3lnf - Revision history

OCA at 08:41, 6 September 2023

OCA — Wed, 06 Sep 2023 08:41:03 GMT

←Older revision		Revision as of 08:41, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3lnf' size='340' side='right'caption='[[3lnf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3lnf' size='340' side='right'caption='[[3lnf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lnf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LNF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lnf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LNF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3lnd\|3lnd]], [[3lne\|3lne]], [[3lng\|3lng]], [[3lnh\|3lnh]], [[3lni\|3lni]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Cdh1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [https://pdbe.org/3lnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [https://www.ebi.ac.uk/pdbsum/3lnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lnf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [https://pdbe.org/3lnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [https://www.ebi.ac.uk/pdbsum/3lnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lnf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).	+	[https://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Harrison, O]]	+	[[Category: Harrison O]]
-	[[Category: Jin, X]]	+	[[Category: Jin X]]
-	[[Category: Shapiro, L]]	+	[[Category: Shapiro L]]
-	~~[[Category: Cadherin]]~~	+
-	~~[[Category: Calcium]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 12:36, 13 October 2021

OCA — Wed, 13 Oct 2021 12:36:42 GMT

←Older revision		Revision as of 12:36, 13 October 2021
Line 1:		Line 1:

	==Crystal structure of E-cadherin EC12 K14EW2A==		==Crystal structure of E-cadherin EC12 K14EW2A==
-	<StructureSection load='3lnf' size='340' side='right' caption='[[3lnf]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3lnf' size='340' side='right'caption='[[3lnf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lnf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3LNF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lnf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LNF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lnd\|3lnd]], [[3lne\|3lne]], [[3lng\|3lng]], [[3lnh\|3lnh]], [[3lni\|3lni]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3lnd\|3lnd]], [[3lne\|3lne]], [[3lng\|3lng]], [[3lnh\|3lnh]], [[3lni\|3lni]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [~~http~~://pdbe.org/3lnf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3lnf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3lnf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [https://pdbe.org/3lnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [https://www.ebi.ac.uk/pdbsum/3lnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lnf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).	+	[[https://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Cadherin\|Cadherin]]	+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Harrison, O]]		[[Category: Harrison, O]]

OCA at 07:17, 2 January 2019

OCA — Wed, 02 Jan 2019 07:17:17 GMT

←Older revision		Revision as of 07:17, 2 January 2019
Line 1:		Line 1:
		+
	==Crystal structure of E-cadherin EC12 K14EW2A==		==Crystal structure of E-cadherin EC12 K14EW2A==
	<StructureSection load='3lnf' size='340' side='right' caption='[[3lnf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3lnf' size='340' side='right' caption='[[3lnf]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lnd\|3lnd]], [[3lne\|3lne]], [[3lng\|3lng]], [[3lnh\|3lnh]], [[3lni\|3lni]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lnd\|3lnd]], [[3lne\|3lne]], [[3lng\|3lng]], [[3lnh\|3lnh]], [[3lni\|3lni]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [http://pdbe.org/3lnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [http://www.ebi.ac.uk/pdbsum/3lnf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [http://pdbe.org/3lnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [http://www.ebi.ac.uk/pdbsum/3lnf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lnf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ln/3lnf_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ln/3lnf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 41:		Line 42:
	[[Category: Shapiro, L]]		[[Category: Shapiro, L]]
	[[Category: Cadherin]]		[[Category: Cadherin]]
		+	[[Category: Calcium]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cell junction]]		[[Category: Cell junction]]

OCA at 20:53, 8 February 2016

OCA — Mon, 08 Feb 2016 20:53:23 GMT

←Older revision		Revision as of 20:53, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3lnf' size='340' side='right' caption='[[3lnf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3lnf' size='340' side='right' caption='[[3lnf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LNF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LNF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lnd\|3lnd]], [[3lne\|3lne]], [[3lng\|3lng]], [[3lnh\|3lnh]], [[3lni\|3lni]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lnd\|3lnd]], [[3lne\|3lne]], [[3lng\|3lng]], [[3lnh\|3lnh]], [[3lni\|3lni]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [http://www.ebi.ac.uk/pdbsum/3lnf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [http://pdbe.org/3lnf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [http://www.ebi.ac.uk/pdbsum/3lnf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lnf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3lnf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Harrison, O]]		[[Category: Harrison, O]]
	[[Category: Jin, X]]		[[Category: Jin, X]]

OCA at 02:04, 25 December 2014

OCA — Thu, 25 Dec 2014 02:04:53 GMT

←Older revision		Revision as of 02:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3lnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LNF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3lnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LNF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lnd\|3lnd]], [[3lne\|3lne]], [[3lng\|3lng]], [[3lnh\|3lnh]], [[3lni\|3lni]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lnd\|3lnd]], [[3lne\|3lne]], [[3lng\|3lng]], [[3lnh\|3lnh]], [[3lni\|3lni]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [http://www.ebi.ac.uk/pdbsum/3lnf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [http://www.ebi.ac.uk/pdbsum/3lnf PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CADH1_MOUSE CADH1_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity). E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Harrison, O.]]	+	[[Category: Harrison, O]]
-	[[Category: Jin, X.]]	+	[[Category: Jin, X]]
-	[[Category: Shapiro, L.]]	+	[[Category: Shapiro, L]]
	[[Category: Cadherin]]		[[Category: Cadherin]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 12:39, 29 September 2014

OCA — Mon, 29 Sep 2014 12:39:06 GMT

←Older revision		Revision as of 12:39, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3lnf.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of E-cadherin EC12 K14EW2A==
		+	<StructureSection load='3lnf' size='340' side='right' caption='[[3lnf]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3lnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LNF FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lnd\|3lnd]], [[3lne\|3lne]], [[3lng\|3lng]], [[3lnh\|3lnh]], [[3lni\|3lni]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lnf RCSB], [http://www.ebi.ac.uk/pdbsum/3lnf PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ln/3lnf_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Crystal structures of classical cadherins have revealed two dimeric configurations. In the first, N-terminal beta-strands of EC1 domains 'swap' between partner molecules. The second configuration (the 'X dimer'), also observed for T-cadherin, is mediated by residues near the EC1-EC2 calcium binding sites, and N-terminal beta-strands of partner EC1 domains, though held adjacent, do not swap. Here we show that strand-swapping mutants of type I and II classical cadherins form X dimers. Mutant cadherins impaired for X-dimer formation show no binding in short-time frame surface plasmon resonance assays, but in long-time frame experiments, they have homophilic binding affinities close to that of wild type. Further experiments show that exchange between monomers and dimers is slowed in these mutants. These results reconcile apparently disparate results from prior structural studies and suggest that X dimers are binding intermediates that facilitate the formation of strand-swapped dimers.

-	~~{{STRUCTURE_3lnf\| PDB=3lnf \| SCENE= }}~~	+	Two-step adhesive binding by classical cadherins.,Harrison OJ, Bahna F, Katsamba PS, Jin X, Brasch J, Vendome J, Ahlsen G, Carroll KJ, Price SR, Honig B, Shapiro L Nat Struct Mol Biol. 2010 Mar;17(3):348-57. Epub 2010 Feb 28. PMID:20190754<ref>PMID:20190754</ref>

-	~~===Crystal structure~~ of ~~E-cadherin EC12 K14EW2A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20190754}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3lnf]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA].~~	+

	==See Also==		==See Also==
	*[[Cadherin\|Cadherin]]		*[[Cadherin\|Cadherin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020190754<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Harrison, O.]]		[[Category: Harrison, O.]]

OCA at 11:26, 20 October 2012

OCA — Sat, 20 Oct 2012 11:26:41 GMT

←Older revision		Revision as of 11:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3lnf]] is a 2 chain structure ~~of [[Cadherin]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA].	+	[[3lnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA].

	==See Also==		==See Also==

OCA: Protected "3lnf" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 05:23:16 GMT

Protected "3lnf" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:23, 26 July 2012

OCA at 05:23, 26 July 2012

OCA — Thu, 26 Jul 2012 05:23:14 GMT

←Older revision		Revision as of 05:23, 26 July 2012
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-	{{Seed}}
	[[Image:3lnf.png\|left\|200px]]		[[Image:3lnf.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3lnf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3lnf\| PDB=3lnf \| SCENE= }}		{{STRUCTURE_3lnf\| PDB=3lnf \| SCENE= }}

	===Crystal structure of E-cadherin EC12 K14EW2A===		===Crystal structure of E-cadherin EC12 K14EW2A===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20190754}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20190754 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20190754}}		{{ABSTRACT_PUBMED_20190754}}

	==About this Structure==		==About this Structure==
-	~~3LNF~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA].	+	[[3lnf]] is a 2 chain structure of [[Cadherin]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA].
		+
		+	==See Also==
		+	*[[Cadherin\|Cadherin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20190754~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020190754</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Harrison, O.]]		[[Category: Harrison, O.]]
Line 29:		Line 20:
	[[Category: Shapiro, L.]]		[[Category: Shapiro, L.]]
	[[Category: Cadherin]]		[[Category: Cadherin]]
-	[[Category: Calcium]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
Line 35:		Line 25:
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 08:51:13 2010''

OCA at 06:51, 17 March 2010

OCA — Wed, 17 Mar 2010 06:51:14 GMT

←Older revision		Revision as of 06:51, 17 March 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3lnf.~~jpg~~\|left\|200px]]	+	[[Image:3lnf.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of E-cadherin EC12 K14EW2A===		===Crystal structure of E-cadherin EC12 K14EW2A===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20190754}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20190754 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20190754}}

	==About this Structure==		==About this Structure==
	3LNF is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA].		3LNF is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LNF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20190754</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Harrison, O.]]		[[Category: Harrison, O.]]
Line 27:		Line 36:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 17:25:40 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 08:51:13 2010''