3mkv - Revision history

OCA at 13:08, 16 January 2019

OCA — Wed, 16 Jan 2019 13:08:50 GMT

←Older revision		Revision as of 13:08, 16 January 2019
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/3mkv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/3mkv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:01, 11 August 2016

OCA — Thu, 11 Aug 2016 10:01:49 GMT

←Older revision		Revision as of 10:01, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of amidohydrolase eaj56179==		==Crystal structure of amidohydrolase eaj56179==
	<StructureSection load='3mkv' size='340' side='right' caption='[[3mkv]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3mkv' size='340' side='right' caption='[[3mkv]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EAJ56179 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32644 miscellaneous nucleic acid])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EAJ56179 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32644 miscellaneous nucleic acid])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mkv RCSB], [http://www.ebi.ac.uk/pdbsum/3mkv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mkv OCA], [http://pdbe.org/3mkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mkv RCSB], [http://www.ebi.ac.uk/pdbsum/3mkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mkv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mkv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mkv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:19, 6 November 2014

OCA — Thu, 06 Nov 2014 13:19:47 GMT

←Older revision		Revision as of 13:19, 6 November 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mkv~~\| ~~PDB~~=3mkv \| ~~SCENE~~= }}	+	==Crystal structure of amidohydrolase eaj56179==
-	===~~Crystal~~ structure of ~~amidohydrolase eaj56179~~===	+	<StructureSection load='3mkv' size='340' side='right' caption='[[3mkv]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20604542}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mkv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Miscellaneous_nucleic_acid Miscellaneous nucleic acid]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2r8c 2r8c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MKV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EAJ56179 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32644 miscellaneous nucleic acid])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mkv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mkv RCSB], [http://www.ebi.ac.uk/pdbsum/3mkv PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/3mkv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Two uncharacterized enzymes from the amidohydrolase superfamily belonging to cog1228 were cloned, expressed and purified to homogeneity. The two proteins, Sgx9260c (gi\|44242006) and Sgx9260b (gi\|44479596), were derived from environmental DNA samples originating from the Sargasso Sea. The catalytic function and substrate profiles for Sgx9260c and Sgx9260b were determined using a comprehensive library of dipeptides and N-acyl derivative of L-amino acids. Sgx9260c catalyzes the hydrolysis of Gly-L-Pro, L-Ala-L-Pro and N-acyl derivatives of L-Pro. The best substrate identified to date is N-acetyl-L-Pro with a value of kcat/Km of 3 x 105 M-1 s-1. Sgx9260b catalyzes the hydrolysis of L-hydrophobic L-Pro dipeptides and N-acyl derivatives of L-Pro. The best substrate identified to date is N-propionyl-L-Pro with a value of kcat/Km of 1 x 105 M-1 s-1. Three dimensional structures of both proteins were determined by X-ray diffraction methods (PDB codes: 3MKV and 3FEQ). These proteins fold as distorted (beta/alpha)8-barrels with two divalent cations in the active site. The structure of Sgx9260c was also determined as a complex with the N-methyl phosphonate derivative of L-Pro (PDB code: 3N2C). In this structure the phosphonate moiety bridges the binuclear metal center and one oxygen atom interacts with His-140. The alpha-carboxylate of the inhibitor interacts with Tyr-231. The proline side chain occupies a small substrate binding cavity formed by residues contributed from the loop that follows beta-strand 7 within the (beta/alpha)8-barrel. A total of 38 other proteins from cog1228 are predicted to have the same substrate profile based on conservation of the substrate binding residues. The structure of an evolutionarily related protein, Cc2672 from Caulobacter crecentus, was determined as a complex with the N-methyl phosphonate derivative of L-arginine (PDB code: 3MTW).

-	~~==About this~~ Structure==	+	Functional Identification and Structure Determination of Two Novel Prolidases from cog1228 in the Amidohydrolase Superfamily.,Xiang DF, Patskovsky Y, Xu C, Fedorov A, Fedorov EV, Sisco AA, Sauder JM, Burley SK, Almo S, Raushel FM Biochemistry. 2010 Jul 6. PMID:20604542<ref>PMID:20604542</ref>
-	~~[[3mkv]] is a 8 chain structure with sequence~~ from ~~[http://en.wikipedia.org/wiki/Miscellaneous_nucleic_acid Miscellaneous nucleic acid]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.~~il/oca-bin/send-pdb?obs=1&id=2r8c 2r8c]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3MKV OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020604542</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Miscellaneous nucleic acid]]		[[Category: Miscellaneous nucleic acid]]
-	[[Category: Almo, S C.]]	+	[[Category: Almo, S C]]
-	[[Category: Bain, K.]]	+	[[Category: Bain, K]]
-	[[Category: Bonanno, J.]]	+	[[Category: Bonanno, J]]
-	[[Category: Burley, S K.]]	+	[[Category: Burley, S K]]
-	[[Category: Freeman, J.]]	+	[[Category: Freeman, J]]
-	[[Category: ~~NYSGXRC, New York SGX Research Center for~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Ozyurt, S.]]	+	[[Category: Ozyurt, S]]
-	[[Category: Patskovsky, Y.]]	+	[[Category: Patskovsky, Y]]
-	[[Category: Raushel, F M.]]	+	[[Category: Raushel, F M]]
-	[[Category: Rodgers, L.]]	+	[[Category: Rodgers, L]]
-	[[Category: Sauder, J M.]]	+	[[Category: Sauder, J M]]
-	[[Category: Smith, D.]]	+	[[Category: Smith, D]]
-	[[Category: Wasserman, S R.]]	+	[[Category: Wasserman, S R]]
-	[[Category: Wu, B.]]	+	[[Category: Wu, B]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: New ~~york sgx research center~~ for ~~structural genomic]]~~	+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
-	~~[[Category: New york structural genomix research consortium]]~~	+
-	~~[[Category: Nysgxrc~~]]	+
	[[Category: Prolidase]]		[[Category: Prolidase]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi~~]]	+
	[[Category: Sargasso sea]]		[[Category: Sargasso sea]]
-	[[Category: Structural genomic]]

OCA at 06:51, 2 April 2014

OCA — Wed, 02 Apr 2014 06:51:26 GMT

←Older revision		Revision as of 06:51, 2 April 2014
Line 1:		Line 1:
-	[[Image:3mkv.png\|left\|200px]]
-
	{{STRUCTURE_3mkv\| PDB=3mkv \| SCENE= }}		{{STRUCTURE_3mkv\| PDB=3mkv \| SCENE= }}
-
	===Crystal structure of amidohydrolase eaj56179===		===Crystal structure of amidohydrolase eaj56179===
-
	{{ABSTRACT_PUBMED_20604542}}		{{ABSTRACT_PUBMED_20604542}}

	==About this Structure==		==About this Structure==
-	[[3mkv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Unidentified Unidentified~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2r8c 2r8c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKV OCA].	+	[[3mkv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Miscellaneous_nucleic_acid Miscellaneous nucleic acid]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2r8c 2r8c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020604542</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020604542</ref><references group="xtra"/><references/>
-	[[Category: ~~Unidentified~~]]	+	[[Category: Miscellaneous nucleic acid]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]
	[[Category: Bain, K.]]		[[Category: Bain, K.]]

OCA at 15:22, 28 November 2012

OCA — Wed, 28 Nov 2012 15:22:33 GMT

←Older revision		Revision as of 15:22, 28 November 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3mkv]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2r8c 2r8c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKV OCA].	+	[[3mkv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Unidentified Unidentified]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2r8c 2r8c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKV OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:020604542</ref><references group="xtra"/>		<ref group="xtra">PMID:020604542</ref><references group="xtra"/>
		+	[[Category: Unidentified]]
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]
	[[Category: Bain, K.]]		[[Category: Bain, K.]]

OCA: Protected "3mkv" [edit=sysop:move=sysop]

OCA — Wed, 10 Oct 2012 06:15:15 GMT

Protected "3mkv" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 10 October 2012

OCA at 06:15, 10 October 2012

OCA — Wed, 10 Oct 2012 06:15:13 GMT

←Older revision		Revision as of 06:15, 10 October 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3mkv.png\|left\|200px]]
-	[[Image:3mkv.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mkv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3mkv\| PDB=3mkv \| SCENE= }}		{{STRUCTURE_3mkv\| PDB=3mkv \| SCENE= }}

	===Crystal structure of amidohydrolase eaj56179===		===Crystal structure of amidohydrolase eaj56179===

		+	{{ABSTRACT_PUBMED_20604542}}

	==About this Structure==		==About this Structure==
-	~~3MKV~~ is a 8 ~~chains~~ structure ~~with sequences from [http://en.wikipedia.org/wiki/Undefined Undefined]~~. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2r8c 2r8c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKV OCA].	+	[[3mkv]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2r8c 2r8c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKV OCA].
-	~~[[Category~~: ~~Undefined]]~~	+
		+	==Reference==
		+	<ref group="xtra">PMID:020604542</ref><references group="xtra"/>
	[[Category: Almo, S C.]]		[[Category: Almo, S C.]]
	[[Category: Bain, K.]]		[[Category: Bain, K.]]
Line 39:		Line 35:
	[[Category: Sargasso sea]]		[[Category: Sargasso sea]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:42:22 2010''

OCA at 07:42, 28 April 2010

OCA — Wed, 28 Apr 2010 07:42:26 GMT

←Older revision		Revision as of 07:42, 28 April 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mkv.jpg\|left\|200px]]

-	The ~~entry 3mkv~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mkv", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mkv\| PDB=3mkv \| SCENE= }}

-	~~Authors: Patskovsky, Y., Bonanno, J., Ozyurt, S., Sauder, J.M., Freeman, J., Wu, B., Smith, D., Bain, K., Rodgers, L., Wasserman, S.R., Raushel, F., Burley, S.K., Almo, S.C.~~	+	===Crystal structure of amidohydrolase eaj56179===

-	Description: CRYSTAL STRUCTURE OF AMIDOHYDROLASE EAJ56179

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr ~~21 09~~:39:58 2010''	+	==About this Structure==
		+	3MKV is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Undefined Undefined]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2r8c 2r8c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MKV OCA].
		+	[[Category: Undefined]]
		+	[[Category: Almo, S C.]]
		+	[[Category: Bain, K.]]
		+	[[Category: Bonanno, J.]]
		+	[[Category: Burley, S K.]]
		+	[[Category: Freeman, J.]]
		+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
		+	[[Category: Ozyurt, S.]]
		+	[[Category: Patskovsky, Y.]]
		+	[[Category: Raushel, F M.]]
		+	[[Category: Rodgers, L.]]
		+	[[Category: Sauder, J M.]]
		+	[[Category: Smith, D.]]
		+	[[Category: Wasserman, S R.]]
		+	[[Category: Wu, B.]]
		+	[[Category: Hydrolase]]
		+	[[Category: New york sgx research center for structural genomic]]
		+	[[Category: New york structural genomix research consortium]]
		+	[[Category: Nysgxrc]]
		+	[[Category: Prolidase]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi]]
		+	[[Category: Sargasso sea]]
		+	[[Category: Structural genomic]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:42:22 2010''

OCA: New page: '''Unreleased structure''' The entry 3mkv is ON HOLD Authors: Patskovsky, Y., Bonanno, J., Ozyurt, S., Sauder, J.M., Freeman, J., Wu, B., Smith, D., Bain, K., Rodgers, L., Wasserman, S....

OCA — Wed, 21 Apr 2010 06:39:58 GMT

New page: '''Unreleased structure''' The entry 3mkv is ON HOLD Authors: Patskovsky, Y., Bonanno, J., Ozyurt, S., Sauder, J.M., Freeman, J., Wu, B., Smith, D., Bain, K., Rodgers, L., Wasserman, S....

New page

'''Unreleased structure'''

The entry 3mkv is ON HOLD

Authors: Patskovsky, Y., Bonanno, J., Ozyurt, S., Sauder, J.M., Freeman, J., Wu, B., Smith, D., Bain, K., Rodgers, L., Wasserman, S.R., Raushel, F., Burley, S.K., Almo, S.C.

Description: CRYSTAL STRUCTURE OF AMIDOHYDROLASE EAJ56179

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 21 09:39:58 2010''