3nve - Revision history

OCA at 10:01, 14 February 2024

OCA — Wed, 14 Feb 2024 10:01:29 GMT

←Older revision		Revision as of 10:01, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='3nve' size='340' side='right'caption='[[3nve]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3nve' size='340' side='right'caption='[[3nve]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NVE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nve]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NVE FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[3nvf\|3nvf]]~~, [[~~3nvg~~\|~~3nvg~~]]~~, [[3nvh\|3nvh]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nve OCA], [https://pdbe.org/3nve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nve RCSB], [https://www.ebi.ac.uk/pdbsum/3nve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nve ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nve OCA], [https://pdbe.org/3nve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nve RCSB], [https://www.ebi.ac.uk/pdbsum/3nve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nve ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.	+	[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref>	+	[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Prion represents a unique class of pathogens devoid of nucleic acid. The deadly diseases transmitted by it between members of one species and, in certain instances to members of other species, present a public health concern. Transmissibility and the barriers to transmission between species have been suggested to arise from the degree to which a pathological protein conformation from an individual of one species can seed a pathological conformation in another species. However, this hypothesis has never been illustrated at an atomic level. Here we present three X-ray atomic structures of the same segment from human, mouse, and hamster PrP, which is critical for forming amyloid and confers species specificity in PrP seeding experiments. The structures reveal that different sequences encode different steric zippers and suggest that the degree of dissimilarity of these zipper structures gives rise to transmission barriers in prion disease, such as those that protect humans from acquiring bovine spongiform encephalopathy (BSE) and chronic wasting disease (CWD).	+
-		+
-	Atomic structures suggest determinants of transmission barriers in mammalian prion disease.,Apostol MI, Wiltzius JJ, Sawaya MR, Cascio D, Eisenberg D Biochemistry. 2011 Feb 16. PMID:21323366<ref>PMID:21323366</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3nve" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 28:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Apostol, M I~~]]	+	[[Category: Mesocricetus auratus]]
-	[[Category: ~~Eisenberg, D~~]]	+	[[Category: Apostol MI]]
-	[[Category: ~~Sawaya, M R~~]]	+	[[Category: Eisenberg D]]
-	[[Category: ~~Amyloid-like protofibril]]~~	+	[[Category: Sawaya MR]]
-	~~[[Category: Protein fibril~~]]	+

OCA at 07:10, 12 May 2022

OCA — Thu, 12 May 2022 07:10:06 GMT

←Older revision		Revision as of 07:10, 12 May 2022
Line 3:		Line 3:
	<StructureSection load='3nve' size='340' side='right'caption='[[3nve]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3nve' size='340' side='right'caption='[[3nve]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NVE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NVE FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nvf\|3nvf]], [[3nvg\|3nvg]], [[3nvh\|3nvh]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nvf\|3nvf]], [[3nvg\|3nvg]], [[3nvh\|3nvh]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nve OCA], [~~http~~://pdbe.org/3nve PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nve RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nve PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nve ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nve OCA], [https://pdbe.org/3nve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nve RCSB], [https://www.ebi.ac.uk/pdbsum/3nve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nve ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.	+	[[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref>	+	[[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:39, 29 January 2020

OCA — Wed, 29 Jan 2020 16:39:32 GMT

←Older revision		Revision as of 16:39, 29 January 2020
Line 1:		Line 1:

	==MMHFGN segment 138-143 from Syrian Hamster prion==		==MMHFGN segment 138-143 from Syrian Hamster prion==
-	<StructureSection load='3nve' size='340' side='right' caption='[[3nve]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3nve' size='340' side='right'caption='[[3nve]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3nve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NVE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3nve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NVE FirstGlance]. <br>
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Prion\|Prion]]	+	*[[Prion 3D structures\|Prion 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Apostol, M I]]		[[Category: Apostol, M I]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]

OCA at 07:22, 4 August 2016

OCA — Thu, 04 Aug 2016 07:22:49 GMT

←Older revision		Revision as of 07:22, 4 August 2016
Line 1:		Line 1:
		+
	==MMHFGN segment 138-143 from Syrian Hamster prion==		==MMHFGN segment 138-143 from Syrian Hamster prion==
	<StructureSection load='3nve' size='340' side='right' caption='[[3nve]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3nve' size='340' side='right' caption='[[3nve]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3nve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NVE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3nve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NVE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nvf\|3nvf]], [[3nvg\|3nvg]], [[3nvh\|3nvh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nvf\|3nvf]], [[3nvg\|3nvg]], [[3nvh\|3nvh]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nve OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nve RCSB], [http://www.ebi.ac.uk/pdbsum/3nve PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nve OCA], [http://pdbe.org/3nve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nve RCSB], [http://www.ebi.ac.uk/pdbsum/3nve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nve ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nve" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:34, 19 December 2014

OCA — Fri, 19 Dec 2014 06:34:04 GMT

←Older revision		Revision as of 06:34, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3nve\| PDB=3nve \| SCENE= }}~~	+	==MMHFGN segment 138-143 from Syrian Hamster prion==
-	===MMHFGN segment 138-143 from Syrian Hamster prion===	+	<StructureSection load='3nve' size='340' side='right' caption='[[3nve]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21323366}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3nve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NVE FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nvf\|3nvf]], [[3nvg\|3nvg]], [[3nvh\|3nvh]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nve OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nve RCSB], [http://www.ebi.ac.uk/pdbsum/3nve PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.		[[http://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Prion represents a unique class of pathogens devoid of nucleic acid. The deadly diseases transmitted by it between members of one species and, in certain instances to members of other species, present a public health concern. Transmissibility and the barriers to transmission between species have been suggested to arise from the degree to which a pathological protein conformation from an individual of one species can seed a pathological conformation in another species. However, this hypothesis has never been illustrated at an atomic level. Here we present three X-ray atomic structures of the same segment from human, mouse, and hamster PrP, which is critical for forming amyloid and confers species specificity in PrP seeding experiments. The structures reveal that different sequences encode different steric zippers and suggest that the degree of dissimilarity of these zipper structures gives rise to transmission barriers in prion disease, such as those that protect humans from acquiring bovine spongiform encephalopathy (BSE) and chronic wasting disease (CWD).

-	~~==Function==~~	+	Atomic structures suggest determinants of transmission barriers in mammalian prion disease.,Apostol MI, Wiltzius JJ, Sawaya MR, Cascio D, Eisenberg D Biochemistry. 2011 Feb 16. PMID:21323366<ref>PMID:21323366</ref>
-	~~[[http://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role~~ in ~~neuronal development and synaptic plasticity~~. ~~May be required for neuronal myelin sheath maintenance~~. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:~~19059915~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3nve]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3NVE OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Prion\|Prion]]		*[[Prion\|Prion]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021323366</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
-	[[Category: Apostol, M I.]]	+	</StructureSection>
-	[[Category: Eisenberg, D.]]	+	[[Category: Apostol, M I]]
-	[[Category: Sawaya, M R.]]	+	[[Category: Eisenberg, D]]
		+	[[Category: Sawaya, M R]]
	[[Category: Amyloid-like protofibril]]		[[Category: Amyloid-like protofibril]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]

OCA at 09:03, 24 March 2013

OCA — Sun, 24 Mar 2013 09:03:29 GMT

←Older revision		Revision as of 09:03, 24 March 2013
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-	[[Image:3nve.png\|left\|200px]]
-
	{{STRUCTURE_3nve\| PDB=3nve \| SCENE= }}		{{STRUCTURE_3nve\| PDB=3nve \| SCENE= }}
-
	===MMHFGN segment 138-143 from Syrian Hamster prion===		===MMHFGN segment 138-143 from Syrian Hamster prion===
		+	{{ABSTRACT_PUBMED_21323366}}

-	~~{{ABSTRACT_PUBMED_21323366}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021323366</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021323366</ref><references group="xtra"/><references/>
	[[Category: Apostol, M I.]]		[[Category: Apostol, M I.]]
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]

OCA at 13:52, 20 October 2012

OCA — Sat, 20 Oct 2012 13:52:25 GMT

←Older revision		Revision as of 13:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3nve]] is a 2 chain structure ~~of [[Prion]]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA].	+	[[3nve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA].

	==See Also==		==See Also==

OCA at 13:22, 26 July 2012

OCA — Thu, 26 Jul 2012 13:22:43 GMT

←Older revision		Revision as of 13:22, 26 July 2012
Line 1:		Line 1:
	[[Image:3nve.png\|left\|200px]]		[[Image:3nve.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3nve\| PDB=3nve \| SCENE= }}		{{STRUCTURE_3nve\| PDB=3nve \| SCENE= }}

	===MMHFGN segment 138-143 from Syrian Hamster prion===		===MMHFGN segment 138-143 from Syrian Hamster prion===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21323366}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21323366 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21323366}}		{{ABSTRACT_PUBMED_21323366}}

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	==See Also==		==See Also==
-	*[[Prion]]	+	*[[Prion\|Prion]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21323366~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021323366</ref><references group="xtra"/>
	[[Category: Apostol, M I.]]		[[Category: Apostol, M I.]]
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
	[[Category: Sawaya, M R.]]		[[Category: Sawaya, M R.]]
		+	[[Category: Amyloid-like protofibril]]
		+	[[Category: Protein fibril]]

OCA at 04:34, 13 April 2011

OCA — Wed, 13 Apr 2011 04:34:54 GMT

←Older revision		Revision as of 04:34, 13 April 2011
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-	[[Image:3nve.~~jpg~~\|left\|200px]]	+	[[Image:3nve.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	[[3nve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA].	+	[[3nve]] is a 2 chain structure of [[Prion]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NVE OCA].
		+
		+	==See Also==
		+	*[[Prion]]

	==Reference==		==Reference==

OCA: Protected "3nve" [edit=sysop:move=sysop]

OCA — Wed, 02 Mar 2011 07:01:15 GMT

Protected "3nve" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:01, 2 March 2011