3m3q - Revision history

OCA at 16:28, 1 November 2023

OCA — Wed, 01 Nov 2023 16:28:57 GMT

←Older revision		Revision as of 16:28, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3m3q' size='340' side='right'caption='[[3m3q]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3m3q' size='340' side='right'caption='[[3m3q]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Agrae Agrae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M3Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyclocybe_aegerita Cyclocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M3Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BGC:BETA~~-~~D-GLUCOSE'>BGC</scene>~~, ~~<scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~SIA~~:O-~~SIALIC+ACID~~'>~~SIA~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3afk\|3afk]], [[3m3c\|3m3c]], [[3m3e\|3m3e]], [[3m3o\|3m3o]]~~</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">AAL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5400 AGRAE])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3q OCA], [https://pdbe.org/3m3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m3q RCSB], [https://www.ebi.ac.uk/pdbsum/3m3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m3q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3q OCA], [https://pdbe.org/3m3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m3q RCSB], [https://www.ebi.ac.uk/pdbsum/3m3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m3q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~ATLE_AGRAE ATLE_AGRAE]~~] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.<ref>PMID:12757412</ref>	+	[https://www.uniprot.org/uniprot/ATLE_CYCAE ATLE_CYCAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).<ref>PMID:12757412</ref> <ref>PMID:16051274</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Agrae~~]]	+	[[Category: Cyclocybe aegerita]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Feng, L]]	+	[[Category: Feng L]]
-	[[Category: Li, D]]	+	[[Category: Li D]]
-	[[Category: Wang, D]]	+	[[Category: Wang D]]
-	~~[[Category: Aal]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Galectin]]~~	+
-	~~[[Category: Ganglosides gm1]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Nuclease~~]]	+

OCA at 13:43, 4 May 2022

OCA — Wed, 04 May 2022 13:43:48 GMT

←Older revision		Revision as of 13:43, 4 May 2022
Line 1:		Line 1:

	==Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide==		==Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide==
-	<StructureSection load='3m3q' size='340' side='right' caption='[[3m3q]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3m3q' size='340' side='right'caption='[[3m3q]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m3q]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=3M3Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M3Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afk\|3afk]], [[3m3c\|3m3c]], [[3m3e\|3m3e]], [[3m3o\|3m3o]]</td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AAL ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5400 AGRAE])</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3afk\|3afk]], [[3m3c\|3m3c]], [[3m3e\|3m3e]], [[3m3o\|3m3o]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3m3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3q OCA], [~~http~~://pdbe.org/3m3q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3m3q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3m3q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3m3q ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AAL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5400 AGRAE])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3q OCA], [https://pdbe.org/3m3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m3q RCSB], [https://www.ebi.ac.uk/pdbsum/3m3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m3q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ATLE_AGRAE ATLE_AGRAE]] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.<ref>PMID:12757412</ref>	+	[[https://www.uniprot.org/uniprot/ATLE_AGRAE ATLE_AGRAE]] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.<ref>PMID:12757412</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Agrae]]		[[Category: Agrae]]
		+	[[Category: Large Structures]]
	[[Category: Feng, L]]		[[Category: Feng, L]]
	[[Category: Li, D]]		[[Category: Li, D]]

OCA at 08:04, 8 November 2017

OCA — Wed, 08 Nov 2017 08:04:06 GMT

←Older revision		Revision as of 08:04, 8 November 2017
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3m3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M3Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[3m3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M3Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afk\|3afk]], [[3m3c\|3m3c]], [[3m3e\|3m3e]], [[3m3o\|3m3o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afk\|3afk]], [[3m3c\|3m3c]], [[3m3e\|3m3e]], [[3m3o\|3m3o]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5400 AGRAE])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5400 AGRAE])</td></tr>

OCA at 19:37, 4 August 2016

OCA — Thu, 04 Aug 2016 19:37:23 GMT

←Older revision		Revision as of 19:37, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide==		==Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide==
	<StructureSection load='3m3q' size='340' side='right' caption='[[3m3q]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3m3q' size='340' side='right' caption='[[3m3q]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Agrocybe_aegerita Agrocybe aegerita~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M3Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrae Agrae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M3Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afk\|3afk]], [[3m3c\|3m3c]], [[3m3e\|3m3e]], [[3m3o\|3m3o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afk\|3afk]], [[3m3c\|3m3c]], [[3m3e\|3m3e]], [[3m3o\|3m3o]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5400 ~~Agrocybe aegerita~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5400 AGRAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m3q RCSB], [http://www.ebi.ac.uk/pdbsum/3m3q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3q OCA], [http://pdbe.org/3m3q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m3q RCSB], [http://www.ebi.ac.uk/pdbsum/3m3q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m3q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3m3q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Agrocybe aegerita~~]]	+	[[Category: Agrae]]
	[[Category: Feng, L]]		[[Category: Feng, L]]
	[[Category: Li, D]]		[[Category: Li, D]]

OCA at 12:28, 25 December 2014

OCA — Thu, 25 Dec 2014 12:28:34 GMT

←Older revision		Revision as of 12:28, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m3q RCSB], [http://www.ebi.ac.uk/pdbsum/3m3q PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m3q RCSB], [http://www.ebi.ac.uk/pdbsum/3m3q PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATLE_AGRAE ATLE_AGRAE]] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.<ref>PMID:12757412</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:03, 18 December 2014

OCA — Thu, 18 Dec 2014 17:03:21 GMT

←Older revision		Revision as of 17:03, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3m3q\| PDB=3m3q \| SCENE= }}~~	+	==Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide==
-	===Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide===	+	<StructureSection load='3m3q' size='340' side='right' caption='[[3m3q]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20530247}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3m3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrocybe_aegerita Agrocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M3Q FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3afk\|3afk]], [[3m3c\|3m3c]], [[3m3e\|3m3e]], [[3m3o\|3m3o]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5400 Agrocybe aegerita])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m3q RCSB], [http://www.ebi.ac.uk/pdbsum/3m3q PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thomsen-Friedenreich (TF) antigen, which plays an important role in the regulation of cancer cell proliferation, occurs in approximately 90% of all human cancers and precancerous conditions. Although TF antigen has been known for almost 80 yr as a pancarcinoma antigen, the recognition mechanism between TF antigen and target protein has not been structurally characterized. A number of studies indicated that TF disaccharide is a potential ligand of the galactoside-binding galectins. In this work, we identified the TF antigen as a potential ligand of the antitumor galectin AAL (Agrocybe aegerita lectin) through glycan array analysis and reported the crystal structure of AAL complexed with the TF antigen. The structure provides a first look at the recognition mode between AAL and TF antigen, which is unique in a conservative (Glu-water-Arg-water) structural motif-based hydrogen bond network. Structure-based mutagenesis analysis further revealed the residues responsible for recognition specificity and binding affinity. Crystal structures of AAL complexed with two other TF-containing glycans showed that the unique TF recognition mode is kept intact, which may be commonly adopted in some cancer-related galectins. The finding provided the new target and approach for the antitumor drug design and relative strategy based on the AAL-TF recognition mode as a prototype model.

-	~~==Function==~~	+	Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen.,Feng L, Sun H, Zhang Y, Li DF, Wang DC FASEB J. 2010 Oct;24(10):3861-8. Epub 2010 Jun 7. PMID:20530247<ref>PMID:20530247</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/ATLE_AGRAE ATLE_AGRAE]] Anti~~-~~tumor lectin with DNase activity~~. ~~Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells~~.<ref>PMID:~~12757412~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3m3q]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Agrocybe_aegerita Agrocybe aegerita]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020530247</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Agrocybe aegerita]]		[[Category: Agrocybe aegerita]]
-	[[Category: Feng, L.]]	+	[[Category: Feng, L]]
-	[[Category: Li, D.]]	+	[[Category: Li, D]]
-	[[Category: Wang, D.]]	+	[[Category: Wang, D]]
	[[Category: Aal]]		[[Category: Aal]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA: Protected "3m3q" [edit=sysop:move=sysop]

OCA — Wed, 10 Apr 2013 23:07:59 GMT

Protected "3m3q" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:07, 10 April 2013

OCA at 23:07, 10 April 2013

OCA — Wed, 10 Apr 2013 23:07:56 GMT

←Older revision		Revision as of 23:07, 10 April 2013
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-	{{Seed}}
-	[[Image:3m3q.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3m3q", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3m3q\| PDB=3m3q \| SCENE= }}		{{STRUCTURE_3m3q\| PDB=3m3q \| SCENE= }}
-
	===Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide===		===Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide===
		+	{{ABSTRACT_PUBMED_20530247}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/ATLE_AGRAE ATLE_AGRAE]] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.<ref>PMID:12757412</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20530247}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20530247 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20530247}}~~	+

	==About this Structure==		==About this Structure==
-	~~3M3Q~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Agrocybe_aegerita Agrocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA].	+	[[3m3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrocybe_aegerita Agrocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20530247~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020530247</ref><references group="xtra"/><references/>
	[[Category: Agrocybe aegerita]]		[[Category: Agrocybe aegerita]]
	[[Category: Feng, L.]]		[[Category: Feng, L.]]
Line 35:		Line 22:
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Nuclease]]		[[Category: Nuclease]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:30:43 2010''

OCA at 08:18, 1 December 2010

OCA — Wed, 01 Dec 2010 08:18:56 GMT

←Older revision		Revision as of 08:18, 1 December 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3m3q.jpg\|left\|200px]]

-	The ~~entry 3m3q~~ is ~~ON HOLD~~ ~~until Mar 09 2012~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3m3q", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3m3q\| PDB=3m3q \| SCENE= }}

-	~~Authors: Feng, L., Li, D., Wang, D.~~	+	===Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide===

-	Description: Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May~~ 5 11:37:43 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20530247}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20530247 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20530247}}
		+
		+	==About this Structure==
		+	3M3Q is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Agrocybe_aegerita Agrocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20530247</ref><references group="xtra"/>
		+	[[Category: Agrocybe aegerita]]
		+	[[Category: Feng, L.]]
		+	[[Category: Li, D.]]
		+	[[Category: Wang, D.]]
		+	[[Category: Aal]]
		+	[[Category: Apoptosis]]
		+	[[Category: Galectin]]
		+	[[Category: Ganglosides gm1]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lectin]]
		+	[[Category: Nuclease]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:30:43 2010''

OCA at 08:37, 5 May 2010

OCA — Wed, 05 May 2010 08:37:43 GMT

←Older revision		Revision as of 08:37, 5 May 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3m3q is ON HOLD	+	The entry 3m3q is ON HOLD until Mar 09 2012

	Authors: Feng, L., Li, D., Wang, D.		Authors: Feng, L., Li, D., Wang, D.
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	Description: Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide		Description: Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr~~ ~~7 10~~:21:04 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:37:43 2010''