

←Older revision		Revision as of 19:59, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3laq.png\|left\|200px]]		[[Image:3laq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3laq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3laq\| PDB=3laq \| SCENE= }}		{{STRUCTURE_3laq\| PDB=3laq \| SCENE= }}

	===Structure-based engineering of species selectivity in the uPA-uPAR interaction===		===Structure-based engineering of species selectivity in the uPA-uPAR interaction===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20133942}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20133942 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20133942}}		{{ABSTRACT_PUBMED_20133942}}

	==About this Structure==		==About this Structure==
-	~~3LAQ~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA].	+	[[3laq]] is a 4 chain structure of [[Urokinase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA].
		+
		+	==See Also==
		+	*[[Urokinase\|Urokinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20133942~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020133942</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
	[[Category: Huang, M.]]		[[Category: Huang, M.]]
-	[[Category: Alternative splicing]]
	[[Category: Atf]]		[[Category: Atf]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
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	[[Category: Upar]]		[[Category: Upar]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:29:25 2010''

OCA at 07:29, 12 May 2010

OCA — Wed, 12 May 2010 07:29:25 GMT

←Older revision		Revision as of 07:29, 12 May 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3laq.~~jpg~~\|left\|200px]]	+	[[Image:3laq.png\|left\|200px]]

	<!--		<!--
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	===Structure-based engineering of species selectivity in the uPA-uPAR interaction===		===Structure-based engineering of species selectivity in the uPA-uPAR interaction===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20133942}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20133942 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20133942}}

	==About this Structure==		==About this Structure==
	3LAQ is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA].		3LAQ is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20133942</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: U-plasminogen activator]]		[[Category: U-plasminogen activator]]
Line 26:		Line 35:
	[[Category: Gpi-anchor]]		[[Category: Gpi-anchor]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase receptor complex]]
	[[Category: Kringle]]		[[Category: Kringle]]
	[[Category: Lipoprotein]]		[[Category: Lipoprotein]]
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	[[Category: Zymogen]]		[[Category: Zymogen]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 3~~ 10:02:48 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:29:25 2010''

OCA at 08:02, 3 February 2010

OCA — Wed, 03 Feb 2010 08:02:48 GMT

←Older revision		Revision as of 08:02, 3 February 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3laq.jpg\|left\|200px]]

-	The ~~entry 3laq~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3laq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3laq\| PDB=3laq \| SCENE= }}

-	~~Authors: Huang, M.~~	+	===Structure-based engineering of species selectivity in the uPA-uPAR interaction===

-	Description: Structure-based engineering of species selectivity in the uPA-uPAR interaction

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 27 19~~:17:07 2010''	+	==About this Structure==
		+	3LAQ is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LAQ OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: U-plasminogen activator]]
		+	[[Category: Huang, M.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Atf]]
		+	[[Category: Cell membrane]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Egf-like domain]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Gpi-anchor]]
		+	[[Category: Hydrolase]]
		+	[[Category: Kringle]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Matf]]
		+	[[Category: Membrane]]
		+	[[Category: Plasminogen activation]]
		+	[[Category: Protease]]
		+	[[Category: Receptor]]
		+	[[Category: Secreted]]
		+	[[Category: Serine protease]]
		+	[[Category: Smupar]]
		+	[[Category: Supar]]
		+	[[Category: Upa]]
		+	[[Category: Upar]]
		+	[[Category: Zymogen]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 10:02:48 2010''

OCA at 17:17, 27 January 2010

OCA — Wed, 27 Jan 2010 17:17:08 GMT

←Older revision		Revision as of 17:17, 27 January 2010
Line 3:		Line 3:
	The entry 3laq is ON HOLD		The entry 3laq is ON HOLD

-	Authors: Huang, M	+	Authors: Huang, M.

	Description: Structure-based engineering of species selectivity in the uPA-uPAR interaction		Description: Structure-based engineering of species selectivity in the uPA-uPAR interaction

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan ~~13 13~~:38:04 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:17:07 2010''