3nf3 - Revision history

OCA at 09:14, 6 September 2023

OCA — Wed, 06 Sep 2023 09:14:19 GMT

←Older revision		Revision as of 09:14, 6 September 2023
Line 1:		Line 1:

	==Crystal structure of BoNT/A LC with JTH-NB-7239 peptide==		==Crystal structure of BoNT/A LC with JTH-NB-7239 peptide==
-	<StructureSection load='3nf3' size='340' side='right' caption='[[3nf3]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3nf3' size='340' side='right'caption='[[3nf3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nf3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NF3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nf3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NF3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NI:NICKEL+(II)+ION'>NI</scene~~>, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">bont/a, boNT/A, bonta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nf3 OCA], [https://pdbe.org/3nf3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nf3 RCSB], [https://www.ebi.ac.uk/pdbsum/3nf3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nf3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nf3 OCA], [~~http~~://pdbe.org/3nf3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nf3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nf3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nf3 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7B8V4_CLOBO Q7B8V4_CLOBO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 31:

	==See Also==		==See Also==
-	*[[Botulinum neurotoxin\|Botulinum neurotoxin]]	+	*[[Botulinum neurotoxin 3D structures\|Botulinum neurotoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus botulinus van ermengem 1896~~]]	+	[[Category: Clostridium botulinum]]
-	[[Category: ~~Zuniga, J E~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Botulinum neurotoxin]]~~	+	[[Category: Zuniga JE]]
-	~~[[Category: Botulism]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhibition]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Metalloprotease]]~~	+
-	~~[[Category: Neuromuscular junction]]~~	+
-	~~[[Category: Neurotransmission]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Snare]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 13:00, 16 January 2019

OCA — Wed, 16 Jan 2019 13:00:26 GMT

←Older revision		Revision as of 13:00, 16 January 2019
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/3nf3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/3nf3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:01, 5 August 2016

OCA — Fri, 05 Aug 2016 04:01:12 GMT

←Older revision		Revision as of 04:01, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of BoNT/A LC with JTH-NB-7239 peptide==		==Crystal structure of BoNT/A LC with JTH-NB-7239 peptide==
	<StructureSection load='3nf3' size='340' side='right' caption='[[3nf3]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3nf3' size='340' side='right' caption='[[3nf3]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nf3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Clostridium_botulinum Clostridium botulinum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NF3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nf3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NF3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bont/a, boNT/A, bonta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 ~~Clostridium botulinum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bont/a, boNT/A, bonta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nf3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nf3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nf3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nf3 OCA], [http://pdbe.org/3nf3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nf3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nf3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nf3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nf3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nf3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Botulinum neurotoxin\|Botulinum neurotoxin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clostridium botulinum~~]]	+	[[Category: Bacillus botulinus van ermengem 1896]]
	[[Category: Zuniga, J E]]		[[Category: Zuniga, J E]]
	[[Category: Botulinum neurotoxin]]		[[Category: Botulinum neurotoxin]]

OCA at 15:51, 18 December 2014

OCA — Thu, 18 Dec 2014 15:51:11 GMT

←Older revision		Revision as of 15:51, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3nf3\| PDB=3nf3 \| SCENE= }}~~	+	==Crystal structure of BoNT/A LC with JTH-NB-7239 peptide==
-	===Crystal structure of BoNT/A LC with JTH-NB-7239 peptide===	+	<StructureSection load='3nf3' size='340' side='right' caption='[[3nf3]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20614028}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3nf3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NF3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bont/a, boNT/A, bonta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 Clostridium botulinum])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nf3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nf3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nf3 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/3nf3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The botulinum neurotoxin serotype A light chain (BoNT/A LC) protease is the catalytic component responsible for the neuroparalysis that is characteristic of the disease state botulism. Three related peptide-like molecules (PLMs) were designed using previous information from co-crystal structures, synthesized, and assayed for in vitro inhibition against BoNT/A LC. Our results indicate these PLMS are competitive inhibitors of the BoNT/A LC protease and their K(i) values are in the nM-range. A co-crystal structure for one of these inhibitors was determined and reveals that the PLM, in accord with the goals of our design strategy, simultaneously involves both ionic interactions via its P1 residue and hydrophobic contacts by means of an aromatic group in the P2' position. The PLM adopts a helical conformation similar to previously determined co-crystal structures of PLMs, although there are also major differences to these other structures such as contacts with specific BoNT/A LC residues. Our structure further demonstrates the remarkable plasticity of the substrate binding cleft of the BoNT/A LC protease and provides a paradigm for iterative structure-based design and development of BoNT/A LC inhibitors.

-	~~==About this Structure==~~	+	Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A.,Zuniga JE, Hammill JT, Drory O, Nuss JE, Burnett JC, Gussio R, Wipf P, Bavari S, Brunger AT PLoS One. 2010 Jun 30;5(6):e11378. PMID:20614028<ref>PMID:20614028</ref>
-	~~[[3nf3]] is a 2 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Clostridium_botulinum Clostridium botulinum]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NF3 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020614028</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Clostridium botulinum]]		[[Category: Clostridium botulinum]]
-	[[Category: Zuniga, J E.]]	+	[[Category: Zuniga, J E]]
	[[Category: Botulinum neurotoxin]]		[[Category: Botulinum neurotoxin]]
	[[Category: Botulism]]		[[Category: Botulism]]

OCA: Protected "3nf3" [edit=sysop:move=sysop]

OCA — Wed, 24 Apr 2013 11:46:29 GMT

Protected "3nf3" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:46, 24 April 2013

OCA at 11:46, 24 April 2013

OCA — Wed, 24 Apr 2013 11:46:27 GMT

←Older revision		Revision as of 11:46, 24 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3nf3.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3nf3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3nf3\| PDB=3nf3 \| SCENE= }}		{{STRUCTURE_3nf3\| PDB=3nf3 \| SCENE= }}
-
	===Crystal structure of BoNT/A LC with JTH-NB-7239 peptide===		===Crystal structure of BoNT/A LC with JTH-NB-7239 peptide===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20614028}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20614028 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20614028}}		{{ABSTRACT_PUBMED_20614028}}

	==About this Structure==		==About this Structure==
-	~~3NF3~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF3 OCA].	+	[[3nf3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20614028~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020614028</ref><references group="xtra"/><references/>
	[[Category: Clostridium botulinum]]		[[Category: Clostridium botulinum]]
	[[Category: Zuniga, J E.]]		[[Category: Zuniga, J E.]]
Line 40:		Line 24:
	[[Category: Snare]]		[[Category: Snare]]
	[[Category: Toxin]]		[[Category: Toxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:21:29 2010''

OCA at 06:15, 21 July 2010

OCA — Wed, 21 Jul 2010 06:15:05 GMT

←Older revision		Revision as of 06:15, 21 July 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3nf3.jpg\|left\|200px]]

-	The ~~entry 3nf3~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3nf3", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3nf3\| PDB=3nf3 \| SCENE= }}

-	~~Authors: Zuniga, J.E.~~	+	===Crystal structure of BoNT/A LC with JTH-NB-7239 peptide===

-	Description: Crystal structure of BoNT/A LC with JTH-NB-7239 peptide

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 16 08~~:31:00 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20614028}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20614028 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20614028}}
		+
		+	==About this Structure==
		+	3NF3 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NF3 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20614028</ref><references group="xtra"/>
		+	[[Category: Clostridium botulinum]]
		+	[[Category: Zuniga, J E.]]
		+	[[Category: Botulinum neurotoxin]]
		+	[[Category: Botulism]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Inhibition]]
		+	[[Category: Membrane]]
		+	[[Category: Metal-binding]]
		+	[[Category: Metalloprotease]]
		+	[[Category: Neuromuscular junction]]
		+	[[Category: Neurotransmission]]
		+	[[Category: Protease]]
		+	[[Category: Secreted]]
		+	[[Category: Snare]]
		+	[[Category: Toxin]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:21:29 2010''

OCA: New page: '''Unreleased structure''' The entry 3nf3 is ON HOLD Authors: Zuniga, J.E. Description: Crystal structure of BoNT/A LC with JTH-NB-7239 peptide ''Page seeded by [http://oca.weizmann.a...

OCA — Wed, 16 Jun 2010 04:25:59 GMT

New page: '''Unreleased structure''' The entry 3nf3 is ON HOLD Authors: Zuniga, J.E. Description: Crystal structure of BoNT/A LC with JTH-NB-7239 peptide ''Page seeded by [http://oca.weizmann.a...

New page

'''Unreleased structure'''

The entry 3nf3 is ON HOLD

Authors: Zuniga, J.E.

Description: Crystal structure of BoNT/A LC with JTH-NB-7239 peptide

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:31:00 2010''