3n7n - Revision history

OCA at 10:28, 21 February 2024

OCA — Wed, 21 Feb 2024 10:28:30 GMT

←Older revision		Revision as of 10:28, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3n7n' size='340' side='right'caption='[[3n7n]], [[Resolution\|resolution]] 3.90Å' scene=''>		<StructureSection load='3n7n' size='340' side='right'caption='[[3n7n]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n7n]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3N7N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n7n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N7N FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[3n4r\|3n4r]], [[3n4s\|3n4s]], [[3n4x\|3n4x]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.9Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">CSM1, SPO86, YCR086W, YCR86W ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824]), D9461.25, LRS4, YDR439W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7n OCA], [https://pdbe.org/3n7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n7n RCSB], [https://www.ebi.ac.uk/pdbsum/3n7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7n ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3n7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7n OCA], [~~http~~://pdbe.org/3n7n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3n7n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3n7n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7n ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CSM1_YEAST CSM1_YEAST]] Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Plays also a mitotic role in DNA replication.<ref>PMID:11470404</ref> <ref>PMID:12689592</ref> <ref>PMID:15023545</ref> <ref>PMID:16487579</ref> <ref>PMID:18997772</ref> [[http://www.uniprot.org/uniprot/LRS4_YEAST LRS4_YEAST]] Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing.<ref>PMID:10082585</ref> <ref>PMID:12689592</ref> <ref>PMID:12586695</ref>	+	[https://www.uniprot.org/uniprot/CSM1_YEAST CSM1_YEAST] Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Plays also a mitotic role in DNA replication.<ref>PMID:11470404</ref> <ref>PMID:12689592</ref> <ref>PMID:15023545</ref> <ref>PMID:16487579</ref> <ref>PMID:18997772</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n7n ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n7n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The monopolin complex regulates different types of kinetochore-microtubule attachments in fungi, ensuring sister chromatid co-orientation in Saccharomyces cerevisiae meiosis I and inhibiting merotelic attachment in Schizosaccharomyces pombe mitosis. In addition, the monopolin complex maintains the integrity and silencing of ribosomal DNA (rDNA) repeats in the nucleolus. We show here that the S. cerevisiae Csm1/Lrs4 monopolin subcomplex has a distinctive V-shaped structure, with two pairs of protein-protein interaction domains positioned approximately 10 nm apart. Csm1 presents a conserved hydrophobic surface patch that binds two kinetochore proteins: Dsn1, a subunit of the outer-kinetochore MIND/Mis12 complex, and Mif2/CENP-C. Csm1 point-mutations that disrupt kinetochore-subunit binding also disrupt sister chromatid co-orientation in S. cerevisiae meiosis I. We further show that the same Csm1 point-mutations affect rDNA silencing, probably by disrupting binding to the rDNA-associated protein Tof2. We propose that Csm1/Lrs4 functions as a molecular clamp, crosslinking kinetochore components to enforce sister chromatid co-orientation in S. cerevisiae meiosis I and to suppress merotelic attachment in S. pombe mitosis, and crosslinking rDNA repeats to aid rDNA silencing.
-
-	The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.,Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC Cell. 2010 Aug 20;142(4):556-67. PMID:20723757<ref>PMID:20723757</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3n7n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Corbett, K D~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Harrison, S C~~]]	+	[[Category: Corbett KD]]
-	[[Category: ~~Meiosis]]~~	+	[[Category: Harrison SC]]
-	~~[[Category: Rdna]]~~	+
-	~~[[Category: Replication~~]]	+

OCA at 11:25, 17 July 2019

OCA — Wed, 17 Jul 2019 11:25:42 GMT

←Older revision		Revision as of 11:25, 17 July 2019
Line 1:		Line 1:

	==Structure of Csm1/Lrs4 complex==		==Structure of Csm1/Lrs4 complex==
-	<StructureSection load='3n7n' size='340' side='right' caption='[[3n7n]], [[Resolution\|resolution]] 3.90Å' scene=''>	+	<StructureSection load='3n7n' size='340' side='right'caption='[[3n7n]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3n7n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7N FirstGlance]. <br>		<table><tr><td colspan='2'>[[3n7n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7N FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Corbett, K D]]		[[Category: Corbett, K D]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]

OCA at 13:16, 16 January 2019

OCA — Wed, 16 Jan 2019 13:16:09 GMT

←Older revision		Revision as of 13:16, 16 January 2019
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/3n7n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/3n7n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:18, 4 August 2016

OCA — Thu, 04 Aug 2016 17:18:07 GMT

←Older revision		Revision as of 17:18, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of Csm1/Lrs4 complex==		==Structure of Csm1/Lrs4 complex==
	<StructureSection load='3n7n' size='340' side='right' caption='[[3n7n]], [[Resolution\|resolution]] 3.90Å' scene=''>		<StructureSection load='3n7n' size='340' side='right' caption='[[3n7n]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3n7n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3n7n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7N FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n4r\|3n4r]], [[3n4s\|3n4s]], [[3n4x\|3n4x]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n4r\|3n4r]], [[3n4s\|3n4s]], [[3n4x\|3n4x]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CSM1, SPO86, YCR086W, YCR86W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~]), D9461.25, LRS4, YDR439W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CSM1, SPO86, YCR086W, YCR86W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), D9461.25, LRS4, YDR439W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7n RCSB], [http://www.ebi.ac.uk/pdbsum/3n7n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7n OCA], [http://pdbe.org/3n7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n7n RCSB], [http://www.ebi.ac.uk/pdbsum/3n7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n7n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3n7n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Corbett, K D]]		[[Category: Corbett, K D]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]

OCA at 17:28, 24 December 2014

OCA — Wed, 24 Dec 2014 17:28:40 GMT

←Older revision		Revision as of 17:28, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7n RCSB], [http://www.ebi.ac.uk/pdbsum/3n7n PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7n RCSB], [http://www.ebi.ac.uk/pdbsum/3n7n PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSM1_YEAST CSM1_YEAST]] Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Plays also a mitotic role in DNA replication.<ref>PMID:11470404</ref> <ref>PMID:12689592</ref> <ref>PMID:15023545</ref> <ref>PMID:16487579</ref> <ref>PMID:18997772</ref> [[http://www.uniprot.org/uniprot/LRS4_YEAST LRS4_YEAST]] Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing.<ref>PMID:10082585</ref> <ref>PMID:12689592</ref> <ref>PMID:12586695</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:06, 18 December 2014

OCA — Thu, 18 Dec 2014 15:06:38 GMT

←Older revision		Revision as of 15:06, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3n7n~~\| ~~PDB~~=3n7n \| ~~SCENE~~= }}	+	==Structure of Csm1/Lrs4 complex==
-	===~~Structure~~ of ~~Csm1~~/~~Lrs4 complex~~===	+	<StructureSection load='3n7n' size='340' side='right' caption='[[3n7n]], [[Resolution\|resolution]] 3.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20723757}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3n7n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7N FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3n4r\|3n4r]], [[3n4s\|3n4s]], [[3n4x\|3n4x]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CSM1, SPO86, YCR086W, YCR86W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), D9461.25, LRS4, YDR439W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7n RCSB], [http://www.ebi.ac.uk/pdbsum/3n7n PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/3n7n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The monopolin complex regulates different types of kinetochore-microtubule attachments in fungi, ensuring sister chromatid co-orientation in Saccharomyces cerevisiae meiosis I and inhibiting merotelic attachment in Schizosaccharomyces pombe mitosis. In addition, the monopolin complex maintains the integrity and silencing of ribosomal DNA (rDNA) repeats in the nucleolus. We show here that the S. cerevisiae Csm1/Lrs4 monopolin subcomplex has a distinctive V-shaped structure, with two pairs of protein-protein interaction domains positioned approximately 10 nm apart. Csm1 presents a conserved hydrophobic surface patch that binds two kinetochore proteins: Dsn1, a subunit of the outer-kinetochore MIND/Mis12 complex, and Mif2/CENP-C. Csm1 point-mutations that disrupt kinetochore-subunit binding also disrupt sister chromatid co-orientation in S. cerevisiae meiosis I. We further show that the same Csm1 point-mutations affect rDNA silencing, probably by disrupting binding to the rDNA-associated protein Tof2. We propose that Csm1/Lrs4 functions as a molecular clamp, crosslinking kinetochore components to enforce sister chromatid co-orientation in S. cerevisiae meiosis I and to suppress merotelic attachment in S. pombe mitosis, and crosslinking rDNA repeats to aid rDNA silencing.

-	~~==Function==~~	+	The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.,Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC Cell. 2010 Aug 20;142(4):556-67. PMID:20723757<ref>PMID:20723757</ref>
-	~~[[http://www.uniprot.org/uniprot/CSM1_YEAST CSM1_YEAST]] Component of the~~ monopolin complex ~~which promotes monoorientation during meiosis I, required for~~ chromosome ~~segregation during meiosis~~. ~~Plays also a mitotic role in DNA replication~~.~~<ref>PMID~~:~~11470404</ref> <ref>PMID:12689592</ref> <ref>PMID:15023545</ref> <ref>PMID:16487579</ref> <ref>PMID:18997772</ref> [[http://www~~.uniprot.org/uniprot/LRS4_YEAST LRS4_YEAST]] Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing.<ref>PMID:~~10082585</ref> <ref>PMID:12689592</ref>~~ <ref>PMID:~~12586695~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3n7n]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020723757</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Corbett, K D.]]	+	[[Category: Corbett, K D]]
-	[[Category: Harrison, S C.]]	+	[[Category: Harrison, S C]]
	[[Category: Meiosis]]		[[Category: Meiosis]]
	[[Category: Rdna]]		[[Category: Rdna]]
	[[Category: Replication]]		[[Category: Replication]]

OCA: Protected "3n7n" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 21:09:38 GMT

Protected "3n7n" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:09, 17 April 2013

OCA at 21:09, 17 April 2013

OCA — Wed, 17 Apr 2013 21:09:35 GMT

←Older revision		Revision as of 21:09, 17 April 2013
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-	{{Seed}}
-	[[Image:3n7n.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3n7n", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3n7n\| PDB=3n7n \| SCENE= }}		{{STRUCTURE_3n7n\| PDB=3n7n \| SCENE= }}
-
	===Structure of Csm1/Lrs4 complex===		===Structure of Csm1/Lrs4 complex===
		+	{{ABSTRACT_PUBMED_20723757}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/CSM1_YEAST CSM1_YEAST]] Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Plays also a mitotic role in DNA replication.<ref>PMID:11470404</ref> <ref>PMID:12689592</ref> <ref>PMID:15023545</ref> <ref>PMID:16487579</ref> <ref>PMID:18997772</ref> [[http://www.uniprot.org/uniprot/LRS4_YEAST LRS4_YEAST]] Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing.<ref>PMID:10082585</ref> <ref>PMID:12689592</ref> <ref>PMID:12586695</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20723757}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 20723757 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20723757}}~~	+

	==About this Structure==		==About this Structure==
-	~~3N7N~~ is a 6 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA].	+	[[3n7n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20723757~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020723757</ref><references group="xtra"/><references/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Corbett, K D.]]		[[Category: Corbett, K D.]]
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	[[Category: Rdna]]		[[Category: Rdna]]
	[[Category: Replication]]		[[Category: Replication]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:49:38 2010''

OCA at 05:41, 1 September 2010

OCA — Wed, 01 Sep 2010 05:41:32 GMT

←Older revision		Revision as of 05:41, 1 September 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3n7n.jpg\|left\|200px]]

-	The ~~entry 3n7n~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3n7n", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3n7n\| PDB=3n7n \| SCENE= }}

-	~~Authors: Corbett, K.D., Harrison, S.C.~~	+	===Structure of Csm1/Lrs4 complex===

-	Description: Structure of Csm1/Lrs4 complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 16 08~~:29:22 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20723757}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20723757 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20723757}}
		+
		+	==About this Structure==
		+	3N7N is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7N OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20723757</ref><references group="xtra"/>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Corbett, K D.]]
		+	[[Category: Harrison, S C.]]
		+	[[Category: Meiosis]]
		+	[[Category: Rdna]]
		+	[[Category: Replication]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:49:38 2010''

OCA at 04:24, 16 June 2010

OCA — Wed, 16 Jun 2010 04:24:20 GMT

←Older revision		Revision as of 04:24, 16 June 2010
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3n7n is ON HOLD	+	The entry 3n7n is ON HOLD until Paper Publication

	Authors: Corbett, K.D., Harrison, S.C.		Authors: Corbett, K.D., Harrison, S.C.
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	Description: Structure of Csm1/Lrs4 complex		Description: Structure of Csm1/Lrs4 complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Jun ~~10 10~~:58:22 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:29:22 2010''