3lek - Revision history

OCA at 06:35, 19 July 2023

OCA — Wed, 19 Jul 2023 06:35:50 GMT

←Older revision		Revision as of 06:35, 19 July 2023
Line 3:		Line 3:
	<StructureSection load='3lek' size='340' side='right'caption='[[3lek]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3lek' size='340' side='right'caption='[[3lek]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_49456 Atcc 49456~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LEK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LEK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~"><~~scene name~~='~~pdbligand~~=CA:~~CALCIUM+ION'~~>CA</~~scene~~>, <scene name='pdbligand=NI:~~NICKEL+(II)~~+ION'>NI</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max-height: 3em;'>[[3leo\|3leo]]~~, ~~[[3leg\|3leg]], [[3lei\|3lei]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PRD_900085:Lewis+B+antigen,+alpha+anomer'>PRD_900085</scene></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">samhpaf ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28037 ATCC 49456])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lek OCA], [https://pdbe.org/3lek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lek RCSB], [https://www.ebi.ac.uk/pdbsum/3lek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lek ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lek OCA], [https://pdbe.org/3lek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lek RCSB], [https://www.ebi.ac.uk/pdbsum/3lek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lek ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2PHL4_STRMT Q2PHL4_STRMT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 49456]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Feil, S C~~]]	+	[[Category: Streptococcus mitis]]
-	[[Category: ~~Blood clotting]]~~	+	[[Category: Feil SC]]
-	~~[[Category: Lectin domain of lectinolysin]]~~	+
-	~~[[Category: Lewis b antigen]]~~	+
-	~~[[Category: Nickel~~]]	+

OCA at 12:33, 13 October 2021

OCA — Wed, 13 Oct 2021 12:33:38 GMT

←Older revision		Revision as of 12:33, 13 October 2021
Line 1:		Line 1:

	==Lectin Domain of Lectinolysin complexed with Lewis B Antigen==		==Lectin Domain of Lectinolysin complexed with Lewis B Antigen==
-	<StructureSection load='3lek' size='340' side='right' caption='[[3lek]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3lek' size='340' side='right'caption='[[3lek]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lek]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_49456 Atcc 49456]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3LEK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_49456 Atcc 49456]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LEK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~BCW~~:~~6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-~~(~~1- 4~~)~~-[6-DEOXY-~~ALPHA-L-~~GALACTOPYRANOSYL-(1- 2)-BETA-D-GALACTOPYRANOSYL-(1- 3)]-2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSE~~'>~~BCW~~</scene>, <scene name='pdbligand=CA:~~CALCIUM+ION~~'>CA</scene>, <scene name='pdbligand=NI:~~NICKEL+~~(II)~~+ION~~'>NI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3leo\|3leo]], [[3leg\|3leg]], [[3lei\|3lei]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3leo\|3leo]], [[3leg\|3leg]], [[3lei\|3lei]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">samhpaf ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28037 ATCC 49456])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">samhpaf ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28037 ATCC 49456])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3lek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lek OCA], [~~http~~://pdbe.org/3lek PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3lek RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3lek PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3lek ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lek OCA], [https://pdbe.org/3lek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lek RCSB], [https://www.ebi.ac.uk/pdbsum/3lek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lek ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 49456]]		[[Category: Atcc 49456]]
		+	[[Category: Large Structures]]
	[[Category: Feil, S C]]		[[Category: Feil, S C]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]

OCA at 13:47, 4 August 2016

OCA — Thu, 04 Aug 2016 13:47:14 GMT

←Older revision		Revision as of 13:47, 4 August 2016
Line 1:		Line 1:
		+
	==Lectin Domain of Lectinolysin complexed with Lewis B Antigen==		==Lectin Domain of Lectinolysin complexed with Lewis B Antigen==
	<StructureSection load='3lek' size='340' side='right' caption='[[3lek]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3lek' size='340' side='right' caption='[[3lek]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lek]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_mitis Streptococcus mitis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LEK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lek]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_49456 Atcc 49456]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LEK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCW:6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-(1- 4)-[6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-(1- 2)-BETA-D-GALACTOPYRANOSYL-(1- 3)]-2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSE'>BCW</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCW:6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-(1- 4)-[6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-(1- 2)-BETA-D-GALACTOPYRANOSYL-(1- 3)]-2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSE'>BCW</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3leo\|3leo]], [[3leg\|3leg]], [[3lei\|3lei]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3leo\|3leo]], [[3leg\|3leg]], [[3lei\|3lei]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">samhpaf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28037 ~~Streptococcus mitis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">samhpaf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28037 ATCC 49456])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lek OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lek RCSB], [http://www.ebi.ac.uk/pdbsum/3lek PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lek OCA], [http://pdbe.org/3lek PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lek RCSB], [http://www.ebi.ac.uk/pdbsum/3lek PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lek ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3lek" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptococcus mitis~~]]	+	[[Category: Atcc 49456]]
	[[Category: Feil, S C]]		[[Category: Feil, S C]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]

OCA at 22:54, 3 January 2015

OCA — Sat, 03 Jan 2015 22:54:30 GMT

←Older revision		Revision as of 22:54, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3lek]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LEK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3lek]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LEK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCW:6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-(1- 4)-[6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-(1- 2)-BETA-D-GALACTOPYRANOSYL-(1- 3)]-2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSE'>BCW</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCW:6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-(1- 4)-[6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-(1- 2)-BETA-D-GALACTOPYRANOSYL-(1- 3)]-2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSE'>BCW</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3leo\|3leo]], [[3leg\|3leg]], [[3lei\|3lei]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3leo\|3leo]], [[3leg\|3leg]], [[3lei\|3lei]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">samhpaf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28037 Streptococcus mitis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">samhpaf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28037 Streptococcus mitis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lek OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lek RCSB], [http://www.ebi.ac.uk/pdbsum/3lek PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lek OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lek RCSB], [http://www.ebi.ac.uk/pdbsum/3lek PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 14:
	Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.,Feil SC, Lawrence S, Mulhern TD, Holien JK, Hotze EM, Farrand S, Tweten RK, Parker MW Structure. 2012 Feb 8;20(2):248-58. PMID:22325774<ref>PMID:22325774</ref>		Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.,Feil SC, Lawrence S, Mulhern TD, Holien JK, Hotze EM, Farrand S, Tweten RK, Parker MW Structure. 2012 Feb 8;20(2):248-58. PMID:22325774<ref>PMID:22325774</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Streptococcus mitis]]		[[Category: Streptococcus mitis]]
-	[[Category: Feil, S C.]]	+	[[Category: Feil, S C]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]
	[[Category: Lectin domain of lectinolysin]]		[[Category: Lectin domain of lectinolysin]]
	[[Category: Lewis b antigen]]		[[Category: Lewis b antigen]]
	[[Category: Nickel]]		[[Category: Nickel]]

OCA at 09:49, 21 May 2014

OCA — Wed, 21 May 2014 09:49:58 GMT

←Older revision		Revision as of 09:49, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3lek.~~png~~\|~~left~~\|~~200px~~]]	+	==Lectin Domain of Lectinolysin complexed with Lewis B Antigen==
		+	<StructureSection load='3lek' size='340' side='right' caption='[[3lek]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3lek]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LEK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCW:6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-(1- 4)-[6-DEOXY-ALPHA-L-GALACTOPYRANOSYL-(1- 2)-BETA-D-GALACTOPYRANOSYL-(1- 3)]-2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSE'>BCW</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3leo\|3leo]], [[3leg\|3leg]], [[3lei\|3lei]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">samhpaf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28037 Streptococcus mitis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lek OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lek RCSB], [http://www.ebi.ac.uk/pdbsum/3lek PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cholesterol-dependent cytolysins (CDCs) punch holes in target cell membranes through a highly regulated process. Streptococcus mitis lectinolysin (LLY) exhibits another layer of regulation with a lectin domain that enhances the pore-forming activity of the toxin. We have determined the crystal structures of the lectin domain by itself and in complex with various glycans that reveal the molecular basis for the Lewis antigen specificity of LLY. A small-angle X-ray scattering study of intact LLY reveals the molecule is flat and elongated with the lectin domain oriented so that the Lewis antigen-binding site is exposed. We suggest that the lectin domain enhances the pore-forming activity of LLY by concentrating toxin molecules at fucose-rich sites on membranes, thus promoting the formation of prepore oligomers on the surface of susceptible cells.

-	<!--	+	Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.,Feil SC, Lawrence S, Mulhern TD, Holien JK, Hotze EM, Farrand S, Tweten RK, Parker MW Structure. 2012 Feb 8;20(2):248-58. PMID:22325774<ref>PMID:22325774</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3lek"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3lek\| PDB=3lek \| SCENE= }}~~	+

-	~~===Lectin Domain~~ of ~~Lectinolysin complexed with Lewis B Antigen===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22325774}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22325774 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22325774}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3lek]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022325774<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Streptococcus mitis]]		[[Category: Streptococcus mitis]]
	[[Category: Feil, S C.]]		[[Category: Feil, S C.]]

OCA at 07:57, 29 February 2012

OCA — Wed, 29 Feb 2012 07:57:08 GMT

←Older revision		Revision as of 07:57, 29 February 2012
Line 1:		Line 1:
-	[[Image:3lek.~~jpg~~\|left\|200px]]	+	[[Image:3lek.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===Lectin Domain of Lectinolysin complexed with Lewis B Antigen===		===Lectin Domain of Lectinolysin complexed with Lewis B Antigen===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22325774}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22325774 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22325774}}

	==About this Structure==		==About this Structure==
	[[3lek]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA].		[[3lek]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022325774</ref><references group="xtra"/>
	[[Category: Streptococcus mitis]]		[[Category: Streptococcus mitis]]
	[[Category: Feil, S C.]]		[[Category: Feil, S C.]]

OCA: Protected "3lek" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2010 18:35:06 GMT

Protected "3lek" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:35, 29 December 2010

OCA at 18:35, 29 December 2010

OCA — Wed, 29 Dec 2010 18:35:03 GMT

←Older revision		Revision as of 18:35, 29 December 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3lek.jpg\|left\|200px]]

-	The ~~entry 3lek~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3lek", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3lek\| PDB=3lek \| SCENE= }}

-	~~Authors: Feil, S.C.~~	+	===Lectin Domain of Lectinolysin complexed with Lewis B Antigen===

-	Description: Lectin Domain of Lectinolysin complexed with Lewis B Antigen

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Mar 10 13~~:11:~~59 2010''~~	+	==About this Structure==
		+	[[3lek]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mitis Streptococcus mitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LEK OCA].
		+	[[Category: Streptococcus mitis]]
		+	[[Category: Feil, S C.]]
		+	[[Category: Blood clotting]]
		+	[[Category: Lectin domain of lectinolysin]]
		+	[[Category: Lewis b antigen]]
		+	[[Category: Nickel]]

OCA at 11:12, 10 March 2010

OCA — Wed, 10 Mar 2010 11:12:00 GMT

←Older revision		Revision as of 11:12, 10 March 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3lek is ON HOLD	+	The entry 3lek is ON HOLD until Paper Publication

	Authors: Feil, S.C.		Authors: Feil, S.C.
Line 7:		Line 7:
	Description: Lectin Domain of Lectinolysin complexed with Lewis B Antigen		Description: Lectin Domain of Lectinolysin complexed with Lewis B Antigen

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 27 19~~:18:32 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 13:11:59 2010''

OCA: New page: '''Unreleased structure''' The entry 3lek is ON HOLD Authors: Feil, S.C. Description: Lectin Domain of Lectinolysin complexed with Lewis B Antigen ''Page seeded by [http://oca.weizman...

OCA — Wed, 27 Jan 2010 17:18:32 GMT

New page: '''Unreleased structure''' The entry 3lek is ON HOLD Authors: Feil, S.C. Description: Lectin Domain of Lectinolysin complexed with Lewis B Antigen ''Page seeded by [http://oca.weizman...

New page

'''Unreleased structure'''

The entry 3lek is ON HOLD

Authors: Feil, S.C.

Description: Lectin Domain of Lectinolysin complexed with Lewis B Antigen

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:18:32 2010''