3mfp - Revision history

OCA at 08:48, 7 February 2024

OCA — Wed, 07 Feb 2024 08:48:01 GMT

←Older revision		Revision as of 08:48, 7 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MFP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MFP FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 6.6Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [https://pdbe.org/3mfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [https://www.ebi.ac.uk/pdbsum/3mfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mfp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [https://pdbe.org/3mfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [https://www.ebi.ac.uk/pdbsum/3mfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mfp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	+	[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	F-actin is a helical assembly of actin, which is a component of muscle fibres essential for contraction and has a crucial role in numerous cellular processes, such as the formation of lamellipodia and filopodia, as the most abundant component and regulator of cytoskeletons by dynamic assembly and disassembly (from G-actin to F-actin and vice versa). Actin is a ubiquitous protein and is involved in important biological functions, but the definitive high-resolution structure of F-actin remains unknown. Although a recent atomic model well reproduced X-ray fibre diffraction intensity data from a highly oriented liquid-crystalline sol specimen, its refinement without experimental phase information has certain limitations. Direct visualization of the structure by electron cryomicroscopy, however, has been difficult because it is relatively thin and flexible. Here we report the F-actin structure at 6.6 A resolution, made obtainable by recent advances in electron cryomicroscopy. The density map clearly resolves all the secondary structures of G-actin, such as alpha-helices, beta-structures and loops, and makes unambiguous modelling and refinement possible. Complex domain motions that open the nucleotide-binding pocket on F-actin formation, specific D-loop and terminal conformations, and relatively tight axial but markedly loose interprotofilament interactions hydrophilic in nature are revealed in the F-actin model, and all seem to be important for dynamic functions of actin.	+
-		+
-	~~Direct visualization of secondary structures of F-actin by electron cryomicroscopy.,Fujii T, Iwane AH, Yanagida T, Namba K Nature. 2010 Sep 15. PMID:20844487<ref>PMID:20844487</ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3mfp" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Actin 3D structures\|Actin 3D structures]]		*[[Actin 3D structures\|Actin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Fujii, T]]	+	[[Category: Fujii T]]
-	[[Category: Iwane~~, A H~~]]	+	[[Category: Iwane AH]]
-	[[Category: Namba, K]]	+	[[Category: Namba K]]
-	[[Category: Yanagida, T]]	+	[[Category: Yanagida T]]
-	~~[[Category: Contractile protein]]~~	+
-	~~[[Category: Helical filament]]~~	+
-	~~[[Category: Muscle protein~~]]	+

OCA at 13:46, 4 May 2022

OCA — Wed, 04 May 2022 13:46:26 GMT

←Older revision		Revision as of 13:46, 4 May 2022
Line 3:		Line 3:
	<SX load='3mfp' size='340' side='right' viewer='molstar' caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>		<SX load='3mfp' size='340' side='right' viewer='molstar' caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3MFP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MFP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [~~http~~://pdbe.org/3mfp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mfp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mfp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [https://pdbe.org/3mfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [https://www.ebi.ac.uk/pdbsum/3mfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mfp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	+	[[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:40, 10 April 2020

OCA — Fri, 10 Apr 2020 18:40:36 GMT

←Older revision		Revision as of 18:40, 10 April 2020
Line 3:		Line 3:
	<SX load='3mfp' size='340' side='right' viewer='molstar' caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>		<SX load='3mfp' size='340' side='right' viewer='molstar' caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MFP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3MFP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [http://pdbe.org/3mfp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [http://www.ebi.ac.uk/pdbsum/3mfp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mfp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [http://pdbe.org/3mfp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [http://www.ebi.ac.uk/pdbsum/3mfp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mfp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:44, 6 March 2020

OCA — Fri, 06 Mar 2020 17:44:02 GMT

←Older revision		Revision as of 17:44, 6 March 2020
Line 1:		Line 1:

	==Atomic model of F-actin based on a 6.6 angstrom resolution cryoEM map==		==Atomic model of F-actin based on a 6.6 angstrom resolution cryoEM map==
-	<~~StructureSection~~ load='3mfp' size='340' side='right'caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>	+	<SX load='3mfp' size='340' side='right' viewer='molstar' caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MFP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MFP FirstGlance]. <br>
Line 25:		Line 25:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]

OCA at 08:15, 18 December 2019

OCA — Wed, 18 Dec 2019 08:15:01 GMT

←Older revision		Revision as of 08:15, 18 December 2019
Line 1:		Line 1:

	==Atomic model of F-actin based on a 6.6 angstrom resolution cryoEM map==		==Atomic model of F-actin based on a 6.6 angstrom resolution cryoEM map==
-	<StructureSection load='3mfp' size='340' side='right' caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>	+	<StructureSection load='3mfp' size='340' side='right'caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MFP FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MFP FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Actin\|Actin]]	+	*[[Actin 3D structures\|Actin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Fujii, T]]		[[Category: Fujii, T]]

OCA at 07:23, 5 August 2016

OCA — Fri, 05 Aug 2016 07:23:53 GMT

←Older revision		Revision as of 07:23, 5 August 2016
Line 1:		Line 1:
		+
	==Atomic model of F-actin based on a 6.6 angstrom resolution cryoEM map==		==Atomic model of F-actin based on a 6.6 angstrom resolution cryoEM map==
	<StructureSection load='3mfp' size='340' side='right' caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>		<StructureSection load='3mfp' size='340' side='right' caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [http://www.ebi.ac.uk/pdbsum/3mfp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [http://pdbe.org/3mfp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [http://www.ebi.ac.uk/pdbsum/3mfp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mfp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mfp" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:51, 25 December 2014

OCA — Thu, 25 Dec 2014 16:51:00 GMT

←Older revision		Revision as of 16:51, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [http://www.ebi.ac.uk/pdbsum/3mfp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [http://www.ebi.ac.uk/pdbsum/3mfp PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:28, 21 December 2014

OCA — Sun, 21 Dec 2014 18:28:24 GMT

←Older revision		Revision as of 18:28, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mfp\| PDB=3mfp \| SCENE= }}~~	+	==Atomic model of F-actin based on a 6.6 angstrom resolution cryoEM map==
-	===Atomic model of F-actin based on a 6.6 angstrom resolution cryoEM map===	+	<StructureSection load='3mfp' size='340' side='right' caption='[[3mfp]], [[Resolution\|resolution]] 6.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20844487}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MFP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mfp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mfp RCSB], [http://www.ebi.ac.uk/pdbsum/3mfp PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	F-actin is a helical assembly of actin, which is a component of muscle fibres essential for contraction and has a crucial role in numerous cellular processes, such as the formation of lamellipodia and filopodia, as the most abundant component and regulator of cytoskeletons by dynamic assembly and disassembly (from G-actin to F-actin and vice versa). Actin is a ubiquitous protein and is involved in important biological functions, but the definitive high-resolution structure of F-actin remains unknown. Although a recent atomic model well reproduced X-ray fibre diffraction intensity data from a highly oriented liquid-crystalline sol specimen, its refinement without experimental phase information has certain limitations. Direct visualization of the structure by electron cryomicroscopy, however, has been difficult because it is relatively thin and flexible. Here we report the F-actin structure at 6.6 A resolution, made obtainable by recent advances in electron cryomicroscopy. The density map clearly resolves all the secondary structures of G-actin, such as alpha-helices, beta-structures and loops, and makes unambiguous modelling and refinement possible. Complex domain motions that open the nucleotide-binding pocket on F-actin formation, specific D-loop and terminal conformations, and relatively tight axial but markedly loose interprotofilament interactions hydrophilic in nature are revealed in the F-actin model, and all seem to be important for dynamic functions of actin.

-	~~==Function==~~	+	Direct visualization of secondary structures of F-actin by electron cryomicroscopy.,Fujii T, Iwane AH, Yanagida T, Namba K Nature. 2010 Sep 15. PMID:20844487<ref>PMID:20844487</ref>
-	~~[[http://www~~.~~uniprot~~.~~org~~/~~uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3mfp]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Actin\|Actin]]		*[[Actin\|Actin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020844487</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Fujii, T.]]	+	[[Category: Fujii, T]]
-	[[Category: Iwane, A H.]]	+	[[Category: Iwane, A H]]
-	[[Category: Namba, K.]]	+	[[Category: Namba, K]]
-	[[Category: Yanagida, T.]]	+	[[Category: Yanagida, T]]
	[[Category: Contractile protein]]		[[Category: Contractile protein]]
	[[Category: Helical filament]]		[[Category: Helical filament]]
	[[Category: Muscle protein]]		[[Category: Muscle protein]]

OCA at 14:20, 19 February 2014

OCA — Wed, 19 Feb 2014 14:20:31 GMT

←Older revision		Revision as of 14:20, 19 February 2014
Line 1:		Line 1:
-	[[Image:3mfp.png\|left\|200px]]
-
	{{STRUCTURE_3mfp\| PDB=3mfp \| SCENE= }}		{{STRUCTURE_3mfp\| PDB=3mfp \| SCENE= }}
-
	===Atomic model of F-actin based on a 6.6 angstrom resolution cryoEM map===		===Atomic model of F-actin based on a 6.6 angstrom resolution cryoEM map===
		+	{{ABSTRACT_PUBMED_20844487}}

-	~~{{ABSTRACT_PUBMED_20844487}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

	==About this Structure==		==About this Structure==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020844487</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020844487</ref><references group="xtra"/><references/>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Fujii, T.]]		[[Category: Fujii, T.]]

OCA at 19:07, 20 October 2012

OCA — Sat, 20 Oct 2012 19:07:17 GMT

←Older revision		Revision as of 19:07, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3mfp]] is a 1 chain structure ~~of [[Actin]]~~ with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA].	+	[[3mfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MFP OCA].

	==See Also==		==See Also==