3n3e - Revision history

OCA at 09:07, 6 September 2023

OCA — Wed, 06 Sep 2023 09:07:58 GMT

←Older revision		Revision as of 09:07, 6 September 2023
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	==Zebrafish AlphaA crystallin==		==Zebrafish AlphaA crystallin==
-	<StructureSection load='3n3e' size='340' side='right' caption='[[3n3e]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='3n3e' size='340' side='right'caption='[[3n3e]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n3e]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3N3E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N3E FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~cryaa (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=7955 Brachidanio rerio])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3n3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3e OCA], [~~http~~://pdbe.org/3n3e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3n3e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3n3e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3n3e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3e OCA], [https://pdbe.org/3n3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n3e RCSB], [https://www.ebi.ac.uk/pdbsum/3n3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n3e ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8UUZ6_DANRE Q8UUZ6_DANRE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/3n3e_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/3n3e_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3n3e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3n3e" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Crystallin 3D structures\|Crystallin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
-	[[Category: ~~Eisenberg, D~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Laganowsky, A~~]]	+	[[Category: Eisenberg D]]
-	[[Category: ~~Chaperone]]~~	+	[[Category: Laganowsky A]]
-	~~[[Category: Eye lens transparency]]~~	+
-	~~[[Category: Protein chaperone~~]]	+

OCA at 08:52, 5 August 2016

OCA — Fri, 05 Aug 2016 08:52:00 GMT

←Older revision		Revision as of 08:52, 5 August 2016
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		+
	==Zebrafish AlphaA crystallin==		==Zebrafish AlphaA crystallin==
	<StructureSection load='3n3e' size='340' side='right' caption='[[3n3e]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='3n3e' size='340' side='right' caption='[[3n3e]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Danio_rerio Danio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N3E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N3E FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cryaa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 ~~Danio~~ rerio])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cryaa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n3e RCSB], [http://www.ebi.ac.uk/pdbsum/3n3e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3e OCA], [http://pdbe.org/3n3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n3e RCSB], [http://www.ebi.ac.uk/pdbsum/3n3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n3e ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n3e ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3n3e" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Danio~~ rerio]]	+	[[Category: Brachidanio rerio]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Laganowsky, A]]		[[Category: Laganowsky, A]]

OCA at 15:28, 18 December 2014

OCA — Thu, 18 Dec 2014 15:28:26 GMT

←Older revision		Revision as of 15:28, 18 December 2014
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-	~~{{STRUCTURE_3n3e~~\| ~~PDB~~=3n3e \| ~~SCENE~~= }}	+	==Zebrafish AlphaA crystallin==
-	===~~Zebrafish AlphaA crystallin~~===	+	<StructureSection load='3n3e' size='340' side='right' caption='[[3n3e]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20669149}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3n3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N3E FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cryaa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Danio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n3e RCSB], [http://www.ebi.ac.uk/pdbsum/3n3e PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/3n3e_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In previous work on truncated alpha crystallins (Laganowsky et al., Protein Sci 2010; 19:1031-1043), we determined crystal structures of the alpha crystallin core, a seven beta-stranded immunoglobulin-like domain, with its conserved C-terminal extension. These extensions swap into neighboring cores forming oligomeric assemblies. The extension is palindromic in sequence, binding in either of two directions. Here, we report the crystal structure of a truncated alphaA crystallin (AAC) from zebrafish (Danio rerio) revealing C-terminal extensions in a non three-dimensional (3D) domain swapped, "closed" state. The extension is quasi-palindromic, bound within its own zebrafish core domain, lying in the opposite direction to that of bovine AAC, which is bound within an adjacent core domain (Laganowsky et al., Protein Sci 2010; 19:1031-1043). Our findings establish that the C-terminal extension of alpha crystallin proteins can be either 3D domain swapped or non-3D domain swapped. This duality provides another molecular mechanism for alpha crystallin proteins to maintain the polydispersity that is crucial for eye lens transparency.

-	~~==About this Structure==~~	+	Non-3D domain swapped crystal structure of truncated zebrafish alphaA crystallin.,Laganowsky A, Eisenberg D Protein Sci. 2010 Oct;19(10):1978-84. PMID:20669149<ref>PMID:20669149</ref>
-	~~[[3n3e]] is a 2 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Danio_rerio Danio rerio]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020669149</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Danio rerio]]		[[Category: Danio rerio]]
-	[[Category: Eisenberg, D.]]	+	[[Category: Eisenberg, D]]
-	[[Category: Laganowsky, A.]]	+	[[Category: Laganowsky, A]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Eye lens transparency]]		[[Category: Eye lens transparency]]
	[[Category: Protein chaperone]]		[[Category: Protein chaperone]]

OCA: Protected "3n3e" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 20:58:40 GMT

Protected "3n3e" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:58, 17 April 2013

OCA at 20:58, 17 April 2013

OCA — Wed, 17 Apr 2013 20:58:37 GMT

←Older revision		Revision as of 20:58, 17 April 2013
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-	{{Seed}}
-	[[Image:3n3e.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3n3e", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3n3e\| PDB=3n3e \| SCENE= }}		{{STRUCTURE_3n3e\| PDB=3n3e \| SCENE= }}
-
	===Zebrafish AlphaA crystallin===		===Zebrafish AlphaA crystallin===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20669149}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20669149 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20669149}}		{{ABSTRACT_PUBMED_20669149}}

	==About this Structure==		==About this Structure==
-	~~3N3E~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA].	+	[[3n3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20669149~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020669149</ref><references group="xtra"/><references/>
	[[Category: Danio rerio]]		[[Category: Danio rerio]]
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
Line 30:		Line 14:
	[[Category: Eye lens transparency]]		[[Category: Eye lens transparency]]
	[[Category: Protein chaperone]]		[[Category: Protein chaperone]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:21:35 2010''

OCA at 07:11, 13 October 2010

OCA — Wed, 13 Oct 2010 07:11:47 GMT

←Older revision		Revision as of 07:11, 13 October 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3n3e.~~jpg~~\|left\|200px]]	+	[[Image:3n3e.png\|left\|200px]]

	<!--		<!--
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	===Zebrafish AlphaA crystallin===		===Zebrafish AlphaA crystallin===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20669149}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20669149 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20669149}}

	==About this Structure==		==About this Structure==
	3N3E is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA].		3N3E is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20669149</ref><references group="xtra"/>
	[[Category: Danio rerio]]		[[Category: Danio rerio]]
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
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	[[Category: Protein chaperone]]		[[Category: Protein chaperone]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 11 23~~:58:14 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:21:35 2010''

OCA at 19:50, 11 August 2010

OCA — Wed, 11 Aug 2010 19:50:57 GMT

←Older revision		Revision as of 19:50, 11 August 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3n3e.jpg\|left\|200px]]

-	The ~~entry 3n3e~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3n3e", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3n3e\| PDB=3n3e \| SCENE= }}

-	~~Authors: Laganowsky, A., Eisenberg, D.~~	+	===Zebrafish AlphaA crystallin===

-	Description: Zebrafish AlphaA crystallin

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 10 10~~:58:00 2010''	+	==About this Structure==
		+	3N3E is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3E OCA].
		+	[[Category: Danio rerio]]
		+	[[Category: Eisenberg, D.]]
		+	[[Category: Laganowsky, A.]]
		+	[[Category: Chaperone]]
		+	[[Category: Eye lens transparency]]
		+	[[Category: Protein chaperone]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 11 23:58:14 2010''

OCA at 06:53, 10 June 2010

OCA — Thu, 10 Jun 2010 06:53:13 GMT

←Older revision		Revision as of 06:53, 10 June 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3n3e is ON HOLD	+	The entry 3n3e is ON HOLD until Paper Publication

-	Authors: Laganowsky, ~~Arthur~~, Eisenberg, ~~David~~	+	Authors: Laganowsky, A., Eisenberg, D.

	Description: Zebrafish AlphaA crystallin		Description: Zebrafish AlphaA crystallin

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed May 26 08~~:23:43 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 10:58:00 2010''

OCA: New page: '''Unreleased structure''' The entry 3n3e is ON HOLD Authors: Laganowsky, Arthur, Eisenberg, David Description: Zebrafish AlphaA crystallin ''Page seeded by [http://oca.weizmann.ac.il...

OCA — Wed, 26 May 2010 04:19:32 GMT

New page: '''Unreleased structure''' The entry 3n3e is ON HOLD Authors: Laganowsky, Arthur, Eisenberg, David Description: Zebrafish AlphaA crystallin ''Page seeded by [http://oca.weizmann.ac.il...

New page

'''Unreleased structure'''

The entry 3n3e is ON HOLD

Authors: Laganowsky, Arthur, Eisenberg, David

Description: Zebrafish AlphaA crystallin

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:23:43 2010''