3lqj - Revision history

OCA at 16:50, 28 August 2019

OCA — Wed, 28 Aug 2019 16:50:51 GMT

←Older revision		Revision as of 16:50, 28 August 2019
Line 1:		Line 1:

	==Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide==		==Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide==
-	<StructureSection load='3lqj' size='340' side='right' caption='[[3lqj]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3lqj' size='340' side='right'caption='[[3lqj]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3lqj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LQJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3lqj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LQJ FirstGlance]. <br>
Line 17:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/3lqj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/3lqj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 3lqj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3lqj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Patel, D J]]		[[Category: Patel, D J]]
	[[Category: Wang, Z]]		[[Category: Wang, Z]]

OCA at 05:13, 16 November 2017

OCA — Thu, 16 Nov 2017 05:13:59 GMT

←Older revision		Revision as of 05:13, 16 November 2017
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 3lqj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3lqj" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Histone methyltransferase\|Histone methyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:40, 4 August 2016

OCA — Thu, 04 Aug 2016 10:40:37 GMT

←Older revision		Revision as of 10:40, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide==		==Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide==
	<StructureSection load='3lqj' size='340' side='right' caption='[[3lqj]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3lqj' size='340' side='right' caption='[[3lqj]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lqj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LQJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lqj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LQJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lqh\|3lqh]], [[3lqi\|3lqi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lqh\|3lqh]], [[3lqi\|3lqi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lqj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lqj RCSB], [http://www.ebi.ac.uk/pdbsum/3lqj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lqj OCA], [http://pdbe.org/3lqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lqj RCSB], [http://www.ebi.ac.uk/pdbsum/3lqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lqj ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lqj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3lqj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 39:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Patel, D J]]		[[Category: Patel, D J]]
	[[Category: Wang, Z]]		[[Category: Wang, Z]]

OCA at 17:12, 18 December 2014

OCA — Thu, 18 Dec 2014 17:12:53 GMT

←Older revision		Revision as of 17:12, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3lqj\| PDB=3lqj \| SCENE= }}~~	+	==Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide==
-	===Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide===	+	<StructureSection load='3lqj' size='340' side='right' caption='[[3lqj]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20541251}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3lqj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LQJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lqh\|3lqh]], [[3lqi\|3lqi]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lqj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lqj RCSB], [http://www.ebi.ac.uk/pdbsum/3lqj PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MLL1_HUMAN MLL1_HUMAN]] Defects in MLL are the cause of Wiedemann-Steiner syndrome (WDSTS) [MIM:[http://omim.org/entry/605130 605130]]. A syndrome characterized by hairy elbows (hypertrichosis cubiti), intellectual disability, a distinctive facial appearance, and short stature. Facial characteristics include long eyelashes, thick or arched eyebrows with a lateral flare, and downslanting and vertically narrow palpebral fissures.<ref>PMID:10490642</ref> <ref>PMID:22795537</ref> Note=Chromosomal aberrations involving MLL are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with TET1. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. Fusion proteins MLL-MLLT1, MLL-MLLT3 and MLL-ELL interact with PPP1R15A and, on the contrary to unfused MLL, inhibit PPP1R15A-induced apoptosis.<ref>PMID:10490642</ref> Note=A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11.<ref>PMID:10490642</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MLL1_HUMAN MLL1_HUMAN]] Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.<ref>PMID:10490642</ref> <ref>PMID:12453419</ref> <ref>PMID:15960975</ref> <ref>PMID:19556245</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/3lqj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The MLL1 gene is a frequent target for recurrent chromosomal translocations, resulting in transformation of hematopoietic precursors into leukemia stem cells. Here, we report on structure-function studies that elucidate molecular events in MLL1 binding of histone H3K4me3/2 marks and recruitment of the cyclophilin CyP33. CyP33 contains a PPIase and a RRM domain and regulates MLL1 function through HDAC recruitment. We find that the PPIase domain of CyP33 regulates the conformation of MLL1 through proline isomerization within the PHD3-Bromo linker, thereby disrupting the PHD3-Bromo interface and facilitating binding of the MLL1-PHD3 domain to the CyP33-RRM domain. H3K4me3/2 and CyP33-RRM target different surfaces of MLL1-PHD3 and can bind simultaneously to form a ternary complex. Furthermore, the MLL1-CyP33 interaction is required for repression of HOXA9 and HOXC8 genes in vivo. Our results highlight the role of PHD3-Bromo cassette as a regulatory platform, orchestrating MLL1 binding of H3K4me3/2 marks and cyclophilin-mediated repression through HDAC recruitment.

-	~~==Disease==~~	+	Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.,Wang Z, Song J, Milne TA, Wang GG, Li H, Allis CD, Patel DJ Cell. 2010 Jun 25;141(7):1183-94. Epub 2010 Jun 10. PMID:20541251<ref>PMID:20541251</ref>
-	~~[[http://www.uniprot.org/uniprot/MLL1_HUMAN MLL1_HUMAN]] Defects~~ in ~~MLL are the cause of Wiedemann~~-~~Steiner syndrome (WDSTS) [MIM:[http://omim~~.~~org/entry/605130 605130]]. A syndrome characterized by hairy elbows (hypertrichosis cubiti)~~, ~~intellectual disability~~, ~~a distinctive facial appearance~~, ~~and short stature. Facial characteristics include long eyelashes~~, ~~thick or arched eyebrows with a lateral flare~~, and downslanting and vertically narrow palpebral fissures.<ref>PMID:10490642</ref><ref>PMID:22795537</ref> Note=Chromosomal aberrations involving MLL are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,~~11)(q25~~,~~q23) with GMPS~~; ~~translocation t~~(~~4;11~~)~~(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5~~-~~alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11~~.~~2;q23) with ABI1; translocation t(~~10~~;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13~~.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with TET1. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. Fusion proteins MLL-MLLT1, MLL-MLLT3 and MLL-ELL interact with PPP1R15A and, on the contrary to unfused MLL, inhibit PPP1R15A-induced apoptosis.<ref>PMID:~~10490642</ref> Note=A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11.~~<ref>PMID:~~10490642~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http://www.uniprot.org/uniprot/MLL1_HUMAN MLL1_HUMAN]] Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1~~/~~MLL complex~~, a ~~multiprotein complex that mediates both methylation~~ of ~~'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In~~ the ~~MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation~~. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. ~~Required for transcriptional activation~~ of ~~HOXA9. Promotes PPP1R15A-induced apoptosis~~.<~~ref~~>~~PMID:10490642~~</~~ref~~>~~<ref>PMID:12453419</ref><ref>PMID:15960975</ref><ref>PMID:19556245</ref>~~	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3lqj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQJ OCA].	+

	==See Also==		==See Also==
	*[[Histone methyltransferase\|Histone methyltransferase]]		*[[Histone methyltransferase\|Histone methyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020541251</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Patel, D J.]]	+	[[Category: Patel, D J]]
-	[[Category: Wang, Z.]]	+	[[Category: Wang, Z]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]
	[[Category: Chromosomal protein]]		[[Category: Chromosomal protein]]

OCA: Protected "3lqj" [edit=sysop:move=sysop]

OCA — Sun, 24 Mar 2013 16:44:53 GMT

Protected "3lqj" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:44, 24 March 2013

OCA at 16:44, 24 March 2013

OCA — Sun, 24 Mar 2013 16:44:51 GMT

←Older revision		Revision as of 16:44, 24 March 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3lqj.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3lqj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3lqj\| PDB=3lqj \| SCENE= }}		{{STRUCTURE_3lqj\| PDB=3lqj \| SCENE= }}
-
	===Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide===		===Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide===
		+	{{ABSTRACT_PUBMED_20541251}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MLL1_HUMAN MLL1_HUMAN]] Defects in MLL are the cause of Wiedemann-Steiner syndrome (WDSTS) [MIM:[http://omim.org/entry/605130 605130]]. A syndrome characterized by hairy elbows (hypertrichosis cubiti), intellectual disability, a distinctive facial appearance, and short stature. Facial characteristics include long eyelashes, thick or arched eyebrows with a lateral flare, and downslanting and vertically narrow palpebral fissures.<ref>PMID:10490642</ref><ref>PMID:22795537</ref> Note=Chromosomal aberrations involving MLL are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with TET1. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. Fusion proteins MLL-MLLT1, MLL-MLLT3 and MLL-ELL interact with PPP1R15A and, on the contrary to unfused MLL, inhibit PPP1R15A-induced apoptosis.<ref>PMID:10490642</ref> Note=A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11.<ref>PMID:10490642</ref>

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20541251}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/MLL1_HUMAN MLL1_HUMAN]] Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.<ref>PMID:10490642</ref><ref>PMID:12453419</ref><ref>PMID:15960975</ref><ref>PMID:19556245</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 20541251 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20541251}}~~	+

	==About this Structure==		==About this Structure==
-	~~3LQJ~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQJ OCA].	+	[[3lqj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQJ OCA].
		+
		+	==See Also==
		+	*[[Histone methyltransferase\|Histone methyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20541251~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020541251</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Patel, D J.]]		[[Category: Patel, D J.]]
Line 36:		Line 29:
	[[Category: Phd finger]]		[[Category: Phd finger]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:04:45 2010''

OCA at 07:58, 28 July 2010

OCA — Wed, 28 Jul 2010 07:58:03 GMT

←Older revision		Revision as of 07:58, 28 July 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3lqj.~~jpg~~\|left\|200px]]	+	[[Image:3lqj.png\|left\|200px]]

	<!--		<!--
Line 37:		Line 37:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~7 08~~:41:28 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:04:45 2010''

OCA at 04:35, 7 July 2010

OCA — Wed, 07 Jul 2010 04:35:38 GMT

←Older revision		Revision as of 04:35, 7 July 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3lqj.jpg\|left\|200px]]

-	The ~~entry 3lqj~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3lqj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3lqj\| PDB=3lqj \| SCENE= }}

-	~~Authors: Wang, Z., Patel, D.J.~~	+	===Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide===

-	Description: Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 17 09~~:11:21 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20541251}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20541251 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20541251}}
		+
		+	==About this Structure==
		+	3LQJ is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20541251</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Patel, D J.]]
		+	[[Category: Wang, Z.]]
		+	[[Category: Bromodomain]]
		+	[[Category: Chromosomal protein]]
		+	[[Category: Dna-binding]]
		+	[[Category: Leukemia]]
		+	[[Category: Mll1]]
		+	[[Category: Nucleosome core]]
		+	[[Category: Nucleus]]
		+	[[Category: Phd finger]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 08:41:28 2010''

OCA at 07:11, 17 March 2010

OCA — Wed, 17 Mar 2010 07:11:21 GMT

←Older revision		Revision as of 07:11, 17 March 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3lqj is ON HOLD	+	The entry 3lqj is ON HOLD until Paper Publication

	Authors: Wang, Z., Patel, D.J.		Authors: Wang, Z., Patel, D.J.
Line 7:		Line 7:
	Description: Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide		Description: Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar ~~10 13~~:14:06 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:11:21 2010''

OCA at 11:14, 10 March 2010

OCA — Wed, 10 Mar 2010 11:14:06 GMT

←Older revision		Revision as of 11:14, 10 March 2010
Line 3:		Line 3:
	The entry 3lqj is ON HOLD		The entry 3lqj is ON HOLD

-	Authors: Wang, ~~Zhanxin~~, Patel, ~~Dinshaw~~ J.	+	Authors: Wang, Z., Patel, D.J.

	Description: Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide		Description: Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 17~~ 10:11:43 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 13:14:06 2010''