3nbj - Revision history

OCA at 09:12, 6 September 2023

OCA — Wed, 06 Sep 2023 09:12:21 GMT

←Older revision		Revision as of 09:12, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3nbj' size='340' side='right'caption='[[3nbj]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3nbj' size='340' side='right'caption='[[3nbj]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nbj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3NBJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nbj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Ogataea_angusta Ogataea angusta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NBJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ME0:HYDROXY-L-METHIONINE'>ME0</scene>, <scene name='pdbligand=TY8:2,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY8</scene>, <scene name='pdbligand=TY9:3,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY9</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ME0:HYDROXY-L-METHIONINE'>ME0</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TY8:2,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY8</scene>, <scene name='pdbligand=TY9:3,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY9</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2v\|1a2v]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbj OCA], [https://pdbe.org/3nbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nbj RCSB], [https://www.ebi.ac.uk/pdbsum/3nbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nbj ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Primary-amine_oxidase Primary-amine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.21 1.4.3.21] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3nbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbj OCA], [~~http~~://pdbe.org/3nbj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nbj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nbj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nbj ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AMO_PICAN AMO_PICAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Primary-amine oxidase~~]]	+	[[Category: Ogataea angusta]]
-	[[Category: Chen, Z]]	+	[[Category: Chen Z]]
-	[[Category: Datta, S]]	+	[[Category: Datta S]]
-	[[Category: DuBois~~, J L~~]]	+	[[Category: DuBois JL]]
-	[[Category: Klinman~~, J P~~]]	+	[[Category: Klinman JP]]
-	[[Category: Mathews~~, F S]]~~	+	[[Category: Mathews FS]]
-	~~[[Category: Amine oxidase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Quinoprotein~~]]	+

OCA at 09:02, 21 October 2020

OCA — Wed, 21 Oct 2020 09:02:56 GMT

←Older revision		Revision as of 09:02, 21 October 2020
Line 1:		Line 1:

	==Crystal Structure of Y305F mutant of the copper amine oxidase from Hansenula polymorpha expressed in yeast==		==Crystal Structure of Y305F mutant of the copper amine oxidase from Hansenula polymorpha expressed in yeast==
-	<StructureSection load='3nbj' size='340' side='right' caption='[[3nbj]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3nbj' size='340' side='right'caption='[[3nbj]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nbj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NBJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nbj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3NBJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ME0:HYDROXY-L-METHIONINE'>ME0</scene>, <scene name='pdbligand=TY8:2,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY8</scene>, <scene name='pdbligand=TY9:3,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY9</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ME0:HYDROXY-L-METHIONINE'>ME0</scene>, <scene name='pdbligand=TY8:2,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY8</scene>, <scene name='pdbligand=TY9:3,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY9</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2v\|1a2v]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2v\|1a2v]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Primary-amine_oxidase Primary-amine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.21 1.4.3.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Primary-amine_oxidase Primary-amine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.21 1.4.3.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbj OCA], [http://pdbe.org/3nbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nbj RCSB], [http://www.ebi.ac.uk/pdbsum/3nbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nbj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3nbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbj OCA], [http://pdbe.org/3nbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nbj RCSB], [http://www.ebi.ac.uk/pdbsum/3nbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nbj ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Copper ~~Amine Oxidase~~\|Copper ~~Amine Oxidase~~]]	+	*[[Copper amine oxidase 3D structures\|Copper amine oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Primary-amine oxidase]]		[[Category: Primary-amine oxidase]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]

OCA at 13:37, 16 January 2019

OCA — Wed, 16 Jan 2019 13:37:59 GMT

←Older revision		Revision as of 13:37, 16 January 2019
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/3nbj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/3nbj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:56, 11 August 2016

OCA — Thu, 11 Aug 2016 07:56:58 GMT

←Older revision		Revision as of 07:56, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Y305F mutant of the copper amine oxidase from Hansenula polymorpha expressed in yeast==		==Crystal Structure of Y305F mutant of the copper amine oxidase from Hansenula polymorpha expressed in yeast==
	<StructureSection load='3nbj' size='340' side='right' caption='[[3nbj]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3nbj' size='340' side='right' caption='[[3nbj]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nbj]] is a 6 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Ogataea_angusta Ogataea angusta]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NBJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nbj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NBJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ME0:HYDROXY-L-METHIONINE'>ME0</scene>, <scene name='pdbligand=TY8:2,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY8</scene>, <scene name='pdbligand=TY9:3,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY9</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ME0:HYDROXY-L-METHIONINE'>ME0</scene>, <scene name='pdbligand=TY8:2,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY8</scene>, <scene name='pdbligand=TY9:3,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY9</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2v\|1a2v]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2v\|1a2v]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=870730 Ogataea angusta])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Primary-amine_oxidase Primary-amine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.21 1.4.3.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Primary-amine_oxidase Primary-amine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.21 1.4.3.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nbj RCSB], [http://www.ebi.ac.uk/pdbsum/3nbj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbj OCA], [http://pdbe.org/3nbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nbj RCSB], [http://www.ebi.ac.uk/pdbsum/3nbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nbj ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nbj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nbj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Ogataea angusta]]
	[[Category: Primary-amine oxidase]]		[[Category: Primary-amine oxidase]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]

OCA at 13:05, 5 January 2015

OCA — Mon, 05 Jan 2015 13:05:59 GMT

←Older revision		Revision as of 13:05, 5 January 2015
Line 1:		Line 1:
-	[[~~Image:~~3nbj.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Y305F mutant of the copper amine oxidase from Hansenula polymorpha expressed in yeast==
		+	<StructureSection load='3nbj' size='340' side='right' caption='[[3nbj]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3nbj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ogataea_angusta Ogataea angusta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NBJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ME0:HYDROXY-L-METHIONINE'>ME0</scene>, <scene name='pdbligand=TY8:2,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY8</scene>, <scene name='pdbligand=TY9:3,4-BIS(HYDROPEROXY)-5-HYDROXY-L-PHENYLALANINE'>TY9</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2v\|1a2v]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AMO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=870730 Ogataea angusta])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Primary-amine_oxidase Primary-amine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.21 1.4.3.21] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nbj RCSB], [http://www.ebi.ac.uk/pdbsum/3nbj PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/3nbj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The copper amine oxidases carry out two copper-dependent processes: production of their own redox-active cofactor (2,4,5-trihydroxyphenylalanine quinone, TPQ) and the subsequent oxidative deamination of substrate amines. Because the same active site pocket must facilitate both reactions, individual active site residues may serve multiple roles. We have examined the roles of a strictly conserved active site tyrosine Y305 in the copper amine oxidase from Hansenula polymorpha kinetically, spetroscopically (Dubois and Klinman (2006) Biochemistry 45, 3178), and, in the present work, structurally. While the Y305A enzyme is almost identical to the wild type, a novel, highly oxygenated species replaces TPQ in the Y305F active sites. This new structure not only provides the first direct detection of peroxy intermediates in cofactor biogenesis but also indicates the critical control of oxidation chemistry that can be conferred by a single active site residue.

-	~~{{STRUCTURE_3nbj\| PDB=3nbj \| SCENE= }}~~	+	Mutation at a strictly conserved, active site tyrosine in the copper amine oxidase leads to uncontrolled oxygenase activity.,Chen ZW, Datta S, Dubois JL, Klinman JP, Mathews FS Biochemistry. 2010 Aug 31;49(34):7393-402. PMID:20684524<ref>PMID:20684524</ref>

-	~~===Crystal Structure of Y305F mutant~~ of the ~~copper amine oxidase from Hansenula polymorpha expressed in yeast===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20684524}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3nbj]] is a 6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ogataea_angusta Ogataea angusta]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA].~~	+

	==See Also==		==See Also==
	*[[Copper Amine Oxidase\|Copper Amine Oxidase]]		*[[Copper Amine Oxidase\|Copper Amine Oxidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020684524<~~/~~ref~~><~~ref group="xtra">PMID:009551552</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Ogataea angusta]]		[[Category: Ogataea angusta]]
	[[Category: Primary-amine oxidase]]		[[Category: Primary-amine oxidase]]
-	[[Category: Chen, Z.]]	+	[[Category: Chen, Z]]
-	[[Category: Datta, S.]]	+	[[Category: Datta, S]]
-	[[Category: DuBois, J L.]]	+	[[Category: DuBois, J L]]
-	[[Category: Klinman, J P.]]	+	[[Category: Klinman, J P]]
-	[[Category: Mathews, F S.]]	+	[[Category: Mathews, F S]]
	[[Category: Amine oxidase]]		[[Category: Amine oxidase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Quinoprotein]]		[[Category: Quinoprotein]]

OCA at 18:22, 20 October 2012

OCA — Sat, 20 Oct 2012 18:22:38 GMT

←Older revision		Revision as of 18:22, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3nbj]] is a 6 chain structure ~~of [[Copper Amine Oxidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Ogataea_angusta Ogataea angusta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA].	+	[[3nbj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ogataea_angusta Ogataea angusta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA].

	==See Also==		==See Also==

OCA at 03:53, 27 July 2012

OCA — Fri, 27 Jul 2012 03:53:31 GMT

←Older revision		Revision as of 03:53, 27 July 2012
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	[[Image:3nbj.png\|left\|200px]]		[[Image:3nbj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3nbj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3nbj\| PDB=3nbj \| SCENE= }}		{{STRUCTURE_3nbj\| PDB=3nbj \| SCENE= }}

	===Crystal Structure of Y305F mutant of the copper amine oxidase from Hansenula polymorpha expressed in yeast===		===Crystal Structure of Y305F mutant of the copper amine oxidase from Hansenula polymorpha expressed in yeast===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20684524}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20684524 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20684524}}		{{ABSTRACT_PUBMED_20684524}}

	==About this Structure==		==About this Structure==
-	[[3nbj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pichia_angusta Pichia~~ angusta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA].	+	[[3nbj]] is a 6 chain structure of [[Copper Amine Oxidase]] with sequence from [http://en.wikipedia.org/wiki/Ogataea_angusta Ogataea angusta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA].
		+
		+	==See Also==
		+	*[[Copper Amine Oxidase\|Copper Amine Oxidase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20684524~~</ref><ref group="xtra">PMID:~~9551552~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020684524</ref><ref group="xtra">PMID:009551552</ref><references group="xtra"/>
-	[[Category: ~~Pichia~~ angusta]]	+	[[Category: Ogataea angusta]]
	[[Category: Primary-amine oxidase]]		[[Category: Primary-amine oxidase]]
	[[Category: Chen, Z.]]		[[Category: Chen, Z.]]

OCA: Protected "3nbj" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 19:12:08 GMT

Protected "3nbj" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:12, 14 March 2011

OCA at 19:12, 14 March 2011

OCA — Mon, 14 Mar 2011 19:12:07 GMT

←Older revision		Revision as of 19:12, 14 March 2011
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-	{{Seed}}
	[[Image:3nbj.png\|left\|200px]]		[[Image:3nbj.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~3NBJ~~ is a 6 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Pichia_angusta Pichia angusta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA].	+	[[3nbj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pichia_angusta Pichia angusta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBJ OCA].

	==Reference==		==Reference==
Line 34:		Line 33:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Quinoprotein]]		[[Category: Quinoprotein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Sep 10 13:33:18 2010''

OCA at 09:24, 10 September 2010

OCA — Fri, 10 Sep 2010 09:24:48 GMT

←Older revision		Revision as of 09:24, 10 September 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3nbj.~~jpg~~\|left\|200px]]	+	[[Image:3nbj.png\|left\|200px]]

	<!--		<!--
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	[[Category: Quinoprotein]]		[[Category: Quinoprotein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Aug 25 08~~:59:20 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Sep 10 13:33:18 2010''