3ngl - Revision history

OCA at 10:00, 14 February 2024

OCA — Wed, 14 Feb 2024 10:00:14 GMT

←Older revision		Revision as of 10:00, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='3ngl' size='340' side='right'caption='[[3ngl]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3ngl' size='340' side='right'caption='[[3ngl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ngl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NGL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ngl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NGL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAP:NADP+NICOTINAMIDE~~-~~ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3ngx\|3ngx]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ngl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngl OCA], [https://pdbe.org/3ngl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ngl RCSB], [https://www.ebi.ac.uk/pdbsum/3ngl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ngl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngl OCA], [https://pdbe.org/3ngl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ngl RCSB], [https://www.ebi.ac.uk/pdbsum/3ngl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FOLD_THEAC FOLD_THEAC]] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate (By similarity).	+	[https://www.uniprot.org/uniprot/FOLD_THEAC FOLD_THEAC] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Folate co-enzymes play a pivotal role in one-carbon transfer cellular processes. Many eukaryotes encode the tri-functional tetrahydrofolate dehydrogenase/cyclohydrolase/synthetase (deh/cyc/syn) enzyme, which consists of a N-terminal bifunctional domain (deh/cyc) and a C-terminal monofunctional domain (syn). Here, we report the first analogous archeal enzyme structures, for the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum (TaMTHFDC) as the native protein and also as its NADP complex. The TaMTHFDC structure is a dimer with a polar interface, as well as a NADP binding site that shows minor conformational change. The orientations of the residues in the NADP binding site do not change on ligand binding, incorporating three water molecules which are hydrogen bonded with phosphate groups of NADP in the structure of the complex. Our structural information will contribute to an improved understanding of the basis of THF and one-carbon metabolism.	+
-		+
-	Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum.,Lee WH, Sung MW, Kim JH, Kim YK, Han A, Hwang KY Biochem Biophys Res Commun. 2011 Mar 18;406(3):459-63. Epub 2011 Feb 17. PMID:21333632<ref>PMID:21333632</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3ngl" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hwang, K Y~~]]	+	[[Category: Thermoplasma acidophilum]]
-	[[Category: ~~Lee, W H~~]]	+	[[Category: Hwang KY]]
-	[[Category: ~~Sung, M W~~]]	+	[[Category: Lee WH]]
-	[[Category: ~~10-methenyltetrahydrofolate]]~~	+	[[Category: Sung MW]]
-	~~[[Category: 10-methenyltetrahydrofolate to 10-formyltetrahydrofolate]]~~	+
-	~~[[Category: 10-methylenetetrahydrofolate to 5]]~~	+
-	~~[[Category: Catalyzes the oxidation of 5]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Methylenetetrahydrofolate dehydrogenase/cyclohydrolase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: The hydrolysis of 5~~]]	+

OCA at 07:01, 12 May 2022

OCA — Thu, 12 May 2022 07:01:26 GMT

←Older revision		Revision as of 07:01, 12 May 2022
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	<StructureSection load='3ngl' size='340' side='right'caption='[[3ngl]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3ngl' size='340' side='right'caption='[[3ngl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ngl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NGL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ngl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NGL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ngx\|3ngx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ngx\|3ngx]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ngl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngl OCA], [~~http~~://pdbe.org/3ngl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ngl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ngl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ngl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngl OCA], [https://pdbe.org/3ngl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ngl RCSB], [https://www.ebi.ac.uk/pdbsum/3ngl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FOLD_THEAC FOLD_THEAC]] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate (By similarity).	+	[[https://www.uniprot.org/uniprot/FOLD_THEAC FOLD_THEAC]] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:11, 14 August 2019

OCA — Wed, 14 Aug 2019 18:11:52 GMT

←Older revision		Revision as of 18:11, 14 August 2019
Line 1:		Line 1:

	==Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum==		==Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum==
-	<StructureSection load='3ngl' size='340' side='right' caption='[[3ngl]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3ngl' size='340' side='right'caption='[[3ngl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ngl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NGL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ngl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NGL FirstGlance]. <br>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hwang, K Y]]		[[Category: Hwang, K Y]]
	[[Category: Lee, W H]]		[[Category: Lee, W H]]

OCA at 11:46, 4 August 2016

OCA — Thu, 04 Aug 2016 11:46:06 GMT

←Older revision		Revision as of 11:46, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum==		==Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum==
	<StructureSection load='3ngl' size='340' side='right' caption='[[3ngl]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3ngl' size='340' side='right' caption='[[3ngl]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ngl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermoplasma_acidophilum Thermoplasma acidophilum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NGL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ngl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NGL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ngx\|3ngx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ngx\|3ngx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ngl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ngl RCSB], [http://www.ebi.ac.uk/pdbsum/3ngl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ngl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngl OCA], [http://pdbe.org/3ngl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ngl RCSB], [http://www.ebi.ac.uk/pdbsum/3ngl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ngl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Thermoplasma acidophilum]]
	[[Category: Hwang, K Y]]		[[Category: Hwang, K Y]]
	[[Category: Lee, W H]]		[[Category: Lee, W H]]

OCA at 14:05, 24 December 2014

OCA — Wed, 24 Dec 2014 14:05:59 GMT

←Older revision		Revision as of 14:05, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ngl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ngl RCSB], [http://www.ebi.ac.uk/pdbsum/3ngl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ngl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ngl RCSB], [http://www.ebi.ac.uk/pdbsum/3ngl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FOLD_THEAC FOLD_THEAC]] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:53, 18 December 2014

OCA — Thu, 18 Dec 2014 17:53:42 GMT

←Older revision		Revision as of 17:53, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ngl\| PDB=3ngl \| SCENE= }}~~	+	==Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum==
-	===Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum===	+	<StructureSection load='3ngl' size='340' side='right' caption='[[3ngl]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21333632}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ngl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NGL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ngx\|3ngx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ngl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ngl RCSB], [http://www.ebi.ac.uk/pdbsum/3ngl PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Folate co-enzymes play a pivotal role in one-carbon transfer cellular processes. Many eukaryotes encode the tri-functional tetrahydrofolate dehydrogenase/cyclohydrolase/synthetase (deh/cyc/syn) enzyme, which consists of a N-terminal bifunctional domain (deh/cyc) and a C-terminal monofunctional domain (syn). Here, we report the first analogous archeal enzyme structures, for the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum (TaMTHFDC) as the native protein and also as its NADP complex. The TaMTHFDC structure is a dimer with a polar interface, as well as a NADP binding site that shows minor conformational change. The orientations of the residues in the NADP binding site do not change on ligand binding, incorporating three water molecules which are hydrogen bonded with phosphate groups of NADP in the structure of the complex. Our structural information will contribute to an improved understanding of the basis of THF and one-carbon metabolism.

-	~~==Function==~~	+	Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum.,Lee WH, Sung MW, Kim JH, Kim YK, Han A, Hwang KY Biochem Biophys Res Commun. 2011 Mar 18;406(3):459-63. Epub 2011 Feb 17. PMID:21333632<ref>PMID:21333632</ref>
-	~~[[http://www.uniprot.org/uniprot/FOLD_THEAC FOLD_THEAC]] Catalyzes the oxidation~~ of 5,10-methylenetetrahydrofolate ~~to 5~~,~~10-methenyltetrahydrofolate and then the hydrolysis of 5~~,~~10-methenyltetrahydrofolate to 10-formyltetrahydrofolate~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ngl]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021333632</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thermoplasma acidophilum]]		[[Category: Thermoplasma acidophilum]]
-	[[Category: Hwang, K Y.]]	+	[[Category: Hwang, K Y]]
-	[[Category: Lee, W H.]]	+	[[Category: Lee, W H]]
-	[[Category: Sung, M W.]]	+	[[Category: Sung, M W]]
	[[Category: 10-methenyltetrahydrofolate]]		[[Category: 10-methenyltetrahydrofolate]]
	[[Category: 10-methenyltetrahydrofolate to 10-formyltetrahydrofolate]]		[[Category: 10-methenyltetrahydrofolate to 10-formyltetrahydrofolate]]

OCA at 11:56, 24 April 2013

OCA — Wed, 24 Apr 2013 11:56:52 GMT

←Older revision		Revision as of 11:56, 24 April 2013
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-	[[Image:3ngl.jpg\|left\|200px]]
-
-	<!--
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	{{STRUCTURE_3ngl\| PDB=3ngl \| SCENE= }}		{{STRUCTURE_3ngl\| PDB=3ngl \| SCENE= }}
-
	===Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum===		===Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum===
		+	{{ABSTRACT_PUBMED_21333632}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/FOLD_THEAC FOLD_THEAC]] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate (By similarity).
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21333632}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 21333632 is~~ the ~~PubMed ID number.~~	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21333632}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21333632~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021333632</ref><references group="xtra"/><references/>
	[[Category: Thermoplasma acidophilum]]		[[Category: Thermoplasma acidophilum]]
	[[Category: Hwang, K Y.]]		[[Category: Hwang, K Y.]]
	[[Category: Lee, W H.]]		[[Category: Lee, W H.]]
	[[Category: Sung, M W.]]		[[Category: Sung, M W.]]
		+	[[Category: 10-methenyltetrahydrofolate]]
		+	[[Category: 10-methenyltetrahydrofolate to 10-formyltetrahydrofolate]]
		+	[[Category: 10-methylenetetrahydrofolate to 5]]
		+	[[Category: Catalyzes the oxidation of 5]]
		+	[[Category: Hydrolase]]
		+	[[Category: Methylenetetrahydrofolate dehydrogenase/cyclohydrolase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: The hydrolysis of 5]]

OCA: Protected "3ngl" [edit=sysop:move=sysop]

OCA — Thu, 21 Apr 2011 10:34:34 GMT

Protected "3ngl" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:34, 21 April 2011

OCA at 10:34, 21 April 2011

OCA — Thu, 21 Apr 2011 10:34:31 GMT

←Older revision		Revision as of 10:34, 21 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3ngl.jpg\|left\|200px]]

-	The ~~entry 3ngl~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ngl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ngl\| PDB=3ngl \| SCENE= }}

-	~~Authors: Sung~~, ~~M.W., Lee, W.H., Hwang, K.Y.~~	+	===Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum===

-	Description: Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Jul 7 08~~:29:~~08 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21333632}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21333632 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21333632}}
		+
		+	==About this Structure==
		+	[[3ngl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21333632</ref><references group="xtra"/>
		+	[[Category: Thermoplasma acidophilum]]
		+	[[Category: Hwang, K Y.]]
		+	[[Category: Lee, W H.]]
		+	[[Category: Sung, M W.]]

OCA at 04:23, 7 July 2010

OCA — Wed, 07 Jul 2010 04:23:17 GMT

←Older revision		Revision as of 04:23, 7 July 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ngl is ON HOLD	+	The entry 3ngl is ON HOLD until Paper Publication

	Authors: Sung, M.W., Lee, W.H., Hwang, K.Y.		Authors: Sung, M.W., Lee, W.H., Hwang, K.Y.
Line 7:		Line 7:
	Description: Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum		Description: Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase / cyclohydrolase from Thermoplasma acidophilum

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 30 13~~:35:31 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 08:29:08 2010''