3mzg - Revision history

OCA at 09:05, 6 September 2023

OCA — Wed, 06 Sep 2023 09:05:16 GMT

←Older revision		Revision as of 09:05, 6 September 2023
Line 1:		Line 1:

	==Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor==		==Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor==
-	<StructureSection load='3mzg' size='340' side='right' caption='[[3mzg]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3mzg' size='340' side='right'caption='[[3mzg]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mzg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3MZG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mzg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MZG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CL:CHLORIDE+ION'>CL</scene~~>, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[3n06\|3n06]], [[3n0p\|3n0p]], [[3ncb\|3ncb]], [[3ncc\|3ncc]], [[3nce\|3nce]], [[3ncf\|3ncf]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">PRL, Prolactin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode=5&id=9606 HUMAN]), PRLR, Prolactin receptor ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mzg OCA], [https://pdbe.org/3mzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mzg RCSB], [https://www.ebi.ac.uk/pdbsum/3mzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mzg ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3mzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mzg OCA], [~~http~~://pdbe.org/3mzg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3mzg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3mzg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3mzg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PRL_HUMAN PRL_HUMAN]] Prolactin acts primarily on the mammary gland by promoting lactation. [[http://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN]] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref>	+	[https://www.uniprot.org/uniprot/PRL_HUMAN PRL_HUMAN] Prolactin acts primarily on the mammary gland by promoting lactation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Chayen~~, N E~~]]	+	[[Category: Large Structures]]
-	[[Category: Hodsdon~~, M E~~]]	+	[[Category: Chayen NE]]
-	[[Category: Keeler, C]]	+	[[Category: Hodsdon ME]]
-	[[Category: Kulkarni~~, M V~~]]	+	[[Category: Keeler C]]
-	[[Category: Lolis~~, E J~~]]	+	[[Category: Kulkarni MV]]
-	[[Category: Murphy~~, J W~~]]	+	[[Category: Lolis EJ]]
-	[[Category: Myszka~~, D G~~]]	+	[[Category: Murphy JW]]
-	[[Category: Tettamanzi~~, M C]]~~	+	[[Category: Myszka DG]]
-	~~[[Category: Antagonist]]~~	+	[[Category: Tettamanzi MC]]
-	~~[[Category: Ecd]]~~	+
-	~~[[Category: Hematopoietic cytokine]]~~	+
-	~~[[Category: Hormone-hormone receptor complex]]~~	+
-	~~[[Category: Ph dependence~~]]	+

OCA at 13:17, 16 January 2019

OCA — Wed, 16 Jan 2019 13:17:00 GMT

←Older revision		Revision as of 13:17, 16 January 2019
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/3mzg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/3mzg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	==See Also==		==See Also==
	*[[Prolactin\|Prolactin]]		*[[Prolactin\|Prolactin]]
		+	*[[Prolactin receptor\|Prolactin receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:34, 4 August 2016

OCA — Thu, 04 Aug 2016 12:34:06 GMT

←Older revision		Revision as of 12:34, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor==		==Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor==
	<StructureSection load='3mzg' size='340' side='right' caption='[[3mzg]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3mzg' size='340' side='right' caption='[[3mzg]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3mzg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MZG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3mzg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MZG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n06\|3n06]], [[3n0p\|3n0p]], [[3ncb\|3ncb]], [[3ncc\|3ncc]], [[3nce\|3nce]], [[3ncf\|3ncf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n06\|3n06]], [[3n0p\|3n0p]], [[3ncb\|3ncb]], [[3ncc\|3ncc]], [[3nce\|3nce]], [[3ncf\|3ncf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRL, Prolactin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), PRLR, Prolactin receptor ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRL, Prolactin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PRLR, Prolactin receptor ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mzg RCSB], [http://www.ebi.ac.uk/pdbsum/3mzg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mzg OCA], [http://pdbe.org/3mzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mzg RCSB], [http://www.ebi.ac.uk/pdbsum/3mzg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mzg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mzg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3mzg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Prolactin\|Prolactin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chayen, N E]]		[[Category: Chayen, N E]]
	[[Category: Hodsdon, M E]]		[[Category: Hodsdon, M E]]

OCA at 14:33, 24 December 2014

OCA — Wed, 24 Dec 2014 14:33:12 GMT

←Older revision		Revision as of 14:33, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mzg RCSB], [http://www.ebi.ac.uk/pdbsum/3mzg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mzg RCSB], [http://www.ebi.ac.uk/pdbsum/3mzg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRL_HUMAN PRL_HUMAN]] Prolactin acts primarily on the mammary gland by promoting lactation. [[http://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN]] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:07, 18 December 2014

OCA — Thu, 18 Dec 2014 15:07:19 GMT

←Older revision		Revision as of 15:07, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3mzg\| PDB=3mzg \| SCENE= }}~~	+	==Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor==
-	===Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor===	+	<StructureSection load='3mzg' size='340' side='right' caption='[[3mzg]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20889499}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3mzg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MZG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n06\|3n06]], [[3n0p\|3n0p]], [[3ncb\|3ncb]], [[3ncc\|3ncc]], [[3nce\|3nce]], [[3ncf\|3ncf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRL, Prolactin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PRLR, Prolactin receptor ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mzg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mzg RCSB], [http://www.ebi.ac.uk/pdbsum/3mzg PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/3mzg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human prolactin (hPRL), a member of the family of hematopoietic cytokines, functions as both an endocrine hormone and autocrine/paracrine growth factor. We have previously demonstrated that recognition of the hPRL receptor (hPRLr) depends strongly on solution acidity over the physiologic range from pH 6 &- 8. The hPRL-receptor binding interface contains four histidines, whose protonation is hypothesized to regulate pH-dependent receptor recognition. Here, we systematically dissect its molecular origin by characterizing the consequences of His to Ala mutations on pH-dependent receptor-binding kinetics, site-specific histidine protonation, and high resolution structures of the intermolecular interface. Thermodynamic modeling of the pH dependence to receptor-binding affinity reveals large changes in site-specific protonation constants for a majority of interface histidines upon complexation. Removal of individual His imidazoles reduces these perturbations in protonation constants, which is most likely explained by the introduction of solvent-filled, buried cavities in the crystallographic structures without inducing significant conformational rearrangements.

-	~~==Function==~~	+	Two independent histidines, one in human prolactin and one in its receptor, are critical for pH dependent receptor recognition and activation.,Kulkarni MV, Tettamanzi MC, Murphy JW, Keeler C, Myszka DG, Chayen NE, Lolis EJ, Hodsdon ME J Biol Chem. 2010 Sep 30. PMID:20889499<ref>PMID:20889499</ref>
-	~~[[http://www.uniprot.org/uniprot/PRL_HUMAN PRL_HUMAN]] Prolactin acts primarily on the mammary gland by promoting lactation. [[http://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN]] This is a~~ receptor for ~~the anterior pituitary hormone prolactin (PRL)~~. ~~Isoform 4 is unable to transduce prolactin signaling~~. ~~Isoform 6 is unable to transduce prolactin signaling~~.<ref>PMID:~~12580759~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3mzg]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020889499</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chayen, N E.]]	+	[[Category: Chayen, N E]]
-	[[Category: Hodsdon, M E.]]	+	[[Category: Hodsdon, M E]]
-	[[Category: Keeler, C.]]	+	[[Category: Keeler, C]]
-	[[Category: Kulkarni, M V.]]	+	[[Category: Kulkarni, M V]]
-	[[Category: Lolis, E J.]]	+	[[Category: Lolis, E J]]
-	[[Category: Murphy, J W.]]	+	[[Category: Murphy, J W]]
-	[[Category: Myszka, D G.]]	+	[[Category: Myszka, D G]]
-	[[Category: Tettamanzi, M C.]]	+	[[Category: Tettamanzi, M C]]
	[[Category: Antagonist]]		[[Category: Antagonist]]
	[[Category: Ecd]]		[[Category: Ecd]]

OCA: Protected "3mzg" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 21:10:31 GMT

Protected "3mzg" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:10, 17 April 2013

OCA at 21:10, 17 April 2013

OCA — Wed, 17 Apr 2013 21:10:28 GMT

←Older revision		Revision as of 21:10, 17 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3mzg.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3mzg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3mzg\| PDB=3mzg \| SCENE= }}		{{STRUCTURE_3mzg\| PDB=3mzg \| SCENE= }}
-
	===Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor===		===Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor===
		+	{{ABSTRACT_PUBMED_20889499}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/PRL_HUMAN PRL_HUMAN]] Prolactin acts primarily on the mammary gland by promoting lactation. [[http://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN]] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20889499}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears~~ on ~~PubMed at~~ http://www.~~pubmed~~.~~gov), where 20889499~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20889499}}~~	+

	==About this Structure==		==About this Structure==
-	~~3MZG~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA].	+	[[3mzg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20889499~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020889499</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chayen, N E.]]		[[Category: Chayen, N E.]]
Line 38:		Line 25:
	[[Category: Hormone-hormone receptor complex]]		[[Category: Hormone-hormone receptor complex]]
	[[Category: Ph dependence]]		[[Category: Ph dependence]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:07:56 2010''

OCA at 02:57, 20 October 2010

OCA — Wed, 20 Oct 2010 02:57:51 GMT

←Older revision		Revision as of 02:57, 20 October 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3mzg.~~jpg~~\|left\|200px]]	+	[[Image:3mzg.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor===		===Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20889499}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20889499 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20889499}}

	==About this Structure==		==About this Structure==
	3MZG is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA].		3MZG is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20889499</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chayen, N E.]]		[[Category: Chayen, N E.]]
Line 30:		Line 39:
	[[Category: Ph dependence]]		[[Category: Ph dependence]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 29 08~~:15:37 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:07:56 2010''

OCA at 05:06, 29 September 2010

OCA — Wed, 29 Sep 2010 05:06:22 GMT

←Older revision		Revision as of 05:06, 29 September 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3mzg.jpg\|left\|200px]]

-	The ~~entry 3mzg~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3mzg", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3mzg\| PDB=3mzg \| SCENE= }}

-	~~Authors: Kulkarni, M.V., Murphy, J.W., Lolis, E., Hodsdon, M.E.~~	+	===Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor===

-	Description: Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu May 20 09~~:19:57 2010''	+	==About this Structure==
		+	3MZG is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZG OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Chayen, N E.]]
		+	[[Category: Hodsdon, M E.]]
		+	[[Category: Keeler, C.]]
		+	[[Category: Kulkarni, M V.]]
		+	[[Category: Lolis, E J.]]
		+	[[Category: Murphy, J W.]]
		+	[[Category: Myszka, D G.]]
		+	[[Category: Tettamanzi, M C.]]
		+	[[Category: Antagonist]]
		+	[[Category: Ecd]]
		+	[[Category: Hematopoietic cytokine]]
		+	[[Category: Hormone-hormone receptor complex]]
		+	[[Category: Ph dependence]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:15:37 2010''

OCA: New page: '''Unreleased structure''' The entry 3mzg is ON HOLD Authors: Kulkarni, M.V., Murphy, J.W., Lolis, E., Hodsdon, M.E. Description: Crystal structure of a human prolactin receptor antago...

OCA — Thu, 20 May 2010 06:19:57 GMT

New page: '''Unreleased structure''' The entry 3mzg is ON HOLD Authors: Kulkarni, M.V., Murphy, J.W., Lolis, E., Hodsdon, M.E. Description: Crystal structure of a human prolactin receptor antago...

New page

'''Unreleased structure'''

The entry 3mzg is ON HOLD

Authors: Kulkarni, M.V., Murphy, J.W., Lolis, E., Hodsdon, M.E.

Description: Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:19:57 2010''