3nv3 - Revision history

OCA at 16:51, 1 November 2023

OCA — Wed, 01 Nov 2023 16:51:31 GMT

←Older revision		Revision as of 16:51, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3nv3' size='340' side='right'caption='[[3nv3]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='3nv3' size='340' side='right'caption='[[3nv3]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nv3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3NV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NV3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~"><~~scene name~~='~~pdbligand~~=NI:~~NICKEL+(II)+ION'~~>NI</~~scene~~>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.57Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[3nv1\|3nv1]], [[3nv2\|3nv2]], [[3nv4\|3nv4]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [~~http~~://pdbe.org/3nv3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nv3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nv3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [https://pdbe.org/3nv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [https://www.ebi.ac.uk/pdbsum/3nv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>	+	[https://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kamitori, S]]	+	[[Category: Kamitori S]]
-	[[Category: Yoshida, H]]	+	[[Category: Yoshida H]]
-	~~[[Category: Sugar binding]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 08:08, 4 November 2020

OCA — Wed, 04 Nov 2020 08:08:04 GMT

←Older revision		Revision as of 08:08, 4 November 2020
Line 1:		Line 1:

	==Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide==		==Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide==
-	<StructureSection load='3nv3' size='340' side='right' caption='[[3nv3]], [[Resolution\|resolution]] 1.57Å' scene=''>	+	<StructureSection load='3nv3' size='340' side='right'caption='[[3nv3]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3NV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG~~</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nv1\|3nv1]], [[3nv2\|3nv2]], [[3nv4\|3nv4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nv1\|3nv1]], [[3nv2\|3nv2]], [[3nv4\|3nv4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [http://pdbe.org/3nv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nv3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [http://pdbe.org/3nv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Galectin\|Galectin]]	+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kamitori, S]]		[[Category: Kamitori, S]]
	[[Category: Yoshida, H]]		[[Category: Yoshida, H]]
	[[Category: Sugar binding]]		[[Category: Sugar binding]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 10:29, 30 January 2019

OCA — Wed, 30 Jan 2019 10:29:04 GMT

←Older revision		Revision as of 10:29, 30 January 2019
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3nv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3nv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>,~~ <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nv1\|3nv1]], [[3nv2\|3nv2]], [[3nv4\|3nv4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nv1\|3nv1]], [[3nv2\|3nv2]], [[3nv4\|3nv4]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [http://pdbe.org/3nv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nv3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [http://pdbe.org/3nv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nv3 ProSAT]</span></td></tr>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nv/3nv3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nv/3nv3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:29, 5 August 2016

OCA — Fri, 05 Aug 2016 02:29:28 GMT

←Older revision		Revision as of 02:29, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide==		==Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide==
	<StructureSection load='3nv3' size='340' side='right' caption='[[3nv3]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='3nv3' size='340' side='right' caption='[[3nv3]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NV3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nv1\|3nv1]], [[3nv2\|3nv2]], [[3nv4\|3nv4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nv1\|3nv1]], [[3nv2\|3nv2]], [[3nv4\|3nv4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [http://pdbe.org/3nv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q53FQ0_HUMAN Q53FQ0_HUMAN~~]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>	+	[[http://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nv3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nv3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Kamitori, S]]		[[Category: Kamitori, S]]
	[[Category: Yoshida, H]]		[[Category: Yoshida, H]]
	[[Category: Sugar binding]]		[[Category: Sugar binding]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 15:07, 25 December 2014

OCA — Thu, 25 Dec 2014 15:07:29 GMT

←Older revision		Revision as of 15:07, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q53FQ0_HUMAN Q53FQ0_HUMAN]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:49, 9 December 2014

OCA — Tue, 09 Dec 2014 13:49:06 GMT

←Older revision		Revision as of 13:49, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3nv3.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide==
		+	<StructureSection load='3nv3' size='340' side='right' caption='[[3nv3]], [[Resolution\|resolution]] 1.57Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3nv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NV3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nv1\|3nv1]], [[3nv2\|3nv2]], [[3nv4\|3nv4]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nv3 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv3 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nv/3nv3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Galectin-9, a tandem-repeat-type beta-galactoside-specific animal lectin with two carbohydrate recognition domains (CRDs) at the N- and C-terminal ends, is involved in chemoattraction, apoptosis, and the regulation of cell differentiation and has anti-allergic effects. Its ability to recognize carbohydrates is essential for its biological functions. Human galectin-9 (hG9) has high affinity for branched N-glycan-type oligosaccharides (dissociation constants of 0.16-0.70 mum) and linear beta1-3-linked poly-N-acetyllactosamines (0.09-8.3 mum) and significant affinity for the alpha2-3-sialylated oligosaccharides (17-34 mum). Further, its N-terminal CRD (hG9N) and C-terminal CRD (hG9C) differ in specificity. To elucidate this unique feature of hG9, x-ray structures of hG9C in the free form and in complexes with N-acetyllactosamine, the biantennary pyridylaminated oligosaccharide, and alpha2-3-sialyllactose were determined. They are the first x-ray structural analysis of C-terminal CRD of the tandem-repeat-type galectin. The results clearly revealed the mechanism by which branched and alpha2-3-sialylated oligosaccharides are recognized and explained the difference in specificity between hG9N and hG9C. Based on structural comparisons with other galectins, we propose that the wide entrance for ligand binding and the shallow binding site of hG9C are favorable for branched oligosaccharides and that Arg(221) is responsible for recognizing sialylated oligosaccharides.

-	~~{{STRUCTURE_3nv3\| PDB=3nv3 \| SCENE= }}~~	+	X-ray Structures of Human Galectin-9 C-terminal Domain in Complexes with a Biantennary Oligosaccharide and Sialyllactose.,Yoshida H, Teraoka M, Nishi N, Nakakita S, Nakamura T, Hirashima M, Kamitori S J Biol Chem. 2010 Nov 19;285(47):36969-76. Epub 2010 Sep 22. PMID:20861009<ref>PMID:20861009</ref>

-	~~===Crystal structure~~ of ~~human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20861009}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3nv3]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA].~~	+

	==See Also==		==See Also==
	*[[Galectin\|Galectin]]		*[[Galectin\|Galectin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020861009<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Kamitori, S.]]	+	[[Category: Kamitori, S]]
-	[[Category: Yoshida, H.]]	+	[[Category: Yoshida, H]]
	[[Category: Sugar binding]]		[[Category: Sugar binding]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA: Protected "3nv3" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 18:08:48 GMT

Protected "3nv3" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:08, 20 October 2012

OCA at 18:08, 20 October 2012

OCA — Sat, 20 Oct 2012 18:08:46 GMT

←Older revision		Revision as of 18:08, 20 October 2012
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-	{{Seed}}
	[[Image:3nv3.png\|left\|200px]]		[[Image:3nv3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3nv3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3nv3\| PDB=3nv3 \| SCENE= }}		{{STRUCTURE_3nv3\| PDB=3nv3 \| SCENE= }}

	===Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide===		===Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20861009}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20861009 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20861009}}		{{ABSTRACT_PUBMED_20861009}}

	==About this Structure==		==About this Structure==
-	~~3NV3~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA].	+	[[3nv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA].
		+
		+	==See Also==
		+	*[[Galectin\|Galectin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20861009~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020861009</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kamitori, S.]]		[[Category: Kamitori, S.]]
Line 29:		Line 20:
	[[Category: Sugar binding]]		[[Category: Sugar binding]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:21:57 2010''

OCA at 21:10, 17 November 2010

OCA — Wed, 17 Nov 2010 21:10:43 GMT

←Older revision		Revision as of 21:10, 17 November 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3nv3.~~jpg~~\|left\|200px]]	+	[[Image:3nv3.png\|left\|200px]]

	<!--		<!--
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	===Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide===		===Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20861009}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20861009 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20861009}}

	==About this Structure==		==About this Structure==
	3NV3 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA].		3NV3 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20861009</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Kamitori, S.]]		[[Category: Kamitori, S.]]
Line 21:		Line 30:
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Sep 22 14~~:47:53 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:21:57 2010''

OCA at 11:38, 22 September 2010

OCA — Wed, 22 Sep 2010 11:38:55 GMT

←Older revision		Revision as of 11:38, 22 September 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3nv3.jpg\|left\|200px]]

-	The ~~entry 3nv3~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3nv3", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3nv3\| PDB=3nv3 \| SCENE= }}

-	~~Authors: Yoshida, H., Kamitori, S.~~	+	===Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide===

-	Description: Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 4 08~~:50:09 2010''	+	==About this Structure==
		+	3NV3 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV3 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Kamitori, S.]]
		+	[[Category: Yoshida, H.]]
		+	[[Category: Sugar binding]]
		+	[[Category: Sugar binding protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:47:53 2010''