3mhv - Revision history

OCA at 16:34, 1 November 2023

OCA — Wed, 01 Nov 2023 16:34:34 GMT

←Older revision		Revision as of 16:34, 1 November 2023
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	==Crystal Structure of Vps4 and Vta1==		==Crystal Structure of Vps4 and Vta1==
-	<StructureSection load='3mhv' size='340' side='right' caption='[[3mhv]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='3mhv' size='340' side='right'caption='[[3mhv]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mhv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MHV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mhv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MHV FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>VPS4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~4932 ATCC 18824])~~, ~~VTA1 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mhv OCA], [~~http~~://pdbe.org/3mhv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mhv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mhv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mhv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mhv OCA], [https://pdbe.org/3mhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mhv RCSB], [https://www.ebi.ac.uk/pdbsum/3mhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mhv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/VPS4_YEAST VPS4_YEAST]] Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex.<ref>PMID:11329380</ref> <ref>PMID:9155008</ref> <ref>PMID:9606181</ref> [[http://www.uniprot.org/uniprot/VTA1_YEAST VTA1_YEAST]] Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold.<ref>PMID:12953057</ref> <ref>PMID:14701806</ref> <ref>PMID:16505166</ref> <ref>PMID:16601096</ref>	+	[https://www.uniprot.org/uniprot/VPS4_YEAST VPS4_YEAST] Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex.<ref>PMID:11329380</ref> <ref>PMID:9155008</ref> <ref>PMID:9606181</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Vacuolar protein sorting-associated protein\|Vacuolar protein sorting-associated protein]]	+	*[[Vacuolar protein sorting-associated protein 3D structures\|Vacuolar protein sorting-associated protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 18824~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Hurley, J H~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Yang, D~~]]	+	[[Category: Hurley JH]]
-	[[Category: ~~Aaa]]~~	+	[[Category: Yang D]]
-	~~[[Category: Atpase]]~~	+
-	~~[[Category: Escrt]]~~	+
-	~~[[Category: Mvb]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Sorting]]~~	+
-	~~[[Category: Vps4]]~~	+
-	~~[[Category: Vta1~~]]	+

OCA at 07:44, 9 January 2019

OCA — Wed, 09 Jan 2019 07:44:43 GMT

←Older revision		Revision as of 07:44, 9 January 2019
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/3mhv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/3mhv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 3mhv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3mhv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Vacuolar protein sorting-associated protein\|Vacuolar protein sorting-associated protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:55, 4 August 2016

OCA — Thu, 04 Aug 2016 11:55:01 GMT

←Older revision		Revision as of 11:55, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Vps4 and Vta1==		==Crystal Structure of Vps4 and Vta1==
	<StructureSection load='3mhv' size='340' side='right' caption='[[3mhv]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='3mhv' size='340' side='right' caption='[[3mhv]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mhv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MHV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mhv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MHV FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VPS4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~]), VTA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VPS4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), VTA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mhv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mhv RCSB], [http://www.ebi.ac.uk/pdbsum/3mhv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mhv OCA], [http://pdbe.org/3mhv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mhv RCSB], [http://www.ebi.ac.uk/pdbsum/3mhv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mhv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mhv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mhv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Hurley, J H]]		[[Category: Hurley, J H]]
	[[Category: Yang, D]]		[[Category: Yang, D]]

OCA at 09:03, 25 December 2014

OCA — Thu, 25 Dec 2014 09:03:22 GMT

←Older revision		Revision as of 09:03, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mhv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mhv RCSB], [http://www.ebi.ac.uk/pdbsum/3mhv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mhv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mhv RCSB], [http://www.ebi.ac.uk/pdbsum/3mhv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VPS4_YEAST VPS4_YEAST]] Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex.<ref>PMID:11329380</ref> <ref>PMID:9155008</ref> <ref>PMID:9606181</ref> [[http://www.uniprot.org/uniprot/VTA1_YEAST VTA1_YEAST]] Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold.<ref>PMID:12953057</ref> <ref>PMID:14701806</ref> <ref>PMID:16505166</ref> <ref>PMID:16601096</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:59, 18 December 2014

OCA — Thu, 18 Dec 2014 17:59:05 GMT

←Older revision		Revision as of 17:59, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mhv~~\| ~~PDB~~=3mhv \| ~~SCENE~~= }}	+	==Crystal Structure of Vps4 and Vta1==
-	===~~Crystal Structure~~ of ~~Vps4~~ and ~~Vta1~~===	+	<StructureSection load='3mhv' size='340' side='right' caption='[[3mhv]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20696398}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mhv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MHV FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VPS4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), VTA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mhv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mhv RCSB], [http://www.ebi.ac.uk/pdbsum/3mhv PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/3mhv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ESCRT complexes are required for multivesicular body biogenesis, macroautophagy, cytokinesis, and the budding of HIV-1. The final step in the ESCRT cycle is the disassembly of the ESCRT-III lattice by the AAA+ ATPase Vps4. Vps4 assembles on its membrane-bound ESCRT-III substrate with its cofactor, Vta1. The crystal structure of the dimeric VSL domain of yeast Vta1 with the small ATPase and the betadomains of Vps4 was determined. Residues involved in structural interactions are conserved and are required for binding in vitro and for Cps1 sorting in vivo. Modeling of the Vta1 complex in complex with the lower hexameric ring of Vps4 indicates that the two-fold axis of the Vta1 VSL domain is parallel to within approximately 20 degrees of the six-fold axis of the hexamer. This suggests that Vta1 might not crosslink the two hexameric rings of Vps4, but rather stabilizes an array of Vps4-Vta1 complexes for ESCRT-III disassembly.

-	~~==Function==~~	+	Structural role of the Vps4-Vta1 interface in ESCRT-III recycling.,Yang D, Hurley JH Structure. 2010 Aug 11;18(8):976-84. PMID:20696398<ref>PMID:20696398</ref>
-	~~[[http://www.uniprot.org/uniprot/VPS4_YEAST VPS4_YEAST]] Involved in the transport~~ of ~~biosynthetic membrane proteins from~~ the ~~prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP~~-~~dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the~~ ESCRT-III ~~complex~~.~~<ref>PMID:11329380</ref> <ref>PMID:9155008</ref> <ref>PMID:9606181</ref> [[http://www~~.~~uniprot.org/uniprot/VTA1_YEAST VTA1_YEAST]] Has a role in the formation of the multivesicular body~~ (~~MVB~~)~~. Required for the sorting of lipids to form intralumenal vesicles and for fluid~~-~~phase transport to the vacuole~~. ~~Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold.<ref>~~PMID:~~12953057</ref> <ref>PMID:14701806</ref> <ref>PMID:16505166</ref>~~ <ref>PMID:~~16601096~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3mhv]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3MHV OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020696398</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Hurley, J H.]]	+	[[Category: Hurley, J H]]
-	[[Category: Yang, D.]]	+	[[Category: Yang, D]]
	[[Category: Aaa]]		[[Category: Aaa]]
	[[Category: Atpase]]		[[Category: Atpase]]

OCA: Protected "3mhv" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 21:10:00 GMT

Protected "3mhv" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:10, 17 April 2013

OCA at 21:09, 17 April 2013

OCA — Wed, 17 Apr 2013 21:09:54 GMT

←Older revision		Revision as of 21:09, 17 April 2013
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-	{{Seed}}
-	[[Image:3mhv.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mhv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3mhv\| PDB=3mhv \| SCENE= }}		{{STRUCTURE_3mhv\| PDB=3mhv \| SCENE= }}
-
	===Crystal Structure of Vps4 and Vta1===		===Crystal Structure of Vps4 and Vta1===
		+	{{ABSTRACT_PUBMED_20696398}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/VPS4_YEAST VPS4_YEAST]] Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex.<ref>PMID:11329380</ref> <ref>PMID:9155008</ref> <ref>PMID:9606181</ref> [[http://www.uniprot.org/uniprot/VTA1_YEAST VTA1_YEAST]] Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold.<ref>PMID:12953057</ref> <ref>PMID:14701806</ref> <ref>PMID:16505166</ref> <ref>PMID:16601096</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20696398}}, adds~~ the ~~Publication Abstract~~ to the ~~page~~	+
-	(as ~~it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 20696398 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20696398}}~~	+

	==About this Structure==		==About this Structure==
-	~~3MHV~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHV OCA].	+	[[3mhv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20696398~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020696398</ref><references group="xtra"/><references/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Hurley, J H.]]		[[Category: Hurley, J H.]]
Line 35:		Line 22:
	[[Category: Vps4]]		[[Category: Vps4]]
	[[Category: Vta1]]		[[Category: Vta1]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 06:05:44 2010''

OCA at 02:56, 6 October 2010

OCA — Wed, 06 Oct 2010 02:56:14 GMT

←Older revision		Revision as of 02:56, 6 October 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mhv.jpg\|left\|200px]]

-	The ~~entry 3mhv~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mhv", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mhv\| PDB=3mhv \| SCENE= }}

-	~~Authors: Yang, D., Hurley, J.~~	+	===Crystal Structure of Vps4 and Vta1===

-	Description: Crystal Structure of Vps4 and Vta1

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May~~ ~~5 11~~:39:13 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20696398}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20696398 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20696398}}
		+
		+	==About this Structure==
		+	3MHV is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20696398</ref><references group="xtra"/>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Hurley, J H.]]
		+	[[Category: Yang, D.]]
		+	[[Category: Aaa]]
		+	[[Category: Atpase]]
		+	[[Category: Escrt]]
		+	[[Category: Mvb]]
		+	[[Category: Protein transport]]
		+	[[Category: Sorting]]
		+	[[Category: Vps4]]
		+	[[Category: Vta1]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 06:05:44 2010''

OCA at 08:39, 5 May 2010

OCA — Wed, 05 May 2010 08:39:13 GMT

←Older revision		Revision as of 08:39, 5 May 2010
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3mhv is ON HOLD	+	The entry 3mhv is ON HOLD until Paper Publication

	Authors: Yang, D., Hurley, J.		Authors: Yang, D., Hurley, J.
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	Description: Crystal Structure of Vps4 and Vta1		Description: Crystal Structure of Vps4 and Vta1

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 14 09~~:23:52 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:39:13 2010''

OCA: New page: '''Unreleased structure''' The entry 3mhv is ON HOLD Authors: Yang, D., Hurley, J. Description: Crystal Structure of Vps4 and Vta1 ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ...

OCA — Wed, 14 Apr 2010 06:23:53 GMT

New page: '''Unreleased structure''' The entry 3mhv is ON HOLD Authors: Yang, D., Hurley, J. Description: Crystal Structure of Vps4 and Vta1 ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ...

New page

'''Unreleased structure'''

The entry 3mhv is ON HOLD

Authors: Yang, D., Hurley, J.

Description: Crystal Structure of Vps4 and Vta1

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:23:52 2010''