3nw8 - Revision history

OCA at 09:22, 6 September 2023

OCA — Wed, 06 Sep 2023 09:22:44 GMT

←Older revision		Revision as of 09:22, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3nw8' size='340' side='right'caption='[[3nw8]], [[Resolution\|resolution]] 2.76Å' scene=''>		<StructureSection load='3nw8' size='340' side='right'caption='[[3nw8]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nw8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hhv-1 Hhv-~~1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NW8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nw8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_KOS Human alphaherpesvirus 1 strain KOS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NW8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MRY:MESO-ERYTHRITOL'>MRY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75915Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gum\|2gum]], [[3nwa\|3nwa]], [[3nwd\|3nwd]], [[3nwf\|3nwf]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MRY:MESO-ERYTHRITOL'>MRY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gB, UL27 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10306 HHV-1])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw8 OCA], [https://pdbe.org/3nw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nw8 RCSB], [https://www.ebi.ac.uk/pdbsum/3nw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw8 OCA], [https://pdbe.org/3nw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nw8 RCSB], [https://www.ebi.ac.uk/pdbsum/3nw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GB_HHV1K GB_HHV1K]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).<ref>PMID:17299053</ref>	+	[https://www.uniprot.org/uniprot/GB_HHV1K GB_HHV1K] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).<ref>PMID:17299053</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hhv-~~1]]	+	[[Category: Human alphaherpesvirus 1 strain KOS]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cohen~~, G H~~]]	+	[[Category: Cohen GH]]
-	[[Category: Eisenberg~~, R J~~]]	+	[[Category: Eisenberg RJ]]
-	[[Category: Heldwein~~, E E~~]]	+	[[Category: Heldwein EE]]
-	[[Category: Lou, H]]	+	[[Category: Lou H]]
-	[[Category: Stampfer~~, S D]]~~	+	[[Category: Stampfer SD]]
-	~~[[Category: Envelope glycoprotein]]~~	+
-	~~[[Category: Glycoprotein b]]~~	+
-	~~[[Category: Herpesvirus 1]]~~	+
-	~~[[Category: Hsv-1]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane fusion]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 07:10, 12 May 2022

OCA — Thu, 12 May 2022 07:10:32 GMT

←Older revision		Revision as of 07:10, 12 May 2022
Line 1:		Line 1:

	==Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, high-pH==		==Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, high-pH==
-	<StructureSection load='3nw8' size='340' side='right' caption='[[3nw8]], [[Resolution\|resolution]] 2.76Å' scene=''>	+	<StructureSection load='3nw8' size='340' side='right'caption='[[3nw8]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nw8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NW8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nw8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NW8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MRY:MESO-ERYTHRITOL'>MRY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MRY:MESO-ERYTHRITOL'>MRY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gum\|2gum]], [[3nwa\|3nwa]], [[3nwd\|3nwd]], [[3nwf\|3nwf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gum\|2gum]], [[3nwa\|3nwa]], [[3nwd\|3nwd]], [[3nwf\|3nwf]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gB, UL27 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10306 HHV-1])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gB, UL27 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10306 HHV-1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3nw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw8 OCA], [~~http~~://pdbe.org/3nw8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3nw8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3nw8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw8 OCA], [https://pdbe.org/3nw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nw8 RCSB], [https://www.ebi.ac.uk/pdbsum/3nw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GB_HHV1K GB_HHV1K]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).<ref>PMID:17299053</ref>	+	[[https://www.uniprot.org/uniprot/GB_HHV1K GB_HHV1K]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).<ref>PMID:17299053</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Hhv-1]]		[[Category: Hhv-1]]
		+	[[Category: Large Structures]]
	[[Category: Cohen, G H]]		[[Category: Cohen, G H]]
	[[Category: Eisenberg, R J]]		[[Category: Eisenberg, R J]]

OCA at 09:19, 5 August 2016

OCA — Fri, 05 Aug 2016 09:19:48 GMT

←Older revision		Revision as of 09:19, 5 August 2016
Line 1:		Line 1:
		+
	==Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, high-pH==		==Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, high-pH==
	<StructureSection load='3nw8' size='340' side='right' caption='[[3nw8]], [[Resolution\|resolution]] 2.76Å' scene=''>		<StructureSection load='3nw8' size='340' side='right' caption='[[3nw8]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3nw8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_herpesvirus_1 Human herpesvirus~~ 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NW8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3nw8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NW8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MRY:MESO-ERYTHRITOL'>MRY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MRY:MESO-ERYTHRITOL'>MRY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gum\|2gum]], [[3nwa\|3nwa]], [[3nwd\|3nwd]], [[3nwf\|3nwf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gum\|2gum]], [[3nwa\|3nwa]], [[3nwd\|3nwd]], [[3nwf\|3nwf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gB, UL27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~10298 Human herpesvirus~~ 1])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gB, UL27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10306 HHV-1])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nw8 RCSB], [http://www.ebi.ac.uk/pdbsum/3nw8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw8 OCA], [http://pdbe.org/3nw8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nw8 RCSB], [http://www.ebi.ac.uk/pdbsum/3nw8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3nw8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human herpesvirus~~ 1]]	+	[[Category: Hhv-1]]
	[[Category: Cohen, G H]]		[[Category: Cohen, G H]]
	[[Category: Eisenberg, R J]]		[[Category: Eisenberg, R J]]

OCA at 17:36, 25 December 2014

OCA — Thu, 25 Dec 2014 17:36:50 GMT

←Older revision		Revision as of 17:36, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nw8 RCSB], [http://www.ebi.ac.uk/pdbsum/3nw8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nw8 RCSB], [http://www.ebi.ac.uk/pdbsum/3nw8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GB_HHV1K GB_HHV1K]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).<ref>PMID:17299053</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:28, 9 December 2014

OCA — Tue, 09 Dec 2014 12:28:08 GMT

←Older revision		Revision as of 12:28, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3nw8.~~png~~\|~~left~~\|~~200px~~]]	+	==Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, high-pH==
		+	<StructureSection load='3nw8' size='340' side='right' caption='[[3nw8]], [[Resolution\|resolution]] 2.76Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3nw8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NW8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MRY:MESO-ERYTHRITOL'>MRY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gum\|2gum]], [[3nwa\|3nwa]], [[3nwd\|3nwd]], [[3nwf\|3nwf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gB, UL27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10298 Human herpesvirus 1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nw8 RCSB], [http://www.ebi.ac.uk/pdbsum/3nw8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Herpesviruses enter cells by membrane fusion either at the plasma membrane or in endosomes, depending on the cell type. Glycoprotein B (gB) is a conserved component of the multiprotein herpesvirus fusion machinery and functions as a fusion protein, with two internal fusion loops, FL1 and FL2. We determined the crystal structures of the ectodomains of two FL1 mutants of herpes simplex virus type 1 (HSV-1) gB to clarify whether their fusion-null phenotypes were due to global or local effects of the mutations on the structure of the gB ectodomain. Each mutant has a single point mutation of a hydrophobic residue in FL1 that eliminates the hydrophobic side chain. We found that neither mutation affected the conformation of FL1, although one mutation slightly altered the conformation of FL2, and we conclude that the fusion-null phenotype is due to the absence of a hydrophobic side chain at the mutated position. Because the ectodomains of the wild-type and the mutant forms of gB crystallized at both low and neutral pH, we were able to determine the effect of pH on gB conformation at the atomic level. For viruses that enter cells by endocytosis, the low pH of the endosome effects major conformational changes in their fusion proteins, thereby promoting fusion of the viral envelope with the endosomal membrane. We show here that upon exposure of gB to low pH, FL2 undergoes a major relocation, probably driven by protonation of a key histidine residue. Relocation of FL2, as well as additional small conformational changes in the gB ectodomain, helps explain previously noted changes in its antigenic and biochemical properties. However, no global pH-dependent changes in gB structure were detected in either the wild-type or the mutant forms of gB. Thus, low pH causes local conformational changes in gB that are very different from the large-scale fusogenic conformational changes in other viral fusion proteins. We propose that these conformational changes, albeit modest, play an important functional role during endocytic entry of HSV.

-	~~{{STRUCTURE_3nw8\| PDB=3nw8 \| SCENE= }}~~	+	Structural Basis of Local, pH-Dependent Conformational Changes in Glycoprotein B from Herpes Simplex Virus Type 1.,Stampfer SD, Lou H, Cohen GH, Eisenberg RJ, Heldwein EE J Virol. 2010 Dec;84(24):12924-33. Epub 2010 Oct 13. PMID:20943984<ref>PMID:20943984</ref>

-	~~===Glycoprotein B from Herpes simplex virus type 1~~, ~~Y179S mutant, high-pH===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20943984}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3nw8]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_herpesvirus_1 Human herpesvirus 1]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA].~~	+

	==See Also==		==See Also==
	*[[Glycoproteins B and D\|Glycoproteins B and D]]		*[[Glycoproteins B and D\|Glycoproteins B and D]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020943984<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Human herpesvirus 1]]		[[Category: Human herpesvirus 1]]
-	[[Category: Cohen, G H.]]	+	[[Category: Cohen, G H]]
-	[[Category: Eisenberg, R J.]]	+	[[Category: Eisenberg, R J]]
-	[[Category: Heldwein, E E.]]	+	[[Category: Heldwein, E E]]
-	[[Category: Lou, H.]]	+	[[Category: Lou, H]]
-	[[Category: Stampfer, S D.]]	+	[[Category: Stampfer, S D]]
	[[Category: Envelope glycoprotein]]		[[Category: Envelope glycoprotein]]
	[[Category: Glycoprotein b]]		[[Category: Glycoprotein b]]

OCA at 19:32, 20 October 2012

OCA — Sat, 20 Oct 2012 19:32:08 GMT

←Older revision		Revision as of 19:32, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3nw8]] is a 4 chain structure ~~of [[Glycoproteins B and D]]~~ with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA].	+	[[3nw8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA].

	==See Also==		==See Also==

OCA at 07:40, 27 July 2012

OCA — Fri, 27 Jul 2012 07:40:06 GMT

←Older revision		Revision as of 07:40, 27 July 2012
Line 1:		Line 1:
	[[Image:3nw8.png\|left\|200px]]		[[Image:3nw8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3nw8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3nw8\| PDB=3nw8 \| SCENE= }}		{{STRUCTURE_3nw8\| PDB=3nw8 \| SCENE= }}

	===Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, high-pH===		===Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, high-pH===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20943984}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20943984 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20943984}}		{{ABSTRACT_PUBMED_20943984}}

	==About this Structure==		==About this Structure==
-	[[3nw8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA].	+	[[3nw8]] is a 4 chain structure of [[Glycoproteins B and D]] with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA].
		+
		+	==See Also==
		+	*[[Glycoproteins B and D\|Glycoproteins B and D]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20943984~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020943984</ref><references group="xtra"/>
	[[Category: Human herpesvirus 1]]		[[Category: Human herpesvirus 1]]
	[[Category: Cohen, G H.]]		[[Category: Cohen, G H.]]
Line 29:		Line 21:
	[[Category: Lou, H.]]		[[Category: Lou, H.]]
	[[Category: Stampfer, S D.]]		[[Category: Stampfer, S D.]]
		+	[[Category: Envelope glycoprotein]]
		+	[[Category: Glycoprotein b]]
		+	[[Category: Herpesvirus 1]]
		+	[[Category: Hsv-1]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane fusion]]
		+	[[Category: Viral protein]]

OCA: Protected "3nw8" [edit=sysop:move=sysop]

OCA — Wed, 12 Jan 2011 05:26:11 GMT

Protected "3nw8" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 12 January 2011

OCA at 05:26, 12 January 2011

OCA — Wed, 12 Jan 2011 05:26:09 GMT

←Older revision

Revision as of 05:26, 12 January 2011

OCA at 08:20, 1 December 2010

OCA — Wed, 01 Dec 2010 08:20:40 GMT

←Older revision		Revision as of 08:20, 1 December 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3nw8.jpg\|left\|200px]]

-	The ~~entry 3nw8~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3nw8", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3nw8\| PDB=3nw8 \| SCENE= }}

-	~~Authors: Stampfer~~, ~~S.D.~~, ~~Lou, H., Cohen, G.H., Eisenberg, R.J., Heldwein, E.E.~~	+	===Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, high-pH===

-	Description: Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, high-pH

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug~~ ~~4 08~~:50:19 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20943984}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20943984 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20943984}}
		+
		+	==About this Structure==
		+	3NW8 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW8 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20943984</ref><references group="xtra"/>
		+	[[Category: Human herpesvirus 1]]
		+	[[Category: Cohen, G H.]]
		+	[[Category: Eisenberg, R J.]]
		+	[[Category: Heldwein, E E.]]
		+	[[Category: Lou, H.]]
		+	[[Category: Stampfer, S D.]]
		+	[[Category: Envelope glycoprotein]]
		+	[[Category: Glycoprotein b]]
		+	[[Category: Herpesvirus 1]]
		+	[[Category: Hsv-1]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane fusion]]
		+	[[Category: Viral protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:32:26 2010''