3ltf - Revision history

OCA at 08:43, 6 September 2023

OCA — Wed, 06 Sep 2023 08:43:46 GMT

←Older revision		Revision as of 08:43, 6 September 2023
Line 1:		Line 1:

	==Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz==		==Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz==
-	<StructureSection load='3ltf' size='340' side='right' caption='[[3ltf]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='3ltf' size='340' side='right'caption='[[3ltf]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ltf]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3LTF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ltf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LTF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MAN:ALPHA~~-~~D-MANNOSE'>MAN</scene>~~, ~~<scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3i2t\|3i2t]], [[3ltg\|3ltg]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">Egfr, Dmel_CG10079, torpedo, dEGFR, c-erbB, DER, top ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode=5&id=7227 DROME]), CG10334, spi, Spitz ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ltf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltf OCA], [https://pdbe.org/3ltf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ltf RCSB], [https://www.ebi.ac.uk/pdbsum/3ltf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ltf ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ltf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltf OCA], [~~http~~://pdbe.org/3ltf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ltf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ltf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ltf ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/EGFR_DROME EGFR_DROME]] Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Required for embryonic epithelial tissue repair.<ref>PMID:22140578</ref> [[http://www.uniprot.org/uniprot/SPITZ_DROME SPITZ_DROME]] Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination.<ref>PMID:7833286</ref>	+	[https://www.uniprot.org/uniprot/EGFR_DROME EGFR_DROME] Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Required for embryonic epithelial tissue repair.<ref>PMID:22140578</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 31:

	==See Also==		==See Also==
-	*[[Epidermal ~~Growth Factor Receptor~~\|Epidermal ~~Growth Factor Receptor~~]]	+	*[[Epidermal growth factor receptor 3D structures\|Epidermal growth factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
-	[[Category: ~~Alvarado, D~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Klein,~~ D E]]	+	[[Category: Alvarado D]]
-	[[Category: ~~Lemmon, M A~~]]	+	[[Category: Klein DE]]
-	[[Category: ~~Atp-binding]]~~	+	[[Category: Lemmon MA]]
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Differentiation]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Egf-like domain]]~~	+
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Golgi apparatus]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Neurogenesis]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Receptor-ligand complex ectodomain cysteine rich domain egf domain]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-transferase regulator complex]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Tyrosine-protein kinase~~]]	+

OCA at 07:00, 9 January 2019

OCA — Wed, 09 Jan 2019 07:00:37 GMT

←Older revision		Revision as of 07:00, 9 January 2019
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ltf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LTF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ltf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LTF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MLI~~:~~MALONATE+ION~~'>~~MLI~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i2t\|3i2t]], [[3ltg\|3ltg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i2t\|3i2t]], [[3ltg\|3ltg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Egfr, Dmel_CG10079, torpedo, dEGFR, c-erbB, DER, top ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), CG10334, spi, Spitz ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Egfr, Dmel_CG10079, torpedo, dEGFR, c-erbB, DER, top ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), CG10334, spi, Spitz ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lt/3ltf_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lt/3ltf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:20, 5 August 2016

OCA — Fri, 05 Aug 2016 01:20:47 GMT

←Older revision		Revision as of 01:20, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz==		==Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz==
	<StructureSection load='3ltf' size='340' side='right' caption='[[3ltf]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3ltf' size='340' side='right' caption='[[3ltf]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ltf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LTF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ltf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LTF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i2t\|3i2t]], [[3ltg\|3ltg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i2t\|3i2t]], [[3ltg\|3ltg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Egfr, Dmel_CG10079, torpedo, dEGFR, c-erbB, DER, top ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 ~~Drosophila melanogaster~~]), CG10334, spi, Spitz ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 ~~Drosophila melanogaster~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Egfr, Dmel_CG10079, torpedo, dEGFR, c-erbB, DER, top ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), CG10334, spi, Spitz ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ltf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ltf RCSB], [http://www.ebi.ac.uk/pdbsum/3ltf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ltf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltf OCA], [http://pdbe.org/3ltf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ltf RCSB], [http://www.ebi.ac.uk/pdbsum/3ltf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ltf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ltf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ltf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Alvarado, D]]		[[Category: Alvarado, D]]
	[[Category: Klein, D E]]		[[Category: Klein, D E]]

OCA at 21:33, 24 December 2014

OCA — Wed, 24 Dec 2014 21:33:41 GMT

←Older revision		Revision as of 21:33, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ltf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ltf RCSB], [http://www.ebi.ac.uk/pdbsum/3ltf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ltf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ltf RCSB], [http://www.ebi.ac.uk/pdbsum/3ltf PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EGFR_DROME EGFR_DROME]] Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Required for embryonic epithelial tissue repair.<ref>PMID:22140578</ref> [[http://www.uniprot.org/uniprot/SPITZ_DROME SPITZ_DROME]] Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination.<ref>PMID:7833286</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:36, 9 December 2014

OCA — Tue, 09 Dec 2014 08:36:19 GMT

←Older revision		Revision as of 08:36, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3ltf.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz==
		+	<StructureSection load='3ltf' size='340' side='right' caption='[[3ltf]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ltf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LTF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i2t\|3i2t]], [[3ltg\|3ltg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Egfr, Dmel_CG10079, torpedo, dEGFR, c-erbB, DER, top ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]), CG10334, spi, Spitz ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ltf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ltf RCSB], [http://www.ebi.ac.uk/pdbsum/3ltf PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lt/3ltf_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transmembrane signaling by the epidermal growth factor receptor (EGFR) involves ligand-induced dimerization and allosteric regulation of the intracellular tyrosine kinase domain. Crystallographic studies have shown how ligand binding induces dimerization of the EGFR extracellular region but cannot explain the "high-affinity" and "low-affinity" classes of cell-surface EGF-binding sites inferred from curved Scatchard plots. From a series of crystal structures of the Drosophila EGFR extracellular region, we show here how Scatchard plot curvature arises from negatively cooperative ligand binding. The first ligand-binding event induces formation of an asymmetric dimer with only one bound ligand. The unoccupied site in this dimer is structurally restrained, leading to reduced affinity for binding of the second ligand, and thus negative cooperativity. Our results explain the cell-surface binding characteristics of EGF receptors and suggest how individual EGFR ligands might stabilize distinct dimeric species with different signaling properties.

-	~~{{STRUCTURE_3ltf\| PDB=3ltf \| SCENE= }}~~	+	Structural basis for negative cooperativity in growth factor binding to an EGF receptor.,Alvarado D, Klein DE, Lemmon MA Cell. 2010 Aug 20;142(4):568-79. PMID:20723758<ref>PMID:20723758</ref>

-	~~===Crystal Structure~~ of the ~~Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20723758}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ltf]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA].~~	+

	==See Also==		==See Also==
	*[[Epidermal Growth Factor Receptor\|Epidermal Growth Factor Receptor]]		*[[Epidermal Growth Factor Receptor\|Epidermal Growth Factor Receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020723758<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Alvarado, D.]]	+	[[Category: Alvarado, D]]
-	[[Category: Klein, D E.]]	+	[[Category: Klein, D E]]
-	[[Category: Lemmon, M A.]]	+	[[Category: Lemmon, M A]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]

OCA at 09:21, 20 October 2012

OCA — Sat, 20 Oct 2012 09:21:02 GMT

←Older revision		Revision as of 09:21, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ltf]] is a 4 chain structure ~~of [[Epidermal Growth Factor Receptor]]~~ with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA].	+	[[3ltf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA].

	==See Also==		==See Also==

OCA: Protected "3ltf" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 22:34:21 GMT

Protected "3ltf" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:34, 25 July 2012

OCA at 22:34, 25 July 2012

OCA — Wed, 25 Jul 2012 22:34:19 GMT

←Older revision		Revision as of 22:34, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3ltf.png\|left\|200px]]		[[Image:3ltf.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ltf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ltf\| PDB=3ltf \| SCENE= }}		{{STRUCTURE_3ltf\| PDB=3ltf \| SCENE= }}

	===Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz===		===Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20723758}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20723758 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20723758}}		{{ABSTRACT_PUBMED_20723758}}

	==About this Structure==		==About this Structure==
-	~~3LTF~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA].	+	[[3ltf]] is a 4 chain structure of [[Epidermal Growth Factor Receptor]] with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA].
		+
		+	==See Also==
		+	*[[Epidermal Growth Factor Receptor\|Epidermal Growth Factor Receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20723758~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020723758</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Alvarado, D.]]		[[Category: Alvarado, D.]]
Line 47:		Line 38:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Sep 10 13:36:50 2010''

OCA at 09:28, 10 September 2010

OCA — Fri, 10 Sep 2010 09:28:20 GMT

←Older revision		Revision as of 09:28, 10 September 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3ltf.~~jpg~~\|left\|200px]]	+	[[Image:3ltf.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz===		===Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20723758}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20723758 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20723758}}

	==About this Structure==		==About this Structure==
	3LTF is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA].		3LTF is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20723758</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Alvarado, D.]]		[[Category: Alvarado, D.]]
Line 39:		Line 48:
	[[Category: Tyrosine-protein kinase]]		[[Category: Tyrosine-protein kinase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Aug 25 08~~:57:56 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Sep 10 13:36:50 2010''

OCA at 04:50, 25 August 2010

OCA — Wed, 25 Aug 2010 04:50:06 GMT

←Older revision		Revision as of 04:50, 25 August 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ltf.jpg\|left\|200px]]

-	The ~~entry 3ltf~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ltf", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ltf\| PDB=3ltf \| SCENE= }}

-	~~Authors: Alvarado, D., Klein, D.E., Lemmon, M.A.~~	+	===Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz===

-	Description: Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 31 13~~:21:49 2010''	+	==About this Structure==
		+	3LTF is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTF OCA].
		+	[[Category: Drosophila melanogaster]]
		+	[[Category: Alvarado, D.]]
		+	[[Category: Klein, D E.]]
		+	[[Category: Lemmon, M A.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Cell membrane]]
		+	[[Category: Developmental protein]]
		+	[[Category: Differentiation]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Egf-like domain]]
		+	[[Category: Endoplasmic reticulum]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Golgi apparatus]]
		+	[[Category: Kinase]]
		+	[[Category: Membrane]]
		+	[[Category: Neurogenesis]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Receptor]]
		+	[[Category: Receptor-ligand complex ectodomain cysteine rich domain egf domain]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase regulator complex]]
		+	[[Category: Transmembrane]]
		+	[[Category: Tyrosine-protein kinase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:57:56 2010''