3ngq - Revision history

OCA at 08:32, 20 March 2024

OCA — Wed, 20 Mar 2024 08:32:28 GMT

←Older revision		Revision as of 08:32, 20 March 2024
Line 1:		Line 1:

	==Crystal structure of the human CNOT6L nuclease domain==		==Crystal structure of the human CNOT6L nuclease domain==
-	<StructureSection load='3ngq' size='340' side='right' caption='[[3ngq]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3ngq' size='340' side='right'caption='[[3ngq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ngq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NGQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ngq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NGQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=1PS:3-PYRIDINIUM~~-1~~-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3ngn\|3ngn]], [[3ngo\|3ngo]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">CNOT6L, CCR4B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ngq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngq OCA], [https://pdbe.org/3ngq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ngq RCSB], [https://www.ebi.ac.uk/pdbsum/3ngq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ngq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngq OCA], [~~http~~://pdbe.org/3ngq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ngq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ngq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN]] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref>	+	[https://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ngq ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ngq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	CCR4, an evolutionarily conserved member of the CCR4-NOT complex, is the main cytoplasmic deadenylase. It contains a C-terminal nuclease domain with homology to the endonuclease-exonuclease-phosphatase (EEP) family of enzymes. We have determined the high-resolution three-dimensional structure of the nuclease domain of CNOT6L, a human homologue of CCR4, by X-ray crystallography using the single-wavelength anomalous dispersion method. This first structure of a deadenylase belonging to the EEP family adopts a complete alpha/beta sandwich fold typical of hydrolases with highly conserved active site residues similar to APE1. The active site of CNOT6L should recognize the RNA substrate through its negatively charged surface. In vitro deadenylase assays confirm the critical active site residues and show that the nuclease domain of CNOT6L exhibits full Mg(2+)-dependent deadenylase activity with strict poly(A) RNA substrate specificity. To understand the structural basis for poly(A) RNA substrate binding, crystal structures of the CNOT6L nuclease domain have also been determined in complex with AMP and poly(A) DNA. The resulting structures suggest a molecular deadenylase mechanism involving a pentacovalent phosphate transition.
-
-	Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.,Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M, Yamamoto T, Rao Z EMBO J. 2010 Aug 4;29(15):2566-76. Epub 2010 Jul 13. PMID:20628353<ref>PMID:20628353</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3ngq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Bartlam, M]]	+	[[Category: Large Structures]]
-	[[Category: Morita, M]]	+	[[Category: Bartlam M]]
-	[[Category: Rao, Z]]	+	[[Category: Morita M]]
-	[[Category: Wang, H]]	+	[[Category: Rao Z]]
-	[[Category: Yamamoto, T]]	+	[[Category: Wang H]]
-	[[Category: Yang, W]]	+	[[Category: Yamamoto T]]
-	~~[[Category: Alpha/beta sandwich fold]]~~	+	[[Category: Yang W]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 13:04, 16 January 2019

OCA — Wed, 16 Jan 2019 13:04:40 GMT

←Older revision		Revision as of 13:04, 16 January 2019
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/3ngq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/3ngq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:26, 5 August 2016

OCA — Fri, 05 Aug 2016 18:26:36 GMT

←Older revision		Revision as of 18:26, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the human CNOT6L nuclease domain==		==Crystal structure of the human CNOT6L nuclease domain==
	<StructureSection load='3ngq' size='340' side='right' caption='[[3ngq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3ngq' size='340' side='right' caption='[[3ngq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ngq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NGQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ngq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NGQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ngn\|3ngn]], [[3ngo\|3ngo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ngn\|3ngn]], [[3ngo\|3ngo]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CNOT6L, CCR4B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CNOT6L, CCR4B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ngq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ngq RCSB], [http://www.ebi.ac.uk/pdbsum/3ngq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ngq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngq OCA], [http://pdbe.org/3ngq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ngq RCSB], [http://www.ebi.ac.uk/pdbsum/3ngq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ngq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ngq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bartlam, M]]		[[Category: Bartlam, M]]
	[[Category: Morita, M]]		[[Category: Morita, M]]

OCA at 20:57, 25 December 2014

OCA — Thu, 25 Dec 2014 20:57:34 GMT

←Older revision		Revision as of 20:57, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ngq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ngq RCSB], [http://www.ebi.ac.uk/pdbsum/3ngq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ngq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ngq RCSB], [http://www.ebi.ac.uk/pdbsum/3ngq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN]] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:54, 18 December 2014

OCA — Thu, 18 Dec 2014 14:54:56 GMT

←Older revision		Revision as of 14:54, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ngq~~\| ~~PDB~~=3ngq \| ~~SCENE~~= }}	+	==Crystal structure of the human CNOT6L nuclease domain==
-	===~~Crystal~~ structure of the ~~human CNOT6L nuclease domain~~===	+	<StructureSection load='3ngq' size='340' side='right' caption='[[3ngq]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20628353}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ngq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NGQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PS:3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE'>1PS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ngn\|3ngn]], [[3ngo\|3ngo]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CNOT6L, CCR4B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ngq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ngq RCSB], [http://www.ebi.ac.uk/pdbsum/3ngq PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/3ngq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CCR4, an evolutionarily conserved member of the CCR4-NOT complex, is the main cytoplasmic deadenylase. It contains a C-terminal nuclease domain with homology to the endonuclease-exonuclease-phosphatase (EEP) family of enzymes. We have determined the high-resolution three-dimensional structure of the nuclease domain of CNOT6L, a human homologue of CCR4, by X-ray crystallography using the single-wavelength anomalous dispersion method. This first structure of a deadenylase belonging to the EEP family adopts a complete alpha/beta sandwich fold typical of hydrolases with highly conserved active site residues similar to APE1. The active site of CNOT6L should recognize the RNA substrate through its negatively charged surface. In vitro deadenylase assays confirm the critical active site residues and show that the nuclease domain of CNOT6L exhibits full Mg(2+)-dependent deadenylase activity with strict poly(A) RNA substrate specificity. To understand the structural basis for poly(A) RNA substrate binding, crystal structures of the CNOT6L nuclease domain have also been determined in complex with AMP and poly(A) DNA. The resulting structures suggest a molecular deadenylase mechanism involving a pentacovalent phosphate transition.

-	~~==Function==~~	+	Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.,Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M, Yamamoto T, Rao Z EMBO J. 2010 Aug 4;29(15):2566-76. Epub 2010 Jul 13. PMID:20628353<ref>PMID:20628353</ref>
-	~~[[http://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN]] Plays a role in the deadenylation~~ of ~~mRNAs in~~ the ~~cytoplasm. Has 3'-5'~~ poly(A) ~~exoribonuclease activity for synthetic poly(A) RNA~~ substrate. ~~May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism~~. ~~Involved in deadenylation~~-~~dependent degradation of CDKN1B mRNA~~.<ref>PMID:~~17452450~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ngq]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020628353</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bartlam, M.]]	+	[[Category: Bartlam, M]]
-	[[Category: Morita, M.]]	+	[[Category: Morita, M]]
-	[[Category: Rao, Z.]]	+	[[Category: Rao, Z]]
-	[[Category: Wang, H.]]	+	[[Category: Wang, H]]
-	[[Category: Yamamoto, T.]]	+	[[Category: Yamamoto, T]]
-	[[Category: Yang, W.]]	+	[[Category: Yang, W]]
	[[Category: Alpha/beta sandwich fold]]		[[Category: Alpha/beta sandwich fold]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA: Protected "3ngq" [edit=sysop:move=sysop]

OCA — Wed, 24 Apr 2013 11:51:06 GMT

Protected "3ngq" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:51, 24 April 2013

OCA at 11:51, 24 April 2013

OCA — Wed, 24 Apr 2013 11:51:01 GMT

←Older revision		Revision as of 11:51, 24 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3ngq.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ngq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ngq\| PDB=3ngq \| SCENE= }}		{{STRUCTURE_3ngq\| PDB=3ngq \| SCENE= }}
-
	===Crystal structure of the human CNOT6L nuclease domain===		===Crystal structure of the human CNOT6L nuclease domain===
		+	{{ABSTRACT_PUBMED_20628353}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN]] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20628353}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20628353 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20628353}}~~	+

	==About this Structure==		==About this Structure==
-	~~3NGQ~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA].	+	[[3ngq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20628353~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020628353</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bartlam, M.]]		[[Category: Bartlam, M.]]
Line 33:		Line 20:
	[[Category: Alpha/beta sandwich fold]]		[[Category: Alpha/beta sandwich fold]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:42:08 2010''

OCA at 08:35, 28 July 2010

OCA — Wed, 28 Jul 2010 08:35:26 GMT

←Older revision		Revision as of 08:35, 28 July 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ngq.jpg\|left\|200px]]

-	The ~~entry 3ngq~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ngq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ngq\| PDB=3ngq \| SCENE= }}

-	~~Authors: Wang, H., Morita, M., Yang, W., Bartlam, M., Yamamoto, T., Rao, Z.~~	+	===Crystal structure of the human CNOT6L nuclease domain===

-	Description: Crystal structure of the human CNOT6L nuclease domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 23 08~~:43:15 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20628353}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20628353 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20628353}}
		+
		+	==About this Structure==
		+	3NGQ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20628353</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bartlam, M.]]
		+	[[Category: Morita, M.]]
		+	[[Category: Rao, Z.]]
		+	[[Category: Wang, H.]]
		+	[[Category: Yamamoto, T.]]
		+	[[Category: Yang, W.]]
		+	[[Category: Alpha/beta sandwich fold]]
		+	[[Category: Hydrolase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:42:08 2010''

OCA: New page: '''Unreleased structure''' The entry 3ngq is ON HOLD Authors: Wang, H., Morita, M., Yang, W., Bartlam, M., Yamamoto, T., Rao, Z. Description: Crystal structure of the human CNOT6L nucl...

OCA — Wed, 23 Jun 2010 04:37:57 GMT

New page: '''Unreleased structure''' The entry 3ngq is ON HOLD Authors: Wang, H., Morita, M., Yang, W., Bartlam, M., Yamamoto, T., Rao, Z. Description: Crystal structure of the human CNOT6L nucl...

New page

'''Unreleased structure'''

The entry 3ngq is ON HOLD

Authors: Wang, H., Morita, M., Yang, W., Bartlam, M., Yamamoto, T., Rao, Z.

Description: Crystal structure of the human CNOT6L nuclease domain

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:43:15 2010''