3muf - Revision history

OCA at 16:39, 1 November 2023

OCA — Wed, 01 Nov 2023 16:39:42 GMT

←Older revision		Revision as of 16:39, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3muf' size='340' side='right'caption='[[3muf]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3muf' size='340' side='right'caption='[[3muf]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3muf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43504 Atcc 43504~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MUF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3muf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MUF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADP:ADENOSINE~~-~~5-DIPHOSPHATE'>ADP</scene>~~, ~~<scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]], [[3mrs\|3mrs]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>AROK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~210 ATCC 43504])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muf OCA], [https://pdbe.org/3muf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3muf RCSB], [https://www.ebi.ac.uk/pdbsum/3muf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3muf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muf OCA], [https://pdbe.org/3muf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3muf RCSB], [https://www.ebi.ac.uk/pdbsum/3muf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3muf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>	+	[https://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 43504~~]]	+	[[Category: Helicobacter pylori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Shikimate kinase]]~~	+	[[Category: Chen TJ]]
-	[[Category: Chen~~, T J~~]]	+	[[Category: Cheng WC]]
-	[[Category: Cheng~~, W C~~]]	+	[[Category: Lin SC]]
-	[[Category: Lin~~, S C~~]]	+	[[Category: Wang WC]]
-	[[Category: Wang~~, W C]]~~	+
-	~~[[Category: Helix-sheet complex]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:50, 12 May 2022

OCA — Thu, 12 May 2022 06:50:47 GMT

←Older revision		Revision as of 06:50, 12 May 2022
Line 1:		Line 1:

	==Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP==		==Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP==
-	<StructureSection load='3muf' size='340' side='right' caption='[[3muf]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3muf' size='340' side='right'caption='[[3muf]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3muf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MUF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3muf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MUF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]], [[3mrs\|3mrs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]], [[3mrs\|3mrs]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muf OCA], [~~http~~://pdbe.org/3muf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3muf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3muf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3muf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muf OCA], [https://pdbe.org/3muf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3muf RCSB], [https://www.ebi.ac.uk/pdbsum/3muf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3muf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>	+	[[https://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Shikimate kinase\|Shikimate kinase]]	+	*[[Shikimate kinase 3D structures\|Shikimate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43504]]		[[Category: Atcc 43504]]
		+	[[Category: Large Structures]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
	[[Category: Chen, T J]]		[[Category: Chen, T J]]

OCA at 22:37, 4 August 2016

OCA — Thu, 04 Aug 2016 22:37:44 GMT

←Older revision		Revision as of 22:37, 4 August 2016
Line 1:		Line 1:
		+
	==Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP==		==Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP==
	<StructureSection load='3muf' size='340' side='right' caption='[[3muf]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3muf' size='340' side='right' caption='[[3muf]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3muf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Helicobacter_pylori Helicobacter pylori~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3muf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]], [[3mrs\|3mrs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]], [[3mrs\|3mrs]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ~~Helicobacter pylori~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 ATCC 43504])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3muf RCSB], [http://www.ebi.ac.uk/pdbsum/3muf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muf OCA], [http://pdbe.org/3muf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3muf RCSB], [http://www.ebi.ac.uk/pdbsum/3muf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3muf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3muf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Helicobacter pylori~~]]	+	[[Category: Atcc 43504]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
	[[Category: Chen, T J]]		[[Category: Chen, T J]]

OCA at 13:41, 25 December 2014

OCA — Thu, 25 Dec 2014 13:41:49 GMT

←Older revision		Revision as of 13:41, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3muf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUF FirstGlance]. <br>		<table><tr><td colspan='2'>[[3muf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]], [[3mrs\|3mrs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]], [[3mrs\|3mrs]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3muf RCSB], [http://www.ebi.ac.uk/pdbsum/3muf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3muf RCSB], [http://www.ebi.ac.uk/pdbsum/3muf PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.,Cheng WC, Chen YF, Wang HJ, Hsu KC, Lin SC, Chen TJ, Yang JM, Wang WC PLoS One. 2012;7(3):e33481. Epub 2012 Mar 16. PMID:22438938<ref>PMID:22438938</ref>		Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.,Cheng WC, Chen YF, Wang HJ, Hsu KC, Lin SC, Chen TJ, Yang JM, Wang WC PLoS One. 2012;7(3):e33481. Epub 2012 Mar 16. PMID:22438938<ref>PMID:22438938</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Shikimate kinase\|Shikimate kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 28:
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
-	[[Category: Chen, T J.]]	+	[[Category: Chen, T J]]
-	[[Category: Cheng, W C.]]	+	[[Category: Cheng, W C]]
-	[[Category: Lin, S C.]]	+	[[Category: Lin, S C]]
-	[[Category: Wang, W C.]]	+	[[Category: Wang, W C]]
	[[Category: Helix-sheet complex]]		[[Category: Helix-sheet complex]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:22, 28 May 2014

OCA — Wed, 28 May 2014 10:22:56 GMT

←Older revision		Revision as of 10:22, 28 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3muf.~~png~~\|~~left~~\|~~200px~~]]	+	==Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP==
		+	<StructureSection load='3muf' size='340' side='right' caption='[[3muf]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3muf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUF FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zuh\|1zuh]], [[1zui\|1zui]], [[3hr7\|3hr7]], [[3mrs\|3mrs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AROK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3muf RCSB], [http://www.ebi.ac.uk/pdbsum/3muf PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids. This pathway is present in bacteria, fungi, and plants but absent in mammals and therefore represents an attractive target pathway for the development of new antimicrobial agents, herbicides, and antiparasitic agents. Here we investigated the detailed structure-activity relationship of SK from Helicobacter pylori (HpSK). Site-directed mutagenesis and isothermal titration calorimetry studies revealed critical conserved residues (D33, F48, R57, R116, and R132) that interact with shikimate and are therefore involved in catalysis. Crystal structures of HpSK.SO(4), R57A, and HpSKshikimate-3-phosphate ADP show a characteristic three-layer architecture and a conformationally elastic region consisting of F48, R57, R116, and R132, occupied by shikimate. The structure of the inhibitor complex, E114A * 162535, was also determined, which revealed a dramatic shift in the elastic LID region and resulted in conformational locking into a distinctive form. These results reveal considerable insight into the active-site chemistry of SKs and a selective inhibitor-induced-fit mechanism.

-	<!--	+	Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.,Cheng WC, Chen YF, Wang HJ, Hsu KC, Lin SC, Chen TJ, Yang JM, Wang WC PLoS One. 2012;7(3):e33481. Epub 2012 Mar 16. PMID:22438938<ref>PMID:22438938</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3muf"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3muf\| PDB=3muf \| SCENE= }}~~	+

-	~~===Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22438938}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22438938 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22438938}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3muf]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022438938<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]

OCA at 04:48, 30 May 2012

OCA — Wed, 30 May 2012 04:48:31 GMT

←Older revision		Revision as of 04:48, 30 May 2012
Line 1:		Line 1:
-	[[Image:3muf.~~jpg~~\|left\|200px]]	+	[[Image:3muf.png\|left\|200px]]

	<!--		<!--
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	===Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP===		===Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22438938}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22438938 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22438938}}

	==About this Structure==		==About this Structure==
	[[3muf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA].		[[3muf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022438938</ref><references group="xtra"/>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Shikimate kinase]]		[[Category: Shikimate kinase]]
Line 20:		Line 29:
	[[Category: Lin, S C.]]		[[Category: Lin, S C.]]
	[[Category: Wang, W C.]]		[[Category: Wang, W C.]]
		+	[[Category: Helix-sheet complex]]
		+	[[Category: Transferase]]

OCA: Protected "3muf" [edit=sysop:move=sysop]

OCA — Wed, 04 May 2011 06:58:56 GMT

Protected "3muf" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 4 May 2011

OCA at 06:58, 4 May 2011

OCA — Wed, 04 May 2011 06:58:49 GMT

←Older revision		Revision as of 06:58, 4 May 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3muf.jpg\|left\|200px]]

-	The ~~entry 3muf~~ is ~~ON HOLD~~ ~~until May 03 2012~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3muf", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3muf\| PDB=3muf \| SCENE= }}

-	~~Authors: Cheng, W.C., Chen, T.J., Lin, S.C., Wang, W.C.~~	+	===Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP===

-	Description: Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed May 26 08~~:22:~~15 2010''~~	+	==About this Structure==
		+	[[3muf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUF OCA].
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Shikimate kinase]]
		+	[[Category: Chen, T J.]]
		+	[[Category: Cheng, W C.]]
		+	[[Category: Lin, S C.]]
		+	[[Category: Wang, W C.]]

OCA at 04:18, 26 May 2010

OCA — Wed, 26 May 2010 04:18:04 GMT

←Older revision		Revision as of 04:18, 26 May 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3muf is ON HOLD	+	The entry 3muf is ON HOLD until May 03 2012

-	Authors: ~~Wen-Chi~~ Cheng, ~~Tzu-Jung~~ Chen , ~~Shuang-Chih~~ Lin, ~~Wen-Ching~~ Wang	+	Authors: Cheng, W.C., Chen, T.J., Lin, S.C., Wang, W.C.

-	Description: Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP.	+	Description: Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May ~~12 10~~:47:31 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:22:15 2010''

OCA: New page: '''Unreleased structure''' The entry 3muf is ON HOLD Authors: Wen-Chi Cheng, Tzu-Jung Chen , Shuang-Chih Lin, Wen-Ching Wang Description: Shikimate kinase from Helicobacter pylori in c...

OCA — Wed, 12 May 2010 07:47:32 GMT

New page: '''Unreleased structure''' The entry 3muf is ON HOLD Authors: Wen-Chi Cheng, Tzu-Jung Chen , Shuang-Chih Lin, Wen-Ching Wang Description: Shikimate kinase from Helicobacter pylori in c...

New page

'''Unreleased structure'''

The entry 3muf is ON HOLD

Authors: Wen-Chi Cheng, Tzu-Jung Chen , Shuang-Chih Lin, Wen-Ching Wang

Description: Shikimate kinase from Helicobacter pylori in complex with shikimate-3-phosphate and ADP.

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:47:31 2010''