3ny7 - Revision history

OCA at 10:02, 14 February 2024

OCA — Wed, 14 Feb 2024 10:02:04 GMT

←Older revision		Revision as of 10:02, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='3ny7' size='340' side='right'caption='[[3ny7]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='3ny7' size='340' side='right'caption='[[3ny7]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ny7]] is a 2 chain structure with sequence from ~~[https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and~~ [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NY7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ny7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NY7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SXM:3-{[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-3-OXOPROPANOIC+ACID'>SXM</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.922Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ychM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SXM:3-{[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-3-OXOPROPANOIC+ACID'>SXM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny7 OCA], [https://pdbe.org/3ny7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ny7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ny7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ny7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny7 OCA], [https://pdbe.org/3ny7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ny7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ny7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ny7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~C6EHC0_ECOBD C6EHC0_ECOBD~~]~~] Carrier~~ of ~~the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]~~	+	[https://www.uniprot.org/uniprot/DAUA_ECOLI DAUA_ECOLI] Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH (PubMed:23278959). Can transport other C4-dicarboxylic acids such as aspartate and fumarate (PubMed:23278959). May also play a role in the regulation of C4-dicarboxylic acid metabolism at pH 7, via regulation of expression and/or activity of DctA. May act as a co-sensor of DcuS (PubMed:23278959).<ref>PMID:23278959</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract~~ from ~~PubMed ==~~	+
-	~~Escherichia coli YchM is a member of~~ the SLC26 (SulP) family of anion transporters with an N-terminal membrane domain and a C-terminal cytoplasmic STAS domain. Mutations in human members of the SLC26 family, including their STAS domain, are linked to ~~a number of inherited diseases. Herein, we describe~~ the ~~high-resolution crystal structure of the STAS domain from E. coli YchM isolated in complex with acyl-carrier protein~~ (~~ACP~~)~~, an essential component of the fatty acid biosynthesis (FAB) pathway~~. ~~A genome~~-~~wide genetic interaction screen showed that a ychM null mutation is synthetically lethal with mutant alleles of genes~~ (~~fabBDHGAI~~) ~~involved in FAB~~. ~~Endogenous YchM~~ also ~~copurified with proteins involved in fatty acid metabolism. Furthermore,~~ a ~~deletion strain lacking ychM showed altered cellular bicarbonate incorporation~~ in the ~~presence~~ of ~~NaCl and impaired growth~~ at ~~alkaline~~ pH~~. Thus~~, ~~identification~~ of ~~the STAS~~-~~ACP complex suggests that YchM sequesters ACP to the bacterial membrane linking bicarbonate transport with fatty acid metabolism.~~	+
-		+
-	~~Structure~~ of ~~a SLC26 anion transporter STAS domain in complex with acyl carrier protein~~: ~~implications for E. coli YchM in fatty acid metabolism.,Babu M, Greenblatt JF, Emili A, Strynadka NC, Reithmeier RA, Moraes TF Structure. 2010 Nov 10;18(11~~)~~:1450-62~~. ~~PMID:21070944~~<ref>PMID:~~21070944~~</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3ny7" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 26:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus coli migula 1895]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Moraes~~, T F~~]]	+	[[Category: Moraes TF]]
-	[[Category: Reithmeier, R]]	+	[[Category: Reithmeier R]]
-	[[Category: Strynadka~~, N C.S]]~~	+	[[Category: Strynadka NCS]]
-	~~[[Category: 4'-phosphopantetheine]]~~	+
-	~~[[Category: Acyl carrier protein]]~~	+
-	~~[[Category: Anion transport]]~~	+
-	~~[[Category: Bicarbonate transport]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Ser 36 of acp]]~~	+
-	~~[[Category: Slc26]]~~	+
-	~~[[Category: Stas domain]]~~	+
-	~~[[Category: Ychm~~]]	+

OCA at 07:11, 12 May 2022

OCA — Thu, 12 May 2022 07:11:52 GMT

←Older revision		Revision as of 07:11, 12 May 2022
Line 1:		Line 1:

	==STAS domain of YchM bound to ACP==		==STAS domain of YchM bound to ACP==
-	<StructureSection load='3ny7' size='340' side='right' caption='[[3ny7]], [[Resolution\|resolution]] 1.92Å' scene=''>	+	<StructureSection load='3ny7' size='340' side='right'caption='[[3ny7]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ny7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [~~http~~://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3NY7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ny7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NY7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SXM:3-{[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-3-OXOPROPANOIC+ACID'>SXM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SXM:3-{[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-3-OXOPROPANOIC+ACID'>SXM</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ychM ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ychM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny7 OCA], [~~http~~://pdbe.org/3ny7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ny7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ny7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ny7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny7 OCA], [https://pdbe.org/3ny7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ny7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ny7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ny7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/C6EHC0_ECOBD C6EHC0_ECOBD]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]	+	[[https://www.uniprot.org/uniprot/C6EHC0_ECOBD C6EHC0_ECOBD]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Acyl carrier protein\|Acyl carrier protein]]	+	*[[Acyl carrier protein 3D structures\|Acyl carrier protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
		+	[[Category: Large Structures]]
	[[Category: Moraes, T F]]		[[Category: Moraes, T F]]
	[[Category: Reithmeier, R]]		[[Category: Reithmeier, R]]

OCA at 07:50, 5 August 2016

OCA — Fri, 05 Aug 2016 07:50:08 GMT

←Older revision		Revision as of 07:50, 5 August 2016
Line 1:		Line 1:
		+
	==STAS domain of YchM bound to ACP==		==STAS domain of YchM bound to ACP==
	<StructureSection load='3ny7' size='340' side='right' caption='[[3ny7]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='3ny7' size='340' side='right' caption='[[3ny7]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ny7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NY7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ny7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NY7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SXM:3-{[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-3-OXOPROPANOIC+ACID'>SXM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SXM:3-{[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-3-OXOPROPANOIC+ACID'>SXM</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ychM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ychM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ny7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny7 OCA], [http://pdbe.org/3ny7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ny7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ny7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~C5W3Z7_ECOBB C5W3Z7_ECOBB~~]] Carrier of the growing fatty acid chain in fatty acid biosynthesis ~~(By similarity)~~.[RuleBase:RU003545~~][HAMAP-Rule:MF_01217~~]	+	[[http://www.uniprot.org/uniprot/C6EHC0_ECOBD C6EHC0_ECOBD]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU003545]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ny7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Moraes, T F]]		[[Category: Moraes, T F]]

OCA at 00:26, 25 December 2014

OCA — Thu, 25 Dec 2014 00:26:42 GMT

←Older revision		Revision as of 00:26, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ny7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ny7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C5W3Z7_ECOBB C5W3Z7_ECOBB]] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[RuleBase:RU003545][HAMAP-Rule:MF_01217]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:24, 19 December 2014

OCA — Fri, 19 Dec 2014 07:24:58 GMT

←Older revision		Revision as of 07:24, 19 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ny7\| PDB=3ny7 \| SCENE= }}~~	+	==STAS domain of YchM bound to ACP==
-	===STAS domain of YchM bound to ACP===	+	<StructureSection load='3ny7' size='340' side='right' caption='[[3ny7]], [[Resolution\|resolution]] 1.92Å' scene=''>
-	{{~~ABSTRACT_PUBMED_21070944~~}}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ny7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NY7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SXM:3-{[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-3-OXOPROPANOIC+ACID'>SXM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ychM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ny7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ny7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Escherichia coli YchM is a member of the SLC26 (SulP) family of anion transporters with an N-terminal membrane domain and a C-terminal cytoplasmic STAS domain. Mutations in human members of the SLC26 family, including their STAS domain, are linked to a number of inherited diseases. Herein, we describe the high-resolution crystal structure of the STAS domain from E. coli YchM isolated in complex with acyl-carrier protein (ACP), an essential component of the fatty acid biosynthesis (FAB) pathway. A genome-wide genetic interaction screen showed that a ychM null mutation is synthetically lethal with mutant alleles of genes (fabBDHGAI) involved in FAB. Endogenous YchM also copurified with proteins involved in fatty acid metabolism. Furthermore, a deletion strain lacking ychM showed altered cellular bicarbonate incorporation in the presence of NaCl and impaired growth at alkaline pH. Thus, identification of the STAS-ACP complex suggests that YchM sequesters ACP to the bacterial membrane linking bicarbonate transport with fatty acid metabolism.

-	~~==Function==~~	+	Structure of a SLC26 anion transporter STAS domain in complex with acyl carrier protein: implications for E. coli YchM in fatty acid metabolism.,Babu M, Greenblatt JF, Emili A, Strynadka NC, Reithmeier RA, Moraes TF Structure. 2010 Nov 10;18(11):1450-62. PMID:21070944<ref>PMID:21070944</ref>
-	~~[[http~~:~~//www~~.~~uniprot.org/uniprot/C5W3Z7_ECOBB C5W3Z7_ECOBB]] Carrier of the growing fatty acid chain~~ in fatty acid ~~biosynthesis~~ (~~By similarity~~)~~.[RuleBase~~:~~RU003545][HAMAP~~-~~Rule~~:~~MF_01217]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ny7]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021070944</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Acyl carrier protein\|Acyl carrier protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Moraes, T F.]]	+	[[Category: Moraes, T F]]
-	[[Category: Reithmeier, R.]]	+	[[Category: Reithmeier, R]]
-	[[Category: Strynadka, N C.S.]]	+	[[Category: Strynadka, N C.S]]
	[[Category: 4'-phosphopantetheine]]		[[Category: 4'-phosphopantetheine]]
	[[Category: Acyl carrier protein]]		[[Category: Acyl carrier protein]]

OCA: Protected "3ny7" [edit=sysop:move=sysop]

OCA — Wed, 24 Apr 2013 12:08:09 GMT

Protected "3ny7" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:08, 24 April 2013

OCA at 12:08, 24 April 2013

OCA — Wed, 24 Apr 2013 12:08:06 GMT

←Older revision		Revision as of 12:08, 24 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3ny7.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ny7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ny7\| PDB=3ny7 \| SCENE= }}		{{STRUCTURE_3ny7\| PDB=3ny7 \| SCENE= }}
-
	===STAS domain of YchM bound to ACP===		===STAS domain of YchM bound to ACP===
		+	{{ABSTRACT_PUBMED_21070944}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/C5W3Z7_ECOBB C5W3Z7_ECOBB]] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[RuleBase:RU003545][HAMAP-Rule:MF_01217]
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21070944}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 21070944 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21070944}}~~	+

	==About this Structure==		==About this Structure==
-	~~3NY7~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA].	+	[[3ny7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21070944~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021070944</ref><references group="xtra"/><references/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Moraes, T F.]]		[[Category: Moraes, T F.]]
Line 37:		Line 24:
	[[Category: Stas domain]]		[[Category: Stas domain]]
	[[Category: Ychm]]		[[Category: Ychm]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:33:04 2010''

OCA at 08:21, 1 December 2010

OCA — Wed, 01 Dec 2010 08:21:18 GMT

←Older revision		Revision as of 08:21, 1 December 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ny7.jpg\|left\|200px]]

-	The ~~entry 3ny7~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ny7", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ny7\| PDB=3ny7 \| SCENE= }}

-	~~Authors: Moraes, T.F., Reithmeier, R., Strynadka, N.C.S.~~	+	===STAS domain of YchM bound to ACP===

-	Description: STAS domain of YchM bound to ACP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 28 12~~:26:36 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21070944}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21070944 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21070944}}
		+
		+	==About this Structure==
		+	3NY7 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY7 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21070944</ref><references group="xtra"/>
		+	[[Category: Escherichia coli]]
		+	[[Category: Moraes, T F.]]
		+	[[Category: Reithmeier, R.]]
		+	[[Category: Strynadka, N C.S.]]
		+	[[Category: 4'-phosphopantetheine]]
		+	[[Category: Acyl carrier protein]]
		+	[[Category: Anion transport]]
		+	[[Category: Bicarbonate transport]]
		+	[[Category: Membrane protein]]
		+	[[Category: Ser 36 of acp]]
		+	[[Category: Slc26]]
		+	[[Category: Stas domain]]
		+	[[Category: Ychm]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:33:04 2010''

OCA at 08:19, 28 July 2010

OCA — Wed, 28 Jul 2010 08:19:53 GMT

←Older revision		Revision as of 08:19, 28 July 2010
Line 3:		Line 3:
	The entry 3ny7 is ON HOLD		The entry 3ny7 is ON HOLD

-	Authors: Moraes, T.F, Reithmeier, R, Strynadka N.C.S	+	Authors: Moraes, T.F., Reithmeier, R., Strynadka, N.C.S.

	Description: STAS domain of YchM bound to ACP		Description: STAS domain of YchM bound to ACP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~21 10~~:07:06 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:26:36 2010''

OCA: New page: '''Unreleased structure''' The entry 3ny7 is ON HOLD Authors: Moraes, T.F, Reithmeier, R, Strynadka N.C.S Description: STAS domain of YchM bound to ACP ''Page seeded by [http://oca.we...

OCA — Wed, 21 Jul 2010 06:00:41 GMT

New page: '''Unreleased structure''' The entry 3ny7 is ON HOLD Authors: Moraes, T.F, Reithmeier, R, Strynadka N.C.S Description: STAS domain of YchM bound to ACP ''Page seeded by [http://oca.we...

New page

'''Unreleased structure'''

The entry 3ny7 is ON HOLD

Authors: Moraes, T.F, Reithmeier, R, Strynadka N.C.S

Description: STAS domain of YchM bound to ACP

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:07:06 2010''