3m93 - Revision history

OCA at 12:14, 6 March 2024

OCA — Wed, 06 Mar 2024 12:14:19 GMT

←Older revision		Revision as of 12:14, 6 March 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q6PKX2_ASCSU Q6PKX2_ASCSU]		[https://www.uniprot.org/uniprot/Q6PKX2_ASCSU Q6PKX2_ASCSU]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Metazoan spliced leader (SL) trans-splicing generates mRNAs with an m(2,2,7)G-cap and a common downstream SL RNA sequence. The mechanism for eIF4E binding an m(2,2,7)G-cap is unknown. Here, we describe the first structure of an eIF4E with an m(2,2,7)G-cap and compare it to the cognate m(7)G-eIF4E complex. These structures and Nuclear Magnetic Resonance (NMR) data indicate that the nematode Ascaris suum eIF4E binds the two different caps in a similar manner except for the loss of a single hydrogen bond on binding the m(2,2,7)G-cap. Nematode and mammalian eIF4E both have a low affinity for m(2,2,7)G-cap compared with the m(7)G-cap. Nematode eIF4E binding to the m(7)G-cap, m(2,2,7)G-cap and the m(2,2,7)G-SL 22-nt RNA leads to distinct eIF4E conformational changes. Additional interactions occur between Ascaris eIF4E and the SL on binding the m(2,2,7)G-SL. We propose interactions between Ascaris eIF4E and the SL impact eIF4G and contribute to translation initiation, whereas these interactions do not occur when only the m(2,2,7)G-cap is present. These data have implications for the contribution of 5'-UTRs in mRNA translation and the function of different eIF4E isoforms.
-
-	Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation.,Liu W, Jankowska-Anyszka M, Piecyk K, Dickson L, Wallace A, Niedzwiecka A, Stepinski J, Stolarski R, Darzynkiewicz E, Kieft J, Zhao R, Jones DN, Davis RE Nucleic Acids Res. 2011 Sep 29. PMID:21965542<ref>PMID:21965542</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3m93" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Eukaryotic initiation factor 3D structures\|Eukaryotic initiation factor 3D structures]]		*[[Eukaryotic initiation factor 3D structures\|Eukaryotic initiation factor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:49, 6 September 2023

OCA — Wed, 06 Sep 2023 08:49:53 GMT

←Older revision		Revision as of 08:49, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3m93' size='340' side='right'caption='[[3m93]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3m93' size='340' side='right'caption='[[3m93]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m93]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ascsu Ascsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m93]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M93 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=M7G:7N~~-~~METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3m94\|3m94]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ascaris suum ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6253 ASCSU])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m93 OCA], [https://pdbe.org/3m93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m93 RCSB], [https://www.ebi.ac.uk/pdbsum/3m93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m93 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m93 OCA], [https://pdbe.org/3m93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m93 RCSB], [https://www.ebi.ac.uk/pdbsum/3m93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m93 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~4EBP1_HUMAN 4EBP1_HUMAN~~]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref>	+	[https://www.uniprot.org/uniprot/Q6PKX2_ASCSU Q6PKX2_ASCSU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ascsu~~]]	+	[[Category: Ascaris suum]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Liu W]]
-	[[Category: Liu, W]]	+
-	~~[[Category: Bsgc]]~~	+
-	~~[[Category: Eif4e]]~~	+
-	~~[[Category: Translation~~]]	+

OCA at 13:44, 4 May 2022

OCA — Wed, 04 May 2022 13:44:58 GMT

←Older revision		Revision as of 13:44, 4 May 2022
Line 1:		Line 1:

	==Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap==		==Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap==
-	<StructureSection load='3m93' size='340' side='right' caption='[[3m93]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='3m93' size='340' side='right'caption='[[3m93]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m93]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ascsu Ascsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3M93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m93]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ascsu Ascsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M93 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m94\|3m94]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3m94\|3m94]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ascaris suum ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6253 ASCSU])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ascaris suum ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6253 ASCSU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m93 OCA], [~~http~~://pdbe.org/3m93 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3m93 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3m93 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3m93 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m93 OCA], [https://pdbe.org/3m93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m93 RCSB], [https://www.ebi.ac.uk/pdbsum/3m93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m93 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref>	+	[[https://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Eukaryotic initiation factor\|Eukaryotic initiation factor]]	+	*[[Eukaryotic initiation factor 3D structures\|Eukaryotic initiation factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Ascsu]]		[[Category: Ascsu]]
		+	[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Liu, W]]		[[Category: Liu, W]]

OCA at 11:57, 5 August 2016

OCA — Fri, 05 Aug 2016 11:57:09 GMT

←Older revision		Revision as of 11:57, 5 August 2016
Line 1:		Line 1:
		+
	==Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap==		==Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap==
	<StructureSection load='3m93' size='340' side='right' caption='[[3m93]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3m93' size='340' side='right' caption='[[3m93]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3m93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Ascaris_suum Ascaris suum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M93 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3m93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascsu Ascsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M93 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m94\|3m94]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m94\|3m94]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ascaris suum ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6253 ~~Ascaris suum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ascaris suum ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6253 ASCSU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m93 RCSB], [http://www.ebi.ac.uk/pdbsum/3m93 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m93 OCA], [http://pdbe.org/3m93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m93 RCSB], [http://www.ebi.ac.uk/pdbsum/3m93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m93 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3m93" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ascaris suum~~]]	+	[[Category: Ascsu]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Liu, W]]		[[Category: Liu, W]]

OCA at 02:15, 25 December 2014

OCA — Thu, 25 Dec 2014 02:15:22 GMT

←Older revision		Revision as of 02:15, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m93 RCSB], [http://www.ebi.ac.uk/pdbsum/3m93 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m93 RCSB], [http://www.ebi.ac.uk/pdbsum/3m93 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:46, 9 December 2014

OCA — Tue, 09 Dec 2014 08:46:32 GMT

←Older revision		Revision as of 08:46, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3m93.~~png~~\|~~left~~\|~~200px~~]]	+	==Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap==
		+	<StructureSection load='3m93' size='340' side='right' caption='[[3m93]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3m93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M93 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3m94\|3m94]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ascaris suum ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6253 Ascaris suum])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m93 RCSB], [http://www.ebi.ac.uk/pdbsum/3m93 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Metazoan spliced leader (SL) trans-splicing generates mRNAs with an m(2,2,7)G-cap and a common downstream SL RNA sequence. The mechanism for eIF4E binding an m(2,2,7)G-cap is unknown. Here, we describe the first structure of an eIF4E with an m(2,2,7)G-cap and compare it to the cognate m(7)G-eIF4E complex. These structures and Nuclear Magnetic Resonance (NMR) data indicate that the nematode Ascaris suum eIF4E binds the two different caps in a similar manner except for the loss of a single hydrogen bond on binding the m(2,2,7)G-cap. Nematode and mammalian eIF4E both have a low affinity for m(2,2,7)G-cap compared with the m(7)G-cap. Nematode eIF4E binding to the m(7)G-cap, m(2,2,7)G-cap and the m(2,2,7)G-SL 22-nt RNA leads to distinct eIF4E conformational changes. Additional interactions occur between Ascaris eIF4E and the SL on binding the m(2,2,7)G-SL. We propose interactions between Ascaris eIF4E and the SL impact eIF4G and contribute to translation initiation, whereas these interactions do not occur when only the m(2,2,7)G-cap is present. These data have implications for the contribution of 5'-UTRs in mRNA translation and the function of different eIF4E isoforms.

-	~~{{STRUCTURE_3m93\| PDB=3m93 \| SCENE= }}~~	+	Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation.,Liu W, Jankowska-Anyszka M, Piecyk K, Dickson L, Wallace A, Niedzwiecka A, Stepinski J, Stolarski R, Darzynkiewicz E, Kieft J, Zhao R, Jones DN, Davis RE Nucleic Acids Res. 2011 Sep 29. PMID:21965542<ref>PMID:21965542</ref>

-	~~===Complex crystal structure~~ of ~~Ascaris suum eIF4E-3 with m7G cap===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21965542}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3m93]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ascaris_suum Ascaris suum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA].~~	+

	==See Also==		==See Also==
	*[[Eukaryotic initiation factor\|Eukaryotic initiation factor]]		*[[Eukaryotic initiation factor\|Eukaryotic initiation factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021965542<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Ascaris suum]]		[[Category: Ascaris suum]]
-	[[Category: ~~BSGC, Berkeley~~ Structural ~~Genomics Center.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Liu, W~~.]]~~	+	[[Category: Liu, W]]
-	~~[[Category: Berkeley structural genomics center~~]]	+
	[[Category: Bsgc]]		[[Category: Bsgc]]
	[[Category: Eif4e]]		[[Category: Eif4e]]
	[[Category: Translation]]		[[Category: Translation]]

OCA at 11:31, 20 October 2012

OCA — Sat, 20 Oct 2012 11:31:15 GMT

←Older revision		Revision as of 11:31, 20 October 2012
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	[[Image:3m93.png\|left\|200px]]		[[Image:3m93.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3m93\| PDB=3m93 \| SCENE= }}		{{STRUCTURE_3m93\| PDB=3m93 \| SCENE= }}

	===Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap===		===Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21965542}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21965542 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21965542}}		{{ABSTRACT_PUBMED_21965542}}

	==About this Structure==		==About this Structure==
	[[3m93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA].		[[3m93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA].
		+
		+	==See Also==
		+	*[[Eukaryotic initiation factor\|Eukaryotic initiation factor]]

	==Reference==		==Reference==

OCA at 07:33, 30 October 2011

OCA — Sun, 30 Oct 2011 07:33:50 GMT

←Older revision		Revision as of 07:33, 30 October 2011
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	===Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap===		===Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21965542}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21965542 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21965542}}

	==About this Structure==		==About this Structure==
	[[3m93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA].		[[3m93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021965542</ref><references group="xtra"/>
	[[Category: Ascaris suum]]		[[Category: Ascaris suum]]
	[[Category: BSGC, Berkeley Structural Genomics Center.]]		[[Category: BSGC, Berkeley Structural Genomics Center.]]

OCA at 06:12, 27 July 2011

OCA — Wed, 27 Jul 2011 06:12:24 GMT

←Older revision		Revision as of 06:12, 27 July 2011
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-	[[Image:3m93.~~jpg~~\|left\|200px]]	+	[[Image:3m93.png\|left\|200px]]

	<!--		<!--

OCA at 06:51, 20 July 2011

OCA — Wed, 20 Jul 2011 06:51:47 GMT

←Older revision		Revision as of 06:51, 20 July 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3m93.jpg\|left\|200px]]

-	The ~~entry 3m93~~ is ~~ON HOLD~~ ~~until Jul 19 2012~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3m93", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3m93\| PDB=3m93 \| SCENE= }}

-	~~Authors: Liu, W., Berkeley Structural Genomics Center (BSGC)~~	+	===Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap===

-	~~Description: Complex crystal~~ structure of Ascaris suum ~~eIF4E~~-~~3 with m7G cap~~	+
		+	==About this Structure==
		+	[[3m93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ascaris_suum Ascaris suum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M93 OCA].
		+	[[Category: Ascaris suum]]
		+	[[Category: BSGC, Berkeley Structural Genomics Center.]]
		+	[[Category: Liu, W.]]
		+	[[Category: Berkeley structural genomics center]]
		+	[[Category: Bsgc]]
		+	[[Category: Eif4e]]
		+	[[Category: Translation]]