3n1f - Revision history

OCA at 09:06, 6 September 2023

OCA — Wed, 06 Sep 2023 09:06:39 GMT

←Older revision		Revision as of 09:06, 6 September 2023
Line 1:		Line 1:

	==Crystal Structure of IhhN bound to CDOFn3==		==Crystal Structure of IhhN bound to CDOFn3==
-	<StructureSection load='3n1f' size='340' side='right' caption='[[3n1f]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3n1f' size='340' side='right'caption='[[3n1f]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n1f]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3N1F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n1f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N1F FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~>, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[3n1g\|3n1g]], [[3n1m\|3n1m]], [[3n1o\|3n1o]], [[3n1p\|3n1p]], [[3n1q\|3n1q]], [[3n1r\|3n1r]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">IHH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode=5&id=9606 HUMAN]), CDON, CDO ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1f OCA], [https://pdbe.org/3n1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n1f RCSB], [https://www.ebi.ac.uk/pdbsum/3n1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n1f ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3n1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1f OCA], [~~http~~://pdbe.org/3n1f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3n1f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3n1f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3n1f ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/IHH_HUMAN IHH_HUMAN]] Brachydactyly type A1;Acrocapitofemoral dysplasia. Defects in IHH are the cause of brachydactyly type A1 (BDA1) [MIM:[~~http~~://omim.org/entry/112500 112500]]. BDA1 is an autosomal dominant disorder characterized by middle phalanges of all the digits rudimentary or fused with the terminal phalanges. The proximal phalanges of the thumbs and big toes are short.<ref>PMID:11455389</ref> <ref>PMID:12384778</ref> Defects in IHH are a cause of acrocapitofemoral dysplasia (ACFD) [MIM:[~~http~~://omim.org/entry/607778 607778]]. ACFD is a disorder characterized by short stature of variable severity with postnatal onset. The most constant radiographic abnormalities are observed in the tubular bones of the hands and in the proximal part of the femur. Cone-shaped epiphyses or a similar epiphyseal configuration with premature epimetaphyseal fusion result in shortening of the skeletal components involved. Cone-shaped epiphyses were also present to a variable extent at the shoulders, knees, and ankles.<ref>PMID:12632327</ref> [[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:[http://omim.org/entry/614226 614226]]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.	+	[https://www.uniprot.org/uniprot/IHH_HUMAN IHH_HUMAN] Brachydactyly type A1;Acrocapitofemoral dysplasia. Defects in IHH are the cause of brachydactyly type A1 (BDA1) [MIM:[https://omim.org/entry/112500 112500]. BDA1 is an autosomal dominant disorder characterized by middle phalanges of all the digits rudimentary or fused with the terminal phalanges. The proximal phalanges of the thumbs and big toes are short.<ref>PMID:11455389</ref> <ref>PMID:12384778</ref> Defects in IHH are a cause of acrocapitofemoral dysplasia (ACFD) [MIM:[https://omim.org/entry/607778 607778]. ACFD is a disorder characterized by short stature of variable severity with postnatal onset. The most constant radiographic abnormalities are observed in the tubular bones of the hands and in the proximal part of the femur. Cone-shaped epiphyses or a similar epiphyseal configuration with premature epimetaphyseal fusion result in shortening of the skeletal components involved. Cone-shaped epiphyses were also present to a variable extent at the shoulders, knees, and ankles.<ref>PMID:12632327</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IHH_HUMAN IHH_HUMAN]] Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). [[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).	+	[https://www.uniprot.org/uniprot/IHH_HUMAN IHH_HUMAN] Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Kavran, J M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Leahy, D J~~]]	+	[[Category: Kavran JM]]
-	[[Category: ~~Binding site]]~~	+	[[Category: Leahy DJ]]
-	~~[[Category: Cell adhesion molecule]]~~	+
-	~~[[Category: Cell cycle protein]]~~	+
-	~~[[Category: Cell line]]~~	+
-	~~[[Category: Cell surface]]~~	+
-	~~[[Category: Conserved sequence]]~~	+
-	~~[[Category: Fibronectin]]~~	+
-	~~[[Category: Hedgehog protein]]~~	+
-	~~[[Category: Immunoglobulin g]]~~	+
-	~~[[Category: Membrane glycoprotein]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Sequence homology]]~~	+
-	~~[[Category: Signal transduction]]~~	+
-	~~[[Category: Tertiary]]~~	+
-	~~[[Category: Tumor suppressor protein~~]]	+

OCA at 13:45, 16 January 2019

OCA — Wed, 16 Jan 2019 13:45:45 GMT

←Older revision		Revision as of 13:45, 16 January 2019
Line 17:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/3n1f_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/3n1f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:08, 5 August 2016

OCA — Fri, 05 Aug 2016 18:08:06 GMT

←Older revision		Revision as of 18:08, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of IhhN bound to CDOFn3==		==Crystal Structure of IhhN bound to CDOFn3==
	<StructureSection load='3n1f' size='340' side='right' caption='[[3n1f]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3n1f' size='340' side='right' caption='[[3n1f]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n1f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N1F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n1f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N1F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n1g\|3n1g]], [[3n1m\|3n1m]], [[3n1o\|3n1o]], [[3n1p\|3n1p]], [[3n1q\|3n1q]], [[3n1r\|3n1r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n1g\|3n1g]], [[3n1m\|3n1m]], [[3n1o\|3n1o]], [[3n1p\|3n1p]], [[3n1q\|3n1q]], [[3n1r\|3n1r]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IHH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), CDON, CDO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IHH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CDON, CDO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n1f RCSB], [http://www.ebi.ac.uk/pdbsum/3n1f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1f OCA], [http://pdbe.org/3n1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n1f RCSB], [http://www.ebi.ac.uk/pdbsum/3n1f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n1f ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:[http://omim.org/entry/614226 614226]]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.	+	[[http://www.uniprot.org/uniprot/IHH_HUMAN IHH_HUMAN]] Brachydactyly type A1;Acrocapitofemoral dysplasia. Defects in IHH are the cause of brachydactyly type A1 (BDA1) [MIM:[http://omim.org/entry/112500 112500]]. BDA1 is an autosomal dominant disorder characterized by middle phalanges of all the digits rudimentary or fused with the terminal phalanges. The proximal phalanges of the thumbs and big toes are short.<ref>PMID:11455389</ref> <ref>PMID:12384778</ref> Defects in IHH are a cause of acrocapitofemoral dysplasia (ACFD) [MIM:[http://omim.org/entry/607778 607778]]. ACFD is a disorder characterized by short stature of variable severity with postnatal onset. The most constant radiographic abnormalities are observed in the tubular bones of the hands and in the proximal part of the femur. Cone-shaped epiphyses or a similar epiphyseal configuration with premature epimetaphyseal fusion result in shortening of the skeletal components involved. Cone-shaped epiphyses were also present to a variable extent at the shoulders, knees, and ankles.<ref>PMID:12632327</ref> [[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:[http://omim.org/entry/614226 614226]]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).	+	[[http://www.uniprot.org/uniprot/IHH_HUMAN IHH_HUMAN]] Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). [[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n1f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3n1f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Kavran, J M]]		[[Category: Kavran, J M]]
	[[Category: Leahy, D J]]		[[Category: Leahy, D J]]

OCA at 18:01, 18 December 2014

OCA — Thu, 18 Dec 2014 18:01:30 GMT

←Older revision		Revision as of 18:01, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3n1f\| PDB=3n1f \| SCENE= }}~~	+	==Crystal Structure of IhhN bound to CDOFn3==
-	===Crystal Structure of IhhN bound to CDOFn3===	+	<StructureSection load='3n1f' size='340' side='right' caption='[[3n1f]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20519495}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3n1f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N1F FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n1g\|3n1g]], [[3n1m\|3n1m]], [[3n1o\|3n1o]], [[3n1p\|3n1p]], [[3n1q\|3n1q]], [[3n1r\|3n1r]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IHH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CDON, CDO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n1f RCSB], [http://www.ebi.ac.uk/pdbsum/3n1f PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:[http://omim.org/entry/614226 614226]]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.		[[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:[http://omim.org/entry/614226 614226]]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).		[[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/3n1f_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hedgehog (Hh) signaling proteins stimulate cell proliferation, differentiation, and tissue patterning at multiple points in animal development. A single Hh homolog is present in Drosophila, but three Hh homologs, Sonic Hh, Indian Hh, and Desert Hh, are present in mammals. Distribution, movement, and reception of Hh signals are tightly regulated, and abnormal Hh signaling is associated with developmental defects and cancer. In addition to the integral membrane proteins Patched and Smoothened, members of the Drosophila Ihog family of adhesion-like molecules have recently been shown to bind Hh proteins with micromolar affinity and positively regulate Hh signaling. Cell adhesion molecule-related, down-regulated by oncogenes (CDO) and Brother of CDO (BOC) are the closest mammalian relatives of Drosophila Ihog, and CDO binds Sonic Hh with micromolar affinity and positively regulates Hh signaling. Despite these similarities, structural and biochemical studies have shown that Ihog and CDO utilize nonorthologous domains and completely different binding modes to interact with cognate Hh proteins. We report here biochemical and x-ray structural studies of Sonic, Indian, and Desert Hh proteins both alone and complexed with active domains of CDO and BOC. These results show that all mammalian Hh proteins bind CDO and BOC in the same manner. We also show that interactions between Hh proteins and CDO are weakened at low pH. Formation of Hh-mediated Hh oligomers is thought to be an important feature of normal Hh signaling, but no conserved self-interaction between Hh proteins is apparent from inspection of 14 independent Hh-containing crystal lattices.

-	~~==About this Structure==~~	+	All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.,Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ J Biol Chem. 2010 Aug 6;285(32):24584-90. Epub 2010 Jun 1. PMID:20519495<ref>PMID:20519495</ref>
-	~~[[3n1f]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3N1F OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020519495</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Kavran, J M.]]	+	[[Category: Kavran, J M]]
-	[[Category: Leahy, D J.]]	+	[[Category: Leahy, D J]]
	[[Category: Binding site]]		[[Category: Binding site]]
	[[Category: Cell adhesion molecule]]		[[Category: Cell adhesion molecule]]

OCA: Protected "3n1f" [edit=sysop:move=sysop]

OCA — Mon, 25 Mar 2013 03:03:31 GMT

Protected "3n1f" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:03, 25 March 2013

OCA at 03:03, 25 March 2013

OCA — Mon, 25 Mar 2013 03:03:30 GMT

←Older revision		Revision as of 03:03, 25 March 2013
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-	{{Seed}}
-	[[Image:3n1f.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3n1f", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3n1f\| PDB=3n1f \| SCENE= }}		{{STRUCTURE_3n1f\| PDB=3n1f \| SCENE= }}
-
	===Crystal Structure of IhhN bound to CDOFn3===		===Crystal Structure of IhhN bound to CDOFn3===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20519495}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20519495 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20519495}}		{{ABSTRACT_PUBMED_20519495}}

	==Disease==		==Disease==
-	~~Known disease associated with this structure: Acrocapitofemoral dysplasia OMIM:~~[[http://www.~~ncbi~~.~~nlm.nih.gov~~/~~entrez~~/~~dispomim.cgi?id=600726 600726~~]]~~, Brachydactyly,~~ type ~~A1 OMIM~~:[[http://~~www~~.~~ncbi~~.~~nlm~~.~~nih~~.~~gov~~/~~entrez~~/~~dispomim~~.~~cgi?id=600726 600726~~]]	+	[[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:[http://omim.org/entry/614226 614226]]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

	==About this Structure==		==About this Structure==
-	~~3N1F~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA].	+	[[3n1f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20519495~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020519495</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kavran, J M.]]		[[Category: Kavran, J M.]]
	[[Category: Leahy, D J.]]		[[Category: Leahy, D J.]]
	[[Category: Binding site]]		[[Category: Binding site]]
-	[[Category: Calcium]]
	[[Category: Cell adhesion molecule]]		[[Category: Cell adhesion molecule]]
	[[Category: Cell cycle protein]]		[[Category: Cell cycle protein]]
Line 48:		Line 34:
	[[Category: Tertiary]]		[[Category: Tertiary]]
	[[Category: Tumor suppressor protein]]		[[Category: Tumor suppressor protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:13:03 2010''

OCA at 04:08, 16 June 2010

OCA — Wed, 16 Jun 2010 04:08:25 GMT

←Older revision		Revision as of 04:08, 16 June 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3n1f.~~jpg~~\|left\|200px]]	+	[[Image:3n1f.png\|left\|200px]]

	<!--		<!--
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	===Crystal Structure of IhhN bound to CDOFn3===		===Crystal Structure of IhhN bound to CDOFn3===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20519495}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20519495 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20519495}}

	==Disease==		==Disease==
Line 18:		Line 24:
	==About this Structure==		==About this Structure==
	3N1F is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA].		3N1F is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20519495</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kavran, J M.]]		[[Category: Kavran, J M.]]
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	[[Category: Tumor suppressor protein]]		[[Category: Tumor suppressor protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:40:40 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:13:03 2010''

OCA at 04:36, 2 June 2010

OCA — Wed, 02 Jun 2010 04:36:12 GMT

←Older revision		Revision as of 04:36, 2 June 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3n1f.jpg\|left\|200px]]

-	The ~~entry 3n1f~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3n1f", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3n1f\| PDB=3n1f \| SCENE= }}

-	~~Authors: Kavran, J.M., Leahy, D.J.~~	+	===Crystal Structure of IhhN bound to CDOFn3===

-	Description: Crystal Structure of IhhN bound to CDOFn3

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 26~~ 08:23:06 2010''	+	==Disease==
		+	Known disease associated with this structure: Acrocapitofemoral dysplasia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600726 600726]], Brachydactyly, type A1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600726 600726]]
		+
		+	==About this Structure==
		+	3N1F is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Kavran, J M.]]
		+	[[Category: Leahy, D J.]]
		+	[[Category: Binding site]]
		+	[[Category: Calcium]]
		+	[[Category: Cell adhesion molecule]]
		+	[[Category: Cell cycle protein]]
		+	[[Category: Cell line]]
		+	[[Category: Cell surface]]
		+	[[Category: Conserved sequence]]
		+	[[Category: Fibronectin]]
		+	[[Category: Hedgehog protein]]
		+	[[Category: Immunoglobulin g]]
		+	[[Category: Membrane glycoprotein]]
		+	[[Category: Membrane protein]]
		+	[[Category: Protein binding]]
		+	[[Category: Receptor]]
		+	[[Category: Sequence homology]]
		+	[[Category: Signal transduction]]
		+	[[Category: Tertiary]]
		+	[[Category: Tumor suppressor protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:40:40 2010''

OCA: New page: '''Unreleased structure''' The entry 3n1f is ON HOLD until Paper Publication Authors: Kavran, J.M., Leahy, D.J. Description: Crystal Structure of IhhN bound to CDOFn3 ''Page seeded by...

OCA — Wed, 26 May 2010 04:18:55 GMT

New page: '''Unreleased structure''' The entry 3n1f is ON HOLD until Paper Publication Authors: Kavran, J.M., Leahy, D.J. Description: Crystal Structure of IhhN bound to CDOFn3 ''Page seeded by...

New page

'''Unreleased structure'''

The entry 3n1f is ON HOLD until Paper Publication

Authors: Kavran, J.M., Leahy, D.J.

Description: Crystal Structure of IhhN bound to CDOFn3

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:23:06 2010''