3mtc - Revision history

OCA at 09:01, 6 September 2023

OCA — Wed, 06 Sep 2023 09:01:05 GMT

←Older revision		Revision as of 09:01, 6 September 2023
Line 1:		Line 1:

	==Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate==		==Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate==
-	<StructureSection load='3mtc' size='340' side='right' caption='[[3mtc]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3mtc' size='340' side='right'caption='[[3mtc]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mtc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MTC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MTC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PIF:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-TETRAHYDROXY-4-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>PIF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n9v\|3n9v]], [[3nr8\|3nr8]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PIF:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-TETRAHYDROXY-4-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>PIF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">INPP5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtc OCA], [https://pdbe.org/3mtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mtc RCSB], [https://www.ebi.ac.uk/pdbsum/3mtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mtc ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase Phosphoinositide 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.36 3.1.3.36] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtc OCA], [~~http~~://pdbe.org/3mtc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mtc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mtc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mtc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN]] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.<ref>PMID:7721860</ref>	+	[https://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.<ref>PMID:7721860</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 32:
	==See Also==		==See Also==
	*[[Phosphoinositide phosphatase\|Phosphoinositide phosphatase]]		*[[Phosphoinositide phosphatase\|Phosphoinositide phosphatase]]
		+	*[[3D structures of inositol polyphosphate 5-phosphatase OCRL\|3D structures of inositol polyphosphate 5-phosphatase OCRL]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Phosphoinositide 5-phosphatase~~]]	+	[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H]]~~	+	[[Category: Arrowsmith CH]]
-	~~[[Category: Berg, S van der~~]]	+	[[Category: Berglund H]]
-	[[Category: Berglund, H]]	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Collins R]]
-	[[Category: Collins, R]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Flodin S]]
-	[[Category: Flodin, S]]	+	[[Category: Flores A]]
-	[[Category: Flores, A]]	+	[[Category: Graslund S]]
-	[[Category: Graslund, S]]	+	[[Category: Hammarstrom M]]
-	[[Category: Hammarstrom, M]]	+	[[Category: Johansson I]]
-	[[Category: Johansson, I]]	+	[[Category: Karlberg T]]
-	[[Category: Karlberg, T]]	+	[[Category: Kol S]]
-	[[Category: Kol, S]]	+	[[Category: Kotenyova T]]
-	[[Category: Kotenyova, T]]	+	[[Category: Moche M]]
-	[[Category: Moche, M]]	+	[[Category: Nordlund P]]
-	[[Category: Nordlund, P]]	+	[[Category: Nyman T]]
-	[[Category: Nyman, T]]	+	[[Category: Persson C]]
-	[[Category: Persson, C]]	+	[[Category: Schuler H]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Schutz P]]
-	[[Category: Schuler, H]]	+	[[Category: Siponen MI]]
-	[[Category: Schutz, P]]	+	[[Category: Thorsell AG]]
-	[[Category: Siponen~~, M I~~]]	+	[[Category: Tresaugues L]]
-	[[Category: Thorsell~~, A G~~]]	+	[[Category: Wahlberg E]]
-	[[Category: Tresaugues, L]]	+	[[Category: Weigelt J]]
-	[[Category: Wahlberg, E]]	+	[[Category: Welin M]]
-	[[Category: Weigelt, J]]	+	[[Category: Wisniewska M]]
-	[[Category: Welin, M]]	+	[[Category: Van der Berg S]]
-	[[Category: Wisniewska, M]]	+
-	[[Category: ~~Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inositol signalling]]~~	+
-	~~[[Category: Inpp5ba]]~~	+
-	~~[[Category: Magnesium]]~~	+
-	~~[[Category: Phosphatase]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Sgc stockholm~~]]	+

OCA at 13:41, 16 January 2019

OCA — Wed, 16 Jan 2019 13:41:20 GMT

←Older revision		Revision as of 13:41, 16 January 2019
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/3mtc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/3mtc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:33, 4 August 2016

OCA — Thu, 04 Aug 2016 09:33:20 GMT

←Older revision		Revision as of 09:33, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate==		==Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate==
	<StructureSection load='3mtc' size='340' side='right' caption='[[3mtc]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3mtc' size='340' side='right' caption='[[3mtc]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">INPP5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">INPP5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase Phosphoinositide 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.36 3.1.3.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase Phosphoinositide 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.36 3.1.3.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mtc RCSB], [http://www.ebi.ac.uk/pdbsum/3mtc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtc OCA], [http://pdbe.org/3mtc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mtc RCSB], [http://www.ebi.ac.uk/pdbsum/3mtc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mtc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mtc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mtc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoinositide phosphatase\|Phosphoinositide phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:19, 24 December 2014

OCA — Wed, 24 Dec 2014 08:19:03 GMT

←Older revision		Revision as of 08:19, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3mtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MTC FirstGlance]. <br>		<table><tr><td colspan='2'>[[3mtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MTC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PIF:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-TETRAHYDROXY-4-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>PIF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PIF:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-TETRAHYDROXY-4-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>PIF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n9v\|3n9v]], [[3nr8\|3nr8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n9v\|3n9v]], [[3nr8\|3nr8]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">INPP5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">INPP5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase Phosphoinositide 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.36 3.1.3.36] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase Phosphoinositide 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.36 3.1.3.36] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mtc RCSB], [http://www.ebi.ac.uk/pdbsum/3mtc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mtc RCSB], [http://www.ebi.ac.uk/pdbsum/3mtc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN]] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.<ref>PMID:7721860</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.,Tresaugues L, Silvander C, Flodin S, Welin M, Nyman T, Graslund S, Hammarstrom M, Berglund H, Nordlund P Structure. 2014 Apr 2. pii: S0969-2126(14)00073-2. doi:, 10.1016/j.str.2014.01.013. PMID:24704254<ref>PMID:24704254</ref>		Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.,Tresaugues L, Silvander C, Flodin S, Welin M, Nyman T, Graslund S, Hammarstrom M, Berglund H, Nordlund P Structure. 2014 Apr 2. pii: S0969-2126(14)00073-2. doi:, 10.1016/j.str.2014.01.013. PMID:24704254<ref>PMID:24704254</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 33:		Line 35:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Phosphoinositide 5-phosphatase]]		[[Category: Phosphoinositide 5-phosphatase]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Berg, S van der.]]	+	[[Category: Berg, S van der]]
-	[[Category: Berglund, H.]]	+	[[Category: Berglund, H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Collins, R.]]	+	[[Category: Collins, R]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Flodin, S.]]	+	[[Category: Flodin, S]]
-	[[Category: Flores, A.]]	+	[[Category: Flores, A]]
-	[[Category: Graslund, S.]]	+	[[Category: Graslund, S]]
-	[[Category: Hammarstrom, M.]]	+	[[Category: Hammarstrom, M]]
-	[[Category: Johansson, I.]]	+	[[Category: Johansson, I]]
-	[[Category: Karlberg, T.]]	+	[[Category: Karlberg, T]]
-	[[Category: Kol, S.]]	+	[[Category: Kol, S]]
-	[[Category: Kotenyova, T.]]	+	[[Category: Kotenyova, T]]
-	[[Category: Moche, M.]]	+	[[Category: Moche, M]]
-	[[Category: Nordlund, P.]]	+	[[Category: Nordlund, P]]
-	[[Category: Nyman, T.]]	+	[[Category: Nyman, T]]
-	[[Category: Persson, C.]]	+	[[Category: Persson, C]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Schuler, H.]]	+	[[Category: Schuler, H]]
-	[[Category: Schutz, P.]]	+	[[Category: Schutz, P]]
-	[[Category: Siponen, M I.]]	+	[[Category: Siponen, M I]]
-	[[Category: Thorsell, A G.]]	+	[[Category: Thorsell, A G]]
-	[[Category: Tresaugues, L.]]	+	[[Category: Tresaugues, L]]
-	[[Category: Wahlberg, E.]]	+	[[Category: Wahlberg, E]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Welin, M.]]	+	[[Category: Welin, M]]
-	[[Category: Wisniewska, M.]]	+	[[Category: Wisniewska, M]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Inositol signalling]]		[[Category: Inositol signalling]]
Line 66:		Line 68:
	[[Category: Magnesium]]		[[Category: Magnesium]]
	[[Category: Phosphatase]]		[[Category: Phosphatase]]
-	[[Category: Phosphoinositide 5-phosphatase]]
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Sgc stockholm]]		[[Category: Sgc stockholm]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]

OCA at 07:08, 28 May 2014

OCA — Wed, 28 May 2014 07:08:54 GMT

←Older revision		Revision as of 07:08, 28 May 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mtc~~\| ~~PDB~~=3mtc \| ~~SCENE~~= }}	+	==Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate==
-	===~~Crystal Structure~~ of INPP5B in complex with ~~phosphatidylinositol~~ 4-phosphate~~===~~	+	<StructureSection load='3mtc' size='340' side='right' caption='[[3mtc]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MTC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PIF:(2R)-3-{[(S)-HYDROXY{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-TETRAHYDROXY-4-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIOCTANOATE'>PIF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n9v\|3n9v]], [[3nr8\|3nr8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">INPP5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_5-phosphatase Phosphoinositide 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.36 3.1.3.36] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mtc RCSB], [http://www.ebi.ac.uk/pdbsum/3mtc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/3mtc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SHIP2, OCRL, and INPP5B belong to inositol polyphosphate 5-phophatase subfamilies involved in insulin regulation and Lowes syndrome. The structural basis for membrane recognition, substrate specificity, and regulation of inositol polyphosphate 5-phophatases is still poorly understood. We determined the crystal structures of human SHIP2, OCRL, and INPP5B, the latter in complex with phosphoinositide substrate analogs, which revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer. Residues recognizing the 1-phosphate of the substrates are highly conserved among human family members, suggesting similar substrate binding modes. However, 3- and 4-phosphate recognition varies and determines individual substrate specificity profiles. The high conservation of the environment of the scissile 5-phosphate suggests a common reaction geometry for all members of the human 5-phosphatase family.

-	~~==Function==~~	+	Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases.,Tresaugues L, Silvander C, Flodin S, Welin M, Nyman T, Graslund S, Hammarstrom M, Berglund H, Nordlund P Structure. 2014 Apr 2. pii: S0969-2126(14)00073-2. doi:, 10.1016/j.str.2014.01.013. PMID:24704254<ref>PMID:24704254</ref>
-	~~[[http://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN]] Hydrolyzes phosphatidylinositol 4~~,5-~~bisphosphate (PtIns(4~~,~~5)P2) and the signaling molecule phosphatidylinositol 1~~,4,~~5-trisphosphate (PtIns(1~~,4,~~5)P3~~), ~~and thereby modulates cellular signaling events~~.<ref>PMID:~~7721860~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3mtc]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
-	[[Category: ~~Homo sapiens~~]]	+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Phosphoinositide 5-phosphatase]]		[[Category: Phosphoinositide 5-phosphatase]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA: Protected "3mtc" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 21:08:40 GMT

Protected "3mtc" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:08, 17 April 2013

OCA at 21:08, 17 April 2013

OCA — Wed, 17 Apr 2013 21:08:36 GMT

←Older revision		Revision as of 21:08, 17 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3mtc.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mtc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3mtc\| PDB=3mtc \| SCENE= }}		{{STRUCTURE_3mtc\| PDB=3mtc \| SCENE= }}
-
	===Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate===		===Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/I5P2_HUMAN I5P2_HUMAN]] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.<ref>PMID:7721860</ref>

	==About this Structure==		==About this Structure==
-	~~3MTC~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA].	+	[[3mtc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoinositide 5-phosphatase]]		[[Category: Phosphoinositide 5-phosphatase]]
Line 55:		Line 50:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:49:59 2010''

OCA at 09:44, 30 June 2010

OCA — Wed, 30 Jun 2010 09:44:24 GMT

←Older revision		Revision as of 09:44, 30 June 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mtc.jpg\|left\|200px]]

-	The ~~entry 3mtc~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mtc", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mtc\| PDB=3mtc \| SCENE= }}

-	Authors: Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Moche, M., Nyman, T., Persson, C., Schuler, H.,	+	===Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate===

-	Description: Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate (CASP Target)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 12 10~~:47:14 2010''	+	==About this Structure==
		+	3MTC is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTC OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Phosphoinositide 5-phosphatase]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Berg, S van der.]]
		+	[[Category: Berglund, H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Collins, R.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Flodin, S.]]
		+	[[Category: Flores, A.]]
		+	[[Category: Graslund, S.]]
		+	[[Category: Hammarstrom, M.]]
		+	[[Category: Johansson, I.]]
		+	[[Category: Karlberg, T.]]
		+	[[Category: Kol, S.]]
		+	[[Category: Kotenyova, T.]]
		+	[[Category: Moche, M.]]
		+	[[Category: Nordlund, P.]]
		+	[[Category: Nyman, T.]]
		+	[[Category: Persson, C.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Schuler, H.]]
		+	[[Category: Schutz, P.]]
		+	[[Category: Siponen, M I.]]
		+	[[Category: Thorsell, A G.]]
		+	[[Category: Tresaugues, L.]]
		+	[[Category: Wahlberg, E.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Welin, M.]]
		+	[[Category: Wisniewska, M.]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Inositol signalling]]
		+	[[Category: Inpp5ba]]
		+	[[Category: Magnesium]]
		+	[[Category: Phosphatase]]
		+	[[Category: Phosphoinositide 5-phosphatase]]
		+	[[Category: Sgc]]
		+	[[Category: Sgc stockholm]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:49:59 2010''

OCA: New page: '''Unreleased structure''' The entry 3mtc is ON HOLD Authors: Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A.,...

OCA — Wed, 12 May 2010 07:47:14 GMT

New page: '''Unreleased structure''' The entry 3mtc is ON HOLD Authors: Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A.,...

New page

'''Unreleased structure'''

The entry 3mtc is ON HOLD

Authors: Tresaugues, L., Welin, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Moche, M., Nyman, T., Persson, C., Schuler, H.,

Description: Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate (CASP Target)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:47:14 2010''