3nm6 - Revision history

OCA at 00:32, 28 December 2023

OCA — Thu, 28 Dec 2023 00:32:20 GMT

←Older revision		Revision as of 00:32, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='3nm6' size='340' side='right'caption='[[3nm6]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3nm6' size='340' side='right'caption='[[3nm6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nm6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Campylobacter_pylori_j99 Campylobacter~~ pylori ~~j99~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NM6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nm6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_J99 Helicobacter pylori J99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NM6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-~~1~~,3-DIOL'>TRS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.602Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3nm4\|3nm4]], [[3nm5\|3nm5]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">jhp_0082~~, ~~mtn, mtnN, Pfs ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85963 Campylobacter pylori J99])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenosylhomocysteine_nucleosidase Adenosylhomocysteine nucleosidase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~2~~.2.9~~ 3~~.2.2.9]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nm6 OCA], [https://pdbe.org/3nm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nm6 RCSB], [https://www.ebi.ac.uk/pdbsum/3nm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nm6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nm6 OCA], [https://pdbe.org/3nm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nm6 RCSB], [https://www.ebi.ac.uk/pdbsum/3nm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nm6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~MTNN_HELPJ MTNN_HELPJ~~]~~] Responsible for cleavage~~ of the glycosidic bond in ~~both~~ 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) ~~(By similarity)~~.	+	[https://www.uniprot.org/uniprot/MQMTN_HELPJ MQMTN_HELPJ] Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species. Also catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Can also probably use S-adenosylhomocysteine (SAH) as substrate, leading to adenine and S-ribosylhomocysteine. These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2.<ref>PMID:20954236</ref> <ref>PMID:22891633</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenosylhomocysteine nucleosidase]]~~	+	[[Category: Helicobacter pylori J99]]
-	~~[[Category: Campylobacter~~ pylori ~~j99~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Iacopelli~~, N M~~]]	+	[[Category: Iacopelli NM]]
-	[[Category: Ronning~~, D R]]~~	+	[[Category: Ronning DR]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nucleosidase~~]]	+

OCA at 07:05, 12 May 2022

OCA — Thu, 12 May 2022 07:05:59 GMT

←Older revision		Revision as of 07:05, 12 May 2022
Line 1:		Line 1:

	==Helicobacter pylori MTAN complexed with adenine and tris==		==Helicobacter pylori MTAN complexed with adenine and tris==
-	<StructureSection load='3nm6' size='340' side='right' caption='[[3nm6]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3nm6' size='340' side='right'caption='[[3nm6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nm6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Campylobacter_pylori_j99 Campylobacter pylori j99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NM6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nm6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_pylori_j99 Campylobacter pylori j99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NM6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nm4\|3nm4]], [[3nm5\|3nm5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nm4\|3nm4]], [[3nm5\|3nm5]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">jhp_0082, mtn, mtnN, Pfs ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85963 Campylobacter pylori J99])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">jhp_0082, mtn, mtnN, Pfs ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85963 Campylobacter pylori J99])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Adenosylhomocysteine_nucleosidase Adenosylhomocysteine nucleosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.9 3.2.2.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenosylhomocysteine_nucleosidase Adenosylhomocysteine nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.9 3.2.2.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nm6 OCA], [~~http~~://pdbe.org/3nm6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nm6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nm6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nm6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nm6 OCA], [https://pdbe.org/3nm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nm6 RCSB], [https://www.ebi.ac.uk/pdbsum/3nm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nm6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MTNN_HELPJ MTNN_HELPJ]] Responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) (By similarity).	+	[[https://www.uniprot.org/uniprot/MTNN_HELPJ MTNN_HELPJ]] Responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	[[Category: Adenosylhomocysteine nucleosidase]]		[[Category: Adenosylhomocysteine nucleosidase]]
	[[Category: Campylobacter pylori j99]]		[[Category: Campylobacter pylori j99]]
		+	[[Category: Large Structures]]
	[[Category: Iacopelli, N M]]		[[Category: Iacopelli, N M]]
	[[Category: Ronning, D R]]		[[Category: Ronning, D R]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nucleosidase]]		[[Category: Nucleosidase]]

OCA at 08:49, 5 August 2016

OCA — Fri, 05 Aug 2016 08:49:04 GMT

←Older revision		Revision as of 08:49, 5 August 2016
Line 1:		Line 1:
		+
	==Helicobacter pylori MTAN complexed with adenine and tris==		==Helicobacter pylori MTAN complexed with adenine and tris==
	<StructureSection load='3nm6' size='340' side='right' caption='[[3nm6]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3nm6' size='340' side='right' caption='[[3nm6]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Helicobacter_pylori Helicobacter~~ pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NM6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori_j99 Campylobacter pylori j99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NM6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nm4\|3nm4]], [[3nm5\|3nm5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nm4\|3nm4]], [[3nm5\|3nm5]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">jhp_0082, mtn, mtnN, Pfs ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~210 Helicobacter~~ pylori])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">jhp_0082, mtn, mtnN, Pfs ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85963 Campylobacter pylori J99])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteine_nucleosidase Adenosylhomocysteine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.9 3.2.2.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteine_nucleosidase Adenosylhomocysteine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.9 3.2.2.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nm6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nm6 RCSB], [http://www.ebi.ac.uk/pdbsum/3nm6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nm6 OCA], [http://pdbe.org/3nm6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nm6 RCSB], [http://www.ebi.ac.uk/pdbsum/3nm6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nm6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nm6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Adenosylhomocysteine nucleosidase]]		[[Category: Adenosylhomocysteine nucleosidase]]
-	[[Category: ~~Helicobacter~~ pylori]]	+	[[Category: Campylobacter pylori j99]]
	[[Category: Iacopelli, N M]]		[[Category: Iacopelli, N M]]
	[[Category: Ronning, D R]]		[[Category: Ronning, D R]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nucleosidase]]		[[Category: Nucleosidase]]

OCA at 00:54, 25 December 2014

OCA — Thu, 25 Dec 2014 00:54:55 GMT

←Older revision		Revision as of 00:54, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nm6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nm6 RCSB], [http://www.ebi.ac.uk/pdbsum/3nm6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nm6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nm6 RCSB], [http://www.ebi.ac.uk/pdbsum/3nm6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MTNN_HELPJ MTNN_HELPJ]] Responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:26, 18 December 2014

OCA — Thu, 18 Dec 2014 15:26:40 GMT

←Older revision		Revision as of 15:26, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3nm6~~\| ~~PDB~~=3nm6 \| ~~SCENE~~= }}	+	==Helicobacter pylori MTAN complexed with adenine and tris==
-	===Helicobacter pylori ~~MTAN complexed~~ with ~~adenine and tris~~===	+	<StructureSection load='3nm6' size='340' side='right' caption='[[3nm6]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20954236}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3nm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NM6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nm4\|3nm4]], [[3nm5\|3nm5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">jhp_0082, mtn, mtnN, Pfs ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteine_nucleosidase Adenosylhomocysteine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.9 3.2.2.9] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nm6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nm6 RCSB], [http://www.ebi.ac.uk/pdbsum/3nm6 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial enzyme 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) plays a central role in three essential metabolic pathways in bacteria: methionine salvage, purine salvage, and polyamine biosynthesis. Recently, its role in the pathway that leads to the production of autoinducer II, an important component in quorum-sensing, has garnered much interest. Because of this variety of roles, MTAN is an attractive target for developing new classes of inhibitors that influence bacterial virulence and biofilm formation. To gain insight toward the development of new classes of MTAN inhibitors, the interactions between the Helicobacter pylori encoded MTAN and its substrates and substrate analogs were probed using X-ray crystallography. The structures of MTAN, an MTAN-Formycin A complex, and an adenine bound form were solved by molecular replacement and refined to 1.7, 1.8, and 1.6 A, respectively. The ribose binding site in the MTAN and MTAN-adenine co-crystal structures contain a tris[hydroxymethyl]aminomethane molecule, that stabilizes the closed form of the enzyme and displaces a nucleophilic water molecule necessary for catalysis. This research gives insight to the interactions between MTAN and bound ligands that promote closing of the enzyme active site and highlights the potential for designing new classes of MTAN inhibitors using a link/grow or ligand assembly development strategy based on the described H. pylori MTAN crystal structures.

-	~~==Function==~~	+	Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.,Ronning DR, Iacopelli NM, Mishra V Protein Sci. 2010 Oct 15. PMID:20954236<ref>PMID:20954236</ref>
-	~~[[http://www.uniprot.org/uniprot/MTNN_HELPJ MTNN_HELPJ]] Responsible for cleavage of the glycosidic bond~~ in ~~both~~ 5'-methylthioadenosine ~~(MTA) and~~ S-adenosylhomocysteine ~~(SAH) (By similarity)~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3nm6]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Helicobacter_pylori Helicobacter pylori]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020954236</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Adenosylhomocysteine nucleosidase]]		[[Category: Adenosylhomocysteine nucleosidase]]
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
-	[[Category: Iacopelli, N M.]]	+	[[Category: Iacopelli, N M]]
-	[[Category: Ronning, D R.]]	+	[[Category: Ronning, D R]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nucleosidase]]		[[Category: Nucleosidase]]

OCA: Protected "3nm6" [edit=sysop:move=sysop]

OCA — Wed, 24 Apr 2013 11:51:53 GMT

Protected "3nm6" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:51, 24 April 2013

OCA at 11:51, 24 April 2013

OCA — Wed, 24 Apr 2013 11:51:52 GMT

←Older revision		Revision as of 11:51, 24 April 2013
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-	{{Seed}}
-	[[Image:3nm6.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3nm6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3nm6\| PDB=3nm6 \| SCENE= }}		{{STRUCTURE_3nm6\| PDB=3nm6 \| SCENE= }}
-
	===Helicobacter pylori MTAN complexed with adenine and tris===		===Helicobacter pylori MTAN complexed with adenine and tris===
		+	{{ABSTRACT_PUBMED_20954236}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/MTNN_HELPJ MTNN_HELPJ]] Responsible for cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH) (By similarity).
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20954236}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20954236 is~~ the ~~PubMed ID number.~~	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20954236}}~~	+

	==About this Structure==		==About this Structure==
-	~~3NM6~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA].	+	[[3nm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20954236~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020954236</ref><references group="xtra"/><references/>
	[[Category: Adenosylhomocysteine nucleosidase]]		[[Category: Adenosylhomocysteine nucleosidase]]
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
Line 30:		Line 17:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nucleosidase]]		[[Category: Nucleosidase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:21:01 2010''

OCA at 08:08, 8 December 2010

OCA — Wed, 08 Dec 2010 08:08:58 GMT

←Older revision		Revision as of 08:08, 8 December 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3nm6.~~jpg~~\|left\|200px]]	+	[[Image:3nm6.png\|left\|200px]]

	<!--		<!--
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	[[Category: Nucleosidase]]		[[Category: Nucleosidase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 24 14~~:17:16 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:21:01 2010''

OCA at 11:05, 24 November 2010

OCA — Wed, 24 Nov 2010 11:05:46 GMT

←Older revision		Revision as of 11:05, 24 November 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3nm6.jpg\|left\|200px]]

-	The ~~entry 3nm6~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3nm6", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3nm6\| PDB=3nm6 \| SCENE= }}

-	~~Authors: Ronning, D.R., Iacopelli, N.M.~~	+	===Helicobacter pylori MTAN complexed with adenine and tris===

-	Description: Helicobacter pylori MTAN

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 4 08~~:49:02 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20954236}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20954236 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20954236}}
		+
		+	==About this Structure==
		+	3NM6 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NM6 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20954236</ref><references group="xtra"/>
		+	[[Category: Adenosylhomocysteine nucleosidase]]
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Iacopelli, N M.]]
		+	[[Category: Ronning, D R.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nucleosidase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:17:16 2010''

OCA at 04:42, 4 August 2010

OCA — Wed, 04 Aug 2010 04:42:03 GMT

←Older revision		Revision as of 04:42, 4 August 2010
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3nm6 is ON HOLD	+	The entry 3nm6 is ON HOLD until Paper Publication

	Authors: Ronning, D.R., Iacopelli, N.M.		Authors: Ronning, D.R., Iacopelli, N.M.
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	Description: Helicobacter pylori MTAN		Description: Helicobacter pylori MTAN

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 30 13~~:37:05 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 08:49:02 2010''