3n57 - Revision history

OCA at 09:58, 14 February 2024

OCA — Wed, 14 Feb 2024 09:58:49 GMT

←Older revision		Revision as of 09:58, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='3n57' size='340' side='right'caption='[[3n57]], [[Resolution\|resolution]] 3.03Å' scene=''>		<StructureSection load='3n57' size='340' side='right'caption='[[3n57]], [[Resolution\|resolution]] 3.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N57 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N57 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.03Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[2g47\|2g47]]~~, [[~~2wby~~\|~~2wby~~]]~~, [[3cww\|3cww]], [[3h44\|3h44]], [[1t34\|1t34]], [[1yk0\|1yk0]], [[3n56\|3n56]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>IDE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN]), NPPA, ANP, PND ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [https://pdbe.org/3n57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [https://www.ebi.ac.uk/pdbsum/3n57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n57 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [https://pdbe.org/3n57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [https://www.ebi.ac.uk/pdbsum/3n57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n57 ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[https://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[https://omim.org/entry/612201 612201]]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[https://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>	+	[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>

	==See Also==		==See Also==
Line 21:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Insulysin~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Funke, T]]	+	[[Category: Funke T]]
-	[[Category: Guo, Q]]	+	[[Category: Guo Q]]
-	[[Category: Tang, W J]]	+	[[Category: Tang W-J]]
-	~~[[Category: A-beta degrading enzyme]]~~	+
-	~~[[Category: Cardiac]]~~	+
-	~~[[Category: Cardiovascular regulation]]~~	+
-	~~[[Category: Cryptidase]]~~	+
-	~~[[Category: Diabetes mellitus]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Human insulin-degradng enzyme]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hormone complex]]~~	+
-	~~[[Category: Insulin]]~~	+
-	~~[[Category: Insulinase]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Metalloprotease]]~~	+
-	~~[[Category: Natriuretic factor]]~~	+
-	~~[[Category: Natriuretic peptide]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 06:55, 12 May 2022

OCA — Thu, 12 May 2022 06:55:15 GMT

←Older revision		Revision as of 06:55, 12 May 2022
Line 1:		Line 1:

	==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)==		==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)==
-	<StructureSection load='3n57' size='340' side='right' caption='[[3n57]], [[Resolution\|resolution]] 3.03Å' scene=''>	+	<StructureSection load='3n57' size='340' side='right'caption='[[3n57]], [[Resolution\|resolution]] 3.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3N57 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N57 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[1t34\|1t34]], [[1yk0\|1yk0]], [[3n56\|3n56]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[1t34\|1t34]], [[1yk0\|1yk0]], [[3n56\|3n56]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDE ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NPPA, ANP, PND ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NPPA, ANP, PND ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [~~http~~://pdbe.org/3n57 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3n57 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3n57 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [https://pdbe.org/3n57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [https://www.ebi.ac.uk/pdbsum/3n57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n57 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[~~http~~://omim.org/entry/612201 612201]]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref>	+	[[https://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[https://omim.org/entry/612201 612201]]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[~~http~~://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>	+	[[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[https://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>
		+
		+	==See Also==
		+	*[[Insulin-degrading enzyme 3D structures\|Insulin-degrading enzyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 23:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Insulysin]]		[[Category: Insulysin]]
		+	[[Category: Large Structures]]
	[[Category: Funke, T]]		[[Category: Funke, T]]
	[[Category: Guo, Q]]		[[Category: Guo, Q]]

OCA at 08:23, 8 November 2017

OCA — Wed, 08 Nov 2017 08:23:57 GMT

←Older revision		Revision as of 08:23, 8 November 2017
Line 14:		Line 14:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>		[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>
-
-	==See Also==
-	*[[Insulin-Degrading Enzyme\|Insulin-Degrading Enzyme]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:55, 4 August 2016

OCA — Thu, 04 Aug 2016 20:55:44 GMT

←Older revision		Revision as of 20:55, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)==		==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)==
	<StructureSection load='3n57' size='340' side='right' caption='[[3n57]], [[Resolution\|resolution]] 3.03Å' scene=''>		<StructureSection load='3n57' size='340' side='right' caption='[[3n57]], [[Resolution\|resolution]] 3.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N57 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N57 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[1t34\|1t34]], [[1yk0\|1yk0]], [[3n56\|3n56]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[1t34\|1t34]], [[1yk0\|1yk0]], [[3n56\|3n56]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), NPPA, ANP, PND ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NPPA, ANP, PND ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [http://www.ebi.ac.uk/pdbsum/3n57 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [http://pdbe.org/3n57 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [http://www.ebi.ac.uk/pdbsum/3n57 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n57 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Insulysin]]		[[Category: Insulysin]]
	[[Category: Funke, T]]		[[Category: Funke, T]]

OCA at 17:55, 18 December 2014

OCA — Thu, 18 Dec 2014 17:55:40 GMT

←Older revision		Revision as of 17:55, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3n57\| PDB=3n57 \| SCENE= }}~~	+	==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)==
-	===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)===	+	<StructureSection load='3n57' size='340' side='right' caption='[[3n57]], [[Resolution\|resolution]] 3.03Å' scene=''>
-	~~{{ABSTRACT_PUBMED_021098034}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N57 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[http://omim.org/entry/612201 612201]]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g47\|2g47]], [[2wby\|2wby]], [[3cww\|3cww]], [[3h44\|3h44]], [[1t34\|1t34]], [[1yk0\|1yk0]], [[3n56\|3n56]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IDE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), NPPA, ANP, PND ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==Function==	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
-	[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref><ref>PMID:17613531</ref><ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [http://www.ebi.ac.uk/pdbsum/3n57 PDBsum]</span></td></tr>
-		+	</table>
-	~~==About this Structure==~~	+	== Disease ==
-	[[3n57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA].	+	[[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[http://omim.org/entry/612201 612201]]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>

	==See Also==		==See Also==
	*[[Insulin-Degrading Enzyme\|Insulin-Degrading Enzyme]]		*[[Insulin-Degrading Enzyme\|Insulin-Degrading Enzyme]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021098034</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Insulysin]]		[[Category: Insulysin]]
-	[[Category: Funke, T.]]	+	[[Category: Funke, T]]
-	[[Category: Guo, Q.]]	+	[[Category: Guo, Q]]
-	[[Category: Tang, W J.]]	+	[[Category: Tang, W J]]
	[[Category: A-beta degrading enzyme]]		[[Category: A-beta degrading enzyme]]
	[[Category: Cardiac]]		[[Category: Cardiac]]
Line 35:		Line 38:
	[[Category: Insulin]]		[[Category: Insulin]]
	[[Category: Insulinase]]		[[Category: Insulinase]]
-	[[Category: Insulysin]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Metalloprotease]]		[[Category: Metalloprotease]]

OCA at 02:55, 25 March 2013

OCA — Mon, 25 Mar 2013 02:55:21 GMT

←Older revision		Revision as of 02:55, 25 March 2013
Line 1:		Line 1:
-	[[Image:3n57.png\|left\|200px]]
-
	{{STRUCTURE_3n57\| PDB=3n57 \| SCENE= }}		{{STRUCTURE_3n57\| PDB=3n57 \| SCENE= }}
-
	===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)===		===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)===
		+	{{ABSTRACT_PUBMED_021098034}}

-	~~{{ABSTRACT_PUBMED_021098034}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[http://omim.org/entry/612201 612201]]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref><ref>PMID:17613531</ref><ref>PMID:18986166</ref> [[http://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021098034</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021098034</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Insulysin]]		[[Category: Insulysin]]

OCA at 17:01, 20 October 2012

OCA — Sat, 20 Oct 2012 17:01:55 GMT

←Older revision		Revision as of 17:01, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3n57]] is a 4 chain structure ~~of [[Insulin-Degrading Enzyme]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA].	+	[[3n57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA].

	==See Also==		==See Also==

OCA: Protected "3n57" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 23:36:24 GMT

Protected "3n57" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:36, 26 July 2012

OCA at 23:36, 26 July 2012

OCA — Thu, 26 Jul 2012 23:36:22 GMT

←Older revision		Revision as of 23:36, 26 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3n57.png\|left\|200px]]
-	[[Image:3n57.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3n57", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3n57\| PDB=3n57 \| SCENE= }}		{{STRUCTURE_3n57\| PDB=3n57 \| SCENE= }}

	===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)===		===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)===

		+	{{ABSTRACT_PUBMED_021098034}}

	==About this Structure==		==About this Structure==
-	~~3N57~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA].	+	[[3n57]] is a 4 chain structure of [[Insulin-Degrading Enzyme]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA].
		+
		+	==See Also==
		+	*[[Insulin-Degrading Enzyme\|Insulin-Degrading Enzyme]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021098034</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Insulysin]]		[[Category: Insulysin]]
Line 40:		Line 40:
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:50:29 2010''

OCA at 21:39, 17 November 2010

OCA — Wed, 17 Nov 2010 21:39:16 GMT

←Older revision		Revision as of 21:39, 17 November 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3n57.jpg\|left\|200px]]

-	The ~~entry 3n57~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3n57", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3n57\| PDB=3n57 \| SCENE= }}

-	~~Authors: Funke, T., Guo, Q., Tang, W.~~-J.	+	===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)===

-	Description:

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 13 10~~:28:47 2010''	+	==About this Structure==
		+	3N57 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Insulysin]]
		+	[[Category: Funke, T.]]
		+	[[Category: Guo, Q.]]
		+	[[Category: Tang, W J.]]
		+	[[Category: A-beta degrading enzyme]]
		+	[[Category: Cardiac]]
		+	[[Category: Cardiovascular regulation]]
		+	[[Category: Cryptidase]]
		+	[[Category: Diabetes mellitus]]
		+	[[Category: Disease mutation]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Hormone]]
		+	[[Category: Human insulin-degradng enzyme]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hormone complex]]
		+	[[Category: Insulin]]
		+	[[Category: Insulinase]]
		+	[[Category: Insulysin]]
		+	[[Category: Metal-binding]]
		+	[[Category: Metalloprotease]]
		+	[[Category: Natriuretic factor]]
		+	[[Category: Natriuretic peptide]]
		+	[[Category: Protease]]
		+	[[Category: Secreted]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:50:29 2010''