3mn3 - Revision history

OCA at 10:25, 21 February 2024

OCA — Wed, 21 Feb 2024 10:25:52 GMT

←Older revision		Revision as of 10:25, 21 February 2024
Line 1:		Line 1:

	==An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1==		==An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1==
-	<StructureSection load='3mn3' size='340' side='right' caption='[[3mn3]], [[Resolution\|resolution]] 2.38Å' scene=''>	+	<StructureSection load='3mn3' size='340' side='right'caption='[[3mn3]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mn3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MN3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mn3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MN3 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[3hyh\|3hyh]], [[2qlv\|2qlv]], [[2nyc\|2nyc]], [[2nye\|2nye]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.38Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">SNF1, CAT1, CCR1, GLC2, PAS14, YDR477W, D8035~~.~~20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mn3 OCA], [https://pdbe.org/3mn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mn3 RCSB], [https://www.ebi.ac.uk/pdbsum/3mn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mn3 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mn3 OCA], [~~http~~://pdbe.org/3mn3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mn3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mn3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mn3 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SNF1_YEAST SNF1_YEAST]] Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8. Phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, and which is required for transcriptional activation through TBP recruitment to the promoters.<ref>PMID:15719021</ref>	+	[https://www.uniprot.org/uniprot/SNF1_YEAST SNF1_YEAST] Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8. Phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, and which is required for transcriptional activation through TBP recruitment to the promoters.<ref>PMID:15719021</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mn3 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mn3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	AMP-activated protein kinase (AMPK) is a master metabolic regulator for controlling cellular energy homeostasis. Its homolog in yeast, SNF1, is activated in response to glucose depletion and other stresses. The catalytic (alpha) subunit of AMPK/SNF1 in yeast (Snf1) contains a protein Ser/Thr kinase domain (KD), an auto-inhibitory domain (AID) and a region that mediates interactions with the two regulatory (beta and gamma) subunits. Here, the crystal structure of residues 41-440 of Snf1, which include the KD and AID, is reported at 2.4 A resolution. The AID is completely disordered in the crystal. A new inhibited conformation of the KD is observed in a DFG-out conformation and with the glycine-rich loop adopting a structure that blocks ATP binding to the active site.
-
-	An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1.,Rudolph MJ, Amodeo GA, Tong L Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt, 9):999-1002. Epub 2010 Aug 21. PMID:20823513<ref>PMID:20823513</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3mn3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 18824~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Non-specific serine/threonine protein kinase~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Amodeo~~, G A~~]]	+	[[Category: Amodeo GA]]
-	[[Category: Rudolph~~, M J~~]]	+	[[Category: Rudolph MJ]]
-	[[Category: Tong, L]]	+	[[Category: Tong L]]
-	~~[[Category: Autoinhibitory region]]~~	+
-	~~[[Category: Kinase domain]]~~	+
-	~~[[Category: Snf1]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 13:09, 16 January 2019

OCA — Wed, 16 Jan 2019 13:09:15 GMT

←Older revision		Revision as of 13:09, 16 January 2019
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mn/3mn3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mn/3mn3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:32, 4 August 2016

OCA — Thu, 04 Aug 2016 21:32:47 GMT

←Older revision		Revision as of 21:32, 4 August 2016
Line 1:		Line 1:
		+
	==An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1==		==An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1==
	<StructureSection load='3mn3' size='340' side='right' caption='[[3mn3]], [[Resolution\|resolution]] 2.38Å' scene=''>		<StructureSection load='3mn3' size='340' side='right' caption='[[3mn3]], [[Resolution\|resolution]] 2.38Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mn3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MN3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mn3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MN3 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hyh\|3hyh]], [[2qlv\|2qlv]], [[2nyc\|2nyc]], [[2nye\|2nye]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hyh\|3hyh]], [[2qlv\|2qlv]], [[2nyc\|2nyc]], [[2nye\|2nye]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF1, CAT1, CCR1, GLC2, PAS14, YDR477W, D8035.20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF1, CAT1, CCR1, GLC2, PAS14, YDR477W, D8035.20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mn3 RCSB], [http://www.ebi.ac.uk/pdbsum/3mn3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mn3 OCA], [http://pdbe.org/3mn3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mn3 RCSB], [http://www.ebi.ac.uk/pdbsum/3mn3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mn3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mn3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mn3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Saccharomyces cerevisiae]]
	[[Category: Amodeo, G A]]		[[Category: Amodeo, G A]]
	[[Category: Rudolph, M J]]		[[Category: Rudolph, M J]]

OCA at 13:19, 25 December 2014

OCA — Thu, 25 Dec 2014 13:19:22 GMT

←Older revision		Revision as of 13:19, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mn3 RCSB], [http://www.ebi.ac.uk/pdbsum/3mn3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mn3 RCSB], [http://www.ebi.ac.uk/pdbsum/3mn3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SNF1_YEAST SNF1_YEAST]] Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8. Phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, and which is required for transcriptional activation through TBP recruitment to the promoters.<ref>PMID:15719021</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:59, 18 December 2014

OCA — Thu, 18 Dec 2014 14:59:12 GMT

←Older revision		Revision as of 14:59, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mn3\| PDB=3mn3 \| SCENE= }}~~	+	==An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1==
-	===An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1===	+	<StructureSection load='3mn3' size='340' side='right' caption='[[3mn3]], [[Resolution\|resolution]] 2.38Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20823513}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mn3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MN3 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hyh\|3hyh]], [[2qlv\|2qlv]], [[2nyc\|2nyc]], [[2nye\|2nye]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SNF1, CAT1, CCR1, GLC2, PAS14, YDR477W, D8035.20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mn3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mn3 RCSB], [http://www.ebi.ac.uk/pdbsum/3mn3 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mn/3mn3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AMP-activated protein kinase (AMPK) is a master metabolic regulator for controlling cellular energy homeostasis. Its homolog in yeast, SNF1, is activated in response to glucose depletion and other stresses. The catalytic (alpha) subunit of AMPK/SNF1 in yeast (Snf1) contains a protein Ser/Thr kinase domain (KD), an auto-inhibitory domain (AID) and a region that mediates interactions with the two regulatory (beta and gamma) subunits. Here, the crystal structure of residues 41-440 of Snf1, which include the KD and AID, is reported at 2.4 A resolution. The AID is completely disordered in the crystal. A new inhibited conformation of the KD is observed in a DFG-out conformation and with the glycine-rich loop adopting a structure that blocks ATP binding to the active site.

-	~~==Function==~~	+	An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1.,Rudolph MJ, Amodeo GA, Tong L Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt, 9):999-1002. Epub 2010 Aug 21. PMID:20823513<ref>PMID:20823513</ref>
-	~~[[http://www.uniprot.org/uniprot/SNF1_YEAST SNF1_YEAST]] Essential~~ for ~~release from glucose repression. It interacts and has functional relationship to~~ the ~~regulatory~~ protein ~~SNF4~~. ~~Could phosphorylate CAT8. Phosphorylates histone H3 to form H3S10ph~~, ~~which promotes H3K14ac formation~~, ~~and which is required for transcriptional activation through TBP recruitment to the promoters~~.<ref>PMID:~~15719021~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3mn3]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020823513</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Amodeo, G A.]]	+	[[Category: Amodeo, G A]]
-	[[Category: Rudolph, M J.]]	+	[[Category: Rudolph, M J]]
-	[[Category: Tong, L.]]	+	[[Category: Tong, L]]
	[[Category: Autoinhibitory region]]		[[Category: Autoinhibitory region]]
	[[Category: Kinase domain]]		[[Category: Kinase domain]]
	[[Category: Snf1]]		[[Category: Snf1]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA: Protected "3mn3" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 21:01:45 GMT

Protected "3mn3" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:01, 17 April 2013

OCA at 21:01, 17 April 2013

OCA — Wed, 17 Apr 2013 21:01:42 GMT

←Older revision		Revision as of 21:01, 17 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3mn3.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mn3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3mn3\| PDB=3mn3 \| SCENE= }}		{{STRUCTURE_3mn3\| PDB=3mn3 \| SCENE= }}
-
	===An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1===		===An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1===
		+	{{ABSTRACT_PUBMED_20823513}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/SNF1_YEAST SNF1_YEAST]] Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8. Phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, and which is required for transcriptional activation through TBP recruitment to the promoters.<ref>PMID:15719021</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20823513}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 20823513~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20823513}}~~	+

	==About this Structure==		==About this Structure==
-	~~3MN3~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA].	+	[[3mn3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20823513~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020823513</ref><references group="xtra"/><references/>
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
Line 33:		Line 20:
	[[Category: Snf1]]		[[Category: Snf1]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:17:18 2010''

OCA at 11:08, 22 September 2010

OCA — Wed, 22 Sep 2010 11:08:19 GMT

←Older revision		Revision as of 11:08, 22 September 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3mn3.~~jpg~~\|left\|200px]]	+	[[Image:3mn3.png\|left\|200px]]

	<!--		<!--
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	===An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1===		===An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20823513}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20823513 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20823513}}

	==About this Structure==		==About this Structure==
	3MN3 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA].		3MN3 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20823513</ref><references group="xtra"/>
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
Line 25:		Line 34:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~15 10~~:50:16 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:17:18 2010''

OCA at 07:41, 15 September 2010

OCA — Wed, 15 Sep 2010 07:41:35 GMT

←Older revision		Revision as of 07:41, 15 September 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mn3.jpg\|left\|200px]]

-	The ~~entry 3mn3~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mn3", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mn3\| PDB=3mn3 \| SCENE= }}

-	~~Authors: Rudolph, M.J., Amodeo, G.A., Tong, L.~~	+	===An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1===

-	Description: A new, inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 12~~ 10:46:18 2010''	+	==About this Structure==
		+	3MN3 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MN3 OCA].
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Amodeo, G A.]]
		+	[[Category: Rudolph, M J.]]
		+	[[Category: Tong, L.]]
		+	[[Category: Autoinhibitory region]]
		+	[[Category: Kinase domain]]
		+	[[Category: Snf1]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:50:16 2010''

OCA at 07:46, 12 May 2010

OCA — Wed, 12 May 2010 07:46:18 GMT

←Older revision		Revision as of 07:46, 12 May 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3mn3 is ON HOLD	+	The entry 3mn3 is ON HOLD until Paper Publication

-	Authors: Rudolph, M.J.	+	Authors: Rudolph, M.J., Amodeo, G.A., Tong, L.

	Description: A new, inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1		Description: A new, inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May ~~5 11~~:40:44 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:46:18 2010''