3lwl - Revision history

OCA at 16:26, 1 November 2023

OCA — Wed, 01 Nov 2023 16:26:19 GMT

←Older revision		Revision as of 16:26, 1 November 2023
Line 1:		Line 1:

	==Structure of Klenow fragment of Taq polymerase in complex with an abasic site==		==Structure of Klenow fragment of Taq polymerase in complex with an abasic site==
-	<StructureSection load='3lwl' size='340' side='right' caption='[[3lwl]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='3lwl' size='340' side='right'caption='[[3lwl]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3lwl]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_25104 Atcc 25104~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3LWL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3lwl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LWL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ACT:ACETATE+ION'>ACT</scene~~>, ~~<scene name='pdbligand=DDS:~~2~~,3-DIDEOXYADENOSINE+TRIPHOSPHATE'>DDS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=2DA:2,3-DIDEOXYADENOSINE-5-MONOPHOSPHATE'>2DA</scene>, <scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DA:2,3-DIDEOXYADENOSINE-5-MONOPHOSPHATE'>2DA</scene>, <scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DDS:2,3-DIDEOXYADENOSINE+TRIPHOSPHATE'>DDS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">[[3ktq\|3ktq]]~~, ~~[[3lwm\|3lwm]]</td~~></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwl OCA], [https://pdbe.org/3lwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lwl RCSB], [https://www.ebi.ac.uk/pdbsum/3lwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwl ProSAT]</span></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">pol1~~, ~~polA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3lwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwl OCA], [~~http~~://pdbe.org/3lwl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3lwl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3lwl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwl ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DPO1_THEAQ DPO1_THEAQ]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3lwl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3lwl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 25104~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~DNA-directed DNA polymerase~~]]	+	[[Category: Thermus aquaticus]]
-	[[Category: Diederichs, K]]	+	[[Category: Diederichs K]]
-	[[Category: Marx, A]]	+	[[Category: Marx A]]
-	[[Category: Obeid, S]]	+	[[Category: Obeid S]]
-	~~[[Category: Abasic site]]~~	+
-	~~[[Category: Amino acid-templating mechanism]]~~	+
-	~~[[Category: Dna damage]]~~	+
-	~~[[Category: Dna polymerase]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Dna replication]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Dna-directed dna polymerase]]~~	+
-	~~[[Category: Transferase-dna complex]]~~	+
-	~~[[Category: Translesion synthesis~~]]	+

OCA at 07:38, 9 January 2019

OCA — Wed, 09 Jan 2019 07:38:38 GMT

←Older revision		Revision as of 07:38, 9 January 2019
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3lwl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3lwl" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:27, 11 August 2016

OCA — Thu, 11 Aug 2016 17:27:44 GMT

←Older revision		Revision as of 17:27, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of Klenow fragment of Taq polymerase in complex with an abasic site==		==Structure of Klenow fragment of Taq polymerase in complex with an abasic site==
	<StructureSection load='3lwl' size='340' side='right' caption='[[3lwl]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='3lwl' size='340' side='right' caption='[[3lwl]], [[Resolution\|resolution]] 2.25Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol1, polA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol1, polA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lwl RCSB], [http://www.ebi.ac.uk/pdbsum/3lwl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwl OCA], [http://pdbe.org/3lwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lwl RCSB], [http://www.ebi.ac.uk/pdbsum/3lwl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwl ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lwl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3lwl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:43, 20 January 2015

OCA — Tue, 20 Jan 2015 11:43:55 GMT

←Older revision		Revision as of 11:43, 20 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_3lwl\| PDB=3lwl \| SCENE= }}~~	+	==Structure of Klenow fragment of Taq polymerase in complex with an abasic site==
-	===Structure of Klenow fragment of Taq polymerase in complex with an abasic site===	+	<StructureSection load='3lwl' size='340' side='right' caption='[[3lwl]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20400942}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3lwl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LWL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DDS:2,3-DIDEOXYADENOSINE+TRIPHOSPHATE'>DDS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2DA:2,3-DIDEOXYADENOSINE-5-MONOPHOSPHATE'>2DA</scene>, <scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ktq\|3ktq]], [[3lwm\|3lwm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol1, polA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 ATCC 25104])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lwl RCSB], [http://www.ebi.ac.uk/pdbsum/3lwl PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Abasic sites represent the most frequent DNA lesions in the genome that have high mutagenic potential and lead to mutations commonly found in human cancers. Although these lesions are devoid of the genetic information, adenine is most efficiently inserted when abasic sites are bypassed by DNA polymerases, a phenomenon termed A-rule. In this study, we present X-ray structures of a DNA polymerase caught while incorporating a nucleotide opposite an abasic site. We found that a functionally important tyrosine side chain directs for nucleotide incorporation rather than DNA. It fills the vacant space of the absent template nucleobase and thereby mimics a pyrimidine nucleobase directing for preferential purine incorporation opposite abasic residues because of enhanced geometric fit to the active site. This amino acid templating mechanism was corroborated by switching to pyrimidine specificity because of mutation of the templating tyrosine into tryptophan. The tyrosine is located in motif B and highly conserved throughout evolution from bacteria to humans indicating a general amino acid templating mechanism for bypass of non-instructive lesions by DNA polymerases at least from this sequence family.

-	~~==About this Structure==~~	+	Replication through an abasic DNA lesion: structural basis for adenine selectivity.,Obeid S, Blatter N, Kranaster R, Schnur A, Diederichs K, Welte W, Marx A EMBO J. 2010 May 19;29(10):1738-47. Epub 2010 Apr 16. PMID:20400942<ref>PMID:20400942</ref>
-	~~[[3lwl]] is a 3 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Atcc_25104 Atcc 25104]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3LWL OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[DNA polymerase\|DNA polymerase]]		*[[DNA polymerase\|DNA polymerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020400942</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Atcc 25104]]		[[Category: Atcc 25104]]
	[[Category: DNA-directed DNA polymerase]]		[[Category: DNA-directed DNA polymerase]]
-	[[Category: Diederichs, K.]]	+	[[Category: Diederichs, K]]
-	[[Category: Marx, A.]]	+	[[Category: Marx, A]]
-	[[Category: Obeid, S.]]	+	[[Category: Obeid, S]]
	[[Category: Abasic site]]		[[Category: Abasic site]]
	[[Category: Amino acid-templating mechanism]]		[[Category: Amino acid-templating mechanism]]

OCA at 04:20, 13 February 2014

OCA — Thu, 13 Feb 2014 04:20:46 GMT

←Older revision		Revision as of 04:20, 13 February 2014
Line 1:		Line 1:
-	[[Image:3lwl.png\|left\|200px]]
-
	{{STRUCTURE_3lwl\| PDB=3lwl \| SCENE= }}		{{STRUCTURE_3lwl\| PDB=3lwl \| SCENE= }}
-
	===Structure of Klenow fragment of Taq polymerase in complex with an abasic site===		===Structure of Klenow fragment of Taq polymerase in complex with an abasic site===
-
	{{ABSTRACT_PUBMED_20400942}}		{{ABSTRACT_PUBMED_20400942}}

	==About this Structure==		==About this Structure==
-	[[3lwl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_aquaticus Thermus aquaticus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWL OCA].	+	[[3lwl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWL OCA].

	==See Also==		==See Also==
Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020400942</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020400942</ref><references group="xtra"/><references/>
		+	[[Category: Atcc 25104]]
	[[Category: DNA-directed DNA polymerase]]		[[Category: DNA-directed DNA polymerase]]
-	[[Category: Thermus aquaticus]]
	[[Category: Diederichs, K.]]		[[Category: Diederichs, K.]]
	[[Category: Marx, A.]]		[[Category: Marx, A.]]

OCA at 21:26, 20 October 2012

OCA — Sat, 20 Oct 2012 21:26:46 GMT

←Older revision		Revision as of 21:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3lwl]] is a 3 chain structure ~~of [[DNA polymerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWL OCA].	+	[[3lwl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWL OCA].

	==See Also==		==See Also==

OCA: Protected "3lwl" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 13:16:48 GMT

Protected "3lwl" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:16, 27 July 2012

OCA at 13:16, 27 July 2012

OCA — Fri, 27 Jul 2012 13:16:46 GMT

←Older revision		Revision as of 13:16, 27 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3lwl.png\|left\|200px]]
-	[[Image:3lwl.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3lwl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3lwl\| PDB=3lwl \| SCENE= }}		{{STRUCTURE_3lwl\| PDB=3lwl \| SCENE= }}

	===Structure of Klenow fragment of Taq polymerase in complex with an abasic site===		===Structure of Klenow fragment of Taq polymerase in complex with an abasic site===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20400942}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20400942 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20400942}}		{{ABSTRACT_PUBMED_20400942}}

	==About this Structure==		==About this Structure==
-	~~3LWL~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWL OCA].	+	[[3lwl]] is a 3 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWL OCA].
		+
		+	==See Also==
		+	*[[DNA polymerase\|DNA polymerase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20400942~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020400942</ref><references group="xtra"/>
	[[Category: DNA-directed DNA polymerase]]		[[Category: DNA-directed DNA polymerase]]
	[[Category: Thermus aquaticus]]		[[Category: Thermus aquaticus]]
Line 39:		Line 30:
	[[Category: Transferase-dna complex]]		[[Category: Transferase-dna complex]]
	[[Category: Translesion synthesis]]		[[Category: Translesion synthesis]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:53:34 2010''

OCA at 08:53, 5 May 2010

OCA — Wed, 05 May 2010 08:53:35 GMT

←Older revision		Revision as of 08:53, 5 May 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3lwl.jpg\|left\|200px]]

-	The ~~entry 3lwl~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3lwl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3lwl\| PDB=3lwl \| SCENE= }}

-	~~Authors: Marx, A., Diederichs, K., Obeid, S.~~	+	===Structure of Klenow fragment of Taq polymerase in complex with an abasic site===

-	Description: Structure of Klenow fragment of Taq polymerase in complex with an abasic site

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 24 08~~:37:28 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20400942}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20400942 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20400942}}
		+
		+	==About this Structure==
		+	3LWL is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20400942</ref><references group="xtra"/>
		+	[[Category: DNA-directed DNA polymerase]]
		+	[[Category: Thermus aquaticus]]
		+	[[Category: Diederichs, K.]]
		+	[[Category: Marx, A.]]
		+	[[Category: Obeid, S.]]
		+	[[Category: Abasic site]]
		+	[[Category: Amino acid-templating mechanism]]
		+	[[Category: Dna damage]]
		+	[[Category: Dna polymerase]]
		+	[[Category: Dna repair]]
		+	[[Category: Dna replication]]
		+	[[Category: Dna-binding]]
		+	[[Category: Dna-directed dna polymerase]]
		+	[[Category: Transferase-dna complex]]
		+	[[Category: Translesion synthesis]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:53:34 2010''

OCA at 06:37, 24 March 2010

OCA — Wed, 24 Mar 2010 06:37:29 GMT

←Older revision		Revision as of 06:37, 24 March 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3lwl is ON HOLD	+	The entry 3lwl is ON HOLD until Paper Publication

	Authors: Marx, A., Diederichs, K., Obeid, S.		Authors: Marx, A., Diederichs, K., Obeid, S.
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	Description: Structure of Klenow fragment of Taq polymerase in complex with an abasic site		Description: Structure of Klenow fragment of Taq polymerase in complex with an abasic site

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar ~~3 15~~:30:27 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:37:28 2010''