3nsq - Revision history

OCA at 16:51, 1 November 2023

OCA — Wed, 01 Nov 2023 16:51:13 GMT

←Older revision		Revision as of 16:51, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3nsq' size='340' side='right'caption='[[3nsq]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3nsq' size='340' side='right'caption='[[3nsq]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nsq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NSQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nsq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NSQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CHZ:1,8~~-~~DIHYDROXYANTHRACENE-9~~,~~10-DIONE'>CHZ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3nsp\|3nsp]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHZ:1,8-DIHYDROXYANTHRACENE-9,10-DIONE'>CHZ</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">RXRA~~, ~~NR2B1, RP11~~-~~473E2.1~~-~~002~~, ~~hCG_18150 ([https:~~/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsq OCA], [https://pdbe.org/3nsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nsq RCSB], [https://www.ebi.ac.uk/pdbsum/3nsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nsq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsq OCA], [https://pdbe.org/3nsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nsq RCSB], [https://www.ebi.ac.uk/pdbsum/3nsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nsq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>	+	[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, L]]	+	[[Category: Chen L]]
-	[[Category: Hu, L]]	+	[[Category: Hu L]]
-	[[Category: Hu, T]]	+	[[Category: Hu T]]
-	[[Category: Jiang, H]]	+	[[Category: Jiang H]]
-	[[Category: Li, L]]	+	[[Category: Li L]]
-	[[Category: Shen, X]]	+	[[Category: Shen X]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	[[Category: Zhou, R]]	+	[[Category: Zhou R]]
-	~~[[Category: Nuclear receptor retinoic x recepor alpha ligand binding domain antagonist danthron]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:08, 12 May 2022

OCA — Thu, 12 May 2022 07:08:46 GMT

←Older revision		Revision as of 07:08, 12 May 2022
Line 1:		Line 1:

	==Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron==		==Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron==
-	<StructureSection load='3nsq' size='340' side='right' caption='[[3nsq]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3nsq' size='340' side='right'caption='[[3nsq]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nsq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NSQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nsq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NSQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHZ:1,8-DIHYDROXYANTHRACENE-9,10-DIONE'>CHZ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHZ:1,8-DIHYDROXYANTHRACENE-9,10-DIONE'>CHZ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nsp\|3nsp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nsp\|3nsp]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXRA, NR2B1, RP11-473E2.1-002, hCG_18150 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXRA, NR2B1, RP11-473E2.1-002, hCG_18150 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsq OCA], [~~http~~://pdbe.org/3nsq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nsq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nsq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nsq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsq OCA], [https://pdbe.org/3nsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nsq RCSB], [https://www.ebi.ac.uk/pdbsum/3nsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nsq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>	+	[[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Retinoid X receptor\|Retinoid X receptor]]	+	*[[Retinoid X receptor 3D structures\|Retinoid X receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Hu, L]]		[[Category: Hu, L]]

OCA at 07:51, 5 August 2016

OCA — Fri, 05 Aug 2016 07:51:06 GMT

←Older revision		Revision as of 07:51, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron==		==Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron==
	<StructureSection load='3nsq' size='340' side='right' caption='[[3nsq]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3nsq' size='340' side='right' caption='[[3nsq]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nsq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NSQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nsq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NSQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHZ:1,8-DIHYDROXYANTHRACENE-9,10-DIONE'>CHZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHZ:1,8-DIHYDROXYANTHRACENE-9,10-DIONE'>CHZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nsp\|3nsp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nsp\|3nsp]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXRA, NR2B1, RP11-473E2.1-002, hCG_18150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXRA, NR2B1, RP11-473E2.1-002, hCG_18150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nsq RCSB], [http://www.ebi.ac.uk/pdbsum/3nsq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsq OCA], [http://pdbe.org/3nsq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nsq RCSB], [http://www.ebi.ac.uk/pdbsum/3nsq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nsq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q2NL52_HUMAN Q2NL52_HUMAN~~]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>	+	[[http://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nsq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Hu, L]]		[[Category: Hu, L]]

OCA at 17:03, 25 December 2014

OCA — Thu, 25 Dec 2014 17:03:07 GMT

←Older revision		Revision as of 17:03, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nsq RCSB], [http://www.ebi.ac.uk/pdbsum/3nsq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nsq RCSB], [http://www.ebi.ac.uk/pdbsum/3nsq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q2NL52_HUMAN Q2NL52_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:50, 9 December 2014

OCA — Tue, 09 Dec 2014 13:50:02 GMT

←Older revision		Revision as of 13:50, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3nsq.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron==
		+	<StructureSection load='3nsq' size='340' side='right' caption='[[3nsq]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3nsq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NSQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHZ:1,8-DIHYDROXYANTHRACENE-9,10-DIONE'>CHZ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nsp\|3nsp]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RXRA, NR2B1, RP11-473E2.1-002, hCG_18150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nsq RCSB], [http://www.ebi.ac.uk/pdbsum/3nsq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Retinoic X receptor (RXR) is a promising target for drug discovery against cancer and metabolic syndromes. Here, we identified a specific RXRalpha antagonist, danthron, from the traditional Chinese medicine rhubarb. Danthron repressed all tested RXRalpha-involved response element transcription, including the RXRE, PPRE, FXRE, and LXRE. Results from native PAGE and isothermal titration calorimetry (ITC)-based assays indicated that danthron bound to the tetrameric RXRalpha-LBD in a specific stoichimetric ratio, and such a binding could influence the corepressor SMRT affinity to the receptor. Additionally, a unique tetrameric structure of the apo-RXRalpha ligand-binding domain (LBD) was determined, which exhibited a larger tetramer interface and different ligand-binding pocket size compared with the one previously reported. Together with the biochemical and biophysical results, the determined crystal structure of danthron-soaked RXRalpha-LBD suggested a new mechanism for danthron antagonism to tetrameric RXRalpha. Moreover, the in vivo efficient improvement of insulin sensitivity by danthron was observed in diet-induced obese (DIO) mice. Thus, our findings were expected to supply new insights into the structural basis of RXRalpha antagonist for its further potential therapeutic application.

-	~~{{STRUCTURE_3nsq\| PDB=3nsq \| SCENE= }}~~	+	Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.,Zhang H, Zhou R, Li L, Chen J, Chen L, Li C, Ding H, Yu L, Hu L, Jiang H, Shen X J Biol Chem. 2011 Jan 21;286(3):1868-75. Epub 2010 Nov 17. PMID:21084305<ref>PMID:21084305</ref>

-	~~===Crystal structure~~ of ~~tetrameric RXRalpha-LBD complexed with antagonist danthron===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21084305}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3nsq]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA].~~	+

	==See Also==		==See Also==
	*[[Retinoid X receptor\|Retinoid X receptor]]		*[[Retinoid X receptor\|Retinoid X receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021084305<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, L.]]	+	[[Category: Chen, L]]
-	[[Category: Hu, L.]]	+	[[Category: Hu, L]]
-	[[Category: Hu, T.]]	+	[[Category: Hu, T]]
-	[[Category: Jiang, H.]]	+	[[Category: Jiang, H]]
-	[[Category: Li, L.]]	+	[[Category: Li, L]]
-	[[Category: Shen, X.]]	+	[[Category: Shen, X]]
-	[[Category: Zhang, H.]]	+	[[Category: Zhang, H]]
-	[[Category: Zhou, R.]]	+	[[Category: Zhou, R]]
	[[Category: Nuclear receptor retinoic x recepor alpha ligand binding domain antagonist danthron]]		[[Category: Nuclear receptor retinoic x recepor alpha ligand binding domain antagonist danthron]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 19:13, 20 October 2012

OCA — Sat, 20 Oct 2012 19:13:25 GMT

←Older revision		Revision as of 19:13, 20 October 2012
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	[[Image:3nsq.png\|left\|200px]]		[[Image:3nsq.png\|left\|200px]]

-	<!--
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3nsq\| PDB=3nsq \| SCENE= }}		{{STRUCTURE_3nsq\| PDB=3nsq \| SCENE= }}

	===Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron===		===Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21084305}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21084305 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21084305}}		{{ABSTRACT_PUBMED_21084305}}

	==About this Structure==		==About this Structure==
	[[3nsq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA].		[[3nsq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA].
		+
		+	==See Also==
		+	*[[Retinoid X receptor\|Retinoid X receptor]]

	==Reference==		==Reference==

OCA: Protected "3nsq" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2012 06:21:10 GMT

Protected "3nsq" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:21, 11 April 2012

OCA at 06:21, 11 April 2012

OCA — Wed, 11 Apr 2012 06:21:09 GMT

←Older revision		Revision as of 06:21, 11 April 2012
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-	~~{{Seed}}~~	+	[[Image:3nsq.png\|left\|200px]]
-	[[Image:3nsq.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron===		===Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21084305}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21084305 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21084305}}

	==About this Structure==		==About this Structure==
-	~~3NSQ~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA].	+	[[3nsq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021084305</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, L.]]		[[Category: Chen, L.]]
Line 26:		Line 34:
	[[Category: Nuclear receptor retinoic x recepor alpha ligand binding domain antagonist danthron]]		[[Category: Nuclear receptor retinoic x recepor alpha ligand binding domain antagonist danthron]]
	[[Category: Transcription]]		[[Category: Transcription]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:51:12 2010''

OCA at 21:39, 17 November 2010

OCA — Wed, 17 Nov 2010 21:39:58 GMT

←Older revision		Revision as of 21:39, 17 November 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3nsq.jpg\|left\|200px]]

-	The ~~entry 3nsq~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3nsq", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3nsq\| PDB=3nsq \| SCENE= }}

-	~~Authors: Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.~~	+	===Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron===

-	Description: Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Sep 1 09~~:34:25 2010''	+	==About this Structure==
		+	3NSQ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSQ OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Chen, L.]]
		+	[[Category: Hu, L.]]
		+	[[Category: Hu, T.]]
		+	[[Category: Jiang, H.]]
		+	[[Category: Li, L.]]
		+	[[Category: Shen, X.]]
		+	[[Category: Zhang, H.]]
		+	[[Category: Zhou, R.]]
		+	[[Category: Nuclear receptor retinoic x recepor alpha ligand binding domain antagonist danthron]]
		+	[[Category: Transcription]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:51:12 2010''

OCA at 05:26, 1 September 2010

OCA — Wed, 01 Sep 2010 05:26:17 GMT

←Older revision		Revision as of 05:26, 1 September 2010
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3nsq is ON HOLD	+	The entry 3nsq is ON HOLD until Paper Publication

	Authors: Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.		Authors: Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.
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	Description: Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron		Description: Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug~~ ~~4 08~~:49:49 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:34:25 2010''