3n3s - Revision history

OCA: Redirecting to 5sxx

OCA — Fri, 09 Sep 2016 16:44:52 GMT

Redirecting to 5sxx

←Older revision		Revision as of 16:44, 9 September 2016
Line 1:		Line 1:
-		+	#REDIRECT [[5sxx]] This PDB entry is obsolete and replaced by 5sxx
-	~~==Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH==~~	+
-	~~<StructureSection load='3n3s' size='340' side='right' caption='~~[[~~3n3s~~]]~~, [[Resolution\|resolution]] 1.70Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	<table><tr><td colspan='2'>[[3n3s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N3S FirstGlance]. <br>	+
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n3n\|3n3n]], [[3n3o\|3n3o]], [[3n3p\|3n3p]], [[3n3q\|3n3q]], [[3n3r\|3n3r]]</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KatG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3s OCA], [http://pdbe.org/3n3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n3s RCSB], [http://www.ebi.ac.uk/pdbsum/3n3s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n3s ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Function ==~~	+
-	~~[[http://www.uniprot.org/uniprot/C6TXM5_BURPE C6TXM5_BURPE]] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity (By similarity).[HAMAP-Rule:MF_01961]~~	+
-	~~== Evolutionary Conservation ==~~	+
-	~~[[Image:Consurf_key_small.gif\|200px\|right]]~~	+
-	~~Check<jmol>~~	+
-	~~<jmolCheckbox>~~	+
-	~~<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/3n3s_consurf.spt"</scriptWhenChecked>~~	+
-	~~<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>~~	+
-	~~<text>to colour the structure by Evolutionary Conservation</text>~~	+
-	~~</jmolCheckbox>~~	+
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n3s ConSurf].	+
-	~~<div style="clear:both"></div>~~	+
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	~~Activation of the pro-drug isoniazid (INH) as an anti-tubercular drug in Mycobacterium tuberculosis involves its conversion to isonicotinyl-NAD, a reaction that requires the catalase-peroxidase KatG.~~ This report shows that the reaction proceeds in the absence of KatG at a slow rate in a mixture of INH, NAD(+), Mn(2+), and O(2), and that the inclusion of KatG increases the rate by >7 times. Superoxide, generated by either Mn(2+)- or KatG-catalyzed reduction of O(2), is an essential intermediate in the reaction. Elimination of the peroxidatic process by mutation slows the rate of reaction by 60% revealing that the peroxidatic process enhances, but is not essential for isonicotinyl-NAD formation. The isonicotinyl-NAD(*+) radical is identified as a reaction intermediate, and ~~its reduction~~ by superoxide is proposed. Binding sites for INH and its co-substrate, NAD(+), are identified for the first time in crystal complexes of Burkholderia pseudomallei catalase-peroxidase with INH and NAD(+) grown by co-crystallization. The best defined INH binding sites were identified, one in each subunit, on the opposite side of the protein from the entrance to the heme cavity in a funnel-shaped channel. The NAD(+) binding site is approximately 20 A from the entrance to the heme cavity and involves interactions primarily with the AMP portion of the molecule in agreement with the NMR saturation transfer difference results.	+
-		+
-	Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.,Wiseman B, Carpena X, Feliz M, Donald LJ, Pons M, Fita I, Loewen PC J Biol Chem. 2010 Aug 20;285(34):26662-73. Epub 2010 Jun 15. PMID:20554537<ref>PMID:20554537</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3n3s" style="background-color:#fffaf0;"></div>~~	+
-		+
-	~~==See Also==~~	+
-	*[[Catalase\|Catalase]]	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Bacillus pseudomallei whitmore 1913]]~~	+
-	~~[[Category: Catalase]]~~	+
-	~~[[Category: Carpena, X]]~~	+
-	~~[[Category: Fita, I]]~~	+
-	~~[[Category: Loewen, P C]]~~	+
-	~~[[Category: Wiseman, B]]~~	+
-	~~[[Category: Catalase-peroxidase]]~~	+
-	~~[[Category: Isoniazid]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pro-drug activation]]~~	+
-	~~[[Category: Tuberculosis]]~~	+

OCA at 00:42, 5 August 2016

OCA — Fri, 05 Aug 2016 00:42:57 GMT

←Older revision		Revision as of 00:42, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH==		==Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH==
	<StructureSection load='3n3s' size='340' side='right' caption='[[3n3s]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3n3s' size='340' side='right' caption='[[3n3s]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n3s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Burkholderia_pseudomallei Burkholderia~~ pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N3S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n3s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N3S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n3n\|3n3n]], [[3n3o\|3n3o]], [[3n3p\|3n3p]], [[3n3q\|3n3q]], [[3n3r\|3n3r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n3n\|3n3n]], [[3n3o\|3n3o]], [[3n3p\|3n3p]], [[3n3q\|3n3q]], [[3n3r\|3n3r]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KatG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 ~~Burkholderia~~ pseudomallei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KatG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n3s RCSB], [http://www.ebi.ac.uk/pdbsum/3n3s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3s OCA], [http://pdbe.org/3n3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n3s RCSB], [http://www.ebi.ac.uk/pdbsum/3n3s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n3s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~C6TXM5_BURPS C6TXM5_BURPS~~]] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity (By similarity).[HAMAP-Rule:MF_01961]	+	[[http://www.uniprot.org/uniprot/C6TXM5_BURPE C6TXM5_BURPE]] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity (By similarity).[HAMAP-Rule:MF_01961]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n3s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3n3s" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Burkholderia~~ pseudomallei]]	+	[[Category: Bacillus pseudomallei whitmore 1913]]
	[[Category: Catalase]]		[[Category: Catalase]]
	[[Category: Carpena, X]]		[[Category: Carpena, X]]

OCA at 14:27, 25 December 2014

OCA — Thu, 25 Dec 2014 14:27:27 GMT

←Older revision		Revision as of 14:27, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n3s RCSB], [http://www.ebi.ac.uk/pdbsum/3n3s PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n3s RCSB], [http://www.ebi.ac.uk/pdbsum/3n3s PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C6TXM5_BURPS C6TXM5_BURPS]] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity (By similarity).[HAMAP-Rule:MF_01961]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:37, 9 December 2014

OCA — Tue, 09 Dec 2014 09:37:11 GMT

←Older revision		Revision as of 09:37, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3n3s.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH==
		+	<StructureSection load='3n3s' size='340' side='right' caption='[[3n3s]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3n3s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N3S FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n3n\|3n3n]], [[3n3o\|3n3o]], [[3n3p\|3n3p]], [[3n3q\|3n3q]], [[3n3r\|3n3r]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KatG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n3s RCSB], [http://www.ebi.ac.uk/pdbsum/3n3s PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/3n3s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activation of the pro-drug isoniazid (INH) as an anti-tubercular drug in Mycobacterium tuberculosis involves its conversion to isonicotinyl-NAD, a reaction that requires the catalase-peroxidase KatG. This report shows that the reaction proceeds in the absence of KatG at a slow rate in a mixture of INH, NAD(+), Mn(2+), and O(2), and that the inclusion of KatG increases the rate by >7 times. Superoxide, generated by either Mn(2+)- or KatG-catalyzed reduction of O(2), is an essential intermediate in the reaction. Elimination of the peroxidatic process by mutation slows the rate of reaction by 60% revealing that the peroxidatic process enhances, but is not essential for isonicotinyl-NAD formation. The isonicotinyl-NAD(*+) radical is identified as a reaction intermediate, and its reduction by superoxide is proposed. Binding sites for INH and its co-substrate, NAD(+), are identified for the first time in crystal complexes of Burkholderia pseudomallei catalase-peroxidase with INH and NAD(+) grown by co-crystallization. The best defined INH binding sites were identified, one in each subunit, on the opposite side of the protein from the entrance to the heme cavity in a funnel-shaped channel. The NAD(+) binding site is approximately 20 A from the entrance to the heme cavity and involves interactions primarily with the AMP portion of the molecule in agreement with the NMR saturation transfer difference results.

-	~~{{STRUCTURE_3n3s\| PDB=3n3s \| SCENE= }}~~	+	Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.,Wiseman B, Carpena X, Feliz M, Donald LJ, Pons M, Fita I, Loewen PC J Biol Chem. 2010 Aug 20;285(34):26662-73. Epub 2010 Jun 15. PMID:20554537<ref>PMID:20554537</ref>

-	~~===Crystal structure~~ of the ~~E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20554537}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3n3s]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA].~~	+

	==See Also==		==See Also==
	*[[Catalase\|Catalase]]		*[[Catalase\|Catalase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020554537<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
	[[Category: Catalase]]		[[Category: Catalase]]
-	[[Category: Carpena, X.]]	+	[[Category: Carpena, X]]
-	[[Category: Fita, I.]]	+	[[Category: Fita, I]]
-	[[Category: Loewen, P C.]]	+	[[Category: Loewen, P C]]
-	[[Category: Wiseman, B.]]	+	[[Category: Wiseman, B]]
	[[Category: Catalase-peroxidase]]		[[Category: Catalase-peroxidase]]
	[[Category: Isoniazid]]		[[Category: Isoniazid]]

OCA at 17:49, 20 October 2012

OCA — Sat, 20 Oct 2012 17:49:06 GMT

←Older revision		Revision as of 17:49, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3n3s]] is a 2 chain structure ~~of [[Catalase]]~~ with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA].	+	[[3n3s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA].

	==See Also==		==See Also==

OCA: Protected "3n3s" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 02:05:13 GMT

Protected "3n3s" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:05, 27 July 2012

OCA at 02:05, 27 July 2012

OCA — Fri, 27 Jul 2012 02:05:11 GMT

←Older revision		Revision as of 02:05, 27 July 2012
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-	{{Seed}}
	[[Image:3n3s.png\|left\|200px]]		[[Image:3n3s.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3n3s", creates the "Structure Box" on the page.
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3n3s\| PDB=3n3s \| SCENE= }}		{{STRUCTURE_3n3s\| PDB=3n3s \| SCENE= }}

	===Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH===		===Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20554537}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20554537 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20554537}}		{{ABSTRACT_PUBMED_20554537}}

	==About this Structure==		==About this Structure==
-	~~3N3S~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA].	+	[[3n3s]] is a 2 chain structure of [[Catalase]] with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA].
		+
		+	==See Also==
		+	*[[Catalase\|Catalase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20554537~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020554537</ref><references group="xtra"/>
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
	[[Category: Catalase]]		[[Category: Catalase]]
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	[[Category: Pro-drug activation]]		[[Category: Pro-drug activation]]
	[[Category: Tuberculosis]]		[[Category: Tuberculosis]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:19:39 2010''

OCA at 09:14, 30 June 2010

OCA — Wed, 30 Jun 2010 09:14:04 GMT

←Older revision		Revision as of 09:14, 30 June 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3n3s.~~jpg~~\|left\|200px]]	+	[[Image:3n3s.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH===		===Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20554537}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20554537 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20554537}}

	==About this Structure==		==About this Structure==
	3N3S is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA].		3N3S is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20554537</ref><references group="xtra"/>
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
	[[Category: Catalase]]		[[Category: Catalase]]
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	[[Category: Tuberculosis]]		[[Category: Tuberculosis]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun ~~16 08~~:43:52 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:19:39 2010''

OCA at 04:38, 16 June 2010

OCA — Wed, 16 Jun 2010 04:38:51 GMT

←Older revision		Revision as of 04:38, 16 June 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3n3s.jpg\|left\|200px]]

-	The ~~entry 3n3s~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3n3s", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3n3s\| PDB=3n3s \| SCENE= }}

-	~~Authors: Loewen, P.C., Wiseman, B., Carpena, X., Fita, I.~~	+	===Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH===

-	Description: Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:28:37 2010''	+	==About this Structure==
		+	3N3S is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3S OCA].
		+	[[Category: Burkholderia pseudomallei]]
		+	[[Category: Catalase]]
		+	[[Category: Carpena, X.]]
		+	[[Category: Fita, I.]]
		+	[[Category: Loewen, P C.]]
		+	[[Category: Wiseman, B.]]
		+	[[Category: Catalase-peroxidase]]
		+	[[Category: Isoniazid]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Pro-drug activation]]
		+	[[Category: Tuberculosis]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:43:52 2010''

OCA at 04:24, 2 June 2010

OCA — Wed, 02 Jun 2010 04:24:10 GMT

←Older revision		Revision as of 04:24, 2 June 2010
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	The entry 3n3s is ON HOLD		The entry 3n3s is ON HOLD

-	Authors: Wiseman, B., Carpena, X~~., Feliz, M., Donald, L. J., Pons, M~~., Fita, I~~., Loewen, P. C~~.	+	Authors: Loewen, P.C., Wiseman, B., Carpena, X., Fita, I.

-	Description: Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH.	+	Description: Crystal structure of the E198A variant of Burkholderia pseudomallei catalase-peroxidase KatG with INH

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 26~~ 08:23:51 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:28:37 2010''