3lb6 - Revision history

OCA at 06:40, 3 April 2024

OCA — Wed, 03 Apr 2024 06:40:38 GMT

←Older revision		Revision as of 06:40, 3 April 2024
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	<StructureSection load='3lb6' size='340' side='right'caption='[[3lb6]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='3lb6' size='340' side='right'caption='[[3lb6]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lb6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LB6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lb6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LB6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.05Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">IL13, NC30 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lb6 OCA], [https://pdbe.org/3lb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lb6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lb6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lb6 OCA], [https://pdbe.org/3lb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lb6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lb6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[https://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.	+	[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[https://omim.org/entry/607154 607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
	== Function ==		== Function ==
-	~~[[https://www.uniprot.org/uniprot/I13R2_HUMAN I13R2_HUMAN]] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).<ref>PMID:20223216</ref> [~~[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.	+	[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lb6 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lb6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Interleukin-13 is a cytokine important for development of T helper cell type 2 (Th2) responses and plays a critical role in asthma and allergy. The IL-13 Receptor alpha2 (IL-13Ralpha2) is a receptor for IL-13 lacking canonical Jak/STAT signaling functions. Here we present the crystal structure along with a mutational and biophysical analysis of the IL-13/IL-13Ralpha2 complex. While retaining a similar mode of IL-13 binding to its related signaling receptor, IL-13Ralpha1, IL-13Ralpha2 uses peripheral receptor residues unused in the IL-13/IL-13Ralpha1 complex to generate a larger and more complementary interface for IL-13. This results in a four orders of magnitude increase in affinity, to the femtomolar level, compared to IL-13Ralpha1. Alanine scanning mutagenesis of the IL-13 interface reveals several common "hotspot" residues important for binding to both receptors, but also identifies a prominent IL-13Ralpha2-specific contact. These results provide a framework for development of receptor subtype-selective IL-13 antagonists and indicate a decoy function for IL-13Ralpha2.
-
-	Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2.,Lupardus PJ, Birnbaum ME, Garcia KC Structure. 2010 Mar 10;18(3):332-42. PMID:20223216<ref>PMID:20223216</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3lb6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Interleukin 3D structures\|Interleukin 3D structures]]		*[[Interleukin 3D structures\|Interleukin 3D structures]]
	*[[Interleukin receptor 3D structures\|Interleukin receptor 3D structures]]		*[[Interleukin receptor 3D structures\|Interleukin receptor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Birnbaum~~, M E~~]]	+	[[Category: Birnbaum ME]]
-	[[Category: Garcia~~, K C~~]]	+	[[Category: Garcia KC]]
-	[[Category: Lupardus~~, P J]]~~	+	[[Category: Lupardus PJ]]
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Decoy]]~~	+
-	~~[[Category: Decoy receptor]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Signaling protein-signaling protein complex~~]]	+

OCA at 12:32, 13 October 2021

OCA — Wed, 13 Oct 2021 12:32:48 GMT

←Older revision		Revision as of 12:32, 13 October 2021
Line 1:		Line 1:

	==The structure of IL-13 in complex with IL-13Ralpha2==		==The structure of IL-13 in complex with IL-13Ralpha2==
-	<StructureSection load='3lb6' size='340' side='right' caption='[[3lb6]], [[Resolution\|resolution]] 3.05Å' scene=''>	+	<StructureSection load='3lb6' size='340' side='right'caption='[[3lb6]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lb6]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3LB6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lb6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LB6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL13, NC30 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL13, NC30 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lb6 OCA], [~~http~~://pdbe.org/3lb6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3lb6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3lb6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3lb6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lb6 OCA], [https://pdbe.org/3lb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lb6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lb6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[~~http~~://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.	+	[[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[https://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/I13R2_HUMAN I13R2_HUMAN]] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).<ref>PMID:20223216</ref> [[~~http~~://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.	+	[[https://www.uniprot.org/uniprot/I13R2_HUMAN I13R2_HUMAN]] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).<ref>PMID:20223216</ref> [[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:

	==See Also==		==See Also==
-	*[[Interleukin\|Interleukin]]	+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
-	*[[Interleukin receptor\|Interleukin receptor]]	+	*[[Interleukin receptor 3D structures\|Interleukin receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 41:		Line 41:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Birnbaum, M E]]		[[Category: Birnbaum, M E]]
	[[Category: Garcia, K C]]		[[Category: Garcia, K C]]

OCA at 07:03, 2 January 2019

OCA — Wed, 02 Jan 2019 07:03:55 GMT

←Older revision		Revision as of 07:03, 2 January 2019
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/3lb6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/3lb6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:48, 4 August 2016

OCA — Thu, 04 Aug 2016 12:48:34 GMT

←Older revision		Revision as of 12:48, 4 August 2016
Line 1:		Line 1:
		+
	==The structure of IL-13 in complex with IL-13Ralpha2==		==The structure of IL-13 in complex with IL-13Ralpha2==
	<StructureSection load='3lb6' size='340' side='right' caption='[[3lb6]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='3lb6' size='340' side='right' caption='[[3lb6]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lb6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LB6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lb6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LB6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL13, NC30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL13, NC30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lb6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lb6 RCSB], [http://www.ebi.ac.uk/pdbsum/3lb6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lb6 OCA], [http://pdbe.org/3lb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lb6 RCSB], [http://www.ebi.ac.uk/pdbsum/3lb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lb6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.		[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~A8K7E2_HUMAN A8K7E2_HUMAN~~]] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).<ref>PMID:20223216</ref> [[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.	+	[[http://www.uniprot.org/uniprot/I13R2_HUMAN I13R2_HUMAN]] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).<ref>PMID:20223216</ref> [[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lb6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3lb6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 40:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Birnbaum, M E]]		[[Category: Birnbaum, M E]]
	[[Category: Garcia, K C]]		[[Category: Garcia, K C]]

OCA at 15:20, 18 December 2014

OCA — Thu, 18 Dec 2014 15:20:11 GMT

←Older revision		Revision as of 15:20, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3lb6\| PDB=3lb6 \| SCENE= }}~~	+	==The structure of IL-13 in complex with IL-13Ralpha2==
-	===The structure of IL-13 in complex with IL-13Ralpha2===	+	<StructureSection load='3lb6' size='340' side='right' caption='[[3lb6]], [[Resolution\|resolution]] 3.05Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20223216}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3lb6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LB6 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL13, NC30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lb6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lb6 RCSB], [http://www.ebi.ac.uk/pdbsum/3lb6 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.		[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A8K7E2_HUMAN A8K7E2_HUMAN]] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).<ref>PMID:20223216</ref> [[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/3lb6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interleukin-13 is a cytokine important for development of T helper cell type 2 (Th2) responses and plays a critical role in asthma and allergy. The IL-13 Receptor alpha2 (IL-13Ralpha2) is a receptor for IL-13 lacking canonical Jak/STAT signaling functions. Here we present the crystal structure along with a mutational and biophysical analysis of the IL-13/IL-13Ralpha2 complex. While retaining a similar mode of IL-13 binding to its related signaling receptor, IL-13Ralpha1, IL-13Ralpha2 uses peripheral receptor residues unused in the IL-13/IL-13Ralpha1 complex to generate a larger and more complementary interface for IL-13. This results in a four orders of magnitude increase in affinity, to the femtomolar level, compared to IL-13Ralpha1. Alanine scanning mutagenesis of the IL-13 interface reveals several common "hotspot" residues important for binding to both receptors, but also identifies a prominent IL-13Ralpha2-specific contact. These results provide a framework for development of receptor subtype-selective IL-13 antagonists and indicate a decoy function for IL-13Ralpha2.

-	~~==Function==~~	+	Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2.,Lupardus PJ, Birnbaum ME, Garcia KC Structure. 2010 Mar 10;18(3):332-42. PMID:20223216<ref>PMID:20223216</ref>
-	~~[[http://www.uniprot.org/uniprot/A8K7E2_HUMAN A8K7E2_HUMAN]] Binds as a monomer with~~ high affinity ~~to interleukin~~-13 (~~IL13~~)~~, but not to interleukin~~-~~4 (IL4)~~.<ref>PMID:20223216</ref> [[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3lb6]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Interleukin\|Interleukin]]		*[[Interleukin\|Interleukin]]
	*[[Interleukin receptor\|Interleukin receptor]]		*[[Interleukin receptor\|Interleukin receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020223216</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Birnbaum, M E.]]	+	[[Category: Birnbaum, M E]]
-	[[Category: Garcia, K C.]]	+	[[Category: Garcia, K C]]
-	[[Category: Lupardus, P J.]]	+	[[Category: Lupardus, P J]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Decoy]]		[[Category: Decoy]]

OCA at 18:49, 24 March 2013

OCA — Sun, 24 Mar 2013 18:49:57 GMT

←Older revision		Revision as of 18:49, 24 March 2013
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-	[[Image:3lb6.png\|left\|200px]]
-
	{{STRUCTURE_3lb6\| PDB=3lb6 \| SCENE= }}		{{STRUCTURE_3lb6\| PDB=3lb6 \| SCENE= }}
-
	===The structure of IL-13 in complex with IL-13Ralpha2===		===The structure of IL-13 in complex with IL-13Ralpha2===
		+	{{ABSTRACT_PUBMED_20223216}}

-	~~{{ABSTRACT_PUBMED_20223216}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[http://omim.org/entry/607154 607154]]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/A8K7E2_HUMAN A8K7E2_HUMAN]] Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).<ref>PMID:20223216</ref> [[http://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN]] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

	==About this Structure==		==About this Structure==
Line 15:		Line 17:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020223216</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020223216</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Birnbaum, M E.]]		[[Category: Birnbaum, M E.]]

OCA at 06:29, 20 October 2012

OCA — Sat, 20 Oct 2012 06:29:03 GMT

←Older revision		Revision as of 06:29, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3lb6]] is a 4 chain structure ~~of [[Interleukin]] and [[Interleukin receptor]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA].	+	[[3lb6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA].

	==See Also==		==See Also==

OCA: Protected "3lb6" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 13:19:28 GMT

Protected "3lb6" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:19, 25 July 2012

OCA at 13:19, 25 July 2012

OCA — Wed, 25 Jul 2012 13:19:27 GMT

←Older revision		Revision as of 13:19, 25 July 2012
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-	{{Seed}}
	[[Image:3lb6.png\|left\|200px]]		[[Image:3lb6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3lb6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_3lb6\| PDB=3lb6 \| SCENE= }}		{{STRUCTURE_3lb6\| PDB=3lb6 \| SCENE= }}

	===The structure of IL-13 in complex with IL-13Ralpha2===		===The structure of IL-13 in complex with IL-13Ralpha2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20223216}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20223216 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20223216}}		{{ABSTRACT_PUBMED_20223216}}

	==About this Structure==		==About this Structure==
-	~~3LB6~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA].	+	[[3lb6]] is a 4 chain structure of [[Interleukin]] and [[Interleukin receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA].
		+
		+	==See Also==
		+	*[[Interleukin\|Interleukin]]
		+	*[[Interleukin receptor\|Interleukin receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20223216~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020223216</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Birnbaum, M E.]]		[[Category: Birnbaum, M E.]]
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	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Signaling protein-signaling protein complex]]		[[Category: Signaling protein-signaling protein complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:51:51 2010''

OCA at 07:51, 28 April 2010

OCA — Wed, 28 Apr 2010 07:51:53 GMT

←Older revision		Revision as of 07:51, 28 April 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3lb6.~~jpg~~\|left\|200px]]	+	[[Image:3lb6.png\|left\|200px]]

	<!--		<!--
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	===The structure of IL-13 in complex with IL-13Ralpha2===		===The structure of IL-13 in complex with IL-13Ralpha2===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20223216}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20223216 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20223216}}

	==About this Structure==		==About this Structure==
	3LB6 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA].		3LB6 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20223216</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Birnbaum, M E.]]		[[Category: Birnbaum, M E.]]
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	[[Category: Signaling protein-signaling protein complex]]		[[Category: Signaling protein-signaling protein complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 17 09~~:43:30 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:51:51 2010''