3mxo - Revision history

OCA at 12:45, 26 July 2023

OCA — Wed, 26 Jul 2023 12:45:14 GMT

←Older revision		Revision as of 12:45, 26 July 2023
Line 1:		Line 1:

	==Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)==		==Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)==
-	<StructureSection load='3mxo' size='340' side='right' caption='[[3mxo]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3mxo' size='340' side='right'caption='[[3mxo]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mxo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MXO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mxo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MXO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGAM5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxo OCA], [https://pdbe.org/3mxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mxo RCSB], [https://www.ebi.ac.uk/pdbsum/3mxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxo ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxo OCA], [~~http~~://pdbe.org/3mxo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mxo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mxo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxo ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PGAM5_HUMAN PGAM5_HUMAN]] Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.<ref>PMID:18387606</ref> <ref>PMID:19590015</ref> <ref>PMID:22265414</ref>	+	[https://www.uniprot.org/uniprot/PGAM5_HUMAN PGAM5_HUMAN] Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.<ref>PMID:18387606</ref> <ref>PMID:19590015</ref> <ref>PMID:22265414</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/3mxo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/3mxo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mxo ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mxo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PGAM5 is a mitochondrial membrane protein that functions as an atypical Ser/Thr phosphatase and is a regulator of oxidative stress response, necroptosis, and autophagy. Here we present several crystal structures of PGAM5 including the activating N-terminal regulatory sequences, providing a model for structural plasticity, dimerization of the catalytic domain, and the assembly into an enzymatically active dodecameric form. Oligomeric states observed in structures were supported by hydrogen exchange mass spectrometry, size-exclusion chromatography, and analytical ultracentrifugation experiments in solution. We report that the catalytically important N-terminal WDPNWD motif acts as a structural integrator assembling PGAM5 into a dodecamer, allosterically activating the phosphatase by promoting an ordering of the catalytic loop. Additionally the observed active site plasticity enabled visualization of essential conformational rearrangements of catalytic elements. The comprehensive biophysical characterization offers detailed structural models of this key mitochondrial phosphatase that has been associated with the development of diverse diseases.
		+
		+	Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.,Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schroder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S Structure. 2017 Jul 5;25(7):1089-1099.e3. doi: 10.1016/j.str.2017.05.020. Epub, 2017 Jun 22. PMID:28648608<ref>PMID:28648608</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3mxo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Phosphoglycerate ~~Mutase~~\|Phosphoglycerate ~~Mutase]]~~	+	*[[Phosphoglycerate mutase 3D structures\|Phosphoglycerate mutase 3D structures]]
-	*[[Serine/threonine protein phosphatase\|Serine/threonine protein phosphatase]]	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Phosphoprotein phosphatase~~]]	+	[[Category: Large Structures]]
-	[[Category: Alfano, I]]	+	[[Category: Alfano I]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Barr, A]]	+	[[Category: Barr A]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Chaikuad, A]]	+	[[Category: Chaikuad A]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Ichijo H]]
-	[[Category: Ichijo, H]]	+	[[Category: Knapp S]]
-	[[Category: Knapp, S]]	+	[[Category: Picaud S]]
-	[[Category: Picaud, S]]	+	[[Category: Takeda K]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Weigelt J]]
-	[[Category: Takeda, K]]	+	[[Category: Von Delft F]]
-	[[Category: Weigelt, J]]	+
-	[[Category: ~~Bxlbv68]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mgc5352 protein]]~~	+
-	~~[[Category: Pgam5]]~~	+
-	~~[[Category: Phosphoglycerate mutase family member 5]]~~	+
-	~~[[Category: Sgc~~]]	+

OCA at 13:19, 5 August 2016

OCA — Fri, 05 Aug 2016 13:19:26 GMT

←Older revision		Revision as of 13:19, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)==		==Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)==
	<StructureSection load='3mxo' size='340' side='right' caption='[[3mxo]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3mxo' size='340' side='right' caption='[[3mxo]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mxo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mxo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGAM5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGAM5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxo RCSB], [http://www.ebi.ac.uk/pdbsum/3mxo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxo OCA], [http://pdbe.org/3mxo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mxo RCSB], [http://www.ebi.ac.uk/pdbsum/3mxo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mxo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Phosphoglycerate Mutase\|Phosphoglycerate Mutase]]		*[[Phosphoglycerate Mutase\|Phosphoglycerate Mutase]]
		+	*[[Serine/threonine protein phosphatase\|Serine/threonine protein phosphatase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Alfano, I]]		[[Category: Alfano, I]]

OCA at 19:09, 25 December 2014

OCA — Thu, 25 Dec 2014 19:09:16 GMT

←Older revision		Revision as of 19:09, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxo RCSB], [http://www.ebi.ac.uk/pdbsum/3mxo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxo RCSB], [http://www.ebi.ac.uk/pdbsum/3mxo PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGAM5_HUMAN PGAM5_HUMAN]] Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.<ref>PMID:18387606</ref> <ref>PMID:19590015</ref> <ref>PMID:22265414</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 23:
	==See Also==		==See Also==
	*[[Phosphoglycerate Mutase\|Phosphoglycerate Mutase]]		*[[Phosphoglycerate Mutase\|Phosphoglycerate Mutase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:02, 9 December 2014

OCA — Tue, 09 Dec 2014 09:02:58 GMT

←Older revision		Revision as of 09:02, 9 December 2014
Line 1:		Line 1:
-	~~[[Image:3mxo.png\|left\|200px]]~~	+	==Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)==
-		+	<StructureSection load='3mxo' size='340' side='right' caption='[[3mxo]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{STRUCTURE_3mxo\| PDB=3mxo \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3mxo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MXO FirstGlance]. <br>
-	===Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PGAM5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxo RCSB], [http://www.ebi.ac.uk/pdbsum/3mxo PDBsum]</span></td></tr>
-	[[3mxo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA].	+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/3mxo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Phosphoglycerate Mutase\|Phosphoglycerate Mutase]]		*[[Phosphoglycerate Mutase\|Phosphoglycerate Mutase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
-	[[Category: Alfano, I.]]	+	[[Category: Alfano, I]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Barr, A.]]	+	[[Category: Barr, A]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Chaikuad, A.]]	+	[[Category: Chaikuad, A]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Filippakopoulos, P.]]	+	[[Category: Filippakopoulos, P]]
-	[[Category: Ichijo, H.]]	+	[[Category: Ichijo, H]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Picaud, S.]]	+	[[Category: Picaud, S]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Takeda, K.]]	+	[[Category: Takeda, K]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Bxlbv68]]		[[Category: Bxlbv68]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 33:		Line 45:
	[[Category: Phosphoglycerate mutase family member 5]]		[[Category: Phosphoglycerate mutase family member 5]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomics consortium]]

OCA at 20:22, 20 October 2012

OCA — Sat, 20 Oct 2012 20:22:52 GMT

←Older revision		Revision as of 20:22, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3mxo]] is a 2 chain structure ~~of [[Phosphoglycerate Mutase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA].	+	[[3mxo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA].

	==See Also==		==See Also==

OCA: Protected "3mxo" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 10:17:39 GMT

Protected "3mxo" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:17, 27 July 2012

OCA at 10:17, 27 July 2012

OCA — Fri, 27 Jul 2012 10:17:36 GMT

←Older revision		Revision as of 10:17, 27 July 2012
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-	~~{{Seed}}~~	+	[[Image:3mxo.png\|left\|200px]]
-	[[Image:3mxo.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mxo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3mxo\| PDB=3mxo \| SCENE= }}		{{STRUCTURE_3mxo\| PDB=3mxo \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~3MXO~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA].	+	[[3mxo]] is a 2 chain structure of [[Phosphoglycerate Mutase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA].
		+
		+	==See Also==
		+	*[[Phosphoglycerate Mutase\|Phosphoglycerate Mutase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
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	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:50:33 2010''

OCA at 07:41, 15 September 2010

OCA — Wed, 15 Sep 2010 07:41:52 GMT

←Older revision		Revision as of 07:41, 15 September 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mxo.jpg\|left\|200px]]

-	The ~~entry 3mxo~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mxo", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mxo\| PDB=3mxo \| SCENE= }}

-	~~Authors: Chaikuad, A., Filippakopoulos, P., Alfano, I., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Takeda, K., Ichijo, H., Knapp, S., Structural Genomics Consortium~~ (~~SGC~~)	+	===Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)===

-	Description: Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 26 08~~:22:30 2010''	+	==About this Structure==
		+	3MXO is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXO OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Phosphoprotein phosphatase]]
		+	[[Category: Alfano, I.]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Barr, A.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Chaikuad, A.]]
		+	[[Category: Delft, F von.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Filippakopoulos, P.]]
		+	[[Category: Ichijo, H.]]
		+	[[Category: Knapp, S.]]
		+	[[Category: Picaud, S.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Takeda, K.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Bxlbv68]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mgc5352 protein]]
		+	[[Category: Pgam5]]
		+	[[Category: Phosphoglycerate mutase family member 5]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomics consortium]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:50:33 2010''

OCA at 04:18, 26 May 2010

OCA — Wed, 26 May 2010 04:18:19 GMT

←Older revision		Revision as of 04:18, 26 May 2010
Line 3:		Line 3:
	The entry 3mxo is ON HOLD		The entry 3mxo is ON HOLD

-	Authors: Chaikuad, A., Filippakopoulos, P., Alfano, I., , von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Takeda, K., Ichijo, H., Knapp, S., Structural Genomics Consortium (SGC)	+	Authors: Chaikuad, A., Filippakopoulos, P., Alfano, I., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Takeda, K., Ichijo, H., Knapp, S., Structural Genomics Consortium (SGC)

	Description: Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)		Description: Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ May ~~20 09~~:19:17 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:22:30 2010''

OCA: New page: '''Unreleased structure''' The entry 3mxo is ON HOLD Authors: Chaikuad, A., Filippakopoulos, P., Alfano, I., , von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., ...

OCA — Thu, 20 May 2010 06:19:18 GMT

New page: '''Unreleased structure''' The entry 3mxo is ON HOLD Authors: Chaikuad, A., Filippakopoulos, P., Alfano, I., , von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., ...

New page

'''Unreleased structure'''

The entry 3mxo is ON HOLD

Authors: Chaikuad, A., Filippakopoulos, P., Alfano, I., , von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Takeda, K., Ichijo, H., Knapp, S., Structural Genomics Consortium (SGC)

Description: Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:19:17 2010''