3m32 - Revision history

OCA at 18:05, 14 August 2019

OCA — Wed, 14 Aug 2019 18:05:16 GMT

←Older revision		Revision as of 18:05, 14 August 2019
Line 1:		Line 1:

	==Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues==		==Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues==
-	<StructureSection load='3m32' size='340' side='right' caption='[[3m32]], [[Resolution\|resolution]] 1.35Å' scene=''>	+	<StructureSection load='3m32' size='340' side='right'caption='[[3m32]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3m32]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M32 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3m32]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M32 FirstGlance]. <br>
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m3/3m32_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m3/3m32_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Coenzyme-B sulfoethylthiotransferase]]		[[Category: Coenzyme-B sulfoethylthiotransferase]]
		+	[[Category: Large Structures]]
	[[Category: Methanothermobacter marburgensis]]		[[Category: Methanothermobacter marburgensis]]
	[[Category: Cedervall, P E]]		[[Category: Cedervall, P E]]

OCA at 17:23, 9 March 2017

OCA — Thu, 09 Mar 2017 17:23:23 GMT

←Older revision		Revision as of 17:23, 9 March 2017
Line 1:		Line 1:
		+
	==Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues==		==Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues==
	<StructureSection load='3m32' size='340' side='right' caption='[[3m32]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='3m32' size='340' side='right' caption='[[3m32]], [[Resolution\|resolution]] 1.35Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m1v\|3m1v]], [[3m2r\|3m2r]], [[3m2u\|3m2u]], [[3m2v\|3m2v]], [[3m3o\|3m3o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m1v\|3m1v]], [[3m2r\|3m2r]], [[3m2u\|3m2u]], [[3m2v\|3m2v]], [[3m3o\|3m3o]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coenzyme-B_sulfoethylthiotransferase Coenzyme-B sulfoethylthiotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.4.1 2.8.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coenzyme-B_sulfoethylthiotransferase Coenzyme-B sulfoethylthiotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.4.1 2.8.4.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m32 RCSB], [http://www.ebi.ac.uk/pdbsum/3m32 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m32 OCA], [http://pdbe.org/3m32 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m32 RCSB], [http://www.ebi.ac.uk/pdbsum/3m32 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m32 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m32 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3m32" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:32, 20 May 2015

OCA — Wed, 20 May 2015 06:32:27 GMT

←Older revision		Revision as of 06:32, 20 May 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3m32]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M32 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3m32]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M32 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=COM:1-THIOETHANESULFONIC+ACID'>COM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F43:FACTOR+430'>F43</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SHT:O-PHOSPHONO-N-{(2E)-7-[(2-SULFOETHYL)DITHIO]HEPT-2-ENOYL}-L-THREONINE'>SHT</scene>, <scene name='pdbligand=TP7:~~PHOSPHORIC~~+~~ACID+N-(1-HYDROXY-7-MERCAPTO-HEPTYL)THREONINE+ESTER~~'>TP7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=COM:1-THIOETHANESULFONIC+ACID'>COM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F43:FACTOR+430'>F43</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SHT:O-PHOSPHONO-N-{(2E)-7-[(2-SULFOETHYL)DITHIO]HEPT-2-ENOYL}-L-THREONINE'>SHT</scene>, <scene name='pdbligand=TP7:COENZYME+B'>TP7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGM:5-METHYL-ARGININE'>AGM</scene>, <scene name='pdbligand=GL3:THIOGLYCIN'>GL3</scene>, <scene name='pdbligand=MGN:2-METHYL-GLUTAMINE'>MGN</scene>, <scene name='pdbligand=MHS:N1-METHYLATED+HISTIDINE'>MHS</scene>, <scene name='pdbligand=SMC:S-METHYLCYSTEINE'>SMC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGM:5-METHYL-ARGININE'>AGM</scene>, <scene name='pdbligand=GL3:THIOGLYCIN'>GL3</scene>, <scene name='pdbligand=MGN:2-METHYL-GLUTAMINE'>MGN</scene>, <scene name='pdbligand=MHS:N1-METHYLATED+HISTIDINE'>MHS</scene>, <scene name='pdbligand=SMC:S-METHYLCYSTEINE'>SMC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m1v\|3m1v]], [[3m2r\|3m2r]], [[3m2u\|3m2u]], [[3m2v\|3m2v]], [[3m3o\|3m3o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m1v\|3m1v]], [[3m2r\|3m2r]], [[3m2u\|3m2u]], [[3m2v\|3m2v]], [[3m3o\|3m3o]]</td></tr>

OCA at 18:17, 24 December 2014

OCA — Wed, 24 Dec 2014 18:17:13 GMT

←Older revision		Revision as of 18:17, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m32 RCSB], [http://www.ebi.ac.uk/pdbsum/3m32 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m32 RCSB], [http://www.ebi.ac.uk/pdbsum/3m32 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MCRA_METTM MCRA_METTM]] Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide. [[http://www.uniprot.org/uniprot/MCRG_METTM MCRG_METTM]] Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide. [[http://www.uniprot.org/uniprot/MCRB_METTM MCRB_METTM]] Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:15, 18 December 2014

OCA — Thu, 18 Dec 2014 16:15:29 GMT

←Older revision		Revision as of 16:15, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3m32\| PDB=3m32 \| SCENE= }}~~	+	==Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues==
-	===Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues===	+	<StructureSection load='3m32' size='340' side='right' caption='[[3m32]], [[Resolution\|resolution]] 1.35Å' scene=''>
-	{~~{ABSTRACT_PUBMED_20707311}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3m32]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M32 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=COM:1-THIOETHANESULFONIC+ACID'>COM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F43:FACTOR+430'>F43</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SHT:O-PHOSPHONO-N-{(2E)-7-[(2-SULFOETHYL)DITHIO]HEPT-2-ENOYL}-L-THREONINE'>SHT</scene>, <scene name='pdbligand=TP7:PHOSPHORIC+ACID+N-(1-HYDROXY-7-MERCAPTO-HEPTYL)THREONINE+ESTER'>TP7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGM:5-METHYL-ARGININE'>AGM</scene>, <scene name='pdbligand=GL3:THIOGLYCIN'>GL3</scene>, <scene name='pdbligand=MGN:2-METHYL-GLUTAMINE'>MGN</scene>, <scene name='pdbligand=MHS:N1-METHYLATED+HISTIDINE'>MHS</scene>, <scene name='pdbligand=SMC:S-METHYLCYSTEINE'>SMC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m1v\|3m1v]], [[3m2r\|3m2r]], [[3m2u\|3m2u]], [[3m2v\|3m2v]], [[3m3o\|3m3o]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coenzyme-B_sulfoethylthiotransferase Coenzyme-B sulfoethylthiotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.4.1 2.8.4.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m32 RCSB], [http://www.ebi.ac.uk/pdbsum/3m32 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m3/3m32_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Methyl-coenzyme M reductase (MCR) catalyzes the final and rate-limiting step in methane biogenesis: the reduction of methyl-coenzyme M (methyl-SCoM) by coenzyme B (CoBSH) to methane and a heterodisulfide (CoBS-SCoM). Crystallographic studies show that the active site is deeply buried within the enzyme and contains a highly reduced nickel-tetrapyrrole, coenzyme F(430). Methyl-SCoM must enter the active site prior to CoBSH, as species derived from methyl-SCoM are always observed bound to the F(430) nickel in the deepest part of the 30 A long substrate channel that leads from the protein surface to the active site. The seven-carbon mercaptoalkanoyl chain of CoBSH binds within a 16 A predominantly hydrophobic part of the channel close to F(430), with the CoBSH thiolate lying closest to the nickel at a distance of 8.8 A. It has previously been suggested that binding of CoBSH initiates catalysis by inducing a conformational change that moves methyl-SCoM closer to the nickel promoting cleavage of the C-S bond of methyl-SCoM. In order to better understand the structural role of CoBSH early in the MCR mechanism, we have determined crystal structures of MCR in complex with four different CoBSH analogues: pentanoyl, hexanoyl, octanoyl, and nonanoyl derivatives of CoBSH (CoB(5)SH, CoB(6)SH, CoB(8)SH, and CoB(9)SH, respectively). The data presented here reveal that the shorter CoB(5)SH mercaptoalkanoyl chain overlays with that of CoBSH but terminates two units short of the CoBSH thiolate position. In contrast, the mercaptoalkanoyl chain of CoB(6)SH adopts a different conformation, such that its thiolate is coincident with the position of the CoBSH thiolate. This is consistent with the observation that CoB(6)SH is a slow substrate. A labile water in the substrate channel was found to be a sensitive indicator for the presence of CoBSH and HSCoM. The longer CoB(8)SH and CoB(9)SH analogues can be accommodated in the active site through exclusion of this water. These analogues react with Ni(III)-methyl, a proposed MCR catalytic intermediate of methanogenesis. The CoB(8)SH thiolate is 2.6 A closer to the nickel than that of CoBSH, but the additional carbon of CoB(9)SH only decreases the nickel thiolate distance a further 0.3 A. Although the analogues do not induce any structural changes in the substrate channel, the thiolates appear to preferentially bind at two distinct positions in the channel, one being the previously observed CoBSH thiolate position and the other being at a hydrophobic annulus of residues that lines the channel proximal to the nickel.

-	~~==Function==~~	+	Structural insight into methyl-coenzyme M reductase chemistry using coenzyme B analogues .,Cedervall PE, Dey M, Pearson AR, Ragsdale SW, Wilmot CM Biochemistry. 2010 Sep 7;49(35):7683-93. PMID:20707311<ref>PMID:20707311</ref>
-	~~[[http://www.uniprot.org/uniprot/MCRA_METTM MCRA_METTM]] Reduction of~~ methyl-coenzyme M ~~(2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide~~. ~~[[http://www~~.~~uniprot.org/uniprot/MCRG_METTM MCRG_METTM]] Reduction of methyl-coenzyme M (2-~~(~~methylthio~~) ~~ethanesulfonic acid) with 7~~-~~mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide~~. ~~[[http~~:/~~/www.uniprot.org/uniprot/MCRB_METTM MCRB_METTM]] Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3m32]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3M32 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020707311</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Coenzyme-B sulfoethylthiotransferase]]		[[Category: Coenzyme-B sulfoethylthiotransferase]]
	[[Category: Methanothermobacter marburgensis]]		[[Category: Methanothermobacter marburgensis]]
-	[[Category: Cedervall, P E.]]	+	[[Category: Cedervall, P E]]
-	[[Category: Dey, M.]]	+	[[Category: Dey, M]]
-	[[Category: Ragsdale, S W.]]	+	[[Category: Ragsdale, S W]]
-	[[Category: Wilmot, C M.]]	+	[[Category: Wilmot, C M]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Methanogenesis]]		[[Category: Methanogenesis]]

OCA: Protected "3m32" [edit=sysop:move=sysop]

OCA — Wed, 10 Apr 2013 23:11:01 GMT

Protected "3m32" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:11, 10 April 2013

OCA at 23:10, 10 April 2013

OCA — Wed, 10 Apr 2013 23:10:59 GMT

←Older revision		Revision as of 23:10, 10 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3m32.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3m32", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3m32\| PDB=3m32 \| SCENE= }}		{{STRUCTURE_3m32\| PDB=3m32 \| SCENE= }}
-
	===Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues===		===Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues===
		+	{{ABSTRACT_PUBMED_20707311}}

-		+	==Function==
-	<!--	+	[[http://www.uniprot.org/uniprot/MCRA_METTM MCRA_METTM]] Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide. [[http://www.uniprot.org/uniprot/MCRG_METTM MCRG_METTM]] Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide. [[http://www.uniprot.org/uniprot/MCRB_METTM MCRB_METTM]] Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20707311}}, adds the Publication Abstract to the page~~	+
-	(~~as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 20707311 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20707311}}~~	+

	==About this Structure==		==About this Structure==
-	~~3M32~~ is a 6 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M32 OCA].	+	[[3m32]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M32 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20707311~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020707311</ref><references group="xtra"/><references/>
	[[Category: Coenzyme-B sulfoethylthiotransferase]]		[[Category: Coenzyme-B sulfoethylthiotransferase]]
	[[Category: Methanothermobacter marburgensis]]		[[Category: Methanothermobacter marburgensis]]
Line 36:		Line 23:
	[[Category: Nickel]]		[[Category: Nickel]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:49:53 2010''

OCA at 07:41, 15 September 2010

OCA — Wed, 15 Sep 2010 07:41:11 GMT

←Older revision		Revision as of 07:41, 15 September 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3m32.jpg\|left\|200px]]

-	The ~~entry 3m32~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3m32", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3m32\| PDB=3m32 \| SCENE= }}

-	~~Authors: Cedervall, P.E., Dey,~~ M~~., Ragsdale, S.W., Wilmot, C.M.~~	+	===Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues===

-	Description: Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 10~~ 10:57:07 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20707311}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20707311 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20707311}}
		+
		+	==About this Structure==
		+	3M32 is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Methanothermobacter_marburgensis Methanothermobacter marburgensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M32 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20707311</ref><references group="xtra"/>
		+	[[Category: Coenzyme-B sulfoethylthiotransferase]]
		+	[[Category: Methanothermobacter marburgensis]]
		+	[[Category: Cedervall, P E.]]
		+	[[Category: Dey, M.]]
		+	[[Category: Ragsdale, S W.]]
		+	[[Category: Wilmot, C M.]]
		+	[[Category: Metal-binding]]
		+	[[Category: Methanogenesis]]
		+	[[Category: Methyl-coenzyme m reductase]]
		+	[[Category: Methylation]]
		+	[[Category: Nickel]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:49:53 2010''

OCA at 06:52, 10 June 2010

OCA — Thu, 10 Jun 2010 06:52:20 GMT

←Older revision		Revision as of 06:52, 10 June 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3m32 is ON HOLD	+	The entry 3m32 is ON HOLD until Paper Publication

	Authors: Cedervall, P.E., Dey, M., Ragsdale, S.W., Wilmot, C.M.		Authors: Cedervall, P.E., Dey, M., Ragsdale, S.W., Wilmot, C.M.
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	Description: Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues		Description: Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed May 26 08~~:21:41 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 10:57:07 2010''

OCA at 04:17, 26 May 2010

OCA — Wed, 26 May 2010 04:17:30 GMT

←Older revision		Revision as of 04:17, 26 May 2010
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	Authors: Cedervall, P.E., Dey, M., Ragsdale, S.W., Wilmot, C.M.		Authors: Cedervall, P.E., Dey, M., Ragsdale, S.W., Wilmot, C.M.

-	Description: Structural Insight into ~~Inhibition of~~ Methyl-Coenzyme M Reductase by Coenzyme B Analogues	+	Description: Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 17 09~~:13:12 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:21:41 2010''