3mje - Revision history

OCA at 08:54, 6 September 2023

OCA — Wed, 06 Sep 2023 08:54:38 GMT

←Older revision		Revision as of 08:54, 6 September 2023
Line 1:		Line 1:

	==Structure of A-type Ketoreductases from Modular Polyketide Synthase==		==Structure of A-type Ketoreductases from Modular Polyketide Synthase==
-	<StructureSection load='3mje' size='340' side='right' caption='[[3mje]], [[Resolution\|resolution]] 1.36Å' scene=''>	+	<StructureSection load='3mje' size='340' side='right'caption='[[3mje]], [[Resolution\|resolution]] 1.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mje]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~As_4.1459 As 4.1459~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mje]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_nodosus Streptomyces nodosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MJE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.36Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mjc\|3mjc]]~~, [[~~3mjs~~\|~~3mjs]], [[3mjt\|3mjt]], [[3mjv\|3mjv~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>amphB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~40318 AS 4.1459])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mje OCA], [https://pdbe.org/3mje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mje RCSB], [https://www.ebi.ac.uk/pdbsum/3mje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mje ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/3~~-~~oxoacyl~~-~~[acyl~~-~~carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mje OCA], [~~http~~://pdbe.org/3mje PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mje RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mje PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mje ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q93NW7_9ACTN Q93NW7_9ACTN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~As 4 1459~~]]	+	[[Category: Large Structures]]
-	[[Category: Keatinge-Clay~~, A T~~]]	+	[[Category: Streptomyces nodosus]]
-	[[Category: Piasecki~~, S K~~]]	+	[[Category: Keatinge-Clay AT]]
-	[[Category: Taylor~~, C A~~]]	+	[[Category: Piasecki SK]]
-	[[Category: Zheng, J]]	+	[[Category: Taylor CA]]
-	~~[[Category: Oxidoreductase]]~~	+	[[Category: Zheng J]]
-	~~[[Category: Rossmann fold~~]]	+

OCA at 07:46, 9 January 2019

OCA — Wed, 09 Jan 2019 07:46:00 GMT

←Older revision		Revision as of 07:46, 9 January 2019
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mj/3mje_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mj/3mje_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:39, 5 August 2016

OCA — Fri, 05 Aug 2016 11:39:04 GMT

←Older revision		Revision as of 11:39, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of A-type Ketoreductases from Modular Polyketide Synthase==		==Structure of A-type Ketoreductases from Modular Polyketide Synthase==
	<StructureSection load='3mje' size='340' side='right' caption='[[3mje]], [[Resolution\|resolution]] 1.36Å' scene=''>		<StructureSection load='3mje' size='340' side='right' caption='[[3mje]], [[Resolution\|resolution]] 1.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptomyces_nodosus Streptomyces nodosus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1459 As 4.1459]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mjc\|3mjc]], [[3mjs\|3mjs]], [[3mjt\|3mjt]], [[3mjv\|3mjv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mjc\|3mjc]], [[3mjs\|3mjs]], [[3mjt\|3mjt]], [[3mjv\|3mjv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amphB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=40318 ~~Streptomyces nodosus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amphB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=40318 AS 4.1459])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mje RCSB], [http://www.ebi.ac.uk/pdbsum/3mje PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mje OCA], [http://pdbe.org/3mje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mje RCSB], [http://www.ebi.ac.uk/pdbsum/3mje PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mje ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mje ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mje" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptomyces nodosus~~]]	+	[[Category: As 4 1459]]
	[[Category: Keatinge-Clay, A T]]		[[Category: Keatinge-Clay, A T]]
	[[Category: Piasecki, S K]]		[[Category: Piasecki, S K]]

OCA at 22:17, 3 January 2015

OCA — Sat, 03 Jan 2015 22:17:17 GMT

←Older revision		Revision as of 22:17, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_nodosus Streptomyces nodosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_nodosus Streptomyces nodosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mjc\|3mjc]], [[3mjs\|3mjs]], [[3mjt\|3mjt]], [[3mjv\|3mjv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mjc\|3mjc]], [[3mjs\|3mjs]], [[3mjt\|3mjt]], [[3mjv\|3mjv]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amphB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=40318 Streptomyces nodosus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amphB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=40318 Streptomyces nodosus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mje RCSB], [http://www.ebi.ac.uk/pdbsum/3mje PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mje RCSB], [http://www.ebi.ac.uk/pdbsum/3mje PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase.,Zheng J, Taylor CA, Piasecki SK, Keatinge-Clay AT Structure. 2010 Aug 11;18(8):913-22. PMID:20696392<ref>PMID:20696392</ref>		Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase.,Zheng J, Taylor CA, Piasecki SK, Keatinge-Clay AT Structure. 2010 Aug 11;18(8):913-22. PMID:20696392<ref>PMID:20696392</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Streptomyces nodosus]]		[[Category: Streptomyces nodosus]]
-	[[Category: Keatinge-Clay, A T.]]	+	[[Category: Keatinge-Clay, A T]]
-	[[Category: Piasecki, S K.]]	+	[[Category: Piasecki, S K]]
-	[[Category: Taylor, C A.]]	+	[[Category: Taylor, C A]]
-	[[Category: Zheng, J.]]	+	[[Category: Zheng, J]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA: Protected "3mje" [edit=sysop:move=sysop]

OCA — Wed, 28 May 2014 10:41:26 GMT

Protected "3mje" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:41, 28 May 2014

OCA at 10:41, 28 May 2014

OCA — Wed, 28 May 2014 10:41:21 GMT

←Older revision		Revision as of 10:41, 28 May 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==Structure of A-type Ketoreductases from Modular Polyketide Synthase==
-	[[~~Image:~~3mje.~~jpg~~\|~~left~~\|200px]]	+	<StructureSection load='3mje' size='340' side='right' caption='[[3mje]], [[Resolution\|resolution]] 1.36Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_nodosus Streptomyces nodosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3mjc\|3mjc]], [[3mjs\|3mjs]], [[3mjt\|3mjt]], [[3mjv\|3mjv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amphB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=40318 Streptomyces nodosus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mje RCSB], [http://www.ebi.ac.uk/pdbsum/3mje PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mj/3mje_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Complex polyketides are characterized by multiple chiral centers harboring hydroxyl and alkyl substituents. To investigate the mechanisms by which these stereocenters are set, several high-resolution structures of the ketoreductase (KR) domain from the second module of the amphotericin modular polyketide synthase (PKS) were solved. This first structural analysis of an A-type KR helps reveal how these KRs direct polyketide intermediates into their active sites from the side opposite that used by B-type KRs, resulting in a beta-hydroxyl group of opposite stereochemistry. A comparison of structures obtained in the absence and presence of ligands reveals an induced fit mechanism that is important for catalysis. Activity assays of mutants of KRs from the first and second modules of the amphotericin PKS reveal the relative contributions of several active site residues toward catalysis and stereocontrol. Together, these results highlight the possibility of region-specific modification of polyketides through active site engineering of KRs.

-	<!--	+	Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase.,Zheng J, Taylor CA, Piasecki SK, Keatinge-Clay AT Structure. 2010 Aug 11;18(8):913-22. PMID:20696392<ref>PMID:20696392</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3mje"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3mje\| PDB=3mje \| SCENE= }}~~	+

-	~~===Structure~~ of ~~A-type Ketoreductases from Modular Polyketide Synthase===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20696392}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 20696392 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_20696392}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~3MJE is a 2 chains structure with sequences from [http:~~/~~/en.wikipedia.org/wiki/Streptomyces_nodosus Streptomyces nodosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJE OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:20696392<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Streptomyces nodosus]]		[[Category: Streptomyces nodosus]]
	[[Category: Keatinge-Clay, A T.]]		[[Category: Keatinge-Clay, A T.]]
Line 31:		Line 38:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:45:30 2010''

OCA at 07:37, 18 August 2010

OCA — Wed, 18 Aug 2010 07:37:59 GMT

←Older revision		Revision as of 07:37, 18 August 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mje.jpg\|left\|200px]]

-	The ~~entry 3mje~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mje", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mje\| PDB=3mje \| SCENE= }}

-	~~Authors: Zheng, J., Taylor, C.~~A~~., Piasecki, S.K., Keatinge~~-~~Clay, A.T.~~	+	===Structure of A-type Ketoreductases from Modular Polyketide Synthase===

-	Description: Structure of A-type Ketoreductases from Modular Polyketide Synthase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug ~~4 08~~:45:37 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20696392}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20696392 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20696392}}
		+
		+	==About this Structure==
		+	3MJE is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Streptomyces_nodosus Streptomyces nodosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20696392</ref><references group="xtra"/>
		+	[[Category: Streptomyces nodosus]]
		+	[[Category: Keatinge-Clay, A T.]]
		+	[[Category: Piasecki, S K.]]
		+	[[Category: Taylor, C A.]]
		+	[[Category: Zheng, J.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:45:30 2010''

OCA at 04:38, 4 August 2010

OCA — Wed, 04 Aug 2010 04:38:38 GMT

←Older revision		Revision as of 04:38, 4 August 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3mje is ON HOLD	+	The entry 3mje is ON HOLD until Paper Publication

	Authors: Zheng, J., Taylor, C.A., Piasecki, S.K., Keatinge-Clay, A.T.		Authors: Zheng, J., Taylor, C.A., Piasecki, S.K., Keatinge-Clay, A.T.
Line 7:		Line 7:
	Description: Structure of A-type Ketoreductases from Modular Polyketide Synthase		Description: Structure of A-type Ketoreductases from Modular Polyketide Synthase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May~~ ~~5 11~~:39:37 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 08:45:37 2010''

OCA at 08:39, 5 May 2010

OCA — Wed, 05 May 2010 08:39:37 GMT

←Older revision		Revision as of 08:39, 5 May 2010
Line 3:		Line 3:
	The entry 3mje is ON HOLD		The entry 3mje is ON HOLD

-	Authors: Zheng, ~~Jianting~~ , Taylor, ~~Clint~~ A., Piasecki, ~~Shawn~~ K., Keatinge-Clay, ~~Adrian~~ T.	+	Authors: Zheng, J., Taylor, C.A., Piasecki, S.K., Keatinge-Clay, A.T.

	Description: Structure of A-type Ketoreductases from Modular Polyketide Synthase		Description: Structure of A-type Ketoreductases from Modular Polyketide Synthase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 21 09~~:39:02 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:39:37 2010''

OCA: New page: '''Unreleased structure''' The entry 3mje is ON HOLD Authors: Zheng, Jianting , Taylor, Clint A., Piasecki, Shawn K., Keatinge-Clay, Adrian T. Description: Structure of A-type Ketoredu...

OCA — Wed, 21 Apr 2010 06:39:03 GMT

New page: '''Unreleased structure''' The entry 3mje is ON HOLD Authors: Zheng, Jianting , Taylor, Clint A., Piasecki, Shawn K., Keatinge-Clay, Adrian T. Description: Structure of A-type Ketoredu...

New page

'''Unreleased structure'''

The entry 3mje is ON HOLD

Authors: Zheng, Jianting , Taylor, Clint A., Piasecki, Shawn K., Keatinge-Clay, Adrian T.

Description: Structure of A-type Ketoreductases from Modular Polyketide Synthase

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 09:39:02 2010''