3mgm - Revision history

OCA at 16:32, 1 November 2023

OCA — Wed, 01 Nov 2023 16:32:33 GMT

←Older revision		Revision as of 16:32, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3mgm' size='340' side='right'caption='[[3mgm]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3mgm' size='340' side='right'caption='[[3mgm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mgm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MGM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mgm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MGM FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1u20\|1u20]], [[3cou\|3cou]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.801Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">hNUDT16, NUDT16 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mgm OCA], [https://pdbe.org/3mgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mgm RCSB], [https://www.ebi.ac.uk/pdbsum/3mgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mgm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mgm OCA], [https://pdbe.org/3mgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mgm RCSB], [https://www.ebi.ac.uk/pdbsum/3mgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mgm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NUD16_HUMAN NUD16_HUMAN]] RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.	+	[https://www.uniprot.org/uniprot/NUD16_HUMAN NUD16_HUMAN] RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

	==See Also==		==See Also==
Line 15:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao, F]]	+	[[Category: Gao F]]
-	[[Category: Li, Z]]	+	[[Category: Li Z]]
-	[[Category: Lu, G]]	+	[[Category: Lu G]]
-	[[Category: Qi, J]]	+	[[Category: Qi J]]
-	[[Category: Yan, J]]	+	[[Category: Yan J]]
-	[[Category: Zhang, J]]	+	[[Category: Zhang J]]
-	~~[[Category: Dimmer]]~~	+
-	~~[[Category: Hnudt16]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nudix fold]]~~	+
-	~~[[Category: Two domain~~]]	+

OCA at 13:46, 4 May 2022

OCA — Wed, 04 May 2022 13:46:39 GMT

←Older revision		Revision as of 13:46, 4 May 2022
Line 1:		Line 1:

	==Crystal structure of human NUDT16==		==Crystal structure of human NUDT16==
-	<StructureSection load='3mgm' size='340' side='right' caption='[[3mgm]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3mgm' size='340' side='right'caption='[[3mgm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mgm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MGM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MGM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mgm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MGM FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u20\|1u20]], [[3cou\|3cou]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u20\|1u20]], [[3cou\|3cou]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hNUDT16, NUDT16 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hNUDT16, NUDT16 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mgm OCA], [~~http~~://pdbe.org/3mgm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mgm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mgm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mgm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mgm OCA], [https://pdbe.org/3mgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mgm RCSB], [https://www.ebi.ac.uk/pdbsum/3mgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mgm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NUD16_HUMAN NUD16_HUMAN]] RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.	+	[[https://www.uniprot.org/uniprot/NUD16_HUMAN NUD16_HUMAN]] RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
		+
		+	==See Also==
		+	*[[Nudix hydrolase 3D structures\|Nudix hydrolase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gao, F]]		[[Category: Gao, F]]
	[[Category: Li, Z]]		[[Category: Li, Z]]

OCA at 16:36, 4 August 2016

OCA — Thu, 04 Aug 2016 16:36:37 GMT

←Older revision		Revision as of 16:36, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human NUDT16==		==Crystal structure of human NUDT16==
	<StructureSection load='3mgm' size='340' side='right' caption='[[3mgm]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3mgm' size='340' side='right' caption='[[3mgm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mgm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MGM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mgm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MGM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u20\|1u20]], [[3cou\|3cou]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u20\|1u20]], [[3cou\|3cou]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hNUDT16, NUDT16 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hNUDT16, NUDT16 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mgm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mgm RCSB], [http://www.ebi.ac.uk/pdbsum/3mgm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mgm OCA], [http://pdbe.org/3mgm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mgm RCSB], [http://www.ebi.ac.uk/pdbsum/3mgm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mgm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gao, F]]		[[Category: Gao, F]]
	[[Category: Li, Z]]		[[Category: Li, Z]]

OCA at 17:06, 24 December 2014

OCA — Wed, 24 Dec 2014 17:06:01 GMT

←Older revision		Revision as of 17:06, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mgm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mgm RCSB], [http://www.ebi.ac.uk/pdbsum/3mgm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mgm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mgm RCSB], [http://www.ebi.ac.uk/pdbsum/3mgm PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NUD16_HUMAN NUD16_HUMAN]] RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:54, 18 December 2014

OCA — Thu, 18 Dec 2014 17:54:29 GMT

←Older revision		Revision as of 17:54, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mgm\| PDB=3mgm \| SCENE= }}~~	+	==Crystal structure of human NUDT16==
-	===Crystal structure of human NUDT16===	+	<StructureSection load='3mgm' size='340' side='right' caption='[[3mgm]], [[Resolution\|resolution]] 1.80Å' scene=''>
-		+	== Structural highlights ==
-	==~~Function~~==	+	<table><tr><td colspan='2'>[[3mgm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MGM FirstGlance]. <br>
-	[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~NUD16_HUMAN NUD16_HUMAN~~]~~] RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner~~. ~~Part of the U8 snoRNP complex that~~ is ~~required for the accumulation of mature 5~~.~~8S and 28S rRNA~~. ~~Has diphosphatase activity and removes m7G and~~/~~or m227G caps from U8 snoRNA and leaves~~ a ~~5'monophosphate~~ on the ~~RNA. Catalyzes also the cleavage of the cap~~ structure ~~on mRNAs~~. ~~Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG)~~. ~~Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies~~. ~~Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA~~-~~binding~~. ~~May play a role in the regulation of snoRNAs and mRNAs degradation~~. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > ~~dIDP~~ >> ~~GDP~~ = ~~dGDP~~ > ~~XDP~~ = ~~ITP~~ = ~~dITP. Binds strongly to GTP~~, ~~ITP and XTP. Participates in the hydrolysis of dIDP~~/~~IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u20\|1u20]], [[3cou\|3cou]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hNUDT16, NUDT16 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==~~About this Structure==~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mgm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mgm RCSB], [http://www.ebi.ac.uk/pdbsum/3mgm PDBsum]</span></td></tr>
-	[[~~3mgm~~]] ~~is a 2 chain structure with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki~~/~~Homo_sapiens~~ Homo sapiens]. ~~Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~3MGM~~ OCA].	+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gao, F.]]	+	[[Category: Gao, F]]
-	[[Category: Li, Z.]]	+	[[Category: Li, Z]]
-	[[Category: Lu, G.]]	+	[[Category: Lu, G]]
-	[[Category: Qi, J.]]	+	[[Category: Qi, J]]
-	[[Category: Yan, J.]]	+	[[Category: Yan, J]]
-	[[Category: Zhang, J.]]	+	[[Category: Zhang, J]]
	[[Category: Dimmer]]		[[Category: Dimmer]]
	[[Category: Hnudt16]]		[[Category: Hnudt16]]

OCA at 21:04, 17 April 2013

OCA — Wed, 17 Apr 2013 21:04:41 GMT

←Older revision		Revision as of 21:04, 17 April 2013
Line 1:		Line 1:
-	[[Image:3mgm.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mgm", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3mgm\| PDB=3mgm \| SCENE= }}		{{STRUCTURE_3mgm\| PDB=3mgm \| SCENE= }}
-
	===Crystal structure of human NUDT16===		===Crystal structure of human NUDT16===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/NUD16_HUMAN NUD16_HUMAN]] RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

	==About this Structure==		==About this Structure==
Line 21:		Line 14:
	[[Category: Yan, J.]]		[[Category: Yan, J.]]
	[[Category: Zhang, J.]]		[[Category: Zhang, J.]]
		+	[[Category: Dimmer]]
		+	[[Category: Hnudt16]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nudix fold]]
		+	[[Category: Two domain]]

OCA: Protected "3mgm" [edit=sysop:move=sysop]

OCA — Thu, 21 Apr 2011 10:49:43 GMT

Protected "3mgm" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:49, 21 April 2011

OCA at 10:49, 21 April 2011

OCA — Thu, 21 Apr 2011 10:49:39 GMT

←Older revision		Revision as of 10:49, 21 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3mgm.jpg\|left\|200px]]

-	The ~~entry 3mgm~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mgm", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mgm\| PDB=3mgm \| SCENE= }}

-	~~Authors: Yan, J., Lu, G., Zhang, J., Qi, J., Li, Z., Gao, F.~~	+	===Crystal structure of human NUDT16===

-	Description: Crystal structure of human NUDT16

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Jun 2 08~~:27:~~44 2010''~~	+	==About this Structure==
		+	[[3mgm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MGM OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Gao, F.]]
		+	[[Category: Li, Z.]]
		+	[[Category: Lu, G.]]
		+	[[Category: Qi, J.]]
		+	[[Category: Yan, J.]]
		+	[[Category: Zhang, J.]]

OCA at 04:23, 2 June 2010

OCA — Wed, 02 Jun 2010 04:23:16 GMT

←Older revision		Revision as of 04:23, 2 June 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3mgm is ON HOLD	+	The entry 3mgm is ON HOLD until Paper Publication

	Authors: Yan, J., Lu, G., Zhang, J., Qi, J., Li, Z., Gao, F.		Authors: Yan, J., Lu, G., Zhang, J., Qi, J., Li, Z., Gao, F.
Line 7:		Line 7:
	Description: Crystal structure of human NUDT16		Description: Crystal structure of human NUDT16

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 21 09~~:37:46 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:27:44 2010''

OCA at 06:37, 21 April 2010

OCA — Wed, 21 Apr 2010 06:37:47 GMT

←Older revision		Revision as of 06:37, 21 April 2010
Line 3:		Line 3:
	The entry 3mgm is ON HOLD		The entry 3mgm is ON HOLD

-	Authors: Yan, ~~Jinghua~~, Lu, ~~Guangwen~~, Zhang, ~~Jie~~, Qi, ~~Jianxun~~, Li, ~~Zhixin~~, Gao, ~~Feng~~	+	Authors: Yan, J., Lu, G., Zhang, J., Qi, J., Li, Z., Gao, F.

	Description: Crystal structure of human NUDT16		Description: Crystal structure of human NUDT16

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:23:21 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 09:37:46 2010''