3m7s - Revision history

OCA at 16:30, 1 November 2023

OCA — Wed, 01 Nov 2023 16:30:42 GMT

←Older revision		Revision as of 16:30, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3m7s' size='340' side='right'caption='[[3m7s]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3m7s' size='340' side='right'caption='[[3m7s]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m7s]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3M7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m7s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M7S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[3hu7\|3hu7]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRD_900005:beta-cellobiose'>PRD_900005</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3m7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7s OCA], [~~http~~://pdbe.org/3m7s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3m7s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3m7s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3m7s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7s OCA], [https://pdbe.org/3m7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m7s RCSB], [https://www.ebi.ac.uk/pdbsum/3m7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m7s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B2ZGS7_9ASPA B2ZGS7_9ASPA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Scadoxus multiflorus]]		[[Category: Scadoxus multiflorus]]
-	[[Category: Bhushan, A]]	+	[[Category: Bhushan A]]
-	[[Category: Dube, D]]	+	[[Category: Dube D]]
-	[[Category: Kaur, P]]	+	[[Category: Kaur P]]
-	[[Category: Kumar, S]]	+	[[Category: Kumar S]]
-	[[Category: Sharma, S]]	+	[[Category: Sharma S]]
-	[[Category: Singh, N]]	+	[[Category: Singh N]]
-	[[Category: Singh~~, T P~~]]	+	[[Category: Singh TP]]
-	[[Category: Sinha, M]]	+	[[Category: Sinha M]]
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 06:40, 14 October 2020

OCA — Wed, 14 Oct 2020 06:40:05 GMT

←Older revision		Revision as of 06:40, 14 October 2020
Line 1:		Line 1:

	==Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution==		==Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution==
-	<StructureSection load='3m7s' size='340' side='right' caption='[[3m7s]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3m7s' size='340' side='right'caption='[[3m7s]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3M7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3M7S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=~~CBI~~:~~CELLOBIOSE~~'>~~CBI~~</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hu7\|3hu7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hu7\|3hu7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3m7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7s OCA], [http://pdbe.org/3m7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m7s RCSB], [http://www.ebi.ac.uk/pdbsum/3m7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m7s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3m7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7s OCA], [http://pdbe.org/3m7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m7s RCSB], [http://www.ebi.ac.uk/pdbsum/3m7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m7s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Scadoxus multiflorus]]		[[Category: Scadoxus multiflorus]]
	[[Category: Bhushan, A]]		[[Category: Bhushan, A]]

OCA at 07:13, 9 January 2019

OCA — Wed, 09 Jan 2019 07:13:12 GMT

←Older revision		Revision as of 07:13, 9 January 2019
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m7/3m7s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m7/3m7s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:59, 4 August 2016

OCA — Thu, 04 Aug 2016 15:59:04 GMT

←Older revision		Revision as of 15:59, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution==		==Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution==
	<StructureSection load='3m7s' size='340' side='right' caption='[[3m7s]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3m7s' size='340' side='right' caption='[[3m7s]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CBI:CELLOBIOSE'>CBI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CBI:CELLOBIOSE'>CBI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hu7\|3hu7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hu7\|3hu7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m7s RCSB], [http://www.ebi.ac.uk/pdbsum/3m7s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7s OCA], [http://pdbe.org/3m7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m7s RCSB], [http://www.ebi.ac.uk/pdbsum/3m7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m7s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m7s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3m7s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:50, 3 January 2015

OCA — Sat, 03 Jan 2015 22:50:51 GMT

←Older revision		Revision as of 22:50, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3m7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M7S FirstGlance]. <br>		<table><tr><td colspan='2'>[[3m7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M7S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CBI:CELLOBIOSE'>CBI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CBI:CELLOBIOSE'>CBI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hu7\|3hu7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hu7\|3hu7]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m7s RCSB], [http://www.ebi.ac.uk/pdbsum/3m7s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m7s RCSB], [http://www.ebi.ac.uk/pdbsum/3m7s PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 23:
	Crystal structure determination and inhibition studies of a novel xylanase and alpha-amylase inhibitor protein (XAIP) from Scadoxus multiflorus.,Kumar S, Singh N, Sinha M, Dube D, Singh SB, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP FEBS J. 2010 Jul;277(13):2868-82. Epub 2010 May 27. PMID:20528916<ref>PMID:20528916</ref>		Crystal structure determination and inhibition studies of a novel xylanase and alpha-amylase inhibitor protein (XAIP) from Scadoxus multiflorus.,Kumar S, Singh N, Sinha M, Dube D, Singh SB, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP FEBS J. 2010 Jul;277(13):2868-82. Epub 2010 May 27. PMID:20528916<ref>PMID:20528916</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Scadoxus multiflorus]]		[[Category: Scadoxus multiflorus]]
-	[[Category: Bhushan, A.]]	+	[[Category: Bhushan, A]]
-	[[Category: Dube, D.]]	+	[[Category: Dube, D]]
-	[[Category: Kaur, P.]]	+	[[Category: Kaur, P]]
-	[[Category: Kumar, S.]]	+	[[Category: Kumar, S]]
-	[[Category: Sharma, S.]]	+	[[Category: Sharma, S]]
-	[[Category: Singh, N.]]	+	[[Category: Singh, N]]
-	[[Category: Singh, T P.]]	+	[[Category: Singh, T P]]
-	[[Category: Sinha, M.]]	+	[[Category: Sinha, M]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]

OCA at 10:37, 28 May 2014

OCA — Wed, 28 May 2014 10:37:23 GMT

←Older revision		Revision as of 10:37, 28 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3m7s.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution==
		+	<StructureSection load='3m7s' size='340' side='right' caption='[[3m7s]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3m7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M7S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CBI:CELLOBIOSE'>CBI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hu7\|3hu7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m7s RCSB], [http://www.ebi.ac.uk/pdbsum/3m7s PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m7/3m7s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel plant protein isolated from the underground bulbs of Scadoxus multiflorus, xylanase and alpha-amylase inhibitor protein (XAIP), inhibits two structurally and functionally unrelated enzymes: xylanase and alpha-amylase. The mature protein contains 272 amino acid residues which show sequence identities of 48% to the plant chitinase hevamine and 36% to xylanase inhibitor protein-I, a double-headed inhibitor of GH10 and GH11 xylanases. However, unlike hevamine, it is enzymatically inactive and, unlike xylanase inhibitor protein-I, it inhibits two functionally different classes of enzyme. The crystal structure of XAIP has been determined at 2.0 A resolution and refined to R(cryst) and R(free) factors of 15.2% and 18.6%, respectively. The polypeptide chain of XAIP adopts a modified triosephosphate isomerase barrel fold with eight beta-strands in the inner circle and nine alpha-helices forming the outer ring. The structure contains three cis peptide bonds: Gly33-Phe34, Tyr159-Pro160 and Trp253-Asp254. Although hevamine has a long accessible carbohydrate-binding channel, in XAIP this channel is almost completely filled with the side-chains of residues Phe13, Pro77, Lys78 and Trp253. Solution studies indicate that XAIP inhibits GH11 family xylanases and GH13 family alpha-amylases through two independent binding sites located on opposite surfaces of the protein. Comparison of the structure of XAIP with that of xylanase inhibitor protein-I, and docking studies, suggest that loops alpha3-beta4 and alpha4-beta5 may be involved in the binding of GH11 xylanase, and that helix alpha7 and loop beta6-alpha6 are suitable for the interaction with alpha-amylase.

-	<!--	+	Crystal structure determination and inhibition studies of a novel xylanase and alpha-amylase inhibitor protein (XAIP) from Scadoxus multiflorus.,Kumar S, Singh N, Sinha M, Dube D, Singh SB, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP FEBS J. 2010 Jul;277(13):2868-82. Epub 2010 May 27. PMID:20528916<ref>PMID:20528916</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3m7s"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3m7s\| PDB=3m7s \| SCENE= }}~~	+

-	~~===Crystal structure~~ of the ~~complex~~ of ~~xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2~~.~~4 A resolution===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	<~~!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20528916}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http:~~/~~/www.pubmed.gov), where 20528916 is the PubMed ID number.~~	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_20528916}}~~	+
-		+
-	==~~About this Structure~~==	+
-	~~[[3m7s]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA].~~	+
-		+
-	~~==Reference==~~	+
-	<~~ref group="xtra">PMID:020528916</ref><references group="xtra"~~/>	+
	[[Category: Scadoxus multiflorus]]		[[Category: Scadoxus multiflorus]]
	[[Category: Bhushan, A.]]		[[Category: Bhushan, A.]]

OCA: Protected "3m7s" [edit=sysop:move=sysop]

OCA — Wed, 07 Sep 2011 05:26:13 GMT

Protected "3m7s" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 7 September 2011

OCA at 05:26, 7 September 2011

OCA — Wed, 07 Sep 2011 05:26:11 GMT

←Older revision		Revision as of 05:26, 7 September 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3m7s.png\|left\|200px]]
-	[[Image:3m7s.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution===		===Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20528916}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20528916 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20528916}}

	==About this Structure==		==About this Structure==
-	~~3M7S~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA].	+	[[3m7s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:020528916</ref><references group="xtra"/>
	[[Category: Scadoxus multiflorus]]		[[Category: Scadoxus multiflorus]]
	[[Category: Bhushan, A.]]		[[Category: Bhushan, A.]]
Line 26:		Line 34:
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Tim barrel]]		[[Category: Tim barrel]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 12:11:20 2010''

OCA at 09:11, 5 May 2010

OCA — Wed, 05 May 2010 09:11:23 GMT

←Older revision		Revision as of 09:11, 5 May 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3m7s.jpg\|left\|200px]]

-	The ~~entry 3m7s~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3m7s", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3m7s\| PDB=3m7s \| SCENE= }}

-	~~Authors: Kumar, S~~.~~, Dube, D., Singh, N., Sinha, M., Bhushan,~~ A~~., Kaur, P., Sharma, S., Singh, T.P.~~	+	===Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution===

-	Description: Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr~~ ~~7 10~~:21:36 2010''	+	==About this Structure==
		+	3M7S is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Scadoxus_multiflorus Scadoxus multiflorus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7S OCA].
		+	[[Category: Scadoxus multiflorus]]
		+	[[Category: Bhushan, A.]]
		+	[[Category: Dube, D.]]
		+	[[Category: Kaur, P.]]
		+	[[Category: Kumar, S.]]
		+	[[Category: Sharma, S.]]
		+	[[Category: Singh, N.]]
		+	[[Category: Singh, T P.]]
		+	[[Category: Sinha, M.]]
		+	[[Category: Protein binding]]
		+	[[Category: Tim barrel]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 12:11:20 2010''

OCA at 07:21, 7 April 2010

OCA — Wed, 07 Apr 2010 07:21:36 GMT

←Older revision		Revision as of 07:21, 7 April 2010
Line 3:		Line 3:
	The entry 3m7s is ON HOLD		The entry 3m7s is ON HOLD

-	Authors: Kumar, S., Dube, D., Singh, N., Sinha, M, Bhushan, A., Kaur, P., Sharma, S., Singh, T.P.	+	Authors: Kumar, S., Dube, D., Singh, N., Sinha, M., Bhushan, A., Kaur, P., Sharma, S., Singh, T.P.

	Description: Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution		Description: Crystal structure of the complex of xylanase GH-11 and alpha amylase inhibitor protein with cellobiose at 2.4 A resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 24 08~~:39:27 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:21:36 2010''