3mwu - Revision history

OCA at 09:02, 6 September 2023

OCA — Wed, 06 Sep 2023 09:02:57 GMT

←Older revision		Revision as of 09:02, 6 September 2023
Line 1:		Line 1:

	==Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95==		==Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95==
-	<StructureSection load='3mwu' size='340' side='right' caption='[[3mwu]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='3mwu' size='340' side='right'caption='[[3mwu]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mwu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Crypi Crypi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MWU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mwu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_parvum_Iowa_II Cryptosporidium parvum Iowa II]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MWU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=BK3:3-(NAPHTHALEN-1-YLMETHYL)-1-(PIPERIDIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>BK3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ncg\|3ncg]]~~, [[~~3n51~~\|~~3n51]], [[3i79\|3i79]], [[3i7b\|3i7b]], [[3i7c\|3i7c]], [[3igo\|3igo~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BK3:3-(NAPHTHALEN-1-YLMETHYL)-1-(PIPERIDIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>BK3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CDPK1, cgd3_920 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~353152 CRYPI])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwu OCA], [https://pdbe.org/3mwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mwu RCSB], [https://www.ebi.ac.uk/pdbsum/3mwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mwu ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwu OCA], [~~http~~://pdbe.org/3mwu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mwu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mwu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mwu ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A3FQ16_CRYPI A3FQ16_CRYPI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Calcium/calmodulin-dependent protein kinase~~]]	+	[[Category: Cryptosporidium parvum Iowa II]]
-	[[Category: ~~Crypi~~]]	+	[[Category: Large Structures]]
-	[[Category: Larson~~, E T~~]]	+	[[Category: Larson ET]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-	[[Category: Merritt~~, E A]]~~	+	[[Category: Merritt EA]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Bki]]~~	+
-	~~[[Category: Bumped kinase inhibitor]]~~	+
-	~~[[Category: Calcium-binding]]~~	+
-	~~[[Category: Calmodulin]]~~	+
-	~~[[Category: Msgpp]]~~	+
-	~~[[Category: Serine/threonine protein kinase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 13:42, 16 January 2019

OCA — Wed, 16 Jan 2019 13:42:42 GMT

←Older revision		Revision as of 13:42, 16 January 2019
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mw/3mwu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mw/3mwu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3mwu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3mwu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Calcium-dependent protein kinase\|Calcium-dependent protein kinase]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Crypi]]		[[Category: Crypi]]
	[[Category: Larson, E T]]		[[Category: Larson, E T]]
-	[[Category: Merritt, E A]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: Merritt, E A]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Bki]]		[[Category: Bki]]

OCA at 17:50, 4 August 2016

OCA — Thu, 04 Aug 2016 17:50:50 GMT

←Older revision		Revision as of 17:50, 4 August 2016
Line 1:		Line 1:
		+
	==Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95==		==Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95==
	<StructureSection load='3mwu' size='340' side='right' caption='[[3mwu]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='3mwu' size='340' side='right' caption='[[3mwu]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mwu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cryptosporidium_parvum Cryptosporidium parvum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MWU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mwu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Crypi Crypi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MWU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BK3:3-(NAPHTHALEN-1-YLMETHYL)-1-(PIPERIDIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>BK3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BK3:3-(NAPHTHALEN-1-YLMETHYL)-1-(PIPERIDIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>BK3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ncg\|3ncg]], [[3n51\|3n51]], [[3i79\|3i79]], [[3i7b\|3i7b]], [[3i7c\|3i7c]], [[3igo\|3igo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ncg\|3ncg]], [[3n51\|3n51]], [[3i79\|3i79]], [[3i7b\|3i7b]], [[3i7c\|3i7c]], [[3igo\|3igo]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDPK1, cgd3_920 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~5807 Cryptosporidium parvum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDPK1, cgd3_920 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353152 CRYPI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mwu RCSB], [http://www.ebi.ac.uk/pdbsum/3mwu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwu OCA], [http://pdbe.org/3mwu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mwu RCSB], [http://www.ebi.ac.uk/pdbsum/3mwu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mwu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mwu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
-		+	<div class="pdbe-citations 3mwu" style="background-color:#fffaf0;"></div>
-	==~~See Also==~~	+
-	*[[Calcium-dependent protein kinase\|Calcium-~~dependent protein kinase]]~~	+
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
-	[[Category: ~~Cryptosporidium parvum~~]]	+	[[Category: Crypi]]
	[[Category: Larson, E T]]		[[Category: Larson, E T]]
	[[Category: Merritt, E A]]		[[Category: Merritt, E A]]

OCA at 15:39, 18 December 2014

OCA — Thu, 18 Dec 2014 15:39:50 GMT

←Older revision		Revision as of 15:39, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mwu\| PDB=3mwu \| SCENE= }}~~	+	==Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95==
-	===Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95===	+	<StructureSection load='3mwu' size='340' side='right' caption='[[3mwu]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21116453}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mwu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MWU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BK3:3-(NAPHTHALEN-1-YLMETHYL)-1-(PIPERIDIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>BK3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ncg\|3ncg]], [[3n51\|3n51]], [[3i79\|3i79]], [[3i7b\|3i7b]], [[3i7c\|3i7c]], [[3igo\|3igo]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDPK1, cgd3_920 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5807 Cryptosporidium parvum])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mwu RCSB], [http://www.ebi.ac.uk/pdbsum/3mwu PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mw/3mwu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The protozoans Cryptosporidium parvum and Toxoplasma gondii are parasites of major health concern to humans. Both parasites contain a group of calcium-dependent protein kinases (CDPKs), which are found in plants and ciliates but not in humans or fungi. Here we describe a series of potent inhibitors that target CDPK1 in C. parvum (CpCDPK1) and T. gondii (TgCDPK1). These inhibitors are highly selective for CpCDPK1 and TgCDPK1 over the mammalian kinases SRC and ABL. Furthermore, they are able to block an early stage of C. parvum invasion of HCT-8 host cells, which is similar to their effects on T. gondii invasion of human fibroblasts.

-	~~==About this Structure==~~	+	Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.,Murphy RC, Ojo KK, Larson ET, Castellanos-Gonzalez A, Perera BG, Keyloun KR, Kim JE, Bhandari JG, Muller NR, Verlinde CL, White AC, Merritt EA, Van Voorhis WC, Maly DJ ACS Med Chem Lett. 2010 Oct 14;1(7):331-335. PMID:21116453<ref>PMID:21116453</ref>
-	~~[[3mwu]] is a~~ 1 ~~chain structure with sequence~~ from ~~[http://en~~.~~wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium~~ parvum]. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3MWU OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:021116453</ref><ref group~~=~~"xtra">PMID:020436472</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Calcium-dependent protein kinase\|Calcium-dependent protein kinase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
	[[Category: Cryptosporidium parvum]]		[[Category: Cryptosporidium parvum]]
-	[[Category: Larson, E T.]]	+	[[Category: Larson, E T]]
-	[[Category: Merritt, E A.]]	+	[[Category: Merritt, E A]]
-	[[Category: ~~Protozoa, Medical~~ Structural ~~Genomics of Pathogenic.~~]]	+	[[Category: Structural genomic]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Bki]]		[[Category: Bki]]
Line 18:		Line 44:
	[[Category: Calcium-binding]]		[[Category: Calcium-binding]]
	[[Category: Calmodulin]]		[[Category: Calmodulin]]
-	[[Category: Medical structural genomics of pathogenic protozoa]]
	[[Category: Msgpp]]		[[Category: Msgpp]]
	[[Category: Serine/threonine protein kinase]]		[[Category: Serine/threonine protein kinase]]
-	[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

OCA at 21:10, 17 April 2013

OCA — Wed, 17 Apr 2013 21:10:11 GMT

←Older revision		Revision as of 21:10, 17 April 2013
Line 1:		Line 1:
-	[[Image:3mwu.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mwu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3mwu\| PDB=3mwu \| SCENE= }}		{{STRUCTURE_3mwu\| PDB=3mwu \| SCENE= }}
-
	===Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95===		===Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21116453}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21116453 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21116453}}		{{ABSTRACT_PUBMED_21116453}}

Line 22:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21116453~~</ref><ref group="xtra">PMID:~~20436472~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021116453</ref><ref group="xtra">PMID:020436472</ref><references group="xtra"/><references/>
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
	[[Category: Cryptosporidium parvum]]		[[Category: Cryptosporidium parvum]]
Line 28:		Line 13:
	[[Category: Merritt, E A.]]		[[Category: Merritt, E A.]]
	[[Category: Protozoa, Medical Structural Genomics of Pathogenic.]]		[[Category: Protozoa, Medical Structural Genomics of Pathogenic.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Bki]]
		+	[[Category: Bumped kinase inhibitor]]
		+	[[Category: Calcium-binding]]
		+	[[Category: Calmodulin]]
		+	[[Category: Medical structural genomics of pathogenic protozoa]]
		+	[[Category: Msgpp]]
		+	[[Category: Serine/threonine protein kinase]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA: Protected "3mwu" [edit=sysop:move=sysop]

OCA — Wed, 23 Mar 2011 06:23:21 GMT

Protected "3mwu" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:23, 23 March 2011

OCA at 06:23, 23 March 2011

OCA — Wed, 23 Mar 2011 06:23:19 GMT

←Older revision		Revision as of 06:23, 23 March 2011
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-	{{Seed}}
	[[Image:3mwu.png\|left\|200px]]		[[Image:3mwu.png\|left\|200px]]

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	===Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95===		===Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21116453}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21116453 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21116453}}

	==About this Structure==		==About this Structure==
-	~~3MWU~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cryptosporidium_parvum_iowa_ii~~ Cryptosporidium parvum ~~iowa ii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWU OCA].	+	[[3mwu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:20436472</ref><references group="xtra"/>	+	<ref group="xtra">PMID:21116453</ref><ref group="xtra">PMID:20436472</ref><references group="xtra"/>
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
-	[[Category: Cryptosporidium parvum ~~iowa ii~~]]	+	[[Category: Cryptosporidium parvum]]
	[[Category: Larson, E T.]]		[[Category: Larson, E T.]]
	[[Category: Merritt, E A.]]		[[Category: Merritt, E A.]]
	[[Category: Protozoa, Medical Structural Genomics of Pathogenic.]]		[[Category: Protozoa, Medical Structural Genomics of Pathogenic.]]
-	[[Category: Atp-binding]]
-	[[Category: Bki]]
-	[[Category: Bumped kinase inhibitor]]
-	[[Category: Calcium-binding]]
-	[[Category: Calmodulin]]
-	[[Category: Medical structural genomics of pathogenic protozoa]]
-	[[Category: Msgpp]]
-	[[Category: Serine/threonine protein kinase]]
-	[[Category: Structural genomic]]
-	[[Category: Transferase]]
-	[[Category: Transferase-transferase inhibitor complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 11:38:29 2010''

OCA at 08:28, 27 October 2010

OCA — Wed, 27 Oct 2010 08:28:07 GMT

←Older revision		Revision as of 08:28, 27 October 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3mwu.~~jpg~~\|left\|200px]]	+	[[Image:3mwu.png\|left\|200px]]

	<!--		<!--
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	[[Category: Transferase-transferase inhibitor complex]]		[[Category: Transferase-transferase inhibitor complex]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 21 10~~:19:44 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 11:38:29 2010''

OCA at 06:13, 21 July 2010

OCA — Wed, 21 Jul 2010 06:13:19 GMT

←Older revision		Revision as of 06:13, 21 July 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mwu.jpg\|left\|200px]]

-	The ~~entry 3mwu~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mwu", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mwu\| PDB=3mwu \| SCENE= }}

-	~~Authors: Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa~~	+	===Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95===

-	Description: Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 2 08~~:28:12 2010''	+	==About this Structure==
		+	3MWU is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum_iowa_ii Cryptosporidium parvum iowa ii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWU OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20436472</ref><references group="xtra"/>
		+	[[Category: Calcium/calmodulin-dependent protein kinase]]
		+	[[Category: Cryptosporidium parvum iowa ii]]
		+	[[Category: Larson, E T.]]
		+	[[Category: Merritt, E A.]]
		+	[[Category: Protozoa, Medical Structural Genomics of Pathogenic.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Bki]]
		+	[[Category: Bumped kinase inhibitor]]
		+	[[Category: Calcium-binding]]
		+	[[Category: Calmodulin]]
		+	[[Category: Medical structural genomics of pathogenic protozoa]]
		+	[[Category: Msgpp]]
		+	[[Category: Serine/threonine protein kinase]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase-transferase inhibitor complex]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:19:44 2010''

OCA at 04:23, 2 June 2010

OCA — Wed, 02 Jun 2010 04:23:45 GMT

←Older revision		Revision as of 04:23, 2 June 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3mwu is ON HOLD ~~until Paper Publication~~	+	The entry 3mwu is ON HOLD

	Authors: Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa		Authors: Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa
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	Description: Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95		Description: Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor RM-1-95

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 26~~ 08:22:27 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:28:12 2010''