3m91 - Revision history

OCA at 08:47, 7 February 2024

OCA — Wed, 07 Feb 2024 08:47:38 GMT

←Older revision		Revision as of 08:47, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='3m91' size='340' side='right'caption='[[3m91]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3m91' size='340' side='right'caption='[[3m91]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M91 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M91 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>mpa ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~83332 MYCTU])~~, ~~pup (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=83332 MYCTU])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m91 OCA], [https://pdbe.org/3m91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m91 RCSB], [https://www.ebi.ac.uk/pdbsum/3m91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m91 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m91 OCA], [https://pdbe.org/3m91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m91 RCSB], [https://www.ebi.ac.uk/pdbsum/3m91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m91 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~PUP_MYCTU PUP_MYCTU~~]~~] Protein modifier that~~ is ~~covalently attached to lysine residues~~ of ~~substrate~~ proteins, thereby ~~targeting them for~~ proteasomal ~~degradation~~. ~~The tagging system is termed pupylation. Among~~ the ~~identified substrates are the FabD~~, ~~PanB~~ and ~~Mpa proteins~~.<ref>PMID:~~18832610~~</ref> <ref>PMID:~~19448618~~</ref> <ref>PMID:~~20233925~~</ref>	+	[https://www.uniprot.org/uniprot/ARC_MYCTU ARC_MYCTU] ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Is required but not sufficient to confer resistance against the lethal effects of reactive nitrogen intermediates (RNI), antimicrobial molecules produced by activated macrophages and other cell types.[HAMAP-Rule:MF_02112]<ref>PMID:14671303</ref> <ref>PMID:15659170</ref> <ref>PMID:17082771</ref> <ref>PMID:19836337</ref> <ref>PMID:20203624</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Mycobacterium tuberculosis uses a proteasome system that is analogous to the eukaryotic ubiquitin-proteasome pathway and is required for pathogenesis. However, the bacterial analog of ubiquitin, prokaryotic ubiquitin-like protein (Pup), is an intrinsically disordered protein that bears little sequence or structural resemblance to the highly structured ubiquitin. Thus, it was unknown how pupylated proteins were recruited to the proteasome. Here, we show that the Mycobacterium proteasomal ATPase (Mpa) has three pairs of tentacle-like coiled coils that recognize Pup. Mpa bound unstructured Pup through hydrophobic interactions and a network of hydrogen bonds, leading to the formation of an alpha-helix in Pup. Our work describes a binding-induced folding recognition mechanism in the Pup-proteasome system that differs mechanistically from substrate recognition in the ubiquitin-proteasome system. This key difference between the prokaryotic and eukaryotic systems could be exploited for the development of a small molecule-based treatment for tuberculosis.	+
-		+
-	Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation.,Wang T, Darwin KH, Li H Nat Struct Mol Biol. 2010 Oct 17. PMID:20953180<ref>PMID:~~20953180~~</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.~~<br>	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3m91" style="background-color~~:~~#fffaf0;">~~</~~div~~>	+

	==See Also==		==See Also==
Line 26:		Line 17:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Li, H]]	+	[[Category: Li H]]
-	[[Category: Wang, T]]	+	[[Category: Wang T]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Coil coil alpha helix]]~~	+
-	~~[[Category: Hydrolase regulator]]~~	+
-	~~[[Category: Isopeptide bond]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Proteasome]]~~	+
-	~~[[Category: S-nitrosylation]]~~	+
-	~~[[Category: Ubl conjugation pathway]]~~	+
-	~~[[Category: Virulence~~]]	+

OCA at 13:44, 4 May 2022

OCA — Wed, 04 May 2022 13:44:57 GMT

←Older revision		Revision as of 13:44, 4 May 2022
Line 3:		Line 3:
	<StructureSection load='3m91' size='340' side='right'caption='[[3m91]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3m91' size='340' side='right'caption='[[3m91]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m91]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3M91 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M91 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpa ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), pup ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpa ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), pup ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3m91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m91 OCA], [~~http~~://pdbe.org/3m91 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3m91 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3m91 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3m91 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m91 OCA], [https://pdbe.org/3m91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m91 RCSB], [https://www.ebi.ac.uk/pdbsum/3m91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m91 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PUP_MYCTU PUP_MYCTU]] Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Among the identified substrates are the FabD, PanB and Mpa proteins.<ref>PMID:18832610</ref> <ref>PMID:19448618</ref> <ref>PMID:20233925</ref>	+	[[https://www.uniprot.org/uniprot/PUP_MYCTU PUP_MYCTU]] Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Among the identified substrates are the FabD, PanB and Mpa proteins.<ref>PMID:18832610</ref> <ref>PMID:19448618</ref> <ref>PMID:20233925</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 11:20, 17 July 2019

OCA — Wed, 17 Jul 2019 11:20:12 GMT

←Older revision		Revision as of 11:20, 17 July 2019
Line 1:		Line 1:

	==Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa==		==Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa==
-	<StructureSection load='3m91' size='340' side='right' caption='[[3m91]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3m91' size='340' side='right'caption='[[3m91]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3m91]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M91 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3m91]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M91 FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[ATPase\|ATPase]]	+	*[[ATPase 3D structures\|ATPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Li, H]]		[[Category: Li, H]]

OCA at 17:43, 4 August 2016

OCA — Thu, 04 Aug 2016 17:43:28 GMT

←Older revision		Revision as of 17:43, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa==		==Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa==
	<StructureSection load='3m91' size='340' side='right' caption='[[3m91]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3m91' size='340' side='right' caption='[[3m91]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m91]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M91 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m91]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M91 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1773 Mycobacterium tuberculosis~~]), pup ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1773 Mycobacterium tuberculosis~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), pup ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m91 RCSB], [http://www.ebi.ac.uk/pdbsum/3m91 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m91 OCA], [http://pdbe.org/3m91 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m91 RCSB], [http://www.ebi.ac.uk/pdbsum/3m91 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m91 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PUP_MYCTU PUP_MYCTU]] Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Among the identified substrates are the FabD, PanB and Mpa proteins.<ref>PMID:18832610</ref> <ref>PMID:19448618</ref> <ref>PMID:20233925</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3m91" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 21:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Wang, T]]		[[Category: Wang, T]]

OCA at 09:48, 9 December 2014

OCA — Tue, 09 Dec 2014 09:48:23 GMT

←Older revision		Revision as of 09:48, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3m91.~~png~~\|~~left\|200px~~]]	+	==Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa==
		+	<StructureSection load='3m91' size='340' side='right' caption='[[3m91]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3m91]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M91 FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis]), pup ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m91 RCSB], [http://www.ebi.ac.uk/pdbsum/3m91 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacterium tuberculosis uses a proteasome system that is analogous to the eukaryotic ubiquitin-proteasome pathway and is required for pathogenesis. However, the bacterial analog of ubiquitin, prokaryotic ubiquitin-like protein (Pup), is an intrinsically disordered protein that bears little sequence or structural resemblance to the highly structured ubiquitin. Thus, it was unknown how pupylated proteins were recruited to the proteasome. Here, we show that the Mycobacterium proteasomal ATPase (Mpa) has three pairs of tentacle-like coiled coils that recognize Pup. Mpa bound unstructured Pup through hydrophobic interactions and a network of hydrogen bonds, leading to the formation of an alpha-helix in Pup. Our work describes a binding-induced folding recognition mechanism in the Pup-proteasome system that differs mechanistically from substrate recognition in the ubiquitin-proteasome system. This key difference between the prokaryotic and eukaryotic systems could be exploited for the development of a small molecule-based treatment for tuberculosis.

-	~~{{STRUCTURE_3m91\| PDB=3m91 \| SCENE= }}~~	+	Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation.,Wang T, Darwin KH, Li H Nat Struct Mol Biol. 2010 Oct 17. PMID:20953180<ref>PMID:20953180</ref>

-	~~===Crystal structure~~ of the ~~prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20953180}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3m91]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA].~~	+

	==See Also==		==See Also==
	*[[ATPase\|ATPase]]		*[[ATPase\|ATPase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020953180<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
-	[[Category: Wang, T.]]	+	[[Category: Wang, T]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA at 07:39, 20 October 2012

OCA — Sat, 20 Oct 2012 07:39:04 GMT

←Older revision		Revision as of 07:39, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3m91]] is a 4 chain structure ~~of [[ATPase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA].	+	[[3m91]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA].

	==See Also==		==See Also==

OCA at 17:00, 25 July 2012

OCA — Wed, 25 Jul 2012 17:00:37 GMT

←Older revision		Revision as of 17:00, 25 July 2012
Line 1:		Line 1:
	[[Image:3m91.png\|left\|200px]]		[[Image:3m91.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3m91", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3m91\| PDB=3m91 \| SCENE= }}		{{STRUCTURE_3m91\| PDB=3m91 \| SCENE= }}

	===Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa===		===Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20953180}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20953180 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20953180}}		{{ABSTRACT_PUBMED_20953180}}

	==About this Structure==		==About this Structure==
-	[[3m91]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA].	+	[[3m91]] is a 4 chain structure of [[ATPase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA].
		+
		+	==See Also==
		+	*[[ATPase\|ATPase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20953180~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020953180</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Li, H.]]		[[Category: Li, H.]]
	[[Category: Wang, T.]]		[[Category: Wang, T.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Chaperone]]
		+	[[Category: Coil coil alpha helix]]
		+	[[Category: Hydrolase regulator]]
		+	[[Category: Isopeptide bond]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Proteasome]]
		+	[[Category: S-nitrosylation]]
		+	[[Category: Ubl conjugation pathway]]
		+	[[Category: Virulence]]

OCA: Protected "3m91" [edit=sysop:move=sysop]

OCA — Wed, 09 Feb 2011 05:28:24 GMT

Protected "3m91" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:28, 9 February 2011

OCA at 05:28, 9 February 2011

OCA — Wed, 09 Feb 2011 05:28:22 GMT

←Older revision		Revision as of 05:28, 9 February 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3m91.png\|left\|200px]]
-	[[Image:3m91.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3M91~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA].	+	[[3m91]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA].

	==Reference==		==Reference==
Line 27:		Line 26:
	[[Category: Li, H.]]		[[Category: Li, H.]]
	[[Category: Wang, T.]]		[[Category: Wang, T.]]
-	[[Category: Atp-binding]]
-	[[Category: Chaperone]]
-	[[Category: Coil coil alpha helix]]
-	[[Category: Hydrolase regulator]]
-	[[Category: Isopeptide bond]]
-	[[Category: Nucleotide-binding]]
-	[[Category: Proteasome]]
-	[[Category: S-nitrosylation]]
-	[[Category: Ubl conjugation pathway]]
-	[[Category: Virulence]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:11:01 2010''

OCA at 09:00, 27 October 2010

OCA — Wed, 27 Oct 2010 09:00:40 GMT

←Older revision		Revision as of 09:00, 27 October 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3m91.jpg\|left\|200px]]

-	The ~~entry 3m91~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3m91", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3m91\| PDB=3m91 \| SCENE= }}

-	~~Authors: Wang, T., Li, H.~~	+	===Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa===

-	Description: crystal structure of prokaryotic ubiquitin-like protein (Pup) and Coil Coil domain of Mycobacterium Tuberculosis ATPase Mpa

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 5 11~~:38:09 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20953180}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20953180 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20953180}}
		+
		+	==About this Structure==
		+	3M91 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20953180</ref><references group="xtra"/>
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Li, H.]]
		+	[[Category: Wang, T.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Chaperone]]
		+	[[Category: Coil coil alpha helix]]
		+	[[Category: Hydrolase regulator]]
		+	[[Category: Isopeptide bond]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Proteasome]]
		+	[[Category: S-nitrosylation]]
		+	[[Category: Ubl conjugation pathway]]
		+	[[Category: Virulence]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:11:01 2010''