3m10 - Revision history

OCA at 08:46, 6 September 2023

OCA — Wed, 06 Sep 2023 08:46:59 GMT

←Older revision		Revision as of 08:46, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3m10' size='340' side='right'caption='[[3m10]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='3m10' size='340' side='right'caption='[[3m10]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m10]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atlantic_horseshoe_crab Atlantic horseshoe crab~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M10 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m10]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M10 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.727Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1m80\|1m80]], [[1m15\|1m15]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Arginine_kinase Arginine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.3 2.7.3.3]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m10 OCA], [https://pdbe.org/3m10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m10 RCSB], [https://www.ebi.ac.uk/pdbsum/3m10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m10 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m10 OCA], [https://pdbe.org/3m10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m10 RCSB], [https://www.ebi.ac.uk/pdbsum/3m10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m10 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KARG_LIMPO KARG_LIMPO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arginine kinase]]
-	[[Category: Atlantic horseshoe crab]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chapman~~, M S~~]]	+	[[Category: Limulus polyphemus]]
-	[[Category: Clark~~, S A~~]]	+	[[Category: Chapman MS]]
-	[[Category: Ellington~~, W R~~]]	+	[[Category: Clark SA]]
-	[[Category: Pruett~~, P K~~]]	+	[[Category: Ellington WR]]
-	[[Category: Somasundaram, T]]	+	[[Category: Pruett PK]]
-	[[Category: Yousef~~, M S]]~~	+	[[Category: Somasundaram T]]
-	~~[[Category: Alpha-beta]]~~	+	[[Category: Yousef MS]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Guanidino kinase]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphagen kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:41, 13 October 2021

OCA — Wed, 13 Oct 2021 12:41:05 GMT

←Older revision		Revision as of 12:41, 13 October 2021
Line 3:		Line 3:
	<StructureSection load='3m10' size='340' side='right'caption='[[3m10]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='3m10' size='340' side='right'caption='[[3m10]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m10]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atlantic_horseshoe_crab Atlantic horseshoe crab]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3M10 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m10]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atlantic_horseshoe_crab Atlantic horseshoe crab]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M10 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m80\|1m80]], [[1m15\|1m15]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m80\|1m80]], [[1m15\|1m15]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Arginine_kinase Arginine kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.3 2.7.3.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Arginine_kinase Arginine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.3 2.7.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3m10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m10 OCA], [~~http~~://pdbe.org/3m10 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3m10 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3m10 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3m10 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m10 OCA], [https://pdbe.org/3m10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m10 RCSB], [https://www.ebi.ac.uk/pdbsum/3m10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m10 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Arginine Kinase AK\|Arginine Kinase AK]]
	*[[Arginine kinase 3D structures\|Arginine kinase 3D structures]]		*[[Arginine kinase 3D structures\|Arginine kinase 3D structures]]
-	*[[Transthyretin\|Transthyretin]]	+	*[[Transthyretin 3D structures\|Transthyretin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:16, 17 July 2019

OCA — Wed, 17 Jul 2019 11:16:27 GMT

←Older revision		Revision as of 11:16, 17 July 2019
Line 1:		Line 1:

	==Substrate-free form of Arginine Kinase==		==Substrate-free form of Arginine Kinase==
-	<StructureSection load='3m10' size='340' side='right' caption='[[3m10]], [[Resolution\|resolution]] 1.73Å' scene=''>	+	<StructureSection load='3m10' size='340' side='right'caption='[[3m10]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3m10]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atlantic_horseshoe_crab Atlantic horseshoe crab]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M10 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3m10]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atlantic_horseshoe_crab Atlantic horseshoe crab]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M10 FirstGlance]. <br>
Line 31:		Line 31:
	==See Also==		==See Also==
	*[[Arginine Kinase AK\|Arginine Kinase AK]]		*[[Arginine Kinase AK\|Arginine Kinase AK]]
-	*[[Arginine kinase\|Arginine kinase]]	+	*[[Arginine kinase 3D structures\|Arginine kinase 3D structures]]
	*[[Transthyretin\|Transthyretin]]		*[[Transthyretin\|Transthyretin]]
	== References ==		== References ==
Line 39:		Line 39:
	[[Category: Arginine kinase]]		[[Category: Arginine kinase]]
	[[Category: Atlantic horseshoe crab]]		[[Category: Atlantic horseshoe crab]]
		+	[[Category: Large Structures]]
	[[Category: Chapman, M S]]		[[Category: Chapman, M S]]
	[[Category: Clark, S A]]		[[Category: Clark, S A]]

OCA at 07:42, 9 January 2019

OCA — Wed, 09 Jan 2019 07:42:15 GMT

←Older revision		Revision as of 07:42, 9 January 2019
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/3m10_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/3m10_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:04, 10 December 2016

OCA — Sat, 10 Dec 2016 04:04:38 GMT

←Older revision		Revision as of 04:04, 10 December 2016
Line 1:		Line 1:
		+
	==Substrate-free form of Arginine Kinase==		==Substrate-free form of Arginine Kinase==
	<StructureSection load='3m10' size='340' side='right' caption='[[3m10]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='3m10' size='340' side='right' caption='[[3m10]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m10]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Limulus_polyphemus Limulus polyphemus~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M10 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m10]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atlantic_horseshoe_crab Atlantic horseshoe crab]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M10 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m80\|1m80]], [[1m15\|1m15]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m80\|1m80]], [[1m15\|1m15]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginine_kinase Arginine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.3 2.7.3.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginine_kinase Arginine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.3 2.7.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m10 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m10 RCSB], [http://www.ebi.ac.uk/pdbsum/3m10 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m10 OCA], [http://pdbe.org/3m10 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m10 RCSB], [http://www.ebi.ac.uk/pdbsum/3m10 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m10 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m10 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3m10" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Arginine Kinase AK\|Arginine Kinase AK]]
		+	*[[Arginine kinase\|Arginine kinase]]
	*[[Transthyretin\|Transthyretin]]		*[[Transthyretin\|Transthyretin]]
	== References ==		== References ==
Line 34:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Arginine kinase]]		[[Category: Arginine kinase]]
-	[[Category: ~~Limulus polyphemus~~]]	+	[[Category: Atlantic horseshoe crab]]
	[[Category: Chapman, M S]]		[[Category: Chapman, M S]]
	[[Category: Clark, S A]]		[[Category: Clark, S A]]

OCA at 09:56, 9 December 2014

OCA — Tue, 09 Dec 2014 09:56:05 GMT

←Older revision		Revision as of 09:56, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3m10.~~png~~\|~~left~~\|200px]]	+	==Substrate-free form of Arginine Kinase==
		+	<StructureSection load='3m10' size='340' side='right' caption='[[3m10]], [[Resolution\|resolution]] 1.73Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3m10]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M10 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m80\|1m80]], [[1m15\|1m15]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginine_kinase Arginine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.3 2.7.3.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m10 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m10 RCSB], [http://www.ebi.ac.uk/pdbsum/3m10 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/3m10_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The phosphagen kinase family, including creatine and arginine kinases (AKs), catalyzes the reversible transfer of a "high-energy" phosphate between ATP and a phosphoguanidino substrate. They have become a model for the study of both substrate-induced conformational change and intrinsic protein dynamics. Prior crystallographic studies indicated large substrate-induced domain rotations, but differences among a recent set of AK structures were interpreted as a plastic deformation. Here, the structure of Limulus substrate-free AK is refined against high-resolution crystallographic data and compared quantitatively with NMR chemical shifts and residual dipolar couplings (RDCs). This demonstrates the feasibility of this type of RDC analysis of proteins that are large by NMR standards (42 kDa) and illuminates the solution structure, free from crystal-packing constraints. Detailed comparison of the 1.7 A resolution substrate-free crystal structure against the 1.7 A transition-state analog complex shows large substrate-induced domain motions that can be broken down into movements of smaller quasi-rigid bodies. The solution-state structure of substrate-free AK is most consistent with an equilibrium of substrate-free and substrate-bound structures, with the substrate-free form dominating, but with varying displacements of the quasi-rigid groups. Rigid-group rotations evident from the crystal structures are about axes previously associated with intrinsic millisecond dynamics using NMR relaxation dispersion. Thus, "substrate-induced" motions are along modes that are intrinsically flexible in the substrate-free enzyme and likely involve some degree of conformational selection.

-	~~{{STRUCTURE_3m10\| PDB=3m10 \| SCENE= }}~~	+	Arginine kinase: joint crystallographic and NMR RDC analyses link substrate-associated motions to intrinsic flexibility.,Niu X, Bruschweiler-Li L, Davulcu O, Skalicky JJ, Bruschweiler R, Chapman MS J Mol Biol. 2011 Jan 14;405(2):479-96. Epub 2010 Nov 12. PMID:21075117<ref>PMID:21075117</ref>

-	~~===Substrate-free form~~ of ~~Arginine Kinase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21075117}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3m10]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA].~~	+

	==See Also==		==See Also==
	*[[Transthyretin\|Transthyretin]]		*[[Transthyretin\|Transthyretin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021075117<~~/~~ref~~><~~ref group="xtra">PMID:020516627</ref><ref group="xtra">PMID:012493833</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Arginine kinase]]		[[Category: Arginine kinase]]
	[[Category: Limulus polyphemus]]		[[Category: Limulus polyphemus]]
-	[[Category: Chapman, M S.]]	+	[[Category: Chapman, M S]]
-	[[Category: Clark, S A.]]	+	[[Category: Clark, S A]]
-	[[Category: Ellington, W R.]]	+	[[Category: Ellington, W R]]
-	[[Category: Pruett, P K.]]	+	[[Category: Pruett, P K]]
-	[[Category: Somasundaram, T.]]	+	[[Category: Somasundaram, T]]
-	[[Category: Yousef, M S.]]	+	[[Category: Yousef, M S]]
	[[Category: Alpha-beta]]		[[Category: Alpha-beta]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 05:44, 20 October 2012

OCA — Sat, 20 Oct 2012 05:44:47 GMT

←Older revision		Revision as of 05:44, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3m10]] is a 2 chain structure ~~of [[Transthyretin]]~~ with sequence from [http://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA].	+	[[3m10]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA].

	==See Also==		==See Also==

OCA at 10:59, 25 July 2012

OCA — Wed, 25 Jul 2012 10:59:17 GMT

←Older revision		Revision as of 10:59, 25 July 2012
Line 1:		Line 1:
	[[Image:3m10.png\|left\|200px]]		[[Image:3m10.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3m10", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3m10\| PDB=3m10 \| SCENE= }}		{{STRUCTURE_3m10\| PDB=3m10 \| SCENE= }}

	===Substrate-free form of Arginine Kinase===		===Substrate-free form of Arginine Kinase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21075117}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21075117 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21075117}}		{{ABSTRACT_PUBMED_21075117}}

	==About this Structure==		==About this Structure==
-	[[3m10]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA].	+	[[3m10]] is a 2 chain structure of [[Transthyretin]] with sequence from [http://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA].
		+
		+	==See Also==
		+	*[[Transthyretin\|Transthyretin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21075117~~</ref><ref group="xtra">PMID:~~20516627~~</ref><ref group="xtra">PMID:~~12493833~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021075117</ref><ref group="xtra">PMID:020516627</ref><ref group="xtra">PMID:012493833</ref><references group="xtra"/>
	[[Category: Arginine kinase]]		[[Category: Arginine kinase]]
	[[Category: Limulus polyphemus]]		[[Category: Limulus polyphemus]]
Line 31:		Line 23:
	[[Category: Somasundaram, T.]]		[[Category: Somasundaram, T.]]
	[[Category: Yousef, M S.]]		[[Category: Yousef, M S.]]
		+	[[Category: Alpha-beta]]
		+	[[Category: Atp-binding]]
		+	[[Category: Guanidino kinase]]
		+	[[Category: Kinase]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Phosphagen kinase]]
		+	[[Category: Transferase]]

OCA: Protected "3m10" [edit=sysop:move=sysop]

OCA — Wed, 23 Feb 2011 09:26:16 GMT

Protected "3m10" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:26, 23 February 2011

OCA at 09:26, 23 February 2011

OCA — Wed, 23 Feb 2011 09:26:15 GMT

←Older revision		Revision as of 09:26, 23 February 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3m10.png\|left\|200px]]		[[Image:3m10.png\|left\|200px]]

Line 12:		Line 11:
	===Substrate-free form of Arginine Kinase===		===Substrate-free form of Arginine Kinase===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21075117}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21075117 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21075117}}

	==About this Structure==		==About this Structure==
-	~~3M10~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA].	+	[[3m10]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Limulus_polyphemus Limulus polyphemus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1m80 1m80]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M10 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:20516627</ref><ref group="xtra">PMID:12493833</ref><references group="xtra"/>	+	<ref group="xtra">PMID:21075117</ref><ref group="xtra">PMID:20516627</ref><ref group="xtra">PMID:12493833</ref><references group="xtra"/>
	[[Category: Arginine kinase]]		[[Category: Arginine kinase]]
	[[Category: Limulus polyphemus]]		[[Category: Limulus polyphemus]]
Line 26:		Line 31:
	[[Category: Somasundaram, T.]]		[[Category: Somasundaram, T.]]
	[[Category: Yousef, M S.]]		[[Category: Yousef, M S.]]
-	[[Category: Alpha-beta]]
-	[[Category: Atp-binding]]
-	[[Category: Guanidino kinase]]
-	[[Category: Kinase]]
-	[[Category: Nucleotide-binding]]
-	[[Category: Phosphagen kinase]]
-	[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:55:34 2010''